PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins.

PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins.
PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins. Elife. 2019 Oct 30;8: Authors: Berndsen K, Lis P, Yeshaw WM, Wawro PS, Nirujogi RS, Wightman M, Macartney T, Dorward M, Knebel A, Tonelli F, Pfeffer SR, Alessi DR Abstract Mutations that activate LRRK2 protein kinase cause Parkinson's disease. LRRK2 phosphorylates a subset of Rab GTPases within their Switch-II motif ... read more
Source: PubMedPublished on 2019-10-31