Predicting the longitudinal changes of levodopa dose requirements in Parkinson’s disease using item response theory assessment of real-world Unified Parkinson’s Disease Rating Scale

Predicting the longitudinal changes of levodopa dose requirements in Parkinson’s disease using item response theory assessment of real-world Unified Parkinson’s Disease Rating Scale
CPT Pharmacometrics Syst Pharmacol. 2021 May 3. doi: 10.1002/psp4.12632. Online ahead of print.ABSTRACTItem response theory (IRT) has been recently adopted to successfully characterize the progression of Parkinson's disease using serial Unified Parkinson's Disease Rating Scale (UPDRS) measurements. However, it has yet to be applied in predicting the longitudinal changes of levodopa dose requirements in the real-world setting. Here we use ... read more
Source: PubMedPublished on 2021-05-03By Dongwoo Chae