Progression of Clinical and Eye Movement Markers in Preataxic Carriers of Machado-Joseph Disease

Progression of Clinical and Eye Movement Markers in Preataxic Carriers of Machado-Joseph Disease
Mov Disord. 2022 Sep 21. doi: 10.1002/mds.29226. Online ahead of print.ABSTRACTBACKGROUND: Little is known about preclinical stages of Machado-Joseph disease, a polyglutamine disorder characterized by progressive adult-onset ataxia.OBJECTIVE: We aimed to describe the longitudinal progression of clinical and oculomotor variables in the preataxic phase of disease.METHODS: Carriers and noncarriers were assessed at three visits. Preataxic carriers (Scale for Assessment and ... read more
Source: PubMedPublished on 2022-09-21By Camila Maria de Oliveira