Proteostasis unbalance in prion diseases: Mechanisms of neurodegeneration and therapeutic targets

Proteostasis unbalance in prion diseases: Mechanisms of neurodegeneration and therapeutic targets
Front Neurosci. 2022 Sep 6;16:966019. doi: 10.3389/fnins.2022.966019. eCollection 2022.ABSTRACTTransmissible spongiform encephalopathies (TSEs), or prion diseases, are progressive neurodegenerative disorders of the central nervous system that affect humans and animals as sporadic, inherited, and infectious forms. Similarly to Alzheimer's disease and other neurodegenerative disorders, any attempt to reduce TSEs' lethality or increase the life expectancy of affected individuals has been unsuccessful. ... read more
Source: PubMedPublished on 2022-09-23By Stefano Thellung