Regulation of Parkin expression as the key balance between neural survival and cancer cell death

Regulation of Parkin expression as the key balance between neural survival and cancer cell death
Biochem Pharmacol. 2021 Jun 7:114650. doi: 10.1016/j.bcp.2021.114650. Online ahead of print.ABSTRACTParkin is a cytosolic E3 ubiquitin ligase that plays an important role in neuroprotection by targeting several proteins to be degraded by the 26S proteasome. Its dysfunction has been associated not only with Parkinson's disease (PD) but also with other neurodegenerative pathologies, such as Alzheimer's disease and Huntington's disease. More ... read more
Source: PubMedPublished on 2021-06-10By Fátima E Murillo-González