Reply to the Letter “What does characterize exercise guidelines for Parkinson’s disease?”

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• Monthly Research Review – December 2020 December 31, 2020   At the end of each month the SoPD writes a post which provides an overview of some of the major pieces of Parkinson’s-related research that were made available during December 2020. The post is divided into seven parts based on the type of research: Basic biology Disease mechanism Clinical research New clinical trials Clinical trial news Conferences/lectures Other news…
• Coronavirus and treatment for Parkinson’s June 25, 2020 How has the coronavirus crisis affected access to Parkinson’s treatment? Four healthcare professionals share how hospitals in Europe have adapted, and their advice for people with Parkinson’s during the pandemic What do we know about the relationship between coronavirus and Parkinson’s? Joaquim Ferreira, neurologist, Portugal: There is still scarce information regarding many clinical aspects of this infection and its potential…
• Coronavirus and treatment for Parkinson’s June 25, 2020 How has the coronavirus crisis affected access to Parkinson’s treatment? Four healthcare professionals share how hospitals in Europe have adapted, and their advice for people with Parkinson’s during the pandemic What do we know about the relationship between coronavirus and Parkinson’s? Joaquim Ferreira, neurologist, Portugal: There is still scarce information regarding many clinical aspects of this infection and its potential…
• Neurological Mayhem by Dual Antioxidative and Anti-inflammatory Agents in Aged Parkinson’s Mice February 26, 2019 “No person was ever honored for what he received. Honor has been the reward for what he gave.” Calvin Coolidge “The most reliable way to predict the future is to create it.” Abraham Lincoln Introduction: Recently, Jeff Keegan asked me if I had seen the paper by Gil-Martínez et al., an established Parkinson’s research group in Spain (click here to…
• 2020: Year in Review January 1, 2021 # # # # In this end-of-year post, we review the Parkinson’s research that caught our attention at SoPD HQ in 2020. Month-by-month we will briefly discuss some of the major pieces of research/ announcements that have defined the year and advanced our understanding of Parkinson’s. The list is based on nothing more than the author’s personal opinion – apologies…
• The Mitochondrial Permeability Transition: Nexus of Aging, Disease and Longevity. January 10, 2021 Related ArticlesThe Mitochondrial Permeability Transition: Nexus of Aging, Disease and Longevity. Cells. 2021 Jan 06;10(1): Authors: Rottenberg H, Hoek JB Abstract The activity of the mitochondrial permeability transition pore, mPTP, a highly regulated multi-component mega-channel, is enhanced in aging and in aging-driven degenerative diseases. mPTP activity accelerates aging by releasing large amounts of cell-damaging reactive oxygen species, Ca2+ and NAD+.…
• Investigating Users' and Other Stakeholders' Needs in the Development of a Personalized Integrated Care Platform (PROCare4Life) for Older People with Dementia or Parkinson Disease: Protocol for a Mixed Methods Study. January 13, 2021 Related ArticlesInvestigating Users' and Other Stakeholders' Needs in the Development of a Personalized Integrated Care Platform (PROCare4Life) for Older People with Dementia or Parkinson Disease: Protocol for a Mixed Methods Study. JMIR Res Protoc. 2021 Jan 12;10(1):e22463 Authors: Ahmed M, Marín M, Bouça-Machado R, How D, Judica E, Tropea P, Bentlage E, Brach M Abstract BACKGROUND: Dementias-including Alzheimer disease-and Parkinson…
• Pre-ataxic Changes of Clinical Scales and Eye Movement in Machado-Joseph Disease: BIGPRO Study. January 14, 2021 Related ArticlesPre-ataxic Changes of Clinical Scales and Eye Movement in Machado-Joseph Disease: BIGPRO Study. Mov Disord. 2021 Jan 13;: Authors: de Oliveira CM, Leotti VB, Bolzan G, Cappelli AH, Rocha AG, Ecco G, Kersting N, Rieck M, Martins AC, Sena LS, Saraiva-Pereira ML, Jardim LB Abstract BACKGROUND: The pathological burden of spinocerebellar ataxia type 3, also known as Machado-Joseph disease…
• Parkinson's Disease News - Editor's Picks (Archive 2016.10) November 28, 2016 Newsfeed: PD News PD Research News PD Fitness News PD Boxing News PD Web Articles PD Blogs PD Editor's Picks PD Twitter Newsfeed LA Tech’s “Rock Steady Boxing” helping people fight Parkinson’s Disease – Knoe.comKnoe.comLA Tech's 'Rock Steady Boxing' helping people fight Parkinson's DiseaseKnoe.comNeal was an ENT specialist until he got hit by the disease just a few years ago.…
• Neuroimmunology Experts Survey January 9, 2021 “What attracted me to immunology was that the whole thing seemed to revolve around a very simple experiment: take two different antibody molecules and compare their primary sequences. The secret of antibody diversity would emerge from that. Fortunately at the time I was sufficiently ignorant of the subject not to realize how naive I was being.”— César Milstein From Nobel Lecture…
• Moments of Victory® – Jan Grimes Found the Silver Lining in Her Parkinson’s Diagnosis July 5, 2018 What has your life been like since your diagnosis? I retired in May 2017, from Louisiana State University where I was a professional collaborative pianist for 30 years and collaborated in recitals with over 650 faculty members and students. Because my identity as a pianist was so strong, I found it necessary to redefine myself and discover who I was…
• The road ahead: 2020 January 5, 2020 Here at the SoPD, we are primarily interested in disease modification for Parkinson’s. While there is a great deal of interesting research exploring the causes of the condition, novel symptomatic therapies, and other aspects of Parkinson’s, my focus is generally on the science seeking to slow, stop or reverse the condition. At the start of each year, it is a…
• Reply to the letter "Waist circumference or sarcopenic obesity; which is more predictive?" August 2, 2019 Related ArticlesReply to the letter "Waist circumference or sarcopenic obesity; which is more predictive?" Aging Clin Exp Res. 2019 Jul 31;: Authors: Liao Q, Xiu S, Chan P PMID: 31368090 [PubMed - as supplied by publisher]
• The inflammasome field is heating up December 6, 2019   When a cell is sick or damaged it will send out signals alerting the immune system that something is wrong. If enough of these molecules are released, they will initate an “immune response” and this process is called inflammation. There is evidence in neurodegenerative conditions (like Parkinson’s and Alzheimer’s) that the inflammation process is involved, and inhibitors of particular…
• Resveratrol delays 6-hydroxydopamine-induced apoptosis by activating the PI3K/Akt signaling pathway. July 12, 2019 Resveratrol delays 6-hydroxydopamine-induced apoptosis by activating the PI3K/Akt signaling pathway. Exp Gerontol. 2019 Jul 08;:110653 Authors: Huang N, Zhang Y, Chen M, Jin H, Nie J, Luo Y, Zhou S, Shi J, Jin F Abstract This study aimed to determine whether resveratrol (Res) delays the progression of 6-hydroxydopamine (6-OHDA)-induced apoptosis via activating the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) signaling…
• Results in AI for aging research and personal health data management to be presented at Bio-Taiwan June 19, 2017 (InSilico Medicine, Inc.) Monday, 19th of May, 2017, Baltimore, MD - Insilico Medicine, a Baltimore-based artificial intelligence company focused on drug discovery, biomarker development and aging research will present new research at Bio-Taiwan in Taipei, Taiwan, June 28-29. The CEO of Insilico Medicine, Alex Zhavoronkov, PhD, will present new research in deep learned multi-modal biomarkers of aging and unveil a…
• Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). October 26, 2016 Related ArticlesGuidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016;12(1):1-222 Authors: Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S,…
• Changes in Innate Immunity, Cell Waste Disposal Process Linked to Loss of Dopaminergic Neurons in Early Study January 7, 2019 Together with aging, the disruption of a cell’s waste disposal system and exaggerated immune responses can lead to the progressive loss of dopamine-producing neurons seen in diseases like Parkinson’s, according to new research in fruit flies. The study, “Hyperactive Innate Immunity Causes Degeneration of Dopamine Neurons upon Altering Activity of Cdk5,” was published in the journal Cell Reports. Immune responses in…
• The Minnesota UDCA study February 15, 2020   The results of a small clinical study evaluating the safety and tolerability of Ursodeoxycholic acid (or UDCA) in people with Parkinson’s have recently been published. UDCA is a naturally occurring bile acid that is used in the treatment of gallstones. More recently, however, researchers have reported that this clinically available medication has beneficial effects in models of Parkinson’s. The…
• Ubiquitin-related network underlain by (CAG)n loci modulate age at onset in Machado-Joseph disease. March 24, 2017 Ubiquitin-related network underlain by (CAG)n loci modulate age at onset in Machado-Joseph disease. Brain. 2017 Feb 15;: Authors: Chen Z, Wang C, Zheng C, Long Z, Cao L, Li X, Shang H, Yin X, Zhang B, Liu J, Ding D, Peng Y, Peng H, Ye W, Qiu R, Pan Q, Xia K, Chen S, Sequeiros J, Ashizawa T, Tang B,…
• Model of Cell Aging and Damage May Help in Understanding Parkinson’s Onset October 21, 2019 A newly created model helps to clarify the processes by which cells grow old and die, and which are known to be involved in the onset of neurodegenerative disorders like Alzheimer’s and Parkinson’s disease. The study describing this model, “Proteostasis collapse is a driver of cell aging and death,” was published in PNAS. To remain healthy, cells must be able to…
• Would You Want to Know? January 13, 2021 I have been hiding in my living room, with the lights down low, curtains pulled, and with all honesty… not bathing every day.  The first step of recovery is admitting you have a problem… so here goes.  I have just finished 5 Seasons of Outlander on Netflix.  I am addicted to the show.  There, I said it… it’s out there. Whoa. I feel like…