Research sheds light on connection between uric acid and Parkinson′s disease – Medical Dialogues

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• Uric Acid Blood Levels Linked to Dyskinesia Risk in Men with Parkinson’s June 4, 2020 High blood levels of uric acid, a powerful antioxidant, are linked to an increased risk of levodopa-induced dyskinesia in men with Parkinson’s disease, study finds. The study, “Sex-specific association of urate and levodopa-induced dyskinesia in Parkinson’s disease,” was published in the European Journal of Neurology. Dyskinesia, or involuntary muscle movements, is one of the most common complications associated with long-term treatment…
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• A semi-mechanistic exposure-response model to assess the effects of verinurad, a potent URAT1 inhibitor, on serum and urine uric acid in patients with hyperuricemia-associated diseases March 17, 2021 J Pharmacokinet Pharmacodyn. 2021 Mar 17. doi: 10.1007/s10928-021-09747-y. Online ahead of print.ABSTRACTVerinurad, a uric acid transporter 1 (URAT1) inhibitor, lowers serum uric acid by promoting its urinary excretion. Co-administration with a xanthine oxidase inhibitor (XOI) to simultaneously reduce uric acid production rate reduces the potential for renal tubular precipitation of uric acid, which can lead to acute kidney injury. The…
• A semi-mechanistic exposure-response model to assess the effects of verinurad, a potent URAT1 inhibitor, on serum and urine uric acid in patients with hyperuricemia-associated diseases March 17, 2021 J Pharmacokinet Pharmacodyn. 2021 Mar 17. doi: 10.1007/s10928-021-09747-y. Online ahead of print.ABSTRACTVerinurad, a uric acid transporter 1 (URAT1) inhibitor, lowers serum uric acid by promoting its urinary excretion. Co-administration with a xanthine oxidase inhibitor (XOI) to simultaneously reduce uric acid production rate reduces the potential for renal tubular precipitation of uric acid, which can lead to acute kidney injury. The…
• A semi-mechanistic exposure-response model to assess the effects of verinurad, a potent URAT1 inhibitor, on serum and urine uric acid in patients with hyperuricemia-associated diseases March 17, 2021 J Pharmacokinet Pharmacodyn. 2021 Mar 17. doi: 10.1007/s10928-021-09747-y. Online ahead of print.ABSTRACTVerinurad, a uric acid transporter 1 (URAT1) inhibitor, lowers serum uric acid by promoting its urinary excretion. Co-administration with a xanthine oxidase inhibitor (XOI) to simultaneously reduce uric acid production rate reduces the potential for renal tubular precipitation of uric acid, which can lead to acute kidney injury. The…
• A semi-mechanistic exposure-response model to assess the effects of verinurad, a potent URAT1 inhibitor, on serum and urine uric acid in patients with hyperuricemia-associated diseases March 17, 2021 J Pharmacokinet Pharmacodyn. 2021 Mar 17. doi: 10.1007/s10928-021-09747-y. Online ahead of print.ABSTRACTVerinurad, a uric acid transporter 1 (URAT1) inhibitor, lowers serum uric acid by promoting its urinary excretion. Co-administration with a xanthine oxidase inhibitor (XOI) to simultaneously reduce uric acid production rate reduces the potential for renal tubular precipitation of uric acid, which can lead to acute kidney injury. The…
• A semi-mechanistic exposure-response model to assess the effects of verinurad, a potent URAT1 inhibitor, on serum and urine uric acid in patients with hyperuricemia-associated diseases March 17, 2021 J Pharmacokinet Pharmacodyn. 2021 Mar 17. doi: 10.1007/s10928-021-09747-y. Online ahead of print.ABSTRACTVerinurad, a uric acid transporter 1 (URAT1) inhibitor, lowers serum uric acid by promoting its urinary excretion. Co-administration with a xanthine oxidase inhibitor (XOI) to simultaneously reduce uric acid production rate reduces the potential for renal tubular precipitation of uric acid, which can lead to acute kidney injury. The…
• Association of Serum Uric Acid Levels in Meige's Syndrome October 18, 2021 Front Neurosci. 2021 Oct 1;15:755056. doi: 10.3389/fnins.2021.755056. eCollection 2021.ABSTRACTUric acid (URIC) is a natural antioxidant, and it has been shown that low levels of URIC could be a risk factor for the development of Parkinson's disease. Our aim was to investigate whether URIC also plays a role in Meige's syndrome (MS). We conducted a cohort study to compare serum URIC…
• Association of Serum Uric Acid Levels in Meige's Syndrome October 18, 2021 Front Neurosci. 2021 Oct 1;15:755056. doi: 10.3389/fnins.2021.755056. eCollection 2021.ABSTRACTUric acid (URIC) is a natural antioxidant, and it has been shown that low levels of URIC could be a risk factor for the development of Parkinson's disease. Our aim was to investigate whether URIC also plays a role in Meige's syndrome (MS). We conducted a cohort study to compare serum URIC…
• Association of Serum Uric Acid Levels in Meige's Syndrome October 18, 2021 Front Neurosci. 2021 Oct 1;15:755056. doi: 10.3389/fnins.2021.755056. eCollection 2021.ABSTRACTUric acid (URIC) is a natural antioxidant, and it has been shown that low levels of URIC could be a risk factor for the development of Parkinson's disease. Our aim was to investigate whether URIC also plays a role in Meige's syndrome (MS). We conducted a cohort study to compare serum URIC…
• Association of Serum Uric Acid Levels in Meige's Syndrome October 18, 2021 Front Neurosci. 2021 Oct 1;15:755056. doi: 10.3389/fnins.2021.755056. eCollection 2021.ABSTRACTUric acid (URIC) is a natural antioxidant, and it has been shown that low levels of URIC could be a risk factor for the development of Parkinson's disease. Our aim was to investigate whether URIC also plays a role in Meige's syndrome (MS). We conducted a cohort study to compare serum URIC…
• Association of Serum Uric Acid Levels in Meige's Syndrome October 18, 2021 Front Neurosci. 2021 Oct 1;15:755056. doi: 10.3389/fnins.2021.755056. eCollection 2021.ABSTRACTUric acid (URIC) is a natural antioxidant, and it has been shown that low levels of URIC could be a risk factor for the development of Parkinson's disease. Our aim was to investigate whether URIC also plays a role in Meige's syndrome (MS). We conducted a cohort study to compare serum URIC…
• Update on Uric Acid and the Kidney April 14, 2022 Curr Rheumatol Rep. 2022 Apr 14. doi: 10.1007/s11926-022-01069-3. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: In this review, we report on new findings regarding associations of uric acid with kidney health. We discuss kidney stones, effects of uric acid in chronic kidney disease (CKD), and management of gout in CKD. Recent studies on neuroprotective effects of raising uric acid provide interesting…
• Update on Uric Acid and the Kidney April 14, 2022 Curr Rheumatol Rep. 2022 Apr 14. doi: 10.1007/s11926-022-01069-3. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: In this review, we report on new findings regarding associations of uric acid with kidney health. We discuss kidney stones, effects of uric acid in chronic kidney disease (CKD), and management of gout in CKD. Recent studies on neuroprotective effects of raising uric acid provide interesting…
• Update on Uric Acid and the Kidney April 14, 2022 Curr Rheumatol Rep. 2022 Apr 14. doi: 10.1007/s11926-022-01069-3. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: In this review, we report on new findings regarding associations of uric acid with kidney health. We discuss kidney stones, effects of uric acid in chronic kidney disease (CKD), and management of gout in CKD. Recent studies on neuroprotective effects of raising uric acid provide interesting…
• Update on Uric Acid and the Kidney April 14, 2022 Curr Rheumatol Rep. 2022 Apr 14. doi: 10.1007/s11926-022-01069-3. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: In this review, we report on new findings regarding associations of uric acid with kidney health. We discuss kidney stones, effects of uric acid in chronic kidney disease (CKD), and management of gout in CKD. Recent studies on neuroprotective effects of raising uric acid provide interesting…
• Update on Uric Acid and the Kidney April 14, 2022 Curr Rheumatol Rep. 2022 Apr 14. doi: 10.1007/s11926-022-01069-3. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: In this review, we report on new findings regarding associations of uric acid with kidney health. We discuss kidney stones, effects of uric acid in chronic kidney disease (CKD), and management of gout in CKD. Recent studies on neuroprotective effects of raising uric acid provide interesting…
• Update on Uric Acid and the Kidney April 14, 2022 Curr Rheumatol Rep. 2022 Apr 14. doi: 10.1007/s11926-022-01069-3. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: In this review, we report on new findings regarding associations of uric acid with kidney health. We discuss kidney stones, effects of uric acid in chronic kidney disease (CKD), and management of gout in CKD. Recent studies on neuroprotective effects of raising uric acid provide interesting…
• Serum Uric Acid in LRRK2 Related Parkinson's Disease: Longitudinal Data from the PPMI Study March 8, 2021 J Parkinsons Dis. 2021 Mar 4. doi: 10.3233/JPD-202337. Online ahead of print.ABSTRACTBACKGROUND: Previous studies have highlighted serum uric acid as a putative idiopathic Parkinson's disease (iPD) biomarker. Only one study, so far, showed higher levels of serum uric acid in leucine-rich repeat kinase 2 (LRRK + 2) carriers compared to those who developed PD, however a longitudinal comparison between LRRK2…