RIT2 Gene’s Promise in Halting Parkinson’s Disease Progression – Neuroscience News

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• The road ahead: 2022 January 20, 2022 # # # # The first post at the start of each year on the SoPD website tries to provide an overview of where things are in the search for ‘disease modifying’ therapies for Parkinson’s.  It is an exercise in managing expectations as well as discussing what research events are scheduled for the next year so that we can keep…
• The road ahead: 2021 January 25, 2021 # # # # At the start of each year, it is a useful practise to layout what is planned over the next 12 months. The events that are scheduled for the year to come, so that we can keep an eye out for them. Obviously, where 2021 will end actually is unpredictable, but an outline of what is scheduled…
• The road ahead: 2020 January 5, 2020 Here at the SoPD, we are primarily interested in disease modification for Parkinson’s. While there is a great deal of interesting research exploring the causes of the condition, novel symptomatic therapies, and other aspects of Parkinson’s, my focus is generally on the science seeking to slow, stop or reverse the condition. At the start of each year, it is a…
• Rit2 silencing in dopamine neurons drives a progressive Parkinsonian phenotype May 10, 2023 bioRxiv. 2023 Apr 28:2023.04.26.538430. doi: 10.1101/2023.04.26.538430. Preprint.ABSTRACTParkinson's disease (PD) is the second most prevalent neurodegenerative disease and arises from dopamine (DA) neuron death selectively in the substantia nigra pars compacta (SNc) . Rit2 is a reported PD risk allele, and recent single cell transcriptomic studies identified a major RIT2 cluster in PD DA neurons, potentially linking Rit2 expression anomalies to…
• Rit2 silencing in dopamine neurons drives a progressive Parkinsonian phenotype May 10, 2023 bioRxiv. 2023 Apr 28:2023.04.26.538430. doi: 10.1101/2023.04.26.538430. Preprint.ABSTRACTParkinson's disease (PD) is the second most prevalent neurodegenerative disease and arises from dopamine (DA) neuron death selectively in the substantia nigra pars compacta (SNc) . Rit2 is a reported PD risk allele, and recent single cell transcriptomic studies identified a major RIT2 cluster in PD DA neurons, potentially linking Rit2 expression anomalies to…
• Rit2 silencing in dopamine neurons drives a progressive Parkinsonian phenotype May 10, 2023 bioRxiv. 2023 Apr 28:2023.04.26.538430. doi: 10.1101/2023.04.26.538430. Preprint.ABSTRACTParkinson's disease (PD) is the second most prevalent neurodegenerative disease and arises from dopamine (DA) neuron death selectively in the substantia nigra pars compacta (SNc) . Rit2 is a reported PD risk allele, and recent single cell transcriptomic studies identified a major RIT2 cluster in PD DA neurons, potentially linking Rit2 expression anomalies to…
• Rit2 silencing in dopamine neurons drives a progressive Parkinsonian phenotype May 10, 2023 bioRxiv. 2023 Apr 28:2023.04.26.538430. doi: 10.1101/2023.04.26.538430. Preprint.ABSTRACTParkinson's disease (PD) is the second most prevalent neurodegenerative disease and arises from dopamine (DA) neuron death selectively in the substantia nigra pars compacta (SNc) . Rit2 is a reported PD risk allele, and recent single cell transcriptomic studies identified a major RIT2 cluster in PD DA neurons, potentially linking Rit2 expression anomalies to…
• Rit2 silencing in dopamine neurons drives a progressive Parkinsonian phenotype May 10, 2023 bioRxiv. 2023 Apr 28:2023.04.26.538430. doi: 10.1101/2023.04.26.538430. Preprint.ABSTRACTParkinson's disease (PD) is the second most prevalent neurodegenerative disease and arises from dopamine (DA) neuron death selectively in the substantia nigra pars compacta (SNc) . Rit2 is a reported PD risk allele, and recent single cell transcriptomic studies identified a major RIT2 cluster in PD DA neurons, potentially linking Rit2 expression anomalies to…
• The small GTPase Rit2 modulates LRRK2 kinase activity, is required for lysosomal function and protects against alpha-synuclein neuropathology March 27, 2023 NPJ Parkinsons Dis. 2023 Mar 27;9(1):44. doi: 10.1038/s41531-023-00484-2.ABSTRACTIn Parkinson's disease (PD) misfolded alpha-synuclein (aSyn) accumulates in the substantia nigra, where dopaminergic neurons are progressively lost. The mechanisms underlying aSyn pathology are still unclear, but they are hypothesized to involve the autophagy-lysosome pathway (ALP). LRRK2 mutations are a major cause of familial and sporadic PD, and LRRK2 kinase activity has been…
• The small GTPase Rit2 modulates LRRK2 kinase activity, is required for lysosomal function and protects against alpha-synuclein neuropathology March 27, 2023 NPJ Parkinsons Dis. 2023 Mar 27;9(1):44. doi: 10.1038/s41531-023-00484-2.ABSTRACTIn Parkinson's disease (PD) misfolded alpha-synuclein (aSyn) accumulates in the substantia nigra, where dopaminergic neurons are progressively lost. The mechanisms underlying aSyn pathology are still unclear, but they are hypothesized to involve the autophagy-lysosome pathway (ALP). LRRK2 mutations are a major cause of familial and sporadic PD, and LRRK2 kinase activity has been…
• The small GTPase Rit2 modulates LRRK2 kinase activity, is required for lysosomal function and protects against alpha-synuclein neuropathology March 27, 2023 NPJ Parkinsons Dis. 2023 Mar 27;9(1):44. doi: 10.1038/s41531-023-00484-2.ABSTRACTIn Parkinson's disease (PD) misfolded alpha-synuclein (aSyn) accumulates in the substantia nigra, where dopaminergic neurons are progressively lost. The mechanisms underlying aSyn pathology are still unclear, but they are hypothesized to involve the autophagy-lysosome pathway (ALP). LRRK2 mutations are a major cause of familial and sporadic PD, and LRRK2 kinase activity has been…
• RIT2 Gene’s Promise in Halting Parkinson’s Disease Progression May 25, 2023 Researchers identified a protein that could play a significant role in preventing Parkinson's disease. The protein, linked to the RIT2 gene, is believed to control the accumulation of alpha-synuclein, which destroys neuronal cells and is a known indicator of the disease. Experiments conducted in cell models and on mice showed that increasing the expression of the RIT2 gene helped protect…
• A pH-eQTL Interaction at the RIT2-SYT4 Parkinson's Disease Risk Locus in the Substantia Nigra July 26, 2021 Front Aging Neurosci. 2021 Jul 9;13:690632. doi: 10.3389/fnagi.2021.690632. eCollection 2021.ABSTRACTParkinson's disease causes severe motor and cognitive disabilities that result from the progressive loss of dopamine neurons in the substantia nigra. The rs12456492 variant in the RIT2 gene has been repeatedly associated with increased risk for Parkinson's disease. From a transcriptomic perspective, a meta-analysis found that RIT2 gene expression is correlated…
• A pH-eQTL Interaction at the RIT2-SYT4 Parkinson's Disease Risk Locus in the Substantia Nigra July 26, 2021 Front Aging Neurosci. 2021 Jul 9;13:690632. doi: 10.3389/fnagi.2021.690632. eCollection 2021.ABSTRACTParkinson's disease causes severe motor and cognitive disabilities that result from the progressive loss of dopamine neurons in the substantia nigra. The rs12456492 variant in the RIT2 gene has been repeatedly associated with increased risk for Parkinson's disease. From a transcriptomic perspective, a meta-analysis found that RIT2 gene expression is correlated…
• Parkinson's Disease News - Editor's Picks (Archive 2016.09) October 15, 2016 Newsfeed: PD News PD Research News PD Fitness News PD Boxing News PD Web Articles PD Blogs PD Editor's Picks PD Twitter Newsfeed ‘The Terrorist Inside My Husband’s Brain’: Robin Williams’ Widow Details His Disease – Live ScienceLive Science'The Terrorist Inside My Husband's Brain': Robin Williams' Widow Details His DiseaseLive ScienceBut Robin Williams was not diagnosed with Lewy body disease…
• Parkinson's Disease News - Editor's Picks (Archive 2016.07) September 30, 2016 Newsfeed: PD News PD Research News PD Fitness News PD Boxing News PD Web Articles PD Blogs PD Editor's Picks PD Twitter Newsfeed Pedaling for Parkinson’sThat is what it’s like living with Parkinson’s disease. Parkinson’s disease is a chronic, neurodegenerative disorder in which the loss of cells in various parts of the brain leaves people less able to control their…
• Monthly Research Review – July 2021 July 31, 2021 # # # # At the end of each month the SoPD writes a post which provides an overview of some of the major pieces of Parkinson’s-related research that were made available during July 2021. The post is divided into 10 parts based on the type of research: Top 5 pieces of Parkinson’s news Articles of general interest Basic biology…
• Neuroscience week 1 October 2, 2021 Saturday 2 October 2021 The first week of the MSc course in neuroscience I am doing at King’s College London was quite a shock. I had been expecting a gentle introduction: some basics like “what is neuroscience” to lay a foundation, some admin, some meetings with tutors and the like. There were a couple of introductory lectures on topics like…
• The Bluerockers have started July 15, 2021 # # # # On the 8th June, BlueRock Therapeutics put out a press release announcing that the first participant in their Phase I clinical trial of cell transplantation for Parkinson’s had been dosed (Click here to read the press release). The initiation of this clinical trial by the company is a major step forward for them and for the…
• Bayer doubles down on Parkinson’s? December 10, 2020 # # # # News today of two biotech companies merging did not cause much of a ripple in the media, but the wider implications of the move are rather significant for Parkinson’s. Today it was announced that Brain Neurotherapy Bio (BNB) is going to merge with Asklepios Biopharmaceutical (aka AskBio). BNB are currently clinically testing a GDNF gene therapy…
• Monthly Research Review – November 2022 November 30, 2022 # # # # At the end of each month the SoPD writes a post which provides an overview of some of the major pieces of Parkinson’s-related research that were made available during November 2022. The post is divided into 10 parts based on the type of research: Top 5 pieces of Parkinson’s news Articles of general interest Basic biology…
• Prevail lands on a Lilly pad December 15, 2020 # # # # 2020 has been a dreadful year for most of the world – burdened by the outbreak and consequences of COVID-19. Despite this, there has been a steady stream of biotech acquisitions related to Parkinson’s which have helped to keep morale high in the PD research community. In October alone, we saw the Portuguese pharmaceutical company Bial…