Robust α-synuclein pathology in select brainstem neuronal populations is a potential instigator of multiple system atrophy

Robust α-synuclein pathology in select brainstem neuronal populations is a potential instigator of multiple system atrophy
Acta Neuropathol Commun. 2021 May 3;9(1):80. doi: 10.1186/s40478-021-01173-y.ABSTRACTMultiple system atrophy (MSA) is an insidious middle age-onset neurodegenerative disease that clinically presents with variable degrees of parkinsonism and cerebellar ataxia. The pathological hallmark of MSA is the progressive accumulation of glial cytoplasmic inclusions (GCIs) in oligodendrocytes that are comprised of α-synuclein (αSyn) aberrantly polymerized into fibrils. Experimentally, MSA brain samples display ... read more
Source: PubMedPublished on 2021-05-04By Ethan W Hass