Role of post-translational modifications on the alpha-synuclein aggregation-related pathogenesis of Parkinson’s disease

Role of post-translational modifications on the alpha-synuclein aggregation-related pathogenesis of Parkinson’s disease
BMB Rep. 2022 Jun 23:5630. Online ahead of print.ABSTRACTTogether with neuronal loss, the existence of insoluble inclusions of alpha-synuclein (α-syn) in the brain is widely accepted as a hallmark of synucleinopathies including Parkinson's disease (PD), multiple system atrophy, and dementia with Lewy body. Because the α-syn aggregates are deeply involved in the pathogenesis, there have been many attempts to demonstrate ... read more
Source: PubMedPublished on 2022-06-23By Hajung Yoo