Role of TRPA1/TRPV1 in acute ozone exposure induced murine model of airway inflammation and bronchial hyperresponsiveness

Role of TRPA1/TRPV1 in acute ozone exposure induced murine model of airway inflammation and bronchial hyperresponsiveness
J Thorac Dis. 2022 Jul;14(7):2698-2711. doi: 10.21037/jtd-22-315.ABSTRACTBACKGROUND: Transient receptor potential (TRP) ankyrin 1 (TRPA1) and vanilloid 1 (TRPV1) mediate the development of lung injury and inflammation. This study investigated the role and mechanism of the TRPA1/TRPV1 pathway in airway inflammation and bronchial hyperresponsiveness (BHR) induced by acute ozone exposure.METHODS: C57BL/6 mice (8-10 weeks) were intraperitoneally injected with phosphate buffered saline ... read more
Source: PubMedPublished on 2022-08-05By Chenfei Li