Scientists Identify Brain Cells Most Vulnerable to Alzheimer’s Disease – UCSF News Services

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• Natural (born) killers January 28, 2020   Today’s post starts with more of a biology lesson than usual, but it is important to understand where in the grand scheme of things a certain type of blood cell sits. That type of blood cell has a really cool name: Natural killer cells. Recently researchers at the University of Georgia (USA) published a report suggesting that natural killer…
• T-cells: First responders November 4, 2020 # # # # The cause of the cell loss and pathology associated with Parkinson’s is still unknown. While the later stages of the condition have been well investigated based on various pathological marker (ie Braak staging), the early manifestations of the condition are still a mystery. Cells of the immune system are early responders to any signs of trouble…
• The road ahead: 2020 January 5, 2020 Here at the SoPD, we are primarily interested in disease modification for Parkinson’s. While there is a great deal of interesting research exploring the causes of the condition, novel symptomatic therapies, and other aspects of Parkinson’s, my focus is generally on the science seeking to slow, stop or reverse the condition. At the start of each year, it is a…
• Monthly Research Review – November 2020 November 30, 2020   At the end of each month the SoPD writes a post which provides an overview of some of the major pieces of Parkinson’s-related research that were made available during November 2020. The post is divided into seven parts based on the type of research: Basic biology Disease mechanism Clinical research New clinical trials Clinical trial news Conferences/lectures Other news…
• Brain Cells Most Vulnerable to Alzheimer's Disease Identified by Scientists - UCSF News Services January 11, 2021 Brain Cells Most Vulnerable to Alzheimer's Disease Identified by Scientists  UCSF News Services
• Vulnerable, but Not Alone May 14, 2019 “People who know me know I’m strong, but I’m vulnerable.” — Catherine Deneuve Oxford Dictionaries define vulnerability as: “The quality or state of being exposed to the possibility of being attacked or harmed, either physically or emotionally.” Recently, I felt a level of extreme vulnerability that I don’t remember experiencing before. Potentially, this could be due to any of the following…
• Vulnerable, but Not Alone May 14, 2019 “People who know me know I’m strong, but I’m vulnerable.” — Catherine Deneuve Oxford Dictionaries define vulnerability as: “The quality or state of being exposed to the possibility of being attacked or harmed, either physically or emotionally.” Recently, I felt a level of extreme vulnerability that I don’t remember experiencing before. Potentially, this could be due to any of the following…
• Very Keynesian: Cell painting November 25, 2020 # # # # Our ability to grow cells in culture (in petri dishes and flasks in laboratories) has been critical to our efforts to learn more about the biology of Parkinson’s and to screen for novel potential therapies. Recently, researchers have employed more sophisticated methods of characterising cells in culture, to achieve greater insights. These effort have led to…
• New Strategy Targets Parkinson’s by Improving Dopamine Metabolism, Study Reports March 12, 2019 In contrast to what was previously believed, a key protein implicated in Parkinson’s disease — called Nurr1 — can be modulated using naturally existing molecules or engineered small molecules to restore dopamine production in brain cells, according to a study. Conducted by researchers from the University of California San Francisco (UCSF), the new study provides evidence that the activation of Nurr1…
• Milestones in Parkinson’s Disease Research and Discovery April 11, 2017 “The real voyage of discovery consists not in seeking new landscapes, but in having new eyes.” Marcel Proust “The process of scientific discovery is, in effect, a continual flight from wonder.” Albert Einstein Preface:  Happy birthday to James Parkinson (neurologist, geologist, scientist, activist),  born April 11, 1755 and died December 21, 1824.  World Parkinson’s Day April 11, 2017. Introduction to…
• Monthly Research Review – November 2019 November 30, 2019   At the end of each month the SoPD writes a post which provides an overview of some of the major pieces of Parkinson’s-related research that were made available during November 2019. The post is divided into seven parts based on the type of research: Basic biology Disease mechanism Clinical research New clinical trials Clinical trial news Other news Review…
• Monthly research review: February 2020 February 29, 2020   At the end of each month the SoPD writes a post which provides an overview of some of the major pieces of Parkinson’s-related research that were made available during February 2020. The post is divided into seven parts based on the type of research: Basic biology Disease mechanism Clinical research New clinical trials Clinical trial news Other news Review…
• New Brain Pathway Key to Movement Found in PD Patients, Study Reports March 13, 2020 Placing electrodes directly in the brains of people with Parkinson’s disease revealed a “hyperdirect” pathway between two regions of the brain responsible for movement and cognition, a study reported. This pathway was shown to be important in being able to stop body movements once initiated. Modulating or controlling this pathway may be a therapeutic strategy for treating movement disorders such…
• When miro just can’t let go October 8, 2019   Stanford University researchers have recently published an interesting report in which they not only propose a novel biomarker for Parkinson’s, but also provide some compelling data for a novel therapeutic approach. Their research focuses on a protein called Miro, which is involved in the removal of old or faulty mitochondria. Mitochondria are the power stations of each cells, providing…
• That time APOE met Alpha Syn February 10, 2020    Recently two independent research groups published scientific papers providing evidence that a genetic variation associated with Alzheimer’s may also be affecting the severity of pathology in Parkinson’s. The genetic variation associated with Alzheimer’s occurs in a gene (a functional region of DNA) called ApoE, and the Parkinson’s pathology involves the clustering of a protein called alpha synuclein. Specifically, both…
• 2019: Year in review December 31, 2019   In this end-of-year post, we review the Parkinson’s research that caught our attention at SoPD HQ in 2019. Month-by-month we will briefly discuss some of the major pieces of research/announcements that have defined the year and advanced our understanding of Parkinson’s. The list is based on nothing more than the author’s personal opinion – apologies to any researchers who…
• Health charities call for relief as they support vulnerable Ontarians through COVID-19 May 13, 2020 May 7, 2020 Hon. Christine Elliott Minister of Health 5th floor, 777 Bay Street Toronto, Ontario Dear Minister Elliott: As representatives of Ontario’s charitable health sector, we are writing to you with an urgent appeal for a stabilization fund for the province’s nonprofit organizations. The COVID-19 pandemic has posed a fundamental threat to our continued ability to fundraise successfully and…
• Health charities call for relief as they support vulnerable Ontarians through COVID-19 May 13, 2020 May 7, 2020 Hon. Christine Elliott Minister of Health 5th floor, 777 Bay Street Toronto, Ontario Dear Minister Elliott: As representatives of Ontario’s charitable health sector, we are writing to you with an urgent appeal for a stabilization fund for the province’s nonprofit organizations. The COVID-19 pandemic has posed a fundamental threat to our continued ability to fundraise successfully and…
• Health charities call for relief as they support vulnerable Ontarians through COVID-19 May 13, 2020 May 7, 2020 Hon. Christine Elliott Minister of Health 5th floor, 777 Bay Street Toronto, Ontario Dear Minister Elliott: As representatives of Ontario’s charitable health sector, we are writing to you with an urgent appeal for a stabilization fund for the province’s nonprofit organizations. The COVID-19 pandemic has posed a fundamental threat to our continued ability to fundraise successfully and…
• Health charities call for relief as they support vulnerable Ontarians through COVID-19 May 13, 2020 May 7, 2020 Hon. Christine Elliott Minister of Health 5th floor, 777 Bay Street Toronto, Ontario Dear Minister Elliott: As representatives of Ontario’s charitable health sector, we are writing to you with an urgent appeal for a stabilization fund for the province’s nonprofit organizations. The COVID-19 pandemic has posed a fundamental threat to our continued ability to fundraise successfully and…
• Health charities call for relief as they support vulnerable Ontarians through COVID-19 May 13, 2020 May 7, 2020 Hon. Christine Elliott Minister of Health 5th floor, 777 Bay Street Toronto, Ontario Dear Minister Elliott: As representatives of Ontario’s charitable health sector, we are writing to you with an urgent appeal for a stabilization fund for the province’s nonprofit organizations. The COVID-19 pandemic has posed a fundamental threat to our continued ability to fundraise successfully and…
• Health charities call for relief as they support vulnerable Ontarians through COVID-19 May 13, 2020 May 7, 2020 Hon. Christine Elliott Minister of Health 5th floor, 777 Bay Street Toronto, Ontario Dear Minister Elliott: As representatives of Ontario’s charitable health sector, we are writing to you with an urgent appeal for a stabilization fund for the province’s nonprofit organizations. The COVID-19 pandemic has posed a fundamental threat to our continued ability to fundraise successfully and…