Selective activation of striatal indirect pathway suppresses levodopa induced-dyskinesias

Selective activation of striatal indirect pathway suppresses levodopa induced-dyskinesias
Neurobiol Dis. 2022 Nov 19:105930. doi: 10.1016/j.nbd.2022.105930. Online ahead of print.ABSTRACTLevodopa (L-DOPA) administration remains the gold standard therapy for Parkinson's disease (PD). Despite several pharmacological advances in the use of L-DOPA, a high proportion of chronically treated patients continues to suffer disabling involuntary movements, namely, L-DOPA-induced dyskinesias (LIDs). As part of the effort to stop these unwanted side effects, the ... read more
Source: PubMedPublished on 2022-11-22By Iván Castela