SIRT1 Deacetylates TET2 and Promotes Its Ubiquitination Degradation to Achieve Neuroprotection Against Parkinson’s Disease

SIRT1 Deacetylates TET2 and Promotes Its Ubiquitination Degradation to Achieve Neuroprotection Against Parkinson’s Disease
Front Neurol. 2021 Apr 15;12:652882. doi: 10.3389/fneur.2021.652882. eCollection 2021.ABSTRACTThe epigenetic modifications, such as DNA methylation and histone acetylation, play a critical role in the pathogenesis of Parkinson's disease (PD). However, the relationship between DNA methylation and histone acetylation in PD is not fully understood. Previous studies have shown that patients with PD exhibit an epigenetic and transcriptional upregulation of Ten-Eleven ... read more
Source: PubMedPublished on 2021-05-03By Xuan Li