Small extracellular vesicle targeting of hypothalamic AMPKα1 promotes weight loss in leptin receptor deficient mice

Small extracellular vesicle targeting of hypothalamic AMPKα1 promotes weight loss in leptin receptor deficient mice
Metabolism. 2022 Nov 21:155350. doi: 10.1016/j.metabol.2022.155350. Online ahead of print.ABSTRACTBACKGROUND AND AIMS: Leptin receptor (LEPR) deficiency promotes severe obesity and metabolic disorder. However, the current therapeutic options against this syndrome are scarce.METHODS: db/db mice and their wildtypes were systemically treated with neuronal-targeted small extracellular vesicles (sEVs) harboring a plasmid encoding a dominant negative mutant of AMP-activated protein kinase alpha 1 ... read more
Source: PubMedPublished on 2022-11-24By Edward Milbank