Small soluble α-synuclein aggregates are the toxic species in Parkinson’s disease

Small soluble α-synuclein aggregates are the toxic species in Parkinson’s disease
Nat Commun. 2022 Sep 20;13(1):5512. doi: 10.1038/s41467-022-33252-6.ABSTRACTSoluble α-synuclein aggregates varying in size, structure, and morphology have been closely linked to neuronal death in Parkinson's disease. However, the heterogeneity of different co-existing aggregate species makes it hard to isolate and study their individual toxic properties. Here, we show a reliable non-perturbative method to separate a heterogeneous mixture of protein aggregates by ... read more
Source: PubMedPublished on 2022-09-20By Derya Emin