Sorting Through the Extensive and Confusing Roles of Sortilin in Metabolic Disease

Sorting Through the Extensive and Confusing Roles of Sortilin in Metabolic Disease
J Lipid Res. 2022 Jun 17:100243. doi: 10.1016/j.jlr.2022.100243. Online ahead of print.ABSTRACTSortilin is a post-Golgi trafficking receptor homologous to the yeast vacuolar protein sorting receptor 10 (VPS10). The VPS10 motif on sortilin is a 10-bladed β-propeller structure capable of binding > 50 proteins covering a wide range of biological functions, including lipid and lipoprotein metabolism, neuronal growth and death, inflammation, ... read more
Source: PubMedPublished on 2022-06-20By Kelly A Mitok