Spike-Timing-Dependent Plasticity Mediated by Dopamine and its Role in Parkinson’s Disease Pathophysiology

Spike-Timing-Dependent Plasticity Mediated by Dopamine and its Role in Parkinson’s Disease Pathophysiology
Front Netw Physiol. 2022 Mar 4;2:817524. doi: 10.3389/fnetp.2022.817524. eCollection 2022.ABSTRACTParkinson's disease (PD) is a multi-systemic neurodegenerative brain disorder. Motor symptoms of PD are linked to the significant dopamine (DA) loss in substantia nigra pars compacta (SNc) followed by basal ganglia (BG) circuit dysfunction. Increasing experimental and computational evidence indicates that (synaptic) plasticity plays a key role in the emergence of ... read more
Source: PubMedPublished on 2023-03-17By Mojtaba Madadi Asl