Striatal Dopamine Transporter Function Is Facilitated by Converging Biology of α-Synuclein and Cholesterol

Striatal Dopamine Transporter Function Is Facilitated by Converging Biology of α-Synuclein and Cholesterol
Front Cell Neurosci. 2021 Apr 15;15:658244. doi: 10.3389/fncel.2021.658244. eCollection 2021.ABSTRACTStriatal dopamine transporters (DAT) powerfully regulate dopamine signaling, and can contribute risk to degeneration in Parkinson's disease (PD). DATs can interact with the neuronal protein α-synuclein, which is associated with the etiology and molecular pathology of idiopathic and familial PD. Here, we tested whether DAT function in governing dopamine (DA) uptake ... read more
Source: PubMedPublished on 2021-05-03By Sarah Threlfell