Structural analysis of the full-length human LRRK2

Structural analysis of the full-length human LRRK2
Cell. 2021 Jun 3:S0092-8674(21)00601-2. doi: 10.1016/j.cell.2021.05.004. Online ahead of print.ABSTRACTMutations in leucine-rich repeat kinase 2 (LRRK2) are commonly implicated in the pathogenesis of both familial and sporadic Parkinson's disease (PD). LRRK2 regulates critical cellular processes at membranous organelles and forms microtubule-based pathogenic filaments, yet the molecular basis underlying these biological roles of LRRK2 remains largely enigmatic. Here, we determined high-resolution ... read more
Source: PubMedPublished on 2021-06-09By Alexander Myasnikov