Study Shows Age-dependent Spread Of Alpha-synuclein From Gut to Brain in Mice

Study Shows Age-dependent Spread Of Alpha-synuclein From Gut to Brain in Mice
Aggregates of the Parkinson’s disease-associated protein alpha-synuclein can spread from the gut to the brain in mice, but this process is dependent on aging, likely as a result of altered protein dynamics, a new study suggests. The study, “Gut-seeded α-synuclein fibrils promote gut dysfunction and brain pathology specifically in aged mice,” was published in Nature Neuroscience. Parkinson’s disease is characterized by ... read more
Source: Parkinson’s News TodayPublished on 2020-02-24By Marisa Wexler