Synaptic determinants of cholinergic interneurons hyperactivity during parkinsonism

Synaptic determinants of cholinergic interneurons hyperactivity during parkinsonism
Front Synaptic Neurosci. 2022 Sep 6;14:945816. doi: 10.3389/fnsyn.2022.945816. eCollection 2022.ABSTRACTParkinson's disease is a neurodegenerative ailment generated by the loss of dopamine in the basal ganglia, mainly in the striatum. The disease courses with increased striatal levels of acetylcholine, disrupting the balance among these modulatory transmitters. These modifications disturb the excitatory and inhibitory balance in the striatal circuitry, as reflected in ... read more
Source: PubMedPublished on 2022-09-23By Montserrat Padilla-Orozco