Synthesis and human monoamine oxidase inhibitory activity of novel C2-, C3- and C4-substituted phthalonitriles

Synthesis and human monoamine oxidase inhibitory activity of novel C2-, C3- and C4-substituted phthalonitriles
Bioorg Med Chem Lett. 2022 Aug 1:128917. doi: 10.1016/j.bmcl.2022.128917. Online ahead of print.ABSTRACTDevelopment of new selective reversible monoamine oxidase (MAO) B inhibitors is still essential for the treatment of Alzheimer's and Parkinson's disease. Phthalonitrile compounds have been shown to display MAO inhibitory activity with MAO-B selectivity. In this study, we synthesized and evaluated the inhibitory activities of a new series ... read more
Source: PubMedPublished on 2022-08-04By Haytham Elzien Alamin Ali