Taking the parkin brakes off of neuronal NLRP3 drives inflammasome activation and neurodegeneration in Parkinson’s disease

Taking the parkin brakes off of neuronal NLRP3 drives inflammasome activation and neurodegeneration in Parkinson’s disease
Neuron. 2022 Aug 3;110(15):2356-2358. doi: 10.1016/j.neuron.2022.06.015.ABSTRACTNLRP3 is a central driver of neurodegeneration thought to function mainly in microglia. In this issue of Neuron, Panicker et al. (2022) find that NLRP3 is a parkin substrate that contributes significantly to Parkinson's disease pathogenesis by acting in neurons.PMID:35926449 | DOI:10.1016/j.neuron.2022.06.015 ... read more
Source: PubMedPublished on 2022-08-04By Kristine E Zengeler