Targeting Molecular Mediators of Ferroptosis and Oxidative Stress for Neurological Disorders

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• The road ahead: 2022 January 20, 2022 # # # # The first post at the start of each year on the SoPD website tries to provide an overview of where things are in the search for ‘disease modifying’ therapies for Parkinson’s.  It is an exercise in managing expectations as well as discussing what research events are scheduled for the next year so that we can keep…
• The road ahead: 2021 January 25, 2021 # # # # At the start of each year, it is a useful practise to layout what is planned over the next 12 months. The events that are scheduled for the year to come, so that we can keep an eye out for them. Obviously, where 2021 will end actually is unpredictable, but an outline of what is scheduled…
• The road ahead: 2020 January 5, 2020 Here at the SoPD, we are primarily interested in disease modification for Parkinson’s. While there is a great deal of interesting research exploring the causes of the condition, novel symptomatic therapies, and other aspects of Parkinson’s, my focus is generally on the science seeking to slow, stop or reverse the condition. At the start of each year, it is a…
• Is it time to back NAC? October 4, 2019   A lot of Parkinson’s research is focused on antioxidants – molecules that can reduce the level of stress a cell is under when it is not feeling well. One of the most widely discussed antioxidants on Parkinson’s online forums is a molecule called N–acetylcysteine (or NAC). Recently, the results of a small clinical trial – in which NAC was…
• Turn back Bach? November 16, 2021 # # # # Cellular activity generates a lot of waste and by-products. Cells have developed very efficient methods of dealing with this situation. As we age, however, these processes become strained, and in degenerative conditions they appear to be rather dysfunctional.  New research highlights a novel mechanism – Bach1 derepression – which points towards a new class of potential…
• The Yack on NAC (N-Acetyl-Cysteine) and Parkinson’s May 25, 2017 “Once you choose hope, anything’s possible.” Christopher Reeve “Hope is like a road in the country; there was never a road, but when many people walk on it, the road comes into existence.” Lin Yutang Introduction: N-Acetyl-Cysteine (or N-acetylcysteine, usually abbreviated NAC and frequently pronounced like the word ‘knack’) is an altered (modified by an N-acetyl-group) form of the sulfur-containing…
• Monthly Research Review – July 2021 July 31, 2021 # # # # At the end of each month the SoPD writes a post which provides an overview of some of the major pieces of Parkinson’s-related research that were made available during July 2021. The post is divided into 10 parts based on the type of research: Top 5 pieces of Parkinson’s news Articles of general interest Basic biology…
• 2019: Year in review December 31, 2019   In this end-of-year post, we review the Parkinson’s research that caught our attention at SoPD HQ in 2019. Month-by-month we will briefly discuss some of the major pieces of research/announcements that have defined the year and advanced our understanding of Parkinson’s. The list is based on nothing more than the author’s personal opinion – apologies to any researchers who…
• Monthly research review: February 2020 February 29, 2020   At the end of each month the SoPD writes a post which provides an overview of some of the major pieces of Parkinson’s-related research that were made available during February 2020. The post is divided into seven parts based on the type of research: Basic biology Disease mechanism Clinical research New clinical trials Clinical trial news Other news Review…
• Whey Protein Supplements May Increase Glutathione in Parkinson’s January 16, 2019 “Basic research is what I am doing when I don’t know what I am doing.” Wernher von Braun “As far as the laws of mathematics refer to reality, they are not certain, and as far as they are certain, they do not refer to reality.” Albert Einstein Overview: In 1989, Riederer and others demonstrated that dopamine-producing neurons in the basal…
• Targeting Molecular Mediators of Ferroptosis and Oxidative Stress for Neurological Disorders August 1, 2022 Oxid Med Cell Longev. 2022 Jul 22;2022:3999083. doi: 10.1155/2022/3999083. eCollection 2022.ABSTRACTWith the acceleration of population aging, nervous system diseases including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), anxiety, depression, stroke, and traumatic brain injury (TBI) have become a huge burden on families and society. The mechanism of neurological disorders is complex, which also lacks effective treatment, so relevant…
• Targeting Molecular Mediators of Ferroptosis and Oxidative Stress for Neurological Disorders August 1, 2022 Oxid Med Cell Longev. 2022 Jul 22;2022:3999083. doi: 10.1155/2022/3999083. eCollection 2022.ABSTRACTWith the acceleration of population aging, nervous system diseases including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), anxiety, depression, stroke, and traumatic brain injury (TBI) have become a huge burden on families and society. The mechanism of neurological disorders is complex, which also lacks effective treatment, so relevant…
• Targeting Molecular Mediators of Ferroptosis and Oxidative Stress for Neurological Disorders August 1, 2022 Oxid Med Cell Longev. 2022 Jul 22;2022:3999083. doi: 10.1155/2022/3999083. eCollection 2022.ABSTRACTWith the acceleration of population aging, nervous system diseases including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), anxiety, depression, stroke, and traumatic brain injury (TBI) have become a huge burden on families and society. The mechanism of neurological disorders is complex, which also lacks effective treatment, so relevant…
• Targeting Molecular Mediators of Ferroptosis and Oxidative Stress for Neurological Disorders August 1, 2022 Oxid Med Cell Longev. 2022 Jul 22;2022:3999083. doi: 10.1155/2022/3999083. eCollection 2022.ABSTRACTWith the acceleration of population aging, nervous system diseases including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), anxiety, depression, stroke, and traumatic brain injury (TBI) have become a huge burden on families and society. The mechanism of neurological disorders is complex, which also lacks effective treatment, so relevant…
• Monthly Research Review – November 2020 November 30, 2020   At the end of each month the SoPD writes a post which provides an overview of some of the major pieces of Parkinson’s-related research that were made available during November 2020. The post is divided into seven parts based on the type of research: Basic biology Disease mechanism Clinical research New clinical trials Clinical trial news Conferences/lectures Other news…
• Monthly research review – March 2021 March 31, 2021 # # # # At the end of each month the SoPD writes a post which provides an overview of some of the major pieces of Parkinson’s-related research that were made available during March 2021. The post is divided into ten parts based on the type of research: Top 5 pieces of Parkinson’s news Articles of general interest Basic biology…
• Monthly research review – April 2021 April 30, 2021 # # # # At the end of each month the SoPD writes a post which provides an overview of some of the major pieces of Parkinson’s-related research that were made available during April 2021. The post is divided into 10 parts based on the type of research: Top 5 pieces of Parkinson’s news Articles of general interest Basic biology…
• Monthly Research Review: January 2022 January 31, 2022 # # # # At the end of each month the SoPD writes a post which provides an overview of some of the major pieces of Parkinson’s-related research that were made available during January 2022. The post is divided into 10 parts based on the type of research: Top 6 pieces of Parkinson’s news Articles of general interest Basic biology…
• Monthly research review – March 2022 March 31, 2022 # # # # At the end of each month the SoPD writes a post which provides an overview of some of the major pieces of Parkinson’s-related research that were made available during March 2022. The post is divided into 10 parts based on the type of research: Top 5 pieces of Parkinson’s news Articles of general interest Basic biology…
• Monthly research review – November 2021 November 30, 2021 # # # # At the end of each month the SoPD writes a post which provides an overview of some of the major pieces of Parkinson’s-related research that were made available during November 2021. The post is divided into 10 parts based on the type of research: Top 6 pieces of Parkinson’s news Articles of general interest Basic biology…
• Monthly Research Review – September 2021 September 30, 2021 # # # # At the end of each month the SoPD writes a post which provides an overview of some of the major pieces of Parkinson’s-related research that were made available during September 2021. The post is divided into 10 parts based on the type of research: Top 4 pieces of Parkinson’s news Articles of general interest Basic biology…
• Neurological Mayhem by Dual Antioxidative and Anti-inflammatory Agents in Aged Parkinson’s Mice February 26, 2019 “No person was ever honored for what he received. Honor has been the reward for what he gave.” Calvin Coolidge “The most reliable way to predict the future is to create it.” Abraham Lincoln Introduction: Recently, Jeff Keegan asked me if I had seen the paper by Gil-Martínez et al., an established Parkinson’s research group in Spain (click here to…