The Human Hippocampus in Parkinson’s Disease: An Integrative Stereological and Proteomic Study

The Human Hippocampus in Parkinson’s Disease: An Integrative Stereological and Proteomic Study
J Parkinsons Dis. 2021 Jun 4. doi: 10.3233/JPD-202465. Online ahead of print.ABSTRACTBACKGROUND: Parkinson's disease (PD) is a prevalent neurodegenerative disease that is pathologically described as a six-stage α-synucleinopathy. In stage 4, α-synuclein reaches the hippocampus, inducing cognitive deficits, from which it progresses to the isocortex, leading to dementia. Among hippocampal fields, cornu ammonis 2 is particularly affected by this α-synucleinopathy ... read more
Source: PubMedPublished on 2021-06-07By Sandra Villar-Conde