The intestinal luminal sources of α-synuclein: a gastroenterologist perspective

The intestinal luminal sources of α-synuclein: a gastroenterologist perspective
Nutr Rev. 2021 May 3:nuab024. doi: 10.1093/nutrit/nuab024. Online ahead of print.ABSTRACTParkinson's disease is characterized by nonmotor/motor dysfunction, midbrain dopaminergic neuronal death, and α-synuclein (aSN) deposits. The current hypothesis is that aSN accumulates in the enteric nervous system to reach the brain. However, invertebrate, vertebrate, and nutritional sources of aSN reach the luminal compartment. Submitted to local amyloidogenic forces, the oligomerized ... read more
Source: PubMedPublished on 2021-05-04By Aaron Lerner