The KEAP1-NRF2 System and Neurodegenerative Diseases

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• The road ahead: 2022 January 20, 2022 # # # # The first post at the start of each year on the SoPD website tries to provide an overview of where things are in the search for ‘disease modifying’ therapies for Parkinson’s.  It is an exercise in managing expectations as well as discussing what research events are scheduled for the next year so that we can keep…
• The road ahead: 2021 January 25, 2021 # # # # At the start of each year, it is a useful practise to layout what is planned over the next 12 months. The events that are scheduled for the year to come, so that we can keep an eye out for them. Obviously, where 2021 will end actually is unpredictable, but an outline of what is scheduled…
• How to Work Full Time & Live Well with Parkinson’s September 17, 2020 One of the most common challenges people with Parkinson’s face is balancing treatment with everyday activities and responsibilities. Exercising, going to medical appointments, attending support groups, focusing on your mental health, and all the other necessities that help you live well with Parkinson’s require a lot of time and energy. For people working when diagnosed, finding a way to balance these demands with their career responsibilities can seem impossible.    A member of our community…
• The What, Why, and How of Community Action Committees (CACs) January 20, 2021 In our post announcing our Healthy Parkinson’s Communities initiative, we outlined our three goals:  Ensure Parkinson’s community leaders have the knowledge and resources they need to make a positive and sustainable change in their community  Encourage and support data-informed initiatives designed to increase access to and engagement with resources that improve the quality of life for people with Parkinson’s Work with communities to raise awareness…
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• The road ahead: 2020 January 5, 2020 Here at the SoPD, we are primarily interested in disease modification for Parkinson’s. While there is a great deal of interesting research exploring the causes of the condition, novel symptomatic therapies, and other aspects of Parkinson’s, my focus is generally on the science seeking to slow, stop or reverse the condition. At the start of each year, it is a…
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• The KEAP1-NRF2 System and Neurodegenerative Diseases March 17, 2023 Antioxid Redox Signal. 2023 Mar 17. doi: 10.1089/ars.2023.0234. Online ahead of print.ABSTRACTSignificance: Central nervous system (CNS) diseases are disorders of the brain and/or spinal cord and include neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor belonging to the cap-n-collar family that harbors a unique basic leucine…
• The KEAP1-NRF2 System and Neurodegenerative Diseases March 17, 2023 Antioxid Redox Signal. 2023 Mar 17. doi: 10.1089/ars.2023.0234. Online ahead of print.ABSTRACTSignificance: Central nervous system (CNS) diseases are disorders of the brain and/or spinal cord and include neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor belonging to the cap-n-collar family that harbors a unique basic leucine…
• The KEAP1-NRF2 System and Neurodegenerative Diseases March 17, 2023 Antioxid Redox Signal. 2023 Mar 17. doi: 10.1089/ars.2023.0234. Online ahead of print.ABSTRACTSignificance: Central nervous system (CNS) diseases are disorders of the brain and/or spinal cord and include neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor belonging to the cap-n-collar family that harbors a unique basic leucine…
• The KEAP1-NRF2 System and Neurodegenerative Diseases March 17, 2023 Antioxid Redox Signal. 2023 Mar 17. doi: 10.1089/ars.2023.0234. Online ahead of print.ABSTRACTSignificance: Central nervous system (CNS) diseases are disorders of the brain and/or spinal cord and include neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor belonging to the cap-n-collar family that harbors a unique basic leucine…
• 5 Simple Exercises to Train Your Balance & Live Well with Parkinson’s March 1, 2021 Because Parkinson’s can impact the reflexes needed to maintain an upright posture, people with Parkinson’s may feel unstable while standing upright. This postural instability — better known as poor balance and coordination — can make certain physical activities difficult, and it also increases the risk of falling. The good news is that although postural instability is a common Parkinson’s symptom, it can be managed and mitigated with practice. By training your balance frequently, you can improve your postural stability and even regain some of your automatic balance reflexes.  …
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• Turning Data into Action March 3, 2021 Your CAC is ready to roll. You have conducted research and completed a community healthy assessment for Parkinson’s (CHAP). Now, what?  The transition from data collection to action can be difficult for some groups. But it’s a crucial transition; it maintains the group’s momentum and engagement and helps the group build self-efficacy. (We’ve all been part of those committees that meet to talk a lot and then lose steam because they never act. We want to…
• Formularies, Insurance, and Parkinson’s  September 11, 2020 Navigating health insurance is challenging even for people in the best of health, but when you need a variety of medications to treat your motor and non-motor Parkinson’s symptoms, it can feel even more overwhelming. Having a basic understanding of how insurance companies cover prescription medications, though, can help you get the care you need. Here, we’ll explore how formularies work, and we’ll share information about how your medications are covered, how you can make the most out…
• The KEAP1-NRF2 system and neurodegenerative diseases February 3, 2023 Antioxid Redox Signal. 2023 Feb 3. doi: 10.1089/ars.2023.0005. Online ahead of print.ABSTRACTSignificance: Central nervous system (CNS) diseases are disorders of the brain and/or spinal cord and include neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), and multiple sclerosis (MS). NF-E2-related factor 2 (NRF2) is a transcription factor belonging to the cap-n-collar (CNC) family that harbors a unique basic…
• The KEAP1-NRF2 system and neurodegenerative diseases February 3, 2023 Antioxid Redox Signal. 2023 Feb 3. doi: 10.1089/ars.2023.0005. Online ahead of print.ABSTRACTSignificance: Central nervous system (CNS) diseases are disorders of the brain and/or spinal cord and include neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), and multiple sclerosis (MS). NF-E2-related factor 2 (NRF2) is a transcription factor belonging to the cap-n-collar (CNC) family that harbors a unique basic…
• The KEAP1-NRF2 system and neurodegenerative diseases February 3, 2023 Antioxid Redox Signal. 2023 Feb 3. doi: 10.1089/ars.2023.0005. Online ahead of print.ABSTRACTSignificance: Central nervous system (CNS) diseases are disorders of the brain and/or spinal cord and include neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), and multiple sclerosis (MS). NF-E2-related factor 2 (NRF2) is a transcription factor belonging to the cap-n-collar (CNC) family that harbors a unique basic…
• Monthly Research Review – July 2021 July 31, 2021 # # # # At the end of each month the SoPD writes a post which provides an overview of some of the major pieces of Parkinson’s-related research that were made available during July 2021. The post is divided into 10 parts based on the type of research: Top 5 pieces of Parkinson’s news Articles of general interest Basic biology…
• 2016 Tai Chi Study Funded by the Davis Phinney Foundation Continues to Help People Live Well with Parkinson’s April 2, 2021 Before he enrolled in a research study about Tai Chi’s impacts on Parkinson’s symptoms, Rob Scott had never practiced the art. Now, five years later, it is an integral part of his life, helping him live well with Parkinson’s at 67.   “Tai Chi feels like a kind of meditation. A kind of paying attention and letting go at the same time.”   Rob was one of the participants in a…