The Pedunculopontine Tegmental Nucleus is not Important for Breathing Impairments Observed in a Parkinson’s Disease Model

The Pedunculopontine Tegmental Nucleus is not Important for Breathing Impairments Observed in a Parkinson’s Disease Model
Neuroscience. 2023 Jan 20:S0306-4522(22)00630-3. doi: 10.1016/j.neuroscience.2022.12.022. Online ahead of print.ABSTRACTParkinson's disease (PD) is a motor disorder resulting from degeneration of dopaminergic neurons of substantia nigra pars compacta (SNpc), with classical and non-classical symptoms such as respiratory instability. An important region for breathing control, the Pedunculopontine Tegmental Nucleus (PPTg), is composed of cholinergic, glutamatergic, and GABAergic neurons. We hypothesize that degenerated ... read more
Source: PubMedPublished on 2023-01-23By Nicole C Miranda