The PPN and motor control: Preclinical studies to deep brain stimulation for Parkinson’s disease

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• The road ahead: 2020 January 5, 2020 Here at the SoPD, we are primarily interested in disease modification for Parkinson’s. While there is a great deal of interesting research exploring the causes of the condition, novel symptomatic therapies, and other aspects of Parkinson’s, my focus is generally on the science seeking to slow, stop or reverse the condition. At the start of each year, it is a…
• The PPN and motor control: Preclinical studies to deep brain stimulation for Parkinson's disease March 17, 2023 Front Neural Circuits. 2023 Feb 28;17:1095441. doi: 10.3389/fncir.2023.1095441. eCollection 2023.ABSTRACTThe pedunculopontine nucleus (PPN) is the major part of the mesencephalic locomotor region, involved in the control of gait and locomotion. The PPN contains glutamatergic, cholinergic, and GABAergic neurons that all make local connections, but also have long-range ascending and descending connections. While initially thought of as a region only involved…
• The PPN and motor control: Preclinical studies to deep brain stimulation for Parkinson's disease March 17, 2023 Front Neural Circuits. 2023 Feb 28;17:1095441. doi: 10.3389/fncir.2023.1095441. eCollection 2023.ABSTRACTThe pedunculopontine nucleus (PPN) is the major part of the mesencephalic locomotor region, involved in the control of gait and locomotion. The PPN contains glutamatergic, cholinergic, and GABAergic neurons that all make local connections, but also have long-range ascending and descending connections. While initially thought of as a region only involved…
• The PPN and motor control: Preclinical studies to deep brain stimulation for Parkinson's disease March 17, 2023 Front Neural Circuits. 2023 Feb 28;17:1095441. doi: 10.3389/fncir.2023.1095441. eCollection 2023.ABSTRACTThe pedunculopontine nucleus (PPN) is the major part of the mesencephalic locomotor region, involved in the control of gait and locomotion. The PPN contains glutamatergic, cholinergic, and GABAergic neurons that all make local connections, but also have long-range ascending and descending connections. While initially thought of as a region only involved…
• The PPN and motor control: Preclinical studies to deep brain stimulation for Parkinson's disease March 17, 2023 Front Neural Circuits. 2023 Feb 28;17:1095441. doi: 10.3389/fncir.2023.1095441. eCollection 2023.ABSTRACTThe pedunculopontine nucleus (PPN) is the major part of the mesencephalic locomotor region, involved in the control of gait and locomotion. The PPN contains glutamatergic, cholinergic, and GABAergic neurons that all make local connections, but also have long-range ascending and descending connections. While initially thought of as a region only involved…
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