Therapies Which Enhance PLCG2 Activity May Be Effective in Treating Parkinson and Alzheimer Diseases

Therapies Which Enhance PLCG2 Activity May Be Effective in Treating Parkinson and Alzheimer Diseases
Patients with Alzheimer disease (AD) may benefit from therapies which enhance 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 (PLCG2) activity. These findings were published in Science Advances. Patients and controls (N=132) were recruited at Stanford University for this mass cytometric study of peripheral blood mononuclear cells (PBMCs). Participants were split into discovery and validation cohorts. The discovery group consisted of patients with AD (n=28), ... read more
Source: Neurology AdvisorPublished on 2021-01-06By Kwamesha Joseph