Tollip negatively regulates mitophagy by promoting the mitochondrial processing and cytoplasmic release of PINK1

Tollip negatively regulates mitophagy by promoting the mitochondrial processing and cytoplasmic release of PINK1
BMB Rep. 2022 Jun 21:5642. Online ahead of print.ABSTRACTPTEN-induced putative kinase 1 (PINK1) is a serine/threonine kinase that phosphorylates several substrates and exerts neuroprotective effects against stress-induced apoptotic cell death. Mutations in PINK1 have been linked to autosomal recessive forms of Parkinson's disease (PD). Mitophagy is a type of autophagy that selectively promotes mitochondrial turnover and prevents the accumulation of ... read more
Source: PubMedPublished on 2022-06-20By Woo Hyun Shin