Top three unmet needs to target in Parkinson’s disease – Clinical Trials Arena

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• Hope fatigue: will there ever be a cure? February 1, 2020 Saturday 1 February 2020At the start of 2020 there was a flurry of posts on various Parkinson’s forums about all the promising research and clinical trials in progress, not to mention a few puns around “20/20 vision”.Rather than repeat it all here (and probably get some of it wrong), I would refer you instead to The Science of Parkinson’s take…
• Animals in Parkinson's research October 22, 2022 Saturday 22 October 2022  Continuing with the theme of animal models, here is an essay I wrote as part of my MSc neuroscience about the use of animals in Parkinson’s research. Many people, myself included, feel uncomfortable about the use of animals in brain research, an issue for which there are no easy answers. There is quite a bit of…
• PAIN: Does Parkinson's Cause Pain, or Does Pain Make Other PD Symptoms Worse? July 17, 2019 Is pain a symptom of Parkinson’s? Or do the motor symptoms of PD directly or indirectly cause pain? Or is pain a symptom of something else? Arthritis? Aging? Or is pain a result of lack of exercise? Over exercise? Improper exercise form? Improper exercise instruction? Some combination of factors? Those are interesting questions, but more importantly does pain contribute to…
• The road ahead: 2022 January 20, 2022 # # # # The first post at the start of each year on the SoPD website tries to provide an overview of where things are in the search for ‘disease modifying’ therapies for Parkinson’s.  It is an exercise in managing expectations as well as discussing what research events are scheduled for the next year so that we can keep…
• The road ahead: 2021 January 25, 2021 # # # # At the start of each year, it is a useful practise to layout what is planned over the next 12 months. The events that are scheduled for the year to come, so that we can keep an eye out for them. Obviously, where 2021 will end actually is unpredictable, but an outline of what is scheduled…
• The road ahead: 2020 January 5, 2020 Here at the SoPD, we are primarily interested in disease modification for Parkinson’s. While there is a great deal of interesting research exploring the causes of the condition, novel symptomatic therapies, and other aspects of Parkinson’s, my focus is generally on the science seeking to slow, stop or reverse the condition. At the start of each year, it is a…
• The drug development pipeline for Parkinson’s December 2, 2020 # # # # For a long time a regular request from SoPD readers has been to provide an overview of the clinical trial landscape for Parkinson’s, particularly in the area of drug development. Such projects are difficult, however, as the landscape is broad and dynamic – lots of different approaches being applied and new entrants continually entering the arena.…
• EJS-ACT PD June 26, 2021 # # # # This week an announcement was made regarding The Edmond J. Safra Accelerating Clinical Treatments for Parkinson’s Disease (EJS-ACT PD) Initiative. It is hoping to revolutionise the way clinical trials for potentially disease-modifying drugs for Parkinson’s are conducted. The project is focused on the setting up a multi-arm, multi-stage (MAMS) platform for evaluating new therapies for PD.…
• 2020: Year in Review January 1, 2021 # # # # In this end-of-year post, we review the Parkinson’s research that caught our attention at SoPD HQ in 2020. Month-by-month we will briefly discuss some of the major pieces of research/ announcements that have defined the year and advanced our understanding of Parkinson’s. The list is based on nothing more than the author’s personal opinion – apologies…
• Parkinson's Disease Medication Overview July 3, 2019 Medications for PD fall into three categories. The first category includes drugs that increase the level of dopamine in the brain. The second category of PD drugs affects other neurotransmitters in the body in order to ease some of the symptoms of the disease. The third category of drugs prescribed for PD includes medications that help control the non-motor symptoms…
• Monthly Research Review: January 2022 January 31, 2022 # # # # At the end of each month the SoPD writes a post which provides an overview of some of the major pieces of Parkinson’s-related research that were made available during January 2022. The post is divided into 10 parts based on the type of research: Top 6 pieces of Parkinson’s news Articles of general interest Basic biology…
• Early-onset Parkinson's disease: An assessment of unmet psychosocial needs April 10, 2023 Parkinsonism Relat Disord. 2023 Apr 6;110:105395. doi: 10.1016/j.parkreldis.2023.105395. Online ahead of print.ABSTRACTBACKGROUND: Early onset Parkinson's disease (EOPD) affects people in the prime of their lives, typically between 21 and 50 years of age, which results in a variety of challenges that are unique compared to those diagnosed later in life. A better understanding of the unmet needs of this population…
• Early-onset Parkinson's disease: An assessment of unmet psychosocial needs April 10, 2023 Parkinsonism Relat Disord. 2023 Apr 6;110:105395. doi: 10.1016/j.parkreldis.2023.105395. Online ahead of print.ABSTRACTBACKGROUND: Early onset Parkinson's disease (EOPD) affects people in the prime of their lives, typically between 21 and 50 years of age, which results in a variety of challenges that are unique compared to those diagnosed later in life. A better understanding of the unmet needs of this population…
• Early-onset Parkinson's disease: An assessment of unmet psychosocial needs April 10, 2023 Parkinsonism Relat Disord. 2023 Apr 6;110:105395. doi: 10.1016/j.parkreldis.2023.105395. Online ahead of print.ABSTRACTBACKGROUND: Early onset Parkinson's disease (EOPD) affects people in the prime of their lives, typically between 21 and 50 years of age, which results in a variety of challenges that are unique compared to those diagnosed later in life. A better understanding of the unmet needs of this population…
• Early-onset Parkinson's disease: An assessment of unmet psychosocial needs April 10, 2023 Parkinsonism Relat Disord. 2023 Apr 6;110:105395. doi: 10.1016/j.parkreldis.2023.105395. Online ahead of print.ABSTRACTBACKGROUND: Early onset Parkinson's disease (EOPD) affects people in the prime of their lives, typically between 21 and 50 years of age, which results in a variety of challenges that are unique compared to those diagnosed later in life. A better understanding of the unmet needs of this population…
• Early-onset Parkinson's disease: An assessment of unmet psychosocial needs April 10, 2023 Parkinsonism Relat Disord. 2023 Apr 6;110:105395. doi: 10.1016/j.parkreldis.2023.105395. Online ahead of print.ABSTRACTBACKGROUND: Early onset Parkinson's disease (EOPD) affects people in the prime of their lives, typically between 21 and 50 years of age, which results in a variety of challenges that are unique compared to those diagnosed later in life. A better understanding of the unmet needs of this population…
• Monthly research review – March 2021 March 31, 2021 # # # # At the end of each month the SoPD writes a post which provides an overview of some of the major pieces of Parkinson’s-related research that were made available during March 2021. The post is divided into ten parts based on the type of research: Top 5 pieces of Parkinson’s news Articles of general interest Basic biology…
• Monthly Research Review – December 2021 December 31, 2021 # # # # At the end of each month the SoPD writes a post which provides an overview of some of the major pieces of Parkinson’s-related research that were made available during December 2021. The post is divided into 10 parts based on the type of research: Top 5 pieces of Parkinson’s news Articles of general interest Basic biology…
• Monthly Research Review – October 2021 October 31, 2021 # # # # At the end of each month the SoPD writes a post which provides an overview of some of the major pieces of Parkinson’s-related research that were made available during October 2021. The post is divided into 10 parts based on the type of research: Top 5 pieces of Parkinson’s news Articles of general interest Basic biology…
• Unmet Needs of People With Parkinson's Disease and Their Caregivers During COVID-19-Related Confinement: An Explorative Secondary Data Analysis. February 5, 2021 Related ArticlesUnmet Needs of People With Parkinson's Disease and Their Caregivers During COVID-19-Related Confinement: An Explorative Secondary Data Analysis. Front Neurol. 2020;11:615172 Authors: Hanff AM, Pauly C, Pauly L, Schröder VE, Hansen M, Meyers GR, Kaysen A, Hansen L, Wauters F, Krüger R Abstract Self-perceived unmet needs in people with typical and atypical parkinsonism (PwP) and their caregivers, support network,…
• Healthy Parkinson’s Communities™: March Resource Roundup March 26, 2021 In January and February, we shared resources we found meaningful in introducing collective impact, cross-sector collaborations, developing a Community Action Committee, managing effective teams, and building powerful partnerships.   This month, we’re sharing resources to help you get started creating change in your community. Creating change can mean a lot of things; we focus here on determining where to start your…
• Monthly Research Review – November 2022 November 30, 2022 # # # # At the end of each month the SoPD writes a post which provides an overview of some of the major pieces of Parkinson’s-related research that were made available during November 2022. The post is divided into 10 parts based on the type of research: Top 5 pieces of Parkinson’s news Articles of general interest Basic biology…