Toxoplasma gondii Linked to Brain Tumor – Genetic Engineering & Biotechnology News

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• Toxoplasma Brain Parasite Modulates Signaling Pathways Common in Parkinson’s Disease September 20, 2017 Infection with the brain parasite Toxoplasma gondii may increase the likelihood for certain brain disorders, including Parkinson’s and Alzheimer’s disease, a systematic analysis suggests. The study, “Toxoplasma Modulates Signature Pathways of Human Epilepsy, Neurodegeneration & Cancer,” was published in the journal Scientific Reports. Over two billion people are infected with the brain parasite T. gondii. The infection has been reported as dangerous for pregnant…
• Toxoplasma gondii infection and risk of Parkinson and Alzheimer diseases: A systematic review and meta-analysis on observational studies. May 19, 2019 Toxoplasma gondii infection and risk of Parkinson and Alzheimer diseases: A systematic review and meta-analysis on observational studies. Acta Trop. 2019 May 15;: Authors: Bayani M, Riahi SM, Bazrafshan N, Ray Gamble H, Rostami A Abstract In the past decade, Toxoplasma gondii infection has been recognized as a potential risk for many psychiatric and neurological disorders. We performed this systematic…
• The Association between Toxoplasma gondii Infection and Risk of Parkinson's Disease: A Systematic Review and Meta-Analysis. April 2, 2019 Related ArticlesThe Association between Toxoplasma gondii Infection and Risk of Parkinson's Disease: A Systematic Review and Meta-Analysis. Biomed Res Int. 2019;2019:8186017 Authors: Zhou Z, Zhou R, Li K, Wei W, Zhang Z, Zhu Y, Luan R Abstract Background: Several studies have investigated the association between Toxoplasma gondii (T. gondii) infection and risk of Parkinson's disease (PD) with inconsistent results. Clarifying…
• Persistent Toxoplasma Infection of the Brain Induced Neurodegeneration associated with Activation of Complement and Microglia. June 12, 2019 Related ArticlesPersistent Toxoplasma Infection of the Brain Induced Neurodegeneration associated with Activation of Complement and Microglia. Infect Immun. 2019 Jun 10;: Authors: Li Y, Severance EG, Viscidi RP, Yolken RH, Xiao J Abstract Toxoplasma gondii, a common neurotropic parasite, is increasingly being linked to neuropsychiatric disorders including schizophrenia, Alzheimer's disease, and Parkinson's disease. However, the pathogenic mechanisms underlying these associations…
• A plutocratic proposal: iCancer February 2, 2020    Speeding up the clinical development process is a shared goal across many medical conditions (not just Parkinson’s and neurodegeneration), and there are many different approaches to achieving this that are being explored. Some of these approaches could be considered to be bordering on the unethical, but there are aspects of their structure and design that are still worthy of…
• Systems analysis points to links between Toxoplasma infection and common brain diseases September 13, 2017 (University of Chicago Medical Center) Nearly one out of every three humans on earth has a lifelong infection with the brain-dwelling parasite Toxoplasma gondii. In the Sept. 13 issue of Scientific Reports, researchers from multiple institutions describe efforts to learn how infection with the parasite Toxoplasma gondii may alter, and in some cases amplify, several brain disorders, including epilepsy, Alzheimer's…
• 2019: Year in review December 31, 2019   In this end-of-year post, we review the Parkinson’s research that caught our attention at SoPD HQ in 2019. Month-by-month we will briefly discuss some of the major pieces of research/announcements that have defined the year and advanced our understanding of Parkinson’s. The list is based on nothing more than the author’s personal opinion – apologies to any researchers who…
• The road ahead: 2020 January 5, 2020 Here at the SoPD, we are primarily interested in disease modification for Parkinson’s. While there is a great deal of interesting research exploring the causes of the condition, novel symptomatic therapies, and other aspects of Parkinson’s, my focus is generally on the science seeking to slow, stop or reverse the condition. At the start of each year, it is a…
• Monthly Research Review – December 2020 December 31, 2020   At the end of each month the SoPD writes a post which provides an overview of some of the major pieces of Parkinson’s-related research that were made available during December 2020. The post is divided into seven parts based on the type of research: Basic biology Disease mechanism Clinical research New clinical trials Clinical trial news Conferences/lectures Other news…
• Monthly Research Review – August 2019 August 31, 2019   At the end of each month the SoPD writes a post which provides an overview of some of the major pieces of Parkinson’s-related research that were made available during August 2019. The post is divided into seven parts based on the type of research: Basic biology Disease mechanism Clinical research New clinical trials Clinical trial news Other news Review…
• Monthly Research Review – November 2020 November 30, 2020   At the end of each month the SoPD writes a post which provides an overview of some of the major pieces of Parkinson’s-related research that were made available during November 2020. The post is divided into seven parts based on the type of research: Basic biology Disease mechanism Clinical research New clinical trials Clinical trial news Conferences/lectures Other news…
• That time APOE met Alpha Syn February 10, 2020    Recently two independent research groups published scientific papers providing evidence that a genetic variation associated with Alzheimer’s may also be affecting the severity of pathology in Parkinson’s. The genetic variation associated with Alzheimer’s occurs in a gene (a functional region of DNA) called ApoE, and the Parkinson’s pathology involves the clustering of a protein called alpha synuclein. Specifically, both…
• ROPAD + LIPAD = NOT BAD 🙂 December 10, 2019       Approximately 10-20% of Parkinson’s cases are associated with a genetic risk factor which raises the chances of developing the condition. Tremendous efforts are being made to not only better understand the underlying biology of these associations, but also to identify individuals who may be affected and invite them to take part in innovative new clinical trials. The…
• RNA Sequencing Reveals Small and Variable Contributions of Infectious Agents to Transcriptomes of Postmortem Nervous Tissues From Amyotrophic Lateral Sclerosis, Alzheimer's Disease and Parkinson's Disease Subjects, and Increased Expression of… April 16, 2019 Related ArticlesRNA Sequencing Reveals Small and Variable Contributions of Infectious Agents to Transcriptomes of Postmortem Nervous Tissues From Amyotrophic Lateral Sclerosis, Alzheimer's Disease and Parkinson's Disease Subjects, and Increased Expression of Genes From Disease-Activated Microglia. Front Neurosci. 2019;13:235 Authors: Bennett JP, Keeney PM, Brohawn DG Abstract Nervous tissues from both humans with neurodegenerative diseases (NDD) and animals with genetic models…
• Monthy research review – December 2019 December 30, 2019   At the end of each month the SoPD writes a post which provides an overview of some of the major pieces of Parkinson’s-related research that were made available during December 2019. The post is divided into seven parts based on the type of research: Basic biology Disease mechanism Clinical research New clinical trials Clinical trial news Other news Review…
• Monthly Research Review – September 2019 September 30, 2019   At the end of each month the SoPD writes a post which provides an overview of some of the major pieces of Parkinson’s-related research that were made available during September 2019. The post is divided into seven parts based on the type of research: Basic biology Disease mechanism Clinical research New clinical trials Clinical trial news Other news Review…
• Making a strong case for GCase November 25, 2019   Novel therapies are increasing being developed to focus on specific subtypes of Parkinson’s. The hope is that if they work on one type of Parkinson’s, then maybe they will also work on others. Many of these new experimental treatments are focused on specific genetic subtypes of the condition, which involve having a specific genetic variation that increases one’s risk…
• Genetics in PD – More Than What You Inherit June 18, 2019 By Hugh Johnston   Not all genetic causes of PD are inherited; some are likely associated with somatic genetic mutations.  Unfortunately, we do not have a good idea of how large the impact of somatic mutation is in PD, nor do we have an effective test to identify the mosaic of somatic mutations in any given patient.  It is good…
• Genetics in PD – More Than What You Inherit June 18, 2019 By Hugh Johnston   Not all genetic causes of PD are inherited; some are likely associated with somatic genetic mutations.  Unfortunately, we do not have a good idea of how large the impact of somatic mutation is in PD, nor do we have an effective test to identify the mosaic of somatic mutations in any given patient.  It is good…
• Genetics in PD – More Than What You Inherit June 18, 2019 By Hugh Johnston   Not all genetic causes of PD are inherited; some are likely associated with somatic genetic mutations.  Unfortunately, we do not have a good idea of how large the impact of somatic mutation is in PD, nor do we have an effective test to identify the mosaic of somatic mutations in any given patient.  It is good…
• Genetics in PD – More Than What You Inherit June 18, 2019 By Hugh Johnston   Not all genetic causes of PD are inherited; some are likely associated with somatic genetic mutations.  Unfortunately, we do not have a good idea of how large the impact of somatic mutation is in PD, nor do we have an effective test to identify the mosaic of somatic mutations in any given patient.  It is good…
• Monthly research review – October 2019 October 31, 2019   At the end of each month the SoPD writes a post which provides an overview of some of the major pieces of Parkinson’s-related research that were made available during October 2019. The post is divided into seven parts based on the type of research: Basic biology Disease mechanism Clinical research New clinical trials Clinical trial news Other news Review…