Traumatic Brain Injury and Risk of Alzheimer’s Disease and Related Dementias in the Population

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• The road ahead: 2022 January 20, 2022 # # # # The first post at the start of each year on the SoPD website tries to provide an overview of where things are in the search for ‘disease modifying’ therapies for Parkinson’s.  It is an exercise in managing expectations as well as discussing what research events are scheduled for the next year so that we can keep…
• The road ahead: 2021 January 25, 2021 # # # # At the start of each year, it is a useful practise to layout what is planned over the next 12 months. The events that are scheduled for the year to come, so that we can keep an eye out for them. Obviously, where 2021 will end actually is unpredictable, but an outline of what is scheduled…
• The road ahead: 2020 January 5, 2020 Here at the SoPD, we are primarily interested in disease modification for Parkinson’s. While there is a great deal of interesting research exploring the causes of the condition, novel symptomatic therapies, and other aspects of Parkinson’s, my focus is generally on the science seeking to slow, stop or reverse the condition. At the start of each year, it is a…
• 2019: Year in review December 31, 2019   In this end-of-year post, we review the Parkinson’s research that caught our attention at SoPD HQ in 2019. Month-by-month we will briefly discuss some of the major pieces of research/announcements that have defined the year and advanced our understanding of Parkinson’s. The list is based on nothing more than the author’s personal opinion – apologies to any researchers who…
• Traumatic Brain Injury and Risk of Alzheimer's Disease and Related Dementias in the Population June 20, 2022 J Alzheimers Dis. 2022 Jun 13. doi: 10.3233/JAD-220159. Online ahead of print.ABSTRACTBACKGROUND: Epidemiological studies examining associations between traumatic brain injury (TBI) and Alzheimer's disease and related dementias (ADRD) have yielded conflicting results, which may be due methodological differences.OBJECTIVE: To examine the relationship between the presence and severity of TBI and risk of ADRD using a population-based cohort with medical record…
• Traumatic Brain Injury and Risk of Alzheimer's Disease and Related Dementias in the Population June 20, 2022 J Alzheimers Dis. 2022 Jun 13. doi: 10.3233/JAD-220159. Online ahead of print.ABSTRACTBACKGROUND: Epidemiological studies examining associations between traumatic brain injury (TBI) and Alzheimer's disease and related dementias (ADRD) have yielded conflicting results, which may be due methodological differences.OBJECTIVE: To examine the relationship between the presence and severity of TBI and risk of ADRD using a population-based cohort with medical record…
• Traumatic Brain Injury and Risk of Alzheimer's Disease and Related Dementias in the Population June 20, 2022 J Alzheimers Dis. 2022 Jun 13. doi: 10.3233/JAD-220159. Online ahead of print.ABSTRACTBACKGROUND: Epidemiological studies examining associations between traumatic brain injury (TBI) and Alzheimer's disease and related dementias (ADRD) have yielded conflicting results, which may be due methodological differences.OBJECTIVE: To examine the relationship between the presence and severity of TBI and risk of ADRD using a population-based cohort with medical record…
• Traumatic Brain Injury and Risk of Alzheimer's Disease and Related Dementias in the Population June 20, 2022 J Alzheimers Dis. 2022 Jun 13. doi: 10.3233/JAD-220159. Online ahead of print.ABSTRACTBACKGROUND: Epidemiological studies examining associations between traumatic brain injury (TBI) and Alzheimer's disease and related dementias (ADRD) have yielded conflicting results, which may be due methodological differences.OBJECTIVE: To examine the relationship between the presence and severity of TBI and risk of ADRD using a population-based cohort with medical record…
• Parkinson’s: Reflective Gratitude of Life December 20, 2019 “We don’t need more to be thankful for, we just need to be more thankful.” Carlos Castaneda “Take as a gift whatever the day brings forth.” Horace Introduction: The title of this blog post says it all. At the age of 66 years old, I stand before you thinking I need to be more thankful. Really? Yes, many deserve my gratitude…
• Parkinson’s: Reflective Gratitude of Life December 20, 2019 “We don’t need more to be thankful for, we just need to be more thankful.” Carlos Castaneda “Take as a gift whatever the day brings forth.” Horace Introduction: The title of this blog post says it all. At the age of 66 years old, I stand before you thinking I need to be more thankful. Really? Yes, many deserve my gratitude…
• Shining a light on Parkinson’s November 7, 2019   NOTE: The information in today’s post should not be considered an endorsement of PhotoPharmics or the treatment they are proposing. The author of this blog has had no communication with the company. The information in this post is provided because the author has been asked by readers to discuss it. In October 2018, at the annual International Movement Disorders…
• The “What would I do” post? Part 2 January 22, 2022 # # # # I am very regularly asked “what would you do if you were diagnosed with Parkinson’s tomorrow?” As a research scientist I don’t really feel comfortable answering it, but I can see how it is a fair question. I have previously attempted to address it (Click here to read that post), and I point folks who do…
• Speech, Voice & Parkinson’s Q&A with John Dean January 28, 2021 We recently hosted a webinar with speech-language pathologist John Dean. You can get access to the recording here. We received so many questions during the session that we weren’t able to answer them all; so, John was kind enough to do some written Q&A for us. “When is a good time to start speech therapy?” It’s much better to maintain…
• Breathtaking research April 24, 2022 # # # # Breathing is one of those many aspects of life that we all take completely for granted for the vast majority of our time on planet Earth. It represents not only a magnificent means of providing our bodies with oxygen, but also disposing of waste. Recently researchers have attempted to see if there are any components in…
• Neurological Mayhem by Dual Antioxidative and Anti-inflammatory Agents in Aged Parkinson’s Mice February 26, 2019 “No person was ever honored for what he received. Honor has been the reward for what he gave.” Calvin Coolidge “The most reliable way to predict the future is to create it.” Abraham Lincoln Introduction: Recently, Jeff Keegan asked me if I had seen the paper by Gil-Martínez et al., an established Parkinson’s research group in Spain (click here to…
• 2020: Year in Review January 1, 2021 # # # # In this end-of-year post, we review the Parkinson’s research that caught our attention at SoPD HQ in 2020. Month-by-month we will briefly discuss some of the major pieces of research/ announcements that have defined the year and advanced our understanding of Parkinson’s. The list is based on nothing more than the author’s personal opinion – apologies…
• Planet Patient vs Planet Researcher: From Both Sides, Now June 27, 2018 “I cannot always control what goes on outside. But I can always control what goes on inside.” Wayne Dyer “Judge a man by his questions rather than his answers.” Voltaire Setting the Stage: This is Mariëtte Robijn-  She lives in the Netherlands and was diagnosed with Parkinson’s at the young age of 46.  Mariëtte has a dynamic and vibrant blog…
• Planet Patient vs Planet Researcher: From Both Sides, Now June 27, 2018 “I cannot always control what goes on outside. But I can always control what goes on inside.” Wayne Dyer “Judge a man by his questions rather than his answers.” Voltaire Setting the Stage: This is Mariëtte Robijn-  She lives in the Netherlands and was diagnosed with Parkinson’s at the young age of 46.  Mariëtte has a dynamic and vibrant blog…
• Planet Patient vs Planet Researcher: From Both Sides, Now June 27, 2018 “I cannot always control what goes on outside. But I can always control what goes on inside.” Wayne Dyer “Judge a man by his questions rather than his answers.” Voltaire Setting the Stage: This is Mariëtte Robijn-  She lives in the Netherlands and was diagnosed with Parkinson’s at the young age of 46.  Mariëtte has a dynamic and vibrant blog…
• Repurposing bumetanide for Alzheimer’s October 15, 2021 # # # # Bumetanide (Bumex) is a diuretic drug (a medication that removes water, by increasing the production of urine). It is used to treat swelling caused by heart failure or liver or kidney disease. It is a widely used drug that has been well characterised in clinical use. Recently researchers conducted a screening study to identify clinically available…
• ADepTing to the UCB-Novartis deal December 6, 2021 # # # # Alpha synuclein has long been viewed at “Public enemy #1” by the Parkinson’s research community. This sticky, abundant protein starts to cluster (or aggregate) in Parkinson’s. There have been several attempts to reduce levels of the protein floating around outside of cells (using “immunotherapy” approaches) But now clinical research is ramping up to determine if reducing…
• Be one with Vitamin B1 April 13, 2022     # # # # BEFORE WE START: There are some topics that I am reluctant to address on this website, because there are folks within the community who have extremely vested interests in them. Thiamine (or Vitamin B1) is one of those topics. Some members of the Parkinson’s community have indicated to me that high doses of this…