Unveiling the biopathway for the design of novel COMT Inhibitors

Unveiling the biopathway for the design of novel COMT Inhibitors
Drug Discov Today. 2022 Jul 27:S1359-6446(22)00298-7. doi: 10.1016/j.drudis.2022.07.013. Online ahead of print.ABSTRACTCatechol-O-methyltransferase (COMT) is an enzyme responsible for the O-methylation of biologically active catechol-based molecules. It has been associated with several neurological disorders, especially Parkinson's disease (PD), because of its involvement in catecholamine metabolism, and has been considered an important therapeutic target for central nervous system disorders. In this review, ... read more
Source: PubMedPublished on 2022-07-30By Pedro Cruz-Vicente