Using a Supercomputer to Understand Synaptic Transmission – Neuroscience News

Related Articles:

• Neuroscience week 1 October 2, 2021 Saturday 2 October 2021 The first week of the MSc course in neuroscience I am doing at King’s College London was quite a shock. I had been expecting a gentle introduction: some basics like “what is neuroscience” to lay a foundation, some admin, some meetings with tutors and the like. There were a couple of introductory lectures on topics like…
• Parkinson's Disease News - Editor's Picks (Archive 2016.07) September 30, 2016 Newsfeed: PD News PD Research News PD Fitness News PD Boxing News PD Web Articles PD Blogs PD Editor's Picks PD Twitter Newsfeed Pedaling for Parkinson’sThat is what it’s like living with Parkinson’s disease. Parkinson’s disease is a chronic, neurodegenerative disorder in which the loss of cells in various parts of the brain leaves people less able to control their…
• Synaptic Proteins Linked to Parkinson’s Could Aid in Early Intervention, Study Says February 21, 2018 Key proteins involved in neuron communication are potential targets that could aid in early diagnosis and prediction of disease progression in patients with different types of dementias, including Parkinson’s disease, a study suggests. The study, “Synaptic markers of cognitive decline in neurodegenerative diseases: a proteomic approach,” was published in the journal Brain. Specific synaptic proteins, which are involved in neuron-to-neuron communication,…
• The Stimulatory Effects of Intracellular α-Synuclein on Synaptic Transmission Are Attenuated by 2-Octahydroisoquinolin-2(1H)-ylethanamine December 24, 2021 Int J Mol Sci. 2021 Dec 9;22(24):13253. doi: 10.3390/ijms222413253.ABSTRACTα-Synuclein (αSyn) species can be detected in synaptic boutons, where they play a crucial role in the pathogenesis of Parkinson's Disease (PD). However, the effects of intracellular αSyn species on synaptic transmission have not been thoroughly studied. Here, using patch-clamp recordings in hippocampal neurons, we report that αSyn oligomers (αSynO), intracellularly delivered…
• The Stimulatory Effects of Intracellular α-Synuclein on Synaptic Transmission Are Attenuated by 2-Octahydroisoquinolin-2(1H)-ylethanamine December 24, 2021 Int J Mol Sci. 2021 Dec 9;22(24):13253. doi: 10.3390/ijms222413253.ABSTRACTα-Synuclein (αSyn) species can be detected in synaptic boutons, where they play a crucial role in the pathogenesis of Parkinson's Disease (PD). However, the effects of intracellular αSyn species on synaptic transmission have not been thoroughly studied. Here, using patch-clamp recordings in hippocampal neurons, we report that αSyn oligomers (αSynO), intracellularly delivered…
• The Stimulatory Effects of Intracellular α-Synuclein on Synaptic Transmission Are Attenuated by 2-Octahydroisoquinolin-2(1H)-ylethanamine December 24, 2021 Int J Mol Sci. 2021 Dec 9;22(24):13253. doi: 10.3390/ijms222413253.ABSTRACTα-Synuclein (αSyn) species can be detected in synaptic boutons, where they play a crucial role in the pathogenesis of Parkinson's Disease (PD). However, the effects of intracellular αSyn species on synaptic transmission have not been thoroughly studied. Here, using patch-clamp recordings in hippocampal neurons, we report that αSyn oligomers (αSynO), intracellularly delivered…
• The Stimulatory Effects of Intracellular α-Synuclein on Synaptic Transmission Are Attenuated by 2-Octahydroisoquinolin-2(1H)-ylethanamine December 24, 2021 Int J Mol Sci. 2021 Dec 9;22(24):13253. doi: 10.3390/ijms222413253.ABSTRACTα-Synuclein (αSyn) species can be detected in synaptic boutons, where they play a crucial role in the pathogenesis of Parkinson's Disease (PD). However, the effects of intracellular αSyn species on synaptic transmission have not been thoroughly studied. Here, using patch-clamp recordings in hippocampal neurons, we report that αSyn oligomers (αSynO), intracellularly delivered…
• The Stimulatory Effects of Intracellular α-Synuclein on Synaptic Transmission Are Attenuated by 2-Octahydroisoquinolin-2(1H)-ylethanamine December 24, 2021 Int J Mol Sci. 2021 Dec 9;22(24):13253. doi: 10.3390/ijms222413253.ABSTRACTα-Synuclein (αSyn) species can be detected in synaptic boutons, where they play a crucial role in the pathogenesis of Parkinson's Disease (PD). However, the effects of intracellular αSyn species on synaptic transmission have not been thoroughly studied. Here, using patch-clamp recordings in hippocampal neurons, we report that αSyn oligomers (αSynO), intracellularly delivered…
• The Stimulatory Effects of Intracellular α-Synuclein on Synaptic Transmission Are Attenuated by 2-Octahydroisoquinolin-2(1H)-ylethanamine December 24, 2021 Int J Mol Sci. 2021 Dec 9;22(24):13253. doi: 10.3390/ijms222413253.ABSTRACTα-Synuclein (αSyn) species can be detected in synaptic boutons, where they play a crucial role in the pathogenesis of Parkinson's Disease (PD). However, the effects of intracellular αSyn species on synaptic transmission have not been thoroughly studied. Here, using patch-clamp recordings in hippocampal neurons, we report that αSyn oligomers (αSynO), intracellularly delivered…
• The Stimulatory Effects of Intracellular α-Synuclein on Synaptic Transmission Are Attenuated by 2-Octahydroisoquinolin-2(1H)-ylethanamine December 24, 2021 Int J Mol Sci. 2021 Dec 9;22(24):13253. doi: 10.3390/ijms222413253.ABSTRACTα-Synuclein (αSyn) species can be detected in synaptic boutons, where they play a crucial role in the pathogenesis of Parkinson's Disease (PD). However, the effects of intracellular αSyn species on synaptic transmission have not been thoroughly studied. Here, using patch-clamp recordings in hippocampal neurons, we report that αSyn oligomers (αSynO), intracellularly delivered…
• Parkinson's Disease News - Editor's Picks (Archive 2016.09) October 15, 2016 Newsfeed: PD News PD Research News PD Fitness News PD Boxing News PD Web Articles PD Blogs PD Editor's Picks PD Twitter Newsfeed ‘The Terrorist Inside My Husband’s Brain’: Robin Williams’ Widow Details His Disease – Live ScienceLive Science'The Terrorist Inside My Husband's Brain': Robin Williams' Widow Details His DiseaseLive ScienceBut Robin Williams was not diagnosed with Lewy body disease…
• The Art of Neuroscience August 31, 2021 Four year ago I wrote this Letter to A Young Researcher. Having just read it again I’m struck by two things. One, there is very little I would change and two, there is very little that has changed. Perhaps what is needed is a simpler rallying cry, something more actionable. Something every student who pursues studying the brain could easily…
• Functional Differences between Synaptic Mitochondria from the Striatum and the Cerebral Cortex. March 17, 2019 Related ArticlesFunctional Differences between Synaptic Mitochondria from the Striatum and the Cerebral Cortex. Neuroscience. 2019 Mar 12;: Authors: Petersen MH, Willert CW, Andersen JV, Waagepetersen HS, Skotte NH, Nørremølle A Abstract Mitochondrial dysfunction has been shown to play a major role in neurodegenerative disorders such as Huntington's disease, Alzheimer's disease and Parkinson's disease. In these and other neurodegenerative disorders, disruption…
• The road ahead: 2020 January 5, 2020 Here at the SoPD, we are primarily interested in disease modification for Parkinson’s. While there is a great deal of interesting research exploring the causes of the condition, novel symptomatic therapies, and other aspects of Parkinson’s, my focus is generally on the science seeking to slow, stop or reverse the condition. At the start of each year, it is a…
• [Dopamine D2 receptor may be involved in the regulation of cortical-striatum synaptic transmission and autonomic activity in PD mice by exercise]. August 24, 2019 Related Articles[Dopamine D2 receptor may be involved in the regulation of cortical-striatum synaptic transmission and autonomic activity in PD mice by exercise]. Sheng Li Xue Bao. 2019 Aug 25;71(4):547-554 Authors: Zhao G, Zhang DY, Liu XL, Qiao DC Abstract The aim of the present study was to reveal the role of cortical-striatum postsynaptic dopamine D2 receptor (D2R) in improving motor…
• Tau Prevents Synaptic Transmission at Early Stage of Neurodegeneration May 19, 2017 Study reveals Tau proteins disrupt synaptic transmission in early stages of neurodegenerative diseases. The post Tau Prevents Synaptic Transmission at Early Stage of Neurodegeneration appeared first on Neuroscience News.
• The road ahead: 2022 January 20, 2022 # # # # The first post at the start of each year on the SoPD website tries to provide an overview of where things are in the search for ‘disease modifying’ therapies for Parkinson’s.  It is an exercise in managing expectations as well as discussing what research events are scheduled for the next year so that we can keep…
• Synaptic Vesicle Defect Leads to Neurodegeneration in Parkinson’s, Study Suggests June 1, 2018 Impaired intake of neurotransmitters leads to accumulation of toxic dopamine and neurodegeneration in patients with Parkinson’s disease, according to a new Northwestern Medicine study. The study, “LRRK2 phosphorylation of auxilin mediates synaptic defects in dopaminergic neurons from patients with Parkinson’s disease,” appeared in the journal Proceedings of the National Academy of Sciences. Parkinson’s is characterized by a substantial loss of…
• Ginsenoside Rb1 regulates prefrontal cortical GABAergic transmission in MPTP-treated mice. July 18, 2019 Ginsenoside Rb1 regulates prefrontal cortical GABAergic transmission in MPTP-treated mice. Aging (Albany NY). 2019 Jul 17;11: Authors: Liu Y, Zong X, Huang J, Guan Y, Li Y, Du T, Liu K, Kang X, Dou C, Sun X, Wu R, Wen L, Zhang Y Abstract Parkinson's disease (PD) is a common neurodegenerative disease, featured by motor deficits and non-motor symptoms such…
• Synaptic tau: A pathological or physiological phenomenon? September 10, 2021 Acta Neuropathol Commun. 2021 Sep 9;9(1):149. doi: 10.1186/s40478-021-01246-y.ABSTRACTIn this review, we discuss the synaptic aspects of Tau pathology occurring during Alzheimer's disease (AD) and how this may relate to memory impairment, a major hallmark of AD. Whilst the clinical diagnosis of AD patients is a loss of working memory and long-term declarative memory, the histological diagnosis is the presence of…
• Synaptic tau: A pathological or physiological phenomenon? September 10, 2021 Acta Neuropathol Commun. 2021 Sep 9;9(1):149. doi: 10.1186/s40478-021-01246-y.ABSTRACTIn this review, we discuss the synaptic aspects of Tau pathology occurring during Alzheimer's disease (AD) and how this may relate to memory impairment, a major hallmark of AD. Whilst the clinical diagnosis of AD patients is a loss of working memory and long-term declarative memory, the histological diagnosis is the presence of…
• Synaptic tau: A pathological or physiological phenomenon? September 10, 2021 Acta Neuropathol Commun. 2021 Sep 9;9(1):149. doi: 10.1186/s40478-021-01246-y.ABSTRACTIn this review, we discuss the synaptic aspects of Tau pathology occurring during Alzheimer's disease (AD) and how this may relate to memory impairment, a major hallmark of AD. Whilst the clinical diagnosis of AD patients is a loss of working memory and long-term declarative memory, the histological diagnosis is the presence of…