Validation of α-Synuclein in L1CAM-Immunocaptured Exosomes as a Biomarker for the Stratification of Parkinsonian Syndromes

Validation of α-Synuclein in L1CAM-Immunocaptured Exosomes as a Biomarker for the Stratification of Parkinsonian Syndromes
Mov Disord. 2021 Apr 7. doi: 10.1002/mds.28591. Online ahead of print.ABSTRACTBACKGROUND: Parkinson's disease is characterized by intraneuronal α-synuclein aggregation. Currently there is no α-synuclein-based blood test in clinical practice.OBJECTIVES: Our aim was to assess by means of further testing and analysis whether α-synuclein measurements in serum L1CAM-immunocaptured exosomes can differentiate Parkinson's disease from related movement disorders.METHODS: We used poly(carboxybetaine-methacrylate)-coated magnetic ... read more
Source: PubMedPublished on 2021-04-07By Cheng Jiang