Webinar – Does Exenatide reduce Non-motor Symptoms in Parkinson’s?

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• The road ahead: 2020 January 5, 2020 Here at the SoPD, we are primarily interested in disease modification for Parkinson’s. While there is a great deal of interesting research exploring the causes of the condition, novel symptomatic therapies, and other aspects of Parkinson’s, my focus is generally on the science seeking to slow, stop or reverse the condition. At the start of each year, it is a…
• The 2019 Linked Clinical Trials meeting October 16, 2019   Things were a bit quiet on the SoPD over the summer, but for good reasons. There was a short hiatus for a family break, but the rest of the time I was rather occupied with the day job. Tremendous efforts were being made at the Cure Parkinson’s Trust, as we were gearing up for our main event of the…
• An exercise in expectations: Exenatide III October 20, 2019   In August 2017, the results of a Phase II double-blind, placebo controlled clinical trial investigating whether the diabetes drug Exenatide (aka Bydureon) can be repurposed for the treatment of Parkinson’s were published. Despite the fact that the study did not meet most of its end points, the Parkinson’s community got very excited about one of the results: The exenatide…
• An exercise in expectations: Exenatide III October 20, 2019   In August 2017, the results of a Phase II double-blind, placebo controlled clinical trial investigating whether the diabetes drug Exenatide (aka Bydureon) can be repurposed for the treatment of Parkinson’s were published. Despite the fact that the study did not meet most of its end points, the Parkinson’s community got very excited about one of the results: The exenatide…
• Webinar Discussion: 'Does Exenatide reduce non-motor symptoms in Parkinson’s disease?' September 18, 2018 YouTube Video https://www.youtube.com/watch?v=fXg_T47Iob4 We were delighted to hold the first of our new quarterly Parkinson’s webinar series in partnership with Journal of Parkinson’s Disease and Parkinson’s Movement on the 19th June. The webinar discussion led by Chair Professor Patrick Brundin examined the recent paper “What effects might exenatide have on non-motor symptoms in Parkinson’s disease: A post hoc analysis”, by…
• 2019: Year in review December 31, 2019   In this end-of-year post, we review the Parkinson’s research that caught our attention at SoPD HQ in 2019. Month-by-month we will briefly discuss some of the major pieces of research/announcements that have defined the year and advanced our understanding of Parkinson’s. The list is based on nothing more than the author’s personal opinion – apologies to any researchers who…
• Monthly research review: February 2020 February 29, 2020   At the end of each month the SoPD writes a post which provides an overview of some of the major pieces of Parkinson’s-related research that were made available during February 2020. The post is divided into seven parts based on the type of research: Basic biology Disease mechanism Clinical research New clinical trials Clinical trial news Other news Review…
• 2020: Year in Review January 1, 2021 # # # # In this end-of-year post, we review the Parkinson’s research that caught our attention at SoPD HQ in 2020. Month-by-month we will briefly discuss some of the major pieces of research/ announcements that have defined the year and advanced our understanding of Parkinson’s. The list is based on nothing more than the author’s personal opinion – apologies…
• Monthly Research Review: Jaunary 2020 January 31, 2020   At the end of each month the SoPD writes a post which provides an overview of some of the major pieces of Parkinson’s-related research that were made available during January 2020. The post is divided into seven parts based on the type of research: Basic biology, Disease mechanism, Clinical research, New clinical trials, Clinical trial news, Other news, and…
• Monthly Research Review – November 2019 November 30, 2019   At the end of each month the SoPD writes a post which provides an overview of some of the major pieces of Parkinson’s-related research that were made available during November 2019. The post is divided into seven parts based on the type of research: Basic biology Disease mechanism Clinical research New clinical trials Clinical trial news Other news Review…
• Journal of Parkinson’s Disease Awards First Parkinson Prizes July 22, 2020 The winning papers are: Aviles-Olmos I, Dickson, J, Kefalopoulou, Z, Djamshidian, A, Kahan, J, Ell, P, Whitton, P, Wyse, R, Isaacs, T, Lees, A, Limousin, P, Foltynie, T (2014), “Motor and Cognitive Advantages Persist 12 Months After Exenatide Exposure in Parkinson’s Disease,” J Parkinsons Dis, 4, 337–344; and Braak, H, Del Tredici, K (2017), “Neuropathological Staging of Brain Pathology in Sporadic…
• Journal of Parkinson’s Disease Awards First Parkinson Prizes July 22, 2020 The winning papers are: Aviles-Olmos I, Dickson, J, Kefalopoulou, Z, Djamshidian, A, Kahan, J, Ell, P, Whitton, P, Wyse, R, Isaacs, T, Lees, A, Limousin, P, Foltynie, T (2014), “Motor and Cognitive Advantages Persist 12 Months After Exenatide Exposure in Parkinson’s Disease,” J Parkinsons Dis, 4, 337–344; and Braak, H, Del Tredici, K (2017), “Neuropathological Staging of Brain Pathology in Sporadic…
• Journal of Parkinson’s Disease Awards First Parkinson Prizes July 22, 2020 The winning papers are: Aviles-Olmos I, Dickson, J, Kefalopoulou, Z, Djamshidian, A, Kahan, J, Ell, P, Whitton, P, Wyse, R, Isaacs, T, Lees, A, Limousin, P, Foltynie, T (2014), “Motor and Cognitive Advantages Persist 12 Months After Exenatide Exposure in Parkinson’s Disease,” J Parkinsons Dis, 4, 337–344; and Braak, H, Del Tredici, K (2017), “Neuropathological Staging of Brain Pathology in Sporadic…
• Monthy research review – December 2019 December 30, 2019   At the end of each month the SoPD writes a post which provides an overview of some of the major pieces of Parkinson’s-related research that were made available during December 2019. The post is divided into seven parts based on the type of research: Basic biology Disease mechanism Clinical research New clinical trials Clinical trial news Other news Review…
• Monthly Research Review – September 2019 September 30, 2019   At the end of each month the SoPD writes a post which provides an overview of some of the major pieces of Parkinson’s-related research that were made available during September 2019. The post is divided into seven parts based on the type of research: Basic biology Disease mechanism Clinical research New clinical trials Clinical trial news Other news Review…
• Monthly Research Review – December 2020 December 31, 2020   At the end of each month the SoPD writes a post which provides an overview of some of the major pieces of Parkinson’s-related research that were made available during December 2020. The post is divided into seven parts based on the type of research: Basic biology Disease mechanism Clinical research New clinical trials Clinical trial news Conferences/lectures Other news…
• Monthly research review – October 2019 October 31, 2019   At the end of each month the SoPD writes a post which provides an overview of some of the major pieces of Parkinson’s-related research that were made available during October 2019. The post is divided into seven parts based on the type of research: Basic biology Disease mechanism Clinical research New clinical trials Clinical trial news Other news Review…
• The Ambroxol Results January 14, 2020   The new year has started with some pleasing clinical trial news for the Parkinson’s community: The results of the “Ambroxol in Disease Modification in Parkinson Disease” (AiM-PD study) have been published. This is a clinically available drug that is used for the treatment of respiratory issues, which researchers are re-purposing for Parkinson’s based on some interesting properties the drug…
• Monthly Research Review – August 2019 August 31, 2019   At the end of each month the SoPD writes a post which provides an overview of some of the major pieces of Parkinson’s-related research that were made available during August 2019. The post is divided into seven parts based on the type of research: Basic biology Disease mechanism Clinical research New clinical trials Clinical trial news Other news Review…
• Milestones in Parkinson’s Disease Research and Discovery April 11, 2017 “The real voyage of discovery consists not in seeking new landscapes, but in having new eyes.” Marcel Proust “The process of scientific discovery is, in effect, a continual flight from wonder.” Albert Einstein Preface:  Happy birthday to James Parkinson (neurologist, geologist, scientist, activist),  born April 11, 1755 and died December 21, 1824.  World Parkinson’s Day April 11, 2017. Introduction to…
• Diabetes Therapy Byetta Improves Parkinson’s Patients’ Movement, Clinical Trial Shows August 8, 2017 Parkinson’s patients who injected themselves with the diabetes therapy Byetta (exenatide) every week for a year were able to move better, according to a Phase 2 clinical trial. Their improvement contrasted with the continued decline in the movement of the study’s control group, who received a placebo. While the Phase 2 EXENATIDE-PD trial (NCT01971242) suggested that Byetta stopped the progression of Parkinson’s,…
• Planet Patient vs Planet Researcher: From Both Sides, Now June 27, 2018 “I cannot always control what goes on outside. But I can always control what goes on inside.” Wayne Dyer “Judge a man by his questions rather than his answers.” Voltaire Setting the Stage: This is Mariëtte Robijn-  She lives in the Netherlands and was diagnosed with Parkinson’s at the young age of 46.  Mariëtte has a dynamic and vibrant blog…