White matter hyperintensity burden predicts cognitive but not motor decline in Parkinson’s disease. Results from the ONDRI

White matter hyperintensity burden predicts cognitive but not motor decline in Parkinson’s disease. Results from the ONDRI
Eur J Neurol. 2023 Jan 24. doi: 10.1111/ene.15692. Online ahead of print.ABSTRACTBACKGROUND: The pathophysiology of Parkinson's disease (PD) negatively affects brain network connectivity, and in the presence of brain white matter hyperintensities (WMH) cognitive and motor impairments seem to be aggravated. However, the role of WMH in predicting accelerating symptom worsening remains controversial.OBJECTIVE: To investigate whether location and segmental brain ... read more
Source: PubMedPublished on 2023-01-24By Daniela Cristina Carvalho de Abreu