Another Parkinson’s and Coffee Study

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    • #25170

      Fire up your espresso machine.

      In this most recent study published in the journal Parkinsonism and Related Disorders, 79 newly diagnosed PD patients received follow up for 4 years.

      Highlights
      •Caffeine consumption was associated with a reduced accrual of PD motor disability.
      •PD patients with higher caffeine use presented a reduced need for l-Dopa treatment.
      •Non-motor symptoms presented a milder progression among PD patients using caffeine.

      …considering the whole study period, each additional espresso cup per day (50 mg of caffeine) was more likely associated with 5-point lower UPDRS part III total score, and with 5-point lower NMSQuest total score, but not with UPDRS part IV total score.

      UPDRS refers to the Unified Parkinson’s Disease Rating Scale, which is how doctors assess the severity of a patient’s PD. Lower is better. Part III is the clinician-scored and monitored motor evaluation. Part IV, which showed no difference in this study, is about complications of treatment such as dyskinesia and on/off fluctuations. The rating scale is defined at http://www.movementdisorders.org/MDS-Files1/PDFs/Rating-Scales/MDS-UPDRSfinal_Update.pdf

      NMSQuest refers to the Nonmotor Symptoms Questionnaire for Parkinson’s Disease, which attempts to provide a comprehensive assessment of the range of nonmotor symptoms in PD. The rating scale is defined at http://www.movementdisorders.org/MDS-Files1/PDFs/MDS-UPDRS-Rating-Scales/NMSQ.pdf

      Article in the Daily Express: http://www.express.co.uk/life-style/health/710635/Parkinson-s-disease-symptoms-caffeine-coffee-chocolate-walking

      Link to the study abstract (and paid access to full text): http://dx.doi.org/10.1016/j.parkreldis.2016.08.005

    • #93510
      BrettW
      Keymaster

      Recent studies have tried to identify which compounds in coffee may be responsible for potential benefits for people with Parkinson’s.

      One of the compounds that has been receiving attention is EHT (Eicosanoyl-5-hydroxytryptamide), which is found in the waxy coating of the bean. Researchers at Rutgers found that EHT protects the brains of mice against abnormal protein accumulation associated with Parkinson’s disease and Lewy body dementia. In a recent study, they looked at whether EHT and caffeine could work together for even greater brain protection. They gave mice small doses of caffeine or EHT separately, as well as together. Each compound alone was not effective, but when given together they boosted the activity of a catalyst that helps prevent the accumulation of harmful proteins in the brain.

      More detail can be found here: https://www.sciencedaily.com/releases/2018/12/181210122851.htm

      The full study report is here: https://doi.org/10.1073/pnas.1813365115

      It’s important to keep in mind that this is a study on mice, not humans.

      Interestingly enough, after posting this, I see the National Parkinson Foundation also just did a write-up on this: https://parkinson.org/blog/science-news/coffee-and-parkinsons-protection-in-the-making

      • This reply was modified 6 days, 6 hours ago by  BrettW.
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