Is neurodegeneration in Parkinson’s the result of endoplasmic reticulum stress rather than mitochondria failure?

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Home Forums New Research / Cutting Edge Is neurodegeneration in Parkinson’s the result of endoplasmic reticulum stress rather than mitochondria failure?

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    brett
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    New findings challenge current view on origins of Parkinson’s disease

    Issued by the University of Leicester Press Office on 23 June

    The neurodegeneration that occurs in Parkinson’s disease is a result of stress on the endoplasmic reticulum in the cell rather than failure of the mitochondria as previously thought, according to a study in fruit flies. It was found that the death of neurons associated with the disease was prevented when chemicals that block the effects of endoplasmic reticulum stress were used.

    Some inherited forms of early-onset Parkinson’s disease have typically been blamed on poorly functioning mitochondria, the powerhouses of cells. Without reliable sources of energy, neurons wither and die. This may not be the complete picture of what is happening within cells affected by Parkinson’s. Researchers from the MRC Toxicology Unit at the University of Leicester used a common fruit fly to investigate this further; fruit flies were used because they provide a good genetic model for humans.

    University of Leicester Press Release: http://www2.le.ac.uk/offices/press/press-releases/2016/june/new-findings-challenge-current-view-on-origins-of-parkinson2019s-disease

    https://youtu.be/13oA5eiH-8s

    Study to be published here: http://dx.doi.org/10.1038/cddis.2016.173 (not yet available at time of this post)

    Related info:

    Axel H. Schönthal, “Endoplasmic Reticulum Stress: Its Role in Disease and Novel Prospects for Therapy,” Scientifica, vol. 2012, Article ID 857516, 26 pages, 2012. doi:10.6064/2012/857516 http://dx.doi.org/10.6064/2012/857516

    Chaudhari N, Talwar P, Parimisetty A, Lefebvre d’Hellencourt C, Ravanan P. A Molecular Web: Endoplasmic Reticulum Stress, Inflammation, and Oxidative Stress. Frontiers in Cellular Neuroscience. 2014;8:213. doi:10.3389/fncel.2014.00213. http://dx.doi.org/10.3389/fncel.2014.00213

    Dr. Courtney Craig, “Beyond The Mitochondria: Endoplasmic Reticulum Stress” http://www.drcourtneycraig.com/blog/2014/11/29/looking-beyond-the-mitochondria-endoplasmic-reticulum-stress

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