PD Latest Research

Impaired serine metabolism complements LRRK2-G2019S pathogenicity in PD patients. Parkinsonism Relat Disord. 2019 Sep 19;67:48-55 Authors: Nickels SL, Walter J, Bolognin S, Gérard D, Jaeger C, Qing X, Tisserand J, Jarazo J, Hemmer K, Harms A, Halder R, Lucarelli P, Berger E, Antony PMA, Glaab E, Hankemeier T, Klein C, Sauter T, Sinkkonen L, Schwamborn JC Abstract Parkinson's disease (PD) ... read more

Related ArticlesA review on iron chelators as potential therapeutic agents for the treatment of Alzheimer's and Parkinson's diseases. Mol Divers. 2019 May;23(2):509-526 Authors: Singh YP, Pandey A, Vishwakarma S, Modi G Abstract Iron plays a vital role in several cellular functions due to its unique physiochemical properties. Iron concentration increases in the brain with age due to multiple factors. ... read more

Comparing self-reported and objective monitoring of physical activity in Parkinson disease. Parkinsonism Relat Disord. 2019 Sep 05;67:56-59 Authors: Mantri S, Wood S, Duda JE, Morley JF Abstract INTRODUCTION: Monitoring physical activity is important in Parkinson disease (PD), but patient recall may be unreliable. We examined relationships between self-reported activity, objective monitoring, and clinical characteristics. METHODS: Participants completed the self-reported Physical ... read more

Physiotherapy improves motor function in patients with the Parkinson variant of multiple system atrophy: A prospective trial. Parkinsonism Relat Disord. 2019 Sep 24;67:60-65 Authors: Raccagni C, Goebel G, Gaßner H, Granata R, Ndayisaba JP, Seebacher B, Schoenherr G, Mitterhuber J, Hendriks P, Kaindlstorfer C, Eschlboeck S, Fanciulli A, Krismer F, Seppi K, Poewe W, Bloem BR, Klucken J, Wenning GK ... read more

Impulse control symptoms in patients with Parkinson's disease: The influence of dopaminergic agonist. Parkinsonism Relat Disord. 2019 Jun 26;68:17-21 Authors: Vargas AP, Vaz LS, Reuter A, Couto CM, Costa Cardoso FE Abstract BACKGROUND: Impulse control disorders and punding are common in Parkinson's disease patients. Cross-sectional studies suggest an association between dopamine replacement therapy, especially dopaminergic agonists, and impulse control and ... read more

Longitudinal intracortical diffusivity changes in de-novo Parkinson's disease: A promising imaging biomarker. Parkinsonism Relat Disord. 2019 Oct 01;68:22-25 Authors: Sampedro F, Martínez-Horta S, Marín-Lahoz J, Pagonabarraga J, Kulisevsky J Abstract Cognitive impairment and dementia in Parkinson's disease (PD) are highly disabling non-motor symptoms with no effective treatment currently available. As cortical degeneration is thought to be involved in the development ... read more

Systemic LPS-induced neuroinflammation increases the susceptibility for proteasome inhibition-induced degeneration of the nigrostriatal pathway. Parkinsonism Relat Disord. 2019 Sep 23;68:26-32 Authors: Deneyer L, Albertini G, Bentea E, Massie A Abstract INTRODUCTION: Besides proteasome dysfunction, neuroinflammation is a common feature in the pathogenesis of Parkinson's disease (PD). Accordingly, peripheral inflammation has been shown to increase the susceptibility of the brain for ... read more

Objective impairment of tandem gait in Parkinson's disease patients increases with disease severity. Parkinsonism Relat Disord. 2019 Sep 26;68:33-39 Authors: Sharma R, Pillai L, Glover A, Virmani T Abstract INTRODUCTION: Tandem gait abnormalities have been reported to increase with advancing age, play a role in fall-prediction in Parkinson's disease, and distinguish it from atypical parkinsonism. Tandem gait has been scored ... read more

Transcranial sonography in atypical parkinsonism: How reliable is it in real clinical practice? A multicentre comprehensive study. Parkinsonism Relat Disord. 2019 Oct 01;68:40-45 Authors: Alonso-Canovas A, Tembl Ferrairó JI, Martínez-Torres I, Lopez-Sendon Moreno JL, Parees-Moreno I, Monreal-Laguillo E, Pérez-Torre P, Toledano Delgado R, García Ribas G, Sastre Bataller I, Masjuan J, Martinez-Castrillo JC, Walter U Abstract INTRODUCTION: Substantia nigra hyperechogenicity ... read more

How to evaluate effects of occupational therapy - lessons learned from an exploratory randomized controlled trial. Parkinsonism Relat Disord. 2019 Sep 19;67:42-47 Authors: Schaeffer E, Streich S, Wurster I, Schubert R, Reilmann R, Wolfram S, Berg D Abstract BACKGROUND: Although occupational therapy (OT) is frequently prescribed in clinical practice, there is still insufficient evidence regarding its efficacy to improve Parkinson's ... read more

The effect of levodopa on saccades - Oxford Quantification in Parkinsonism study. Parkinsonism Relat Disord. 2019 Sep 27;68:49-56 Authors: Lu Z, Buchanan T, Kennard C, FitzGerald JJ, Antoniades CA Abstract OBJECTIVES: The evaluation of novel disease modifying drugs requires biomarkers that are simultaneously sensitive to disease state but resistant to the effects of background symptomatic treatment. Saccadic eye movement parameters ... read more

Education level affects dual-task gait after deep brain stimulation in Parkinson's disease. Parkinsonism Relat Disord. 2019 Oct 07;68:65-68 Authors: Wegrzyk J, Armand S, Chiuvé SC, Burkhard PR, Allali G Abstract INTRODUCTION: High cognitive reserve is associated with milder cognitive and motor deficits in Parkinson's disease (PD). We investigated whether educational status (as a proxy for cognitive reserve) could modulate dual-task ... read more

Feasibility of repeat and bilateral submandibular gland needle biopsies in Parkinson's disease. Parkinsonism Relat Disord. 2019 Oct 07;68:69-72 Authors: Adler CH, Serrano GE, Zhang N, Hinni ML, Lott DG, Mehta SH, Sue LI, Intorcia A, Beach TG Abstract INTRODUCTION: Submandibular gland (SMG) biopsies detect pathological alpha-synuclein (aSyn) in patients with Parkinson's disease (PD). The objectives of this study were to ... read more

Sex differences in the short-term and long-term effects of subthalamic nucleus stimulation in Parkinson's disease. Parkinsonism Relat Disord. 2019 Sep 30;68:73-78 Authors: Kim R, Yoo D, Choi JH, Shin JH, Park S, Kim HJ, Paek SH, Jeon B Abstract OBJECTIVE: To assess the influence of sex on the short-term and long-term effects of subthalamic nucleus stimulation (STN-DBS) in Parkinson's disease ... read more

Evaluating reflexive saccades and UDPRS as markers of Deep Brain Stimulation and Best Medical Treatment improvements in Parkinson's disease patients: a prospective controlled study. Neurol Neurochir Pol. 2019 Oct 17;: Authors: Szlufik S, Przybyszewski A, Dutkiewicz J, Mandat T, Habela P, Koziorowski D Abstract INTRODUCTION: To date, there has been no clear evidence regarding the evaluation of saccades as a ... read more

Submentalis REM Sleep Muscle Activity: A Potential Biomarker for Synucleinopathy. Ann Neurol. 2019 Oct 17;: Authors: McCarter SJ, Feemster JC, Tabatabai GM, Sandness DJ, Timm PC, McCarter AR, Talley HN, Junna MR, Savica R, Singer W, Coon EA, Benarroch EE, Josephs KA, Boeve BF, Silber MH, St Louis EK Abstract Accurate antemortem diagnosis of Parkinsonism is primarily based on clinical ... read more

Cell therapy for central nervous system disorders: Current obstacles to progress. CNS Neurosci Ther. 2019 Oct 17;: Authors: Yasuhara T, Kawauchi S, Kin K, Morimoto J, Kameda M, Sasaki T, Bonsack B, Kingsbury C, Tajiri N, Borlongan CV, Date I Abstract Cell therapy for disorders of the central nervous system has progressed to a new level of clinical application. Various ... read more

Risk Factors and Metabolism of Different Brain Regions by Positron Emission Tomography in Parkinson Disease with Disabling Dyskinesia. Curr Neurovasc Res. 2019 Oct 08;: Authors: Wei H, Zhao J, Zhan L, Zhou Y Abstract BACKGROUND: Motor fluctuations and dyskinesia are the most common motor complications in Parkinson's disease (PD) and have severe impact on daily life. OBJECTIVE: To investigate risk ... read more

Clinical variability in Chinese families with Parkinson disease and SNCA duplication, including the shortest 139kb duplication. Parkinsonism Relat Disord. 2019 Sep 28;68:60-62 Authors: Du YJ, Shen Y, Wang YX, Sun YM, Liu FT, Chen C, Chen K, Zuo CT, Wu JJ, Wang J, An Y, Yu H PMID: 31621621 [PubMed - as supplied by publisher] ... read more

Drug Choices and Advancements for Managing Depression in Parkinson`s Disease. Curr Neuropharmacol. 2019 Oct 15;: Authors: Assogna F, Pellicano C, Savini C, Macchiusi L, Pellicano GR, Alborghetti M, Caltagirone C, Spalletta G, Pontieri FE Abstract Depression is a frequent non-motor symptom of Parkinson's disease (PD), and may even precede the onset of motor symptoms of parkinsonism. Beyond its negative influence ... read more

Altered brain structural topological properties in Parkinson's disease with levodopa-induced dyskinesias. Parkinsonism Relat Disord. 2019 Sep 19;67:36-41 Authors: Wang L, Wang M, Si Q, Yuan Y, Ma K, Gan C, Zhang K Abstract OBJECTIVES: In this study, the alterations of structural topological properties in Parkinson's disease (PD) patients with levodopa-induced dyskinesias (LIDs) were explored using white matter structural network connectome ... read more

Long-term trends in myocardial sympathetic innervation and function in synucleinopathies. Parkinsonism Relat Disord. 2019 Sep 16;67:27-33 Authors: Lamotte G, Holmes C, Wu T, Goldstein DS Abstract INTRODUCTION: Parkinson disease (PD), pure autonomic failure (PAF), and multiple system atrophy (MSA) are characterized by intra-cerebral deposition of the protein alpha-synuclein and are termed synucleinopathies. Lewy body synucleinopathies involve decreased cardiac sympathetic innervation ... read more

Related ArticlesNeuroprotective and Antioxidant Effect of Naringenin-Loaded Nanoparticles for Nose-to-Brain Delivery. Brain Sci. 2019 Oct 15;9(10): Authors: Md S, Alhakamy NA, Aldawsari HM, Asfour HZ Abstract Parkinson's disease (PD) is a neurodegenerative disorder resulting in a decreased nigrostriatal availability of dopamine. Oxidative stress is one factor contributing to PD. Naringenin (NAR), a flavonoid, is a potent antioxidant shown to be ... read more

Related ArticlesCan therapeutic strategies prevent and manage dyskinesia in Parkinson's disease? An update. Expert Opin Drug Saf. 2019 Oct 16;: Authors: Leta V, Jenner P, Chaudhuri KR, Antonini A Abstract Introduction: Dyskinesia is a motor complication of Parkinson's disease (PD) characterized by clinical heterogeneity and complex pathogenesis and associated with long-term levodopa therapy. Recent and controversial views on the management ... read more

Related ArticlesA randomized controlled efficacy study of the Medido medication dispenser in Parkinson's disease. BMC Geriatr. 2019 Oct 16;19(1):273 Authors: Hannink K, Ter Brake L, Oonk NGM, Wertenbroek AA, Piek M, Vree-Egberts L, Faber MJ, van der Palen J, Dorresteijn LD Abstract BACKGROUND: Complex medication schedules in Parkinson's disease (PD) result in lower therapy adherence, which contributes to suboptimal therapy ... read more