Parkinson’s Disease Latest Research

Related Articles[Effect of afobazole and levodopa on the activity of proline-specific proteinases and adenosine deaminase in blood serum and brain structures of rats with experimental Parkinson's syndrome induced by systemic administration of rotenone]. Biomed Khim. 2017 Nov;63(6):565-569 Authors: Ivanova EA, Zolotov NN, Kapitsa IG, Pozdnev VF, Valdman EA, Voronina TA Abstract Rats with experimental Parkinson's syndrome induced by seven-day intraperitoneal ... read more

Related ArticlesMicroRNA-124 regulates the expression of p62/p38 and promotes autophagy in the inflammatory pathogenesis of Parkinson's disease. FASEB J. 2019 Apr 17;:fj201900363R Authors: Yao L, Zhu Z, Wu J, Zhang Y, Zhang H, Sun X, Qian C, Wang B, Xie L, Zhang S, Lu G Abstract Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor and nonmotor symptoms due ... read more

Related ArticlesManagement of Dysphagia in Patients with Parkinson's Disease and Related Disorders. Intern Med. 2019 Apr 17;: Authors: Umemoto G, Furuya H Abstract Various methods of rehabilitation for dysphagia have been suggested through the experience of treating stroke patients. Although most of these patients recover their swallowing function in a short period, dysphagia in Parkinson's disease (PD) and Parkinson-related disorder ... read more

Related ArticlesL-DOPA-quinone Mediated Recovery from GIRK Channel Firing Inhibition in Dopaminergic Neurons. ACS Med Chem Lett. 2019 Apr 11;10(4):431-436 Authors: Bizzarri BM, Botta L, Aversa D, Mercuri NB, Poli G, Barbieri A, Berretta N, Saladino R Abstract The oxidative degeneration of dopamine-releasing (DAergic) neurons in the substantia nigra pars compacta (SNc) has attracted much interest in preclinical research, due to ... read more

Related ArticlesLarge left posterior fossa meningioma presenting with quadriplegia in a woman with history of carbidopa-levodopa resistant parkinsonism. Neurol Int. 2019 Mar 11;11(1):7815 Authors: Reyes AJ, Ramcharan K, Alvarez M, Greaves W, Rampersad F Abstract A 56-year-old Afro-Trinidadian woman with a history of a carbidopa-levodopa resistance Parkinsonian-like syndrome for 2 years, presented with acute onset spastic quadriplegia and decreased responsiveness. ... read more

Related ArticlesExploring hyperhidrosis and related thermoregulatory symptoms as a possible clinical identifier for the dysautonomic subtype of Parkinson's disease. J Neurol. 2019 Apr 17;: Authors: van Wamelen DJ, Leta V, Podlewska AM, Wan YM, Krbot K, Jaakkola E, Martinez-Martin P, Rizos A, Parry M, Metta V, Ray Chaudhuri K Abstract OBJECTIVE: To identify associated (non-)motor profiles of Parkinson's disease (PD) ... read more

Related ArticlesUsability of a daily mHealth application designed to address mobility, speech and dexterity in Parkinson's disease. Neurodegener Dis Manag. 2019 Apr 18;: Authors: Horin AP, McNeely ME, Harrison EC, Myers PS, Sutter EN, Rawson KS, Earhart GM Abstract Aim: This study investigated the usability of a mobile health (mHealth) smartphone application to treat gait, speech and dexterity in people ... read more

Related ArticlesBarriers and facilitators of communication about off periods in Parkinson's disease: Qualitative analysis of patient, carepartner, and physician Interviews. PLoS One. 2019;14(4):e0215384 Authors: Armstrong MJ, Rastgardani T, Gagliardi AR, Marras C Abstract BACKGROUND: Successful patient-physician communication is critical for improving health outcomes, but research regarding optimal communication practices in Parkinson's disease is limited. The objective of the current study ... read more

Related ArticlesTo stitch or not to stitch: A case review: Auricular lacerations involving cartilage management in the emergency department. Australas Emerg Care. 2018 May;21(2):75-79 Authors: Yuen SM, Jennings N Abstract Patients with Parkinsonism are at risk of frequent falls by virtue of their unstable gait. Auricular lacerations involving the cartilage are usually managed by Plastics Surgeons. Patient Mr Jones (an ... read more

Related ArticlesPrioritized Brain Selenium Retention and Selenoprotein Expression: Nutritional Insights into Parkinson's Disease. Mech Ageing Dev. 2019 Apr 15;: Authors: Zhang X, Liu RP, Cheng WH, Zhu JH Abstract Selenium (Se), an essential trace mineral, confers its physiological functions mainly through selenoproteins, most of which are oxidoreductases. Results from animal, epidemiological, and human genetic studies link Parkinson's disease to Se ... read more

Related ArticlesPhysical activity sustains memory retrieval in dopamine-depleted mice previously treated with L-Dopa. Behav Brain Res. 2019 Apr 15;:111915 Authors: Iggena D, Klein C, Rasińska J, Sparenberg M, Winter Y, Steiner B Abstract The neurodegenerative disorder Parkinson's disease affects motor abilities as well as cognition. The gold standard therapy is L-Dopa, which mainly restores motor skills. Therefore, we require additional ... read more

Related ArticlesDietary Macronutrient Management to Treat Mitochondrial Dysfunction in Parkinson's Disease. Int J Mol Sci. 2019 Apr 15;20(8): Authors: Bajracharya R, Youngson NA, Ballard JWO Abstract Mitochondrial dysfunction has been demonstrated to play an important role in the pathogenesis of Parkinson's disease (PD). The products of several PD-associated genes, including alpha-synuclein, parkin, pink1, protein deglycase DJ-1, and leucine rich repeat ... read more

Related ArticlesQuantitative Characterization of α-Synuclein Aggregation in Living Cells through Automated Microfluidics Feedback Control. Cell Rep. 2019 Apr 16;27(3):916-927.e5 Authors: Perrino G, Wilson C, Santorelli M, di Bernardo D Abstract Aggregation of α-synuclein and formation of inclusions are hallmarks of Parkinson's disease (PD). Aggregate formation is affected by cellular environment, but it has been studied almost exclusively in cell-free systems. ... read more

Related ArticlesQuantifying the Severity of Parkinson Disease by Use of Dopaminergic Neuroimaging. AJR Am J Roentgenol. 2019 Apr 17;:1-6 Authors: Takahashi H, Watanabe Y, Tanaka H, Mochizuki H, Kato H, Hatazawa J, Tomiyama N Abstract OBJECTIVE. Parkinson disease is characterized by dopaminergic neuron loss in the substantia nigra pars compacta resulting in presynaptic nigrostriatal dopamine dysfunction. The purpose of this ... read more

Related ArticlesNobiletin Protects Against Systemic Inflammation-Stimulated Memory Impairment via MAPK and NF-κB Signaling Pathways. J Agric Food Chem. 2019 Apr 17;: Authors: Qi G, Mi Y, Fan R, Li R, Liu Z, Liu X Abstract Neuroinflammation is intensively demonstrated to be related with various neurodegenerative diseases including Parkinson disease (PD), amyotrophic lateral sclerosis (ALS), and Alzheimer disease (AD). As a ... read more

Related ArticlesThe Landscape of Parkin Variants Reveals Pathogenic Mechanisms and Therapeutic Targets in Parkinson's Disease. Hum Mol Genet. 2019 Apr 17;: Authors: Yi W, MacDougall EJ, Tang MY, Krahn AI, Gan-Or Z, Trempe JF, Fon EA Abstract Mutations in Parkin (PARK2), which encodes an E3 ubiquitin ligase implicated in mitophagy, are the most common cause of early onset Parkinson's Disease ... read more

Related Articles7.0T ultrahigh-field MRI directly visualized the pedunculopontine nucleus in Parkinson's disease patients. Clinics (Sao Paulo). 2019;74:e573 Authors: Wang JW, Cong F, Zhuo Y, Chen L, Wang B, Zhang YQ Abstract OBJECTIVES: The pedunculopontine nucleus (PPN) is considered a promising new target for neurostimulation in Parkinson's disease (PD) patients with postural instability and gait disturbance that is refractory to other ... read more

Related ArticlesMachine-learning identifies parkinson's disease patients based on resting-state between-network functional connectivity. Br J Radiol. 2019 Apr 17;:20180886 Authors: Rubbert C, Mathys C, Jockwitz C, Hartmann CJ, Eickhoff SB, Hoffstaedter F, Caspers S, Eickhoff CR, Sigl B, Teichert NA, Südmeyer M, Turowski B, Schnitzler A, Caspers J Abstract OBJECTIVES: Evaluation of a data-driven, model-based classification approach to discriminate idiopathic Parkinson's ... read more

Related ArticlesInflammation in Mild Cognitive Impairment due to Parkinson's disease, Lewy Body disease and Alzheimer's disease. Int J Geriatr Psychiatry. 2019 Apr 16;: Authors: King E, O'Brien J, Donaghy P, Williams-Gray CH, Lawson RA, Morris CM, Barnett N, Olsen K, Martin-Ruiz C, Burn D, Yarnall AJ, Taylor JP, Duncan G, Khoo TK, Thomas A Abstract BACKGROUND: Inflammation appears to play ... read more

Related ArticlesDepression in Neurodegenerative Diseases: Common Mechanisms and Current Treatment Options. Neurosci Biobehav Rev. 2019 Apr 14;: Authors: Galts CPC, Bettio LEB, Jewett DC, Yang CC, Brocardo PS, Rodrigues ALS, Thacker JS, Gil-Mohapel J Abstract Major depressive disorder (MDD) is a highly prevalent psychiatric disorder and a major cause of disability worldwide. This neurological condition is commonly associated with neurodegenerative ... read more

Related ArticlesTranscranial Magneto-Acoustic Stimulation Improves Neuroplasticity in Hippocampus of Parkinson's Disease Model Mice. Neurotherapeutics. 2019 Apr 16;: Authors: Wang Y, Feng L, Liu S, Zhou X, Yin T, Liu Z, Yang Z Abstract In this study, we have, for the first time, demonstrated the beneficial effects of transcranial magneto-acoustic stimulation (TMAS), a technique based on focused ultrasound stimulation within static ... read more

Related ArticlesA first-in-human study to investigate the safety, tolerability, pharmacokinetics, and pharmacodynamics of KM-819 (FAS-associated factor 1 inhibitor), a drug for Parkinson's disease, in healthy volunteers. Drug Des Devel Ther. 2019;13:1011-1022 Authors: Shin W, Lim KS, Kim MK, Kim HS, Hong J, Jhee S, Kim J, Yoo S, Chung YT, Lee JM, Cho DY Abstract Background: KM-819 is a novel ... read more

Related ArticlesAuthor Correction: Biomarkers for closed-loop deep brain stimulation in Parkinson disease and beyond. Nat Rev Neurol. 2019 Apr 16;: Authors: Bouthour W, Mégevand P, Donoghue J, Lüscher C, Birbaumer N, Krack P Abstract In the originally published article, one of the affiliations for Paul Krack was omitted - these should have included 'Movement Disorders Center, Department of Neurology, University ... read more

Related ArticlesCell therapy for Parkinson's disease is coming of age: current challenges and future prospects with a focus on immunomodulation. Gene Ther. 2019 Apr 16;: Authors: Wenker SD, Pitossi FJ Abstract Parkinson's disease (PD) is a neurodegenerative disease that affects more than 1% of people over the age of 60. The principal feature of this disease is the progressive loss ... read more

Related ArticlesDifferent Circulating Trace Amine Profiles in De Novo and Treated Parkinson's Disease Patients. Sci Rep. 2019 Apr 16;9(1):6151 Authors: D'Andrea G, Pizzolato G, Gucciardi A, Stocchero M, Giordano G, Baraldi E, Leon A Abstract Early diagnosis of Parkinson's disease (PD) remains a challenge to date. New evidence highlights the potential clinical value of circulating trace amines (TAs) in early-stage ... read more