PD Latest Research

Related ArticlesWhite matter pathology predicts cognitive decline in PD. Nat Rev Neurol. 2018 12;14(12):690-691 Authors: Wood H AbstractPMID: 30327502 [PubMed - indexed for MEDLINE] ... read more

Related ArticlesStereopsis and ocular alignment in Parkinson's disease patients with and without freezing of gait symptoms. Clin Exp Optom. 2019 Aug 22;: Authors: Alhassan M, Hovis JK, Almeida QJ Abstract BACKGROUND: Parkinson's disease patients are classically described by having motor disorder symptoms. Freezing of gait is one of these motor symptoms that presents in some of these patients. Even though ... read more

A new therapeutic strategy with istradefylline for postural deformities in Parkinson's disease. Neurol Neurochir Pol. 2019 Aug 23;: Authors: Fujioka S, Yoshida R, Nose K, Hayashi Y, Mishima T, Fukae J, Kitano K, Kikuchi H, Tsuboi Y Abstract AIM OF THE STUDY: Postural deformities are common in Parkinson's disease (PD) patients. Several treatment options have been reported, but responses to ... read more

Related Articles[A partition bagging ensemble learning algorithm for Parkinson's speech data mining]. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2019 Aug 25;36(4):548-556 Authors: Li Y, Zhang C, Wang P, Xie T, Zeng X, Zhang Y, Cheng O, Yan F Abstract Methods for achieving diagnosis of Parkinson's disease (PD) based on speech data mining have been proven effective in ... read more

The symptoms asymmetry of drug-induced parkinsonism is not related to nigrostriatal cell degeneration: a SPECT-DaTSCAN study. Neurol Neurochir Pol. 2019 Aug 23;: Authors: Gajos A, Dąbrowski J, Bieńkiewicz M, Płachcińska A, Kuśmierek J, Bogucki A Abstract AIM: Drug-induced parkinsonism (DIP) is the most common form of parkinsonism after Parkinson's disease (PD) itself. It has been widely believed that DIP is ... read more

Bimanual Gesture Imitation Links to Cognition and Olfaction. J Am Geriatr Soc. 2019 Aug 23;: Authors: Tian Q, Chastan N, Thambisetty M, Resnick SM, Ferrucci L, Studenski SA Abstract OBJECTIVES: Given the need to detect subclinical changes in brain health that sometimes occur with aging in apparently healthy older adults, we assessed whether bimanual gesture imitation performance, simple to assess ... read more

Human Pluripotent Stem Cells in Neurodegenerative Diseases: Potentials, Advances, and Limitations. Curr Stem Cell Res Ther. 2019 Aug 23;: Authors: Kolagar TA, Farzaneh M, Nikkar N, Anbiyaiee A, Heydari E, Khoshnam SE Abstract Neurodegenerative diseases are progressive and uncontrolled gradual loss of motor neurons function or death of neuron cells in the central nervous system (CNS) and the mechanisms underlying ... read more

Association of Restless Legs Syndrome With Risk of Suicide and Self-harm. JAMA Netw Open. 2019 Aug 02;2(8):e199966 Authors: Zhuang S, Na M, Winkelman JW, Ba D, Liu CF, Liu G, Gao X Abstract Importance: Restless legs syndrome (RLS) is a common neurologic disorder that has been previously found to be associated with higher odds of suicidal ideation. In the context ... read more

Related ArticlesSynuclein Meeting 2019: where we are and where we need to go. J Neurochem. 2019 Sep;150(5):462-466 Authors: Outeiro TF, Mestre TA Abstract The Synuclein Meetings are a series that has been taking place every 2 years for about 12 years. The Synuclein Meetings bring together leading experts in the field of synuclein and related human conditions with the goal of discussing ... read more

Pro-Saccades Predict Cognitive Decline in Parkinson's Disease: ICICLE-PD. Mov Disord. 2019 Aug 23;: Authors: Stuart S, Lawson RA, Yarnall AJ, Nell J, Alcock L, Duncan GW, Khoo TK, Barker RA, Rochester L, Burn DJ, ICICLE-PD study group Abstract BACKGROUND: Cumulative dementia incidence in Parkinson's disease (PD) is significant, with major personal and socioeconomic impacts on individuals with PD and their ... read more

Pavement patterns can be designed to improve gait in Parkinson's disease patients. Mov Disord. 2019 Aug 23;: Authors: Gál O, Poláková K, Hoskovcová M, Tomandl J, Čapek V, Berka R, Brožová H, Šestáková I, Růžička E Abstract BACKGROUND: Public spaces are usually designed with respect to various patient populations, but not Parkinson's disease. The objective of this study was to ... read more

Design and validation of a new instrument to assess fear of falling in Parkinson's disease. Mov Disord. 2019 Aug 23;: Authors: Terroba-Chambi C, Bruno V, Millar-Vernetti P, Bruce D, Brockman S, Merello M, Starkstein S Abstract BACKGROUND: Fear of falling may be significantly associated with falls in Parkinson's disease (PD) and may have a negative impact on quality of life. ... read more

Enhanced differentiation of human dopaminergic neuronal cell model for preclinical translational research in Parkinson's disease. Biochim Biophys Acta Mol Basis Dis. 2019 Aug 20;:165533 Authors: Harischandra DS, Rokad D, Ghaisas S, Verma S, Robertson A, Jin H, Anantharam V, Kanthasamy A, Kanthasamy AG Abstract Human-derived neuronal cell lines are progressively being utilized in understanding neurobiology and preclinical translational research as ... read more

Interplay of dopamine and GABA in substantia nigra for the regulation of rapid eye movement sleep in rats. Behav Brain Res. 2019 Aug 20;:112169 Authors: Yadav RK, Khanday MA, Mallick BN Abstract Substantia nigra (SN) is rich in dopamine (DA)-ergic and GABA-ergic neurons, which project to and receive inputs from locus coeruleus (LC) and pedunculo-pontine tegmentum (PPT) possessing REM-OFF and ... read more

The therapeutic role of cannabinoid receptors and its agonists or antagonists in Parkinson's disease. Prog Neuropsychopharmacol Biol Psychiatry. 2019 Aug 20;:109745 Authors: Han QW, Yuan YH, Chen NH Abstract Parkinson's disease (PD) is a neurodegenerative disease and its characteristic is the progressive degeneration of dopaminergic neurons within the substantia nigra (SN) of the midbrain. There is hardly any clinically proven ... read more

Lactoferrin protects against iron dysregulation, oxidative stress, and apoptosis in MPTP-induced Parkinson's disease in mice. J Neurochem. 2019 Aug 23;: Authors: Liu H, Wu H, Zhu N, Xu Z, Wang Y, Qu Y, Wang J Abstract Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's disease. Its pathological features are dopaminergic neuronal death in the substantia nigra ... read more

Toward a closed-loop deep brain stimulation in Parkinson's disease using local field potential in parkinsonian rat model. Med Hypotheses. 2019 Aug 13;132:109360 Authors: Amoozegar S, Pooyan M, Roughani M Abstract Deep brain stimulation (DBS) is an invasive method used for treating Parkinson's disease in its advanced stages. Nowadays, the initial adjustment of DBS parameters and their automatic matching proportion to ... read more

Related ArticlesEffects of Verbal Cueing on Respiratory-Swallow Patterning, Lung Volume Initiation, and Swallow Apnea Duration in Parkinson's Disease. Dysphagia. 2019 Aug 22;: Authors: Curtis JA, Troche MS Abstract Respiratory-swallow coordination (RSC) is important for swallowing safety. Atypical RSC is common in Parkinson's disease (PD) and is associated with the presence of dysphagia and aspiration. Verbal cueing is known to affect ... read more

Related ArticlesFocused transcranial ultrasound for treatment of neurodegenerative dementia. Alzheimers Dement (N Y). 2019;5:374-381 Authors: Nicodemus NE, Becerra S, Kuhn TP, Packham HR, Duncan J, Mahdavi K, Iovine J, Kesari S, Pereles S, Whitney M, Mamoun M, Franc D, Bystritsky A, Jordan S Abstract Introduction: Preclinical studies support investigation of focused ultrasound for breakdown of cerebral pathologies in neurodegenerative conditions ... read more

Related ArticlesModulation of dopamine metabolizing enzymes and antioxidant status by Capsicum annuum Lin in rotenone-intoxicated rat brain. Toxicol Rep. 2019;6:795-802 Authors: Ogunruku OO, Ogunyemi BO, Oboh G, Babatunde OO, Boligon AA Abstract Rotenone is a natural pesticide and environmental neurotoxin which mimics key aspects of Parkinson's disease. This study evaluated the effect of ethyl acetate extract of Capsicum annuum L. ... read more

Related ArticlesThe Metabolic Activity of Caudate and Prefrontal Cortex Negatively Correlates with the Severity of Idiopathic Parkinson's Disease. Aging Dis. 2019 Aug;10(4):847-853 Authors: Chu JS, Liu TH, Wang KL, Han CL, Liu YP, Michitomo S, Zhang JG, Fang T, Meng FG Abstract Positron emission tomography (PET) scan with tracer [18F]-fluorodeoxy-glucose (18F-FDG) is widely used to measure the glucose metabolism in ... read more

Related ArticlesIdiopathic Parkinson's Disease and Schizophrenia: Dilemma in Diagnosis and Treatment of a Case. Iran J Psychiatry. 2019 Apr;14(2):179-181 Authors: Sharma S, Aggarwal N Abstract The relationship between schizophrenia and idiopathic Parkinson's disease is still not clear and rare when they coexist. Diagnosing coexisting schizophrenia and idiopathic Parkinson's disease is a chal-lenge, especially in developing countries due to lack of ... read more

Related ArticlesComplex Motor Learning and Police Training: Applied, Cognitive, and Clinical Perspectives. Front Psychol. 2019;10:1797 Authors: Di Nota PM, Huhta JM Abstract The practices surrounding police training of complex motor skills, including the use of force, varies greatly around the world, and even over the course of an officer's career. As the nature of policing changes with society and the ... read more

Related ArticlesMobility Deficits Assessed With Mobile Technology: What Can We Learn From Brain Iron-Altered Animal Models? Front Neurol. 2019;10:833 Authors: Hopfner F, Hobert MA, Maetzler C, Hansen C, Pham MH, Moreau C, Berg D, Devos D, Maetzler W, Fair-Park II study group Abstract Background: Recent developments in mobile technology have enabled the investigation of human movements and mobility under natural ... read more

Related ArticlesOrigins Matter: Culture Impacts Cognitive Testing in Parkinson's Disease. Front Hum Neurosci. 2019;13:269 Authors: Statucka M, Cohn M Abstract Cognitive decline is common in Parkinson's disease (PD), and precise cognitive assessment is important for diagnosis, prognosis, and treatment. To date, there are no studies in PD investigating cultural bias on neuropsychological tests. Clinical practice in multicultural societies such as, ... read more