PD Latest Research

Related ArticlesNeurologists' current practice and perspectives on communicating the diagnosis of a motor neurodegenerative condition: a UK survey. BMC Neurol. 2021 Jan 22;21(1):34 Authors: Anestis E, Eccles FJR, Fletcher I, Simpson J Abstract BACKGROUND: The communication of a life-changing diagnosis can be a difficult task for doctors with potential long-term effects on patient outcomes. Although several studies have addressed the ... read more

Related Articlesα-Synuclein Oligomers Induce Glutamate Release from Astrocytes and Excessive Extrasynaptic NMDAR Activity in Neurons, Thus Contributing to Synapse Loss. J Neurosci. 2021 Jan 22;: Authors: Trudler D, Sanz-Blasco S, Eisele YS, Ghatak S, Bodhinathan K, Akhtar MW, Lynch WP, Piña-Crespo JC, Talantova M, Kelly JW, Lipton SA Abstract Synaptic and neuronal loss are major neuropathological characteristics of Parkinson's disease ... read more

Related ArticlesParkinsonism alters beta burst dynamics across the basal ganglia-motor cortical network. J Neurosci. 2021 Jan 22;: Authors: Yu Y, Escobar Sanabria D, Wang J, Hendrix CM, Zhang J, Nebeck SD, Amundson AM, Busby ZB, Bauer DL, Johnson MD, Johnson LA, Vitek JL Abstract Elevated synchronized oscillatory activity in the beta band has been hypothesized to be a pathophysiological marker ... read more

Related ArticlesLoss of Parkinson's susceptibility gene LRRK2 promotes carcinogen-induced lung tumorigenesis. Sci Rep. 2021 Jan 22;11(1):2097 Authors: Lebovitz C, Wretham N, Osooly M, Milne K, Dash T, Thornton S, Tessier-Cloutier B, Sathiyaseelan P, Bortnik S, Go NE, Halvorsen E, Cederberg RA, Chow N, Dos Santos N, Bennewith KL, Nelson BH, Bally MB, Lam WL, Gorski SM Abstract Pathological links between ... read more

Related ArticlesThe rostro-caudal gradient in the prefrontal cortex and its modulation by subthalamic deep brain stimulation in Parkinson's disease. Sci Rep. 2021 Jan 22;11(1):2138 Authors: Schumacher FK, Schumacher LV, Amtage F, Horn A, Egger K, Piroth T, Weiller C, Schelter BO, Coenen VA, Kaller CP Abstract Deep brain stimulation of the subthalamic nucleus (STN-DBS) alleviates motor symptoms in Parkinson's disease ... read more

Related ArticlesDNA Methyltransferase 1 Is Dysregulated in Parkinson's Disease via Mediation of miR-17. Mol Neurobiol. 2021 Jan 22;: Authors: Zhang HQ, Wang JY, Li ZF, Cui L, Huang SS, Zhu LB, Sun Y, Yang R, Fan HH, Zhang X, Zhu JH Abstract Aberrant DNA methylation is closely associated with the pathogenesis of Parkinson's disease (PD). DNA methyltransferases (DNMTs) are the ... read more

Related ArticlesCardinal role of eukaryotic initiation factor 2 (eIF2α) in progressive dopaminergic neuronal death & DNA fragmentation: Implication of PERK:IRE1α:ATF6 axis in Parkinson's pathology. Cell Signal. 2021 Jan 20;:109922 Authors: Gupta S, Mishra A, Singh S Abstract The study was conducted to assess the role of eukaryotic initiation factor 2 (eIF2α) in progressive dopaminergic neuronal death employing various interventions (YM08, ... read more

Related ArticlesProlonged dopamine D3 receptor stimulation promotes dopamine transporter ubiquitination and degradation through a PKC-dependent mechanism. Pharmacol Res. 2021 Jan 20;:105434 Authors: Luis-Ravelo D, Fumagallo-Reading F, Castro-Hernandez J, Barroso-Chinea P, Afonso-Oramas D, Febles-Casquero A, Cruz-Muros I, Salas-Hernandez J, Mesa-Infante V, Rodriguez-Nuñez J, Gonzalez-Hernandez T Abstract The dopamine transporter (DAT) is a membrane glycoprotein in dopaminergic neurons, which modulates extracellular and ... read more

Related Articles3D Prınted extended release tablets for once daıly use: an ın vıtro and ın vıvo evaluatıon study for a personalızed solıd dosage form. Int J Pharm. 2021 Jan 20;:120222 Authors: Ezgi Gültekin H, Tort S, Tuğcu-Demiröz F, Acartürk F Abstract Fused deposition modeling (FDM)-3D printing enables the manufacturing of dosage forms with personalized doses and controllable release profiles. Parkinson's ... read more

Related ArticlesImpact of the apolipoprotein E ε4 allele on early Parkinson's disease progression. Parkinsonism Relat Disord. 2021 Jan 12;83:66-70 Authors: Kim R, Park S, Yoo D, Jun JS, Jeon B Abstract OBJECTIVE: Emerging evidence shows that apolipoprotein E (APOE) ε4 exacerbates alpha-synuclein pathology. We aimed to investigate whether the APOE ε4 allele contributes to early Parkinson's disease (PD) progression. METHODS: ... read more

Related ArticlesCognitive impairment in Parkinson's disease is associated with Default Mode Network subsystem connectivity and cerebrospinal fluid Aβ. Parkinsonism Relat Disord. 2021 Jan 12;83:71-78 Authors: Zarifkar P, Kim J, La C, Zhang K, YorkWilliams S, Levine TF, Tian L, Borghammer P, Poston KL Abstract INTRODUCTION: To identify clinically implementable biomarkers of cognitive impairment in Parkinson's Disease (PD) derived from resting ... read more

Related ArticlesGeneration of an induced pluripotent stem cell line, FJMUUHi001-A, from a hereditary Parkinson's disease patient with homozygous mutation of c.189dupA in PARK7. Stem Cell Res. 2021 Jan 13;51:102175 Authors: Chen ZT, Zhao ZH, Chen LN, Fan F, Cai GE, Weng HD, Wang YQ, Liao LM, Chen XC, Huang E, Ye QY Abstract PARK7 mutations are accountable for the inherited ... read more

Related ArticlesPrediction of Freezing of Gait in Parkinson's Disease Using Wearables and Machine Learning. Sensors (Basel). 2021 Jan 17;21(2): Authors: Borzì L, Mazzetta I, Zampogna A, Suppa A, Olmo G, Irrera F Abstract Freezing of gait (FOG) is one of the most troublesome symptoms of Parkinson's disease, affecting more than 50% of patients in advanced stages of the disease. Wearable ... read more

Related ArticlesCerebrospinal Fluid α-Synuclein Species in Cognitive and Movements Disorders. Brain Sci. 2021 Jan 17;11(1): Authors: Constantinides VC, Majbour NK, Paraskevas GP, Abdi I, Safieh-Garabedian B, Stefanis L, El-Agnaf OM, Kapaki E Abstract Total CSF α-synuclein (t-α-syn), phosphorylated α-syn (pS129-α-syn) and α-syn oligomers (o-α-syn) have been studied as candidate biomarkers for synucleinopathies, with suboptimal specificity and sensitivity in the differentiation ... read more

Related ArticlesFrom Posttranslational Modifications to Disease Phenotype: A Substrate Selection Hypothesis in Neurodegenerative Diseases. Int J Mol Sci. 2021 Jan 18;22(2): Authors: Baskakov IV Abstract A number of neurodegenerative diseases including prion diseases, tauopathies and synucleinopathies exhibit multiple clinical phenotypes. A diversity of clinical phenotypes has been attributed to the ability of amyloidogenic proteins associated with a particular disease to ... read more

Related ArticlesAssessment of the Telomere Length and Its Effect on the Symptomatology of Parkinson's Disease. Antioxidants (Basel). 2021 Jan 19;10(1): Authors: Levstek T, Redenšek S, Trošt M, Dolžan V, Podkrajšek KT Abstract Telomeres, which are repetitive sequences that cap the end of the chromosomes, shorten with each cell division. Besides cellular aging, there are several other factors that influence telomere ... read more

Related ArticlesMay chronic cough in chronic obstructive pulmonary disease be a contraindication of Percutaneous Endoscopic Gastrostomy placement: a case report. BMC Gastroenterol. 2021 Jan 21;21(1):31 Authors: Gravina AG, Tessitore A, Ormando VM, Nagar F, Romeo M, Amato MR, Dallio M, Loguercio C, Federico A, Romano M, Ferraro F Abstract BACKGROUND: Percutaneous Endoscopic Gastrostomy (PEG) can involve some complications, despite the ... read more

Related ArticlesValidation in French of the Montreal Cognitive Assessment 5-Minute, a brief cognitive screening test for phone administration. Rev Neurol (Paris). 2021 Jan 18;: Authors: Dujardin K, Duhem S, Guerouaou N, Djelad S, Drumez E, Duhamel A, Bombois S, Nasreddine Z, Bordet R, Deplanque D Abstract BACKGROUND: The prevalence of cognitive impairment and dementia is high and steadily increasing. Early ... read more

Related ArticlesAuthor response to comment on "The association between pain and impulse control behaviours in Parkinson's disease". Parkinsonism Relat Disord. 2021 Jan 13;: Authors: Kobylecki C, Silverdale MA PMID: 33478869 [PubMed - as supplied by publisher] ... read more

Related ArticlesSVIP is a molecular determinant of lysosomal dynamic stability, neurodegeneration and lifespan. Nat Commun. 2021 01 21;12(1):513 Authors: Johnson AE, Orr BO, Fetter RD, Moughamian AJ, Primeaux LA, Geier EG, Yokoyama JS, Miller BL, Davis GW Abstract Missense mutations in Valosin-Containing Protein (VCP) are linked to diverse degenerative diseases including IBMPFD, amyotrophic lateral sclerosis (ALS), muscular dystrophy and Parkinson's disease. ... read more

Related ArticlesThe impact of COVID-19 and social distancing on people with Parkinson's disease: a survey study. NPJ Parkinsons Dis. 2021 Jan 21;7(1):10 Authors: Feeney MP, Xu Y, Surface M, Shah H, Vanegas-Arroyave N, Chan AK, Delaney E, Przedborski S, Beck JC, Alcalay RN Abstract As the COVID-19 pandemic continues to affect the international community, very little is known about its ... read more

Related ArticlesDysregulation of epithelial ion transport and neurochemical changes in the colon of a parkinsonian primate. NPJ Parkinsons Dis. 2021 Jan 21;7(1):9 Authors: Coletto E, Tough IR, Pritchard S, Hikima A, Jackson MJ, Jenner P, Ray Chaudhuri K, Cox HM, Iravani MM, Rose S Abstract The pathological changes underlying gastrointestinal (GI) dysfunction in Parkinson's disease (PD) are poorly understood and ... read more

Related ArticlesAstrogliosis and sexually dimorphic neurodegeneration and microgliosis in the olfactory bulb in Parkinson's disease. NPJ Parkinsons Dis. 2021 Jan 21;7(1):11 Authors: Flores-Cuadrado A, Saiz-Sanchez D, Mohedano-Moriano A, Lamas-Cenjor E, Leon-Olmo V, Martinez-Marcos A, Ubeda-Bañon I Abstract Hyposmia is prodromal, and male sex is a risk marker for an enhanced likelihood ratio of Parkinson's disease. The literature regarding olfactory bulb ... read more

Related ArticlesRadiosynthesis and evaluation of 4-(6-[18F]Fluoro-4-(5-isopropoxy-1H-indazol-3-yl)pyridin-2-yl)morpholine as a novel radiotracer candidate targeting leucine-rich repeat kinase 2. RSC Med Chem. 2020 Jun 01;11(6):676-684 Authors: Mori W, Yamasaki T, Hattori Y, Zhang Y, Kumata K, Fujinaga M, Hanyu M, Nengaki N, Zhang H, Zhang MR Abstract Mutations that increase leucine-rich repeat kinase 2 (LRRK2) activity in the brain are associated with Parkinson's ... read more

Related ArticlesGDNF Receptor Agonist Alleviates Motor Imbalance in Unilateral 6-Hydroxydopamine Model of Parkinson's Disease. Front Neurol Neurosci Res. 2020 Nov 24;1:100004 Authors: Renko JM, Voutilainen MH, Visnapuu T, Sidorova YA, Saarma M, Tuominen RK Abstract Parkinson's disease (PD) is an incurable neurodegenerative disorder affecting up to 10 million people in the world. Diagnostic motor symptoms of PD appear as a ... read more