PD Latest Research

Eur J Neurol. 2021 Jul 22. doi: 10.1111/ene.15031. Online ahead of print.ABSTRACTBACKGROUND: Several clinical and demographic factors relate to anatomic spread of adult-onset isolated dystonia, but a predictive model is still lacking.OBJECTIVES: 1) To develop and validate a predictive model of anatomic spread of adult-onset isolated dystonia; 2) to evaluate whether presence of tremor associated with dystonia influences model predictions ... read more

NPJ Parkinsons Dis. 2021 Jul 22;7(1):64. doi: 10.1038/s41531-021-00209-3.ABSTRACTThe bilateral effects of deep brain stimulation (DBS) on motor and non-motor symptoms of Parkinson's disease (PD) have been extensively studied and reviewed. However, the unilateral effects-in particular, the potential lateralized effects of left- versus right-sided DBS-have not been adequately recognized or studied. Here we summarized the current evidence and controversies in the ... read more

J Neurosci Rural Pract. 2021 Jul;12(3):581-585. doi: 10.1055/s-0041-1730086. Epub 2021 May 10.ABSTRACTBackground Little data are available on the spectrum of movement disorders in inpatients, particularly those admitted in neurology specialty. This may be related to the fact that patients presenting with movement disorders are usually evaluated from outpatient clinics. Objective The aim of this study is to provide data on ... read more

Sci Rep. 2021 Jul 22;11(1):14992. doi: 10.1038/s41598-021-94040-8.ABSTRACTDelayed phase 18F-FP-CIT PET (dCIT) can assess the striatal dopamine transporter binding to detect degenerative parkinsonism (DP). Early phase 18F-FP-CIT (eCIT) can assess the regional brain activity for differential diagnosis among parkinsonism similar with 18F-FDG PET. We evaluated the diagnostic performance of dual phase 18F-FP-CIT PET (dual CIT) and 18F-FDG PET compared with clinical ... read more

Front Cell Dev Biol. 2021 Jul 6;9:612476. doi: 10.3389/fcell.2021.612476. eCollection 2021.ABSTRACTParkinson's disease (PD) is an age-related neurodegenerative disorder affecting millions of people worldwide. The disease is characterized by the progressive loss of dopaminergic neurons and spread of Lewy pathology (α-synuclein aggregates) in the brain but the pathogenesis remains elusive. PD presents substantial clinical and genetic variability. Although its complex etiology ... read more

Front Aging Neurosci. 2021 Jul 6;13:620015. doi: 10.3389/fnagi.2021.620015. eCollection 2021.ABSTRACT[This corrects the article DOI: 10.3389/fnagi.2019.00044.].PMID:34295236 | PMC:PMC8290916 | DOI:10.3389/fnagi.2021.620015 ... read more

Front Mol Biosci. 2021 Jun 30;8:676187. doi: 10.3389/fmolb.2021.676187. eCollection 2021.ABSTRACTMitochondrial dysfunction is a central feature of neurodegeneration within the central and peripheral nervous system, highlighting a strong dependence on proper mitochondrial function of neurons with especially high energy consumptions. The fitness of mitochondria critically depends on preservation of distinct processes, including the maintenance of their own genome, mitochondrial dynamics, quality ... read more

Mov Disord Clin Pract. 2021 May 7;8(5):717-724. doi: 10.1002/mdc3.13227. eCollection 2021 Jul.ABSTRACTBACKGROUND: 123I-Metaiodobenzylguanidine (123I-MIBG) myocardial scintigraphy is a useful technique to differentiate Parkinson's disease (PD) from atypical parkinsonisms, since it is generally abnormal in PD and normal in the latter. Reduction of myocardial MIBG uptake is a supportive feature in the latest PD diagnostic criteria.OBJECTIVES: To explore the clinical contribution ... read more

J Neurochem. 2021 Jul 23. doi: 10.1111/jnc.15467. Online ahead of print.ABSTRACTIron accumulation and α-synuclein aggregates (e.g., Lewy bodies) have been linked with the pathogenesis of Parkinson's disease (PD), with yet-to-be-determined interaction. Previous studies have indicated that iron binds to α-synuclein and triggers its aggregation in vitro, and iron is found enriched in Lewy bodies. In the current study, Joppe et ... read more

Clin Psychopharmacol Neurosci. 2021 Aug 31;19(3):572-575. doi: 10.9758/cpn.2021.19.3.572.ABSTRACTParkinson's disease is often complicated by psychiatric symptoms. Psychiatrists are caught in a dilemma between such symptoms and physical treatment since Parkinson's disease sometimes shows treatment resistance based on pharmacological treatment-induced dopamine dysfunction. Here, we report on a 64-year-old woman with a 15-year history of Parkinson's disease with stage IV severity based on ... read more

BMC Neurol. 2021 Jul 23;21(1):286. doi: 10.1186/s12883-021-02308-3.ABSTRACTBACKGROUND: Culminating evidence shows that current care does not optimally meet the needs of persons with parkinsonism, their carers and healthcare professionals. Recently, a new model of care was developed to address the limitations of usual care: Proactive and Integrated Management and Empowerment in Parkinson's Disease (PRIME Parkinson). From 2021 onwards, PRIME Parkinson care ... read more

Brain Behav. 2021 Jul 23. doi: 10.1002/brb3.2278. Online ahead of print.ABSTRACTBACKGROUND AND PURPOSE: Parkinson's disease (PD) is a severe neurodegenerative disease with high morbidity in the elderly population. 6-OHDA-induced cell senescence is reported to be involved in the pathogenesis of PD. Ramelteon is an oral hypnotic agent that specifically targets the receptors of the suprachiasmatic nucleus in the human hypothalamus. ... read more

J Cent Nerv Syst Dis. 2021 Jul 7;13:11795735211029114. doi: 10.1177/11795735211029114. eCollection 2021.ABSTRACTBACKGROUND: Parkinson disease (PD) is the second most common neurodegenerative disease, affecting 2% of the population over 65 years of age. PD diagnosis is based on clinical examination and can only be confirmed during autopsy. In 2018, we reported that heme oxygenase-1 (HO-1), an inducible stress response protein important ... read more

Front Mol Neurosci. 2021 Jul 5;14:695873. doi: 10.3389/fnmol.2021.695873. eCollection 2021.ABSTRACTMetal dyshomeostasis plays a significant role in various neurological diseases such as Alzheimer's disease, Parkinson's disease, Autism Spectrum Disorders (ASD), and many more. Like studies investigating the proteome, transcriptome, epigenome, microbiome, etc., for years, metallomics studies have focused on data from their domain, i.e., trace metal composition, only. Still, few have ... read more

Brain Stimul. 2021 Jul 19:S1935-861X(21)00145-5. doi: 10.1016/j.brs.2021.07.008. Online ahead of print.NO ABSTRACTPMID:34293512 | DOI:10.1016/j.brs.2021.07.008 ... read more

Turk J Med Sci. 2021 Jul 22. doi: 10.3906/sag-2105-74. Online ahead of print.ABSTRACTBACKGROUND/AIM: The present study proposes to investigate the effect of neuropeptide-S (NPS) on cognitive functions and depression-like behavior of MPTP-induced experimental model of Parkinson?s disease (PD).MATERIALS AND METHODS: Three-month-old C57BL/6 mice were randomly divided into three groups as; Control, Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and MPTP+NPS 0.1 nmol (received intraperitoneal injection ... read more

Front Psychol. 2021 Jul 5;12:623721. doi: 10.3389/fpsyg.2021.623721. eCollection 2021.ABSTRACTParkinson's is a neurodegenerative disease characterized by motor and non-motor symptoms which are strongly associated with patients' quality of life, affecting social skills and support. It strikes not only the motor abilities but may harm cognitive and emotional functioning. For the past 15 years, contemporary dance has been employed as an intervention ... read more

Cureus. 2021 Jun 18;13(6):e15750. doi: 10.7759/cureus.15750. eCollection 2021 Jun.ABSTRACTWe report the case of a 67-year-old Japanese Parkinson's disease (PD) patient with depression who was successfully treated with vortioxetine. The patient's PD was being treated with levodopa (100 mg/day). As improvement was noted in PD symptoms, levodopa was continued. Subsequently, she was referred to our department due to worsening of her ... read more

J Neurosci Res. 2021 Jul 22. doi: 10.1002/jnr.24927. Online ahead of print.ABSTRACTAggregation of alpha-synuclein (α-syn) into Lewy bodies and Lewy neurites is a pathological hallmark in the Parkinson´s disease (PD) brain. The formation of α-syn oligomers is believed to be an early pathogenic event and the A30P mutation in the gene encoding α-syn, causing familial PD, has been shown to ... read more

NPJ Parkinsons Dis. 2021 Jul 21;7(1):63. doi: 10.1038/s41531-021-00202-w.ABSTRACTWe evaluate the association of hypertension with PD in an Asian population and performed a meta-analysis on similar studies to address the effect of hypertension on PD risk. A matched case-control study involving 1342 Chinese subjects (671 PD and 671 age and gender-matched controls (with a mean age of 63.9 ± 9.7 and ... read more

Front Mol Neurosci. 2021 Jul 5;14:695873. doi: 10.3389/fnmol.2021.695873. eCollection 2021.ABSTRACTMetal dyshomeostasis plays a significant role in various neurological diseases such as Alzheimer's disease, Parkinson's disease, Autism Spectrum Disorders (ASD), and many more. Like studies investigating the proteome, transcriptome, epigenome, microbiome, etc., for years, metallomics studies have focused on data from their domain, i.e., trace metal composition, only. Still, few have ... read more

Ther Adv Musculoskelet Dis. 2021 Jul 9;13:1759720X211025894. doi: 10.1177/1759720X211025894. eCollection 2021.ABSTRACTTumor necrosis factor alpha (TNF-α) and interleukin-17 (IL-17) are two pro-inflammatory cytokines involved in the pathophysiology of spondyloarthritis (SpA). Therapies targeting TNF-α or IL-17 are used as a second line among SpA patients failing non-steroidal anti-inflammatory drugs. The choice of such treatment has to take into account the patient's comorbidities. ... read more

J Neurosci. 2021 Jul 21:JN-RM-0476-21. doi: 10.1523/JNEUROSCI.0476-21.2021. Online ahead of print.ABSTRACTCell-to-cell transmission of α-synuclein (α-syn) pathology is considered to underlie the spread of neurodegeneration in Parkinson's disease. Previous studies have demonstrated that α-syn is secreted under physiological conditions in neuronal cell lines and primary neurons. However, the molecular mechanisms that regulate extracellular α-syn secretion remain unclear. In this study, we ... read more

Front Neurosci. 2021 Jul 5;15:685050. doi: 10.3389/fnins.2021.685050. eCollection 2021.ABSTRACTObjective: Deep brain stimulation (DBS) of the anterior nucleus of the thalamus (ANT) is a potentially effective, minimally invasive, and reversible method for treating epilepsy. The goal of this study was to explore whether 3 T quantitative susceptibility mapping (QSM) could delineate the ANT from surrounding structures, which is important for the ... read more

Cureus. 2021 Jun 18;13(6):e15750. doi: 10.7759/cureus.15750. eCollection 2021 Jun.ABSTRACTWe report the case of a 67-year-old Japanese Parkinson's disease (PD) patient with depression who was successfully treated with vortioxetine. The patient's PD was being treated with levodopa (100 mg/day). As improvement was noted in PD symptoms, levodopa was continued. Subsequently, she was referred to our department due to worsening of her ... read more