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- The reliability of gait variability measures for individuals with Parkinson’s disease and healthy older adults – The effect of gait speed.
Related ArticlesThe reliability of gait variability measures for individuals with Parkinson's disease and healthy older adults - The effect of gait speed. Gait Posture. 2018 Apr 14;62:505-509 Authors: Rennie L, Löfgren N, Moe-Nilssen R, Opheim A, Dietrichs E, Franzén E Abstract BACKGROUND: Step-to-step variability is a marker of reduced motor ... read more - Present and Future of Ultra-High Field MRI in Neurodegenerative Disorders.Related ArticlesPresent and Future of Ultra-High Field MRI in Neurodegenerative Disorders. Curr Neurol Neurosci Rep. 2018 Apr 20;18(6):31 Authors: Donatelli G, Ceravolo R, Frosini D, Tosetti M, Bonuccelli U, Cosottini M Abstract PURPOSE OF REVIEW: With a high signal-to-noise ratio, unparalleled spatial resolution, and improved contrasts, ultra-high field MR (≥ 7 T) ... read more
- Detecting Risk Of Postural hypotension (DROP): derivation and validation of a prediction score for primary care.Related ArticlesDetecting Risk Of Postural hypotension (DROP): derivation and validation of a prediction score for primary care. BMJ Open. 2018 Apr 20;8(4):e020740 Authors: Clark CE, Thomas D, Warren FC, Llewellyn DJ, Ferrucci L, Campbell JL Abstract OBJECTIVES: Falls are a common problem in older people. Postural hypotension contributes to falls ... read more
- Down-regulation of Nramp1 is associated with MPTP/MPP+ -induced α-synuclein accumulation and neurotoxicity.Related ArticlesDown-regulation of Nramp1 is associated with MPTP/MPP+ -induced α-synuclein accumulation and neurotoxicity. Neuropathol Appl Neurobiol. 2018 Apr 21;: Authors: Wu KC, Liou HH, Lee CY, Lin CJ Abstract AIMS: The accumulation of α-synuclein is a hallmark in the pathogenesis of Parkinson's disease (PD). Natural resistance-associated macrophage protein-1 (Nramp1) was ... read more
- Comparison of the 3D Structures of Mouse and Human α-Synuclein Fibrils by Solid-State NMR and STEM.Related ArticlesComparison of the 3D Structures of Mouse and Human α-Synuclein Fibrils by Solid-State NMR and STEM. J Struct Biol. 2018 Apr 17;: Authors: Hwang S, Fricke P, Zinke M, Giller K, Wall JS, Riedel D, Becker S, Lange A Abstract Intra-neuronal aggregation of α-synuclein into fibrils is the molecular ... read more
- Involvement of gap junctions in astrocyte impairment induced by manganese exposure.Related ArticlesInvolvement of gap junctions in astrocyte impairment induced by manganese exposure. Brain Res Bull. 2018 Apr 17;: Authors: Lu C, Meng Z, He Y, Xiao D, Cai H, Xu Y, Liu X, Wang X, Mo L, Liang Z, Wei X, Ao Q, Liang B, Li X, Tang S, Guo ... read more
- Insights into Pharmacotherapy Management for Parkinson’s Disease Patients Using Wearables Activity Data.Related ArticlesInsights into Pharmacotherapy Management for Parkinson's Disease Patients Using Wearables Activity Data. Stud Health Technol Inform. 2018;247:156-160 Authors: Nguyen V, Kunz H, Taylor P, Acosta D Abstract We investigate what supervised classification models using clinical and wearables data are best suited to address two important questions about the management ... read more
- Internalization of G-protein-coupled receptors: Implication in receptor function, physiology and diseases.Related ArticlesInternalization of G-protein-coupled receptors: Implication in receptor function, physiology and diseases. Best Pract Res Clin Endocrinol Metab. 2018 Apr;32(2):83-91 Authors: Calebiro D, Godbole A Abstract G protein-coupled receptors (GPCRs) are the largest family of membrane receptors and mediate the effects of numerous hormones and neurotransmitters. The nearly 1000 GPCRs ... read more
- Risk factors of symptomatic orthostatic hypotension patients with Parkinson’s disease.Related ArticlesRisk factors of symptomatic orthostatic hypotension patients with Parkinson's disease. J Neurol Sci. 2018 Apr 11;: Authors: Kawada T PMID: 29678331 [PubMed - as supplied by publisher] ... read more
- Association of exercise-induced autophagy upregulation and apoptosis suppression with neuroprotection against pharmacologically induced Parkinson’s disease.Related ArticlesAssociation of exercise-induced autophagy upregulation and apoptosis suppression with neuroprotection against pharmacologically induced Parkinson's disease. J Exerc Nutrition Biochem. 2018 Mar 30;22(1):1-8 Authors: Jang YC, Hwang DJ, Koo JH, Um HS, Lee NH, Yeom DC, Lee Y, Cho JY Abstract PURPOSE: We investigated whether treadmill exercise (TE)-induced neuroprotection was ... read more
- Caregiver burden and caregiver appraisal of psychiatric symptoms are not modulated by subthalamic deep brain stimulation for Parkinson’s disease.Related ArticlesCaregiver burden and caregiver appraisal of psychiatric symptoms are not modulated by subthalamic deep brain stimulation for Parkinson's disease. NPJ Parkinsons Dis. 2018;4:12 Authors: Mosley PE, Breakspear M, Coyne T, Silburn P, Smith D Abstract Subthalamic deep brain stimulation is an advanced therapy that typically improves quality of life ... read more
- β-Glucocerebrosidase modulators promote dimerization of β-glucocerebrosidase and reveal an allosteric binding site.Related Articlesβ-Glucocerebrosidase modulators promote dimerization of β-glucocerebrosidase and reveal an allosteric binding site. J Am Chem Soc. 2018 Apr 20;: Authors: Zheng J, Chen L, Skinner OS, Ysselstein D, Remis J, Lansbury P, Skerlj R, Mrosek M, Heunisch U, Krapp S, Charrow J, Schwake M, Kelleher NL, Silverman RB, Krainc ... read more
- Detection of alpha-synuclein conformational variants from gastro-intestinal biopsy tissue as a potential biomarker for Parkinson’s disease.Related ArticlesDetection of alpha-synuclein conformational variants from gastro-intestinal biopsy tissue as a potential biomarker for Parkinson's disease. Neuropathol Appl Neurobiol. 2018 Apr 19;: Authors: Ruffmann C, Bengoa-Vergniory N, Poggiolini I, Ritchie D, Hu MT, Alegre-Abarrategui J, Parkkinen L Abstract AIMS: Gastrointestinal (GI) α-synuclein (aSyn) detection as a potential biomarker of ... read more
- Clonidine modulates the activity of the subthalamic-supplementary motor loop: evidence from a pharmacological study combining DBS and EEG recordings in Parkinsonian patients.Related ArticlesClonidine modulates the activity of the subthalamic-supplementary motor loop: evidence from a pharmacological study combining DBS and EEG recordings in Parkinsonian patients. J Neurochem. 2018 Apr 20;: Authors: Spay C, Albares M, Lio G, Thobois S, Broussolle E, Lau B, Ballanger B, Boulinguez P Abstract Clonidine is an anti-hypertensive ... read more
- Identification of glia phenotype modulators based on select glial function regulatory signaling pathways.Related ArticlesIdentification of glia phenotype modulators based on select glial function regulatory signaling pathways. Expert Opin Drug Discov. 2018 Apr 20;:1-15 Authors: Lee SH, Suk K Abstract INTRODUCTION: Despite the considerable social and economic burden on the healthcare system worldwide due to neurodegenerative diseases, there are currently few disease-altering treatment ... read more
- Effects of peptidyl-prolyl isomerase 1 depletion in animal models of prion diseases.Related ArticlesEffects of peptidyl-prolyl isomerase 1 depletion in animal models of prion diseases. Prion. 2018 Apr 20;:1-30 Authors: Legname G, Virgilio T, Bistaffa E, De Luca CMG, Catania M, Zago P, Isopi E, Campagnani I, Tagliavini F, Giaccone G, Moda F Abstract Pin1 is a peptidyl-prolyl isomerase that induces the ... read more
- Structural and metabolic brain correlates of apathy in Huntington’s disease.Related ArticlesStructural and metabolic brain correlates of apathy in Huntington's disease. Mov Disord. 2018 Apr 20;: Authors: Martínez-Horta S, Perez-Perez J, Sampedro F, Pagonabarraga J, Horta-Barba A, Carceller-Sindreu M, Gomez-Anson B, Lozano-Martinez GA, Lopez-Mora DA, Camacho V, Fernández-León A, Carrió I, Kulisevsky J Abstract BACKGROUND: Apathy is the most prevalent ... read more
- High-mobility Group Box 1 in Parkinson’s disease: from pathogenesis to therapeutic approaches.Related ArticlesHigh-mobility Group Box 1 in Parkinson's disease: from pathogenesis to therapeutic approaches. J Neurochem. 2018 Apr 20;: Authors: Angelopoulou E, Piperi C, Papavassiliou AG Abstract Parkinson's disease (PD) presents the second most common neurodegenerative disorder with largely unknown pathogenesis and inefficient therapeutic management. Accumulating data indicate that neuroinflammation, autophagy ... read more
- Does cerebellar overactivity contribute to gait and balance deficits in Parkinson’s disease?Related ArticlesDoes cerebellar overactivity contribute to gait and balance deficits in Parkinson's disease? Mov Disord. 2018 Apr 20;: Authors: Lefaivre SC, Brown MJN, Almeida QJ PMID: 29676478 [PubMed - as supplied by publisher] ... read more
- Impact of Neurodegenerative Diseases on Drug Binding to Brain Tissues: From Animal Models to Human Samples.Related ArticlesImpact of Neurodegenerative Diseases on Drug Binding to Brain Tissues: From Animal Models to Human Samples. Neurotherapeutics. 2018 Apr 19;: Authors: Ugarte A, Corbacho D, Aymerich MS, García-Osta A, Cuadrado-Tejedor M, Oyarzabal J Abstract Drug efficacy in the central nervous system (CNS) requires an additional step after crossing the ... read more
- Disturbances of Sleep and Alertness in Parkinson’s Disease.Related ArticlesDisturbances of Sleep and Alertness in Parkinson's Disease. Curr Neurol Neurosci Rep. 2018 Apr 19;18(6):29 Authors: Videnovic A Abstract PURPOSE OF REVIEW: Parkinson's disease (PD) is the second most common neurodegenerative disorder. Sleep dysfunction is one of the most common non-motor manifestations of PD that has gained significant interest ... read more
- Handwritten dynamics assessment through convolutional neural networks: An application to Parkinson’s disease identification.Related ArticlesHandwritten dynamics assessment through convolutional neural networks: An application to Parkinson's disease identification. Artif Intell Med. 2018 Apr 16;: Authors: Pereira CR, Pereira DR, Rosa GH, Albuquerque VHC, Weber SAT, Hook C, Papa JP Abstract BACKGROUND AND OBJECTIVE: Parkinson's disease (PD) is considered a degenerative disorder that affects the ... read more
- Rest tremor quantification based on fuzzy inference systems and wearable sensors.Related ArticlesRest tremor quantification based on fuzzy inference systems and wearable sensors. Int J Med Inform. 2018 Jun;114:6-17 Authors: Sanchez-Perez LA, Sanchez-Fernandez LP, Shaout A, Martinez-Hernandez JM, Alvarez-Noriega MJ Abstract BACKGROUND: Currently the most consistent, widely accepted and detailed instrument to rate Parkinson's disease (PD) is the Movement Disorder Society ... read more
- A Comparative study for striatal-direct and -indirect pathway neurons to DA depletion-induced lesion in a PD rat model.Related ArticlesA Comparative study for striatal-direct and -indirect pathway neurons to DA depletion-induced lesion in a PD rat model. Neurochem Int. 2018 Apr 16;: Authors: Zheng X, Wu J, Zhu Y, Chen S, Chen Z, Chen T, Huang Z, Wei J, Li Y, Lei W Abstract Striatal-direct and -indirect Pathway ... read more
- Longitudinal changes over thirty-six months in postural control dynamics and cognitive function in people with Parkinson’s disease.Related ArticlesLongitudinal changes over thirty-six months in postural control dynamics and cognitive function in people with Parkinson's disease. Gait Posture. 2018 Apr 13;62:468-474 Authors: Pantall A, Din SD, Rochester L Abstract BACKGROUND: Postural instability is a common motor feature in people with Parkinson's disease (PD) together with non-motor features such ... read more