PD Latest Research

J Pharmacol Sci. 2022 Feb;148(2):248-254. doi: 10.1016/j.jphs.2021.12.003. Epub 2021 Dec 14.ABSTRACTAn aging society leads to an increased number of patients with cognitive and movement disorders, such as Parkinson's disease and dementia with Lewy bodies. α-Synuclein accumulation in neuronal cells is a pathological hallmark of α-synucleinopathies. Aberrant soluble oligomeric units of α-synuclein are toxic and disrupt neuronal homeostasis. Fatty acids partially ... read more

Neurobiol Aging. 2021 Dec 25:S0197-4580(21)00361-4. doi: 10.1016/j.neurobiolaging.2021.12.004. Online ahead of print.ABSTRACTNeurological disorders are often associated with a variety of symptoms, which can result from the combined action of genetic variants. We conducted a whole-genome analysis of a previously unreported unique multigenerational Dutch-Canadian family with a complex phenotype presenting with a combination of hearing loss, balance issues or action tremor. Ten ... read more

Int J Surg Case Rep. 2022 Jan 15;91:106773. doi: 10.1016/j.ijscr.2022.106773. Online ahead of print.ABSTRACTINTRODUCTION AND IMPORTANCE: Deep brain stimulation (DBS) implantation is a neurosurgical procedure in which electrodes are implanted in the brain. Complications that may occur include wound infection, issues with the DBS hardware, and others. This case report presents a patient who suffered ear numbness following DBS implantation.CASE ... read more

Clin Nutr ESPEN. 2022 Feb;47:199-205. doi: 10.1016/j.clnesp.2021.12.014. Epub 2021 Dec 23.ABSTRACTBACKGROUND AND AIMS: The association between lifestyle factors and Multiple Sclerosis (MS) disease severity and progression has been investigated to a lesser extent compared with susceptibility to the disease. We aimed to assess the impact of lifetime coffee and tea consumption on MS severity.METHODS: Design: cross-sectional study. Two hundred and ... read more

Sensors (Basel). 2022 Jan 12;22(2):569. doi: 10.3390/s22020569.ABSTRACTEarly identification of mild cognitive impairment (MCI) in Parkinson's disease (PD) patients can lessen emotional and physical complications. In this study, a cognitive functional (CF) feature using cognitive and daily living items of the Unified Parkinson's Disease Rating Scale served to define PD patients as suspected or not for MCI. The study aimed to ... read more

Eur Radiol. 2022 Jan 22. doi: 10.1007/s00330-021-08454-z. Online ahead of print.ABSTRACTOBJECTIVES: This study aimed to compare susceptibility map-weighted imaging (SMwI) using various MRI machines (three vendors) with N-3-fluoropropyl-2-β-carbomethoxy-3-β-(4-iodophe nyl)nortropane (18F-FP-CIT) PET in the diagnosis of neurodegenerative parkinsonism in a multi-centre setting.METHODS: We prospectively recruited 257 subjects, including 157 patients with neurodegenerative parkinsonism, 54 patients with non-neurodegenerative parkinsonism, and 46 healthy ... read more

Behav Brain Res. 2022 Jan 18:113763. doi: 10.1016/j.bbr.2022.113763. Online ahead of print.ABSTRACTDeficits in response inhibition are a central feature of the highly prevalent dysexecutive syndrome found in Parkinson's disease (PD). Such deficits are related to a range of common clinically relevant symptoms including cognitive impairment as well as impulsive and compulsive behaviors. In this study, we explored the cortical dynamics ... read more

Neurosci Biobehav Rev. 2022 Jan 18:104541. doi: 10.1016/j.neubiorev.2022.104541. Online ahead of print.ABSTRACTAlzheimer's disease (AD), Parkinson's disease (PD), and Huntington's disease (HD) are neurodegenerative disorders characterized by progressive structural and functional loss of specific neuronal populations, protein aggregation, an insidious adult onset, and chronic progression. Modeling AD, PD, and HD in animal models is useful for studying the relationship between neuronal ... read more

Sensors (Basel). 2022 Jan 6;22(2):412. doi: 10.3390/s22020412.ABSTRACTBACKGROUND: Current telemedicine approaches lack standardised procedures for the remote assessment of axial impairment in Parkinson's disease (PD). Unobtrusive wearable sensors may be a feasible tool to provide clinicians with practical medical indices reflecting axial dysfunction in PD. This study aims to predict the postural instability/gait difficulty (PIGD) score in PD patients by monitoring ... read more

Brain Res. 2022 Jan 18:147798. doi: 10.1016/j.brainres.2022.147798. Online ahead of print.ABSTRACTLysosomal storage diseases (LSDs) are rare genetic disorders caused by a disruption in cellular clearance, resulting in pathological storage of undegraded lysosomal substrates. Recent clinical and genetic studies have uncovered links between multiple LSDs and common neurodegenerative diseases such as Parkinson's disease (PD). Here, we review recent literature describing the ... read more

Biomed Pharmacother. 2022 Feb;146:112610. doi: 10.1016/j.biopha.2021.112610. Epub 2022 Jan 4.ABSTRACTNeurodegenerative disorders (NDs) including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, and multiple sclerosis have various disease-specific causal factors and pathological features. A very common characteristic of NDs is oxidative stress (OS), which takes place due to the elevated generation of reactive oxygen species during the progression of NDs. ... read more

Sensors (Basel). 2022 Jan 12;22(2):563. doi: 10.3390/s22020563.ABSTRACTWearable global position system (GPS) technology can help those working with older populations and people living with movement disorders monitor and maintain their mobility level. Health research using GPS often employs inconsistent recording lengths due to the lack of a standard minimum GPS recording length for a clinical context. Our work aimed to recommend ... read more

Environ Sci Pollut Res Int. 2022 Jan 22. doi: 10.1007/s11356-021-17667-0. Online ahead of print.ABSTRACTFree radical or oxidative stress may be a fundamental mechanism underlying several human neurologic diseases. Therapy using free radical scavengers (antioxidants) has the potential to prevent, delay, or ameliorate many neurologic disorders. However, the biochemistry of oxidative pathobiology is complex, and optimum antioxidant therapeutic options may vary ... read more

Sensors (Basel). 2022 Jan 6;22(2):409. doi: 10.3390/s22020409.ABSTRACTParkinson's disease (PD) is a progressive neurodegenerative disorder associated with dysfunction of dopaminergic neurons in the brain, lack of dopamine and the formation of abnormal Lewy body protein particles. PD is an idiopathic disease of the nervous system, characterized by motor and nonmotor manifestations without a discrete onset of symptoms until a substantial loss ... read more

Clin Auton Res. 2022 Jan 21. doi: 10.1007/s10286-022-00852-7. Online ahead of print.NO ABSTRACTPMID:35064348 | DOI:10.1007/s10286-022-00852-7 ... read more

Neurology. 2022 Jan 21:10.1212/WNL.0000000000013303. doi: 10.1212/WNL.0000000000013303. Online ahead of print.ABSTRACTBACKGROUND: Epidemiological studies have suggested a link between rheumatoid arthritis and Parkinson's disease (PD). Disease-modifying anti-rheumatic drugs (DMARDs) might explain this association.OBJECTIVE: To evaluate the association between DMARDs and risk of PD in persons with rheumatoid arthritis.METHODS: Nested nationwide case-control study was conducted within the Finnish Parkinson's disease (FINPARK) cohort that ... read more

Vaccines (Basel). 2021 Dec 21;10(1):1. doi: 10.3390/vaccines10010001.ABSTRACTThis mini-review focuses on the mechanisms of how severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) affects the brain, with an emphasis on the role of the spike protein in patients with neurological symptoms. Following infection, patients with a history of neurological complications may be at a higher risk of developing long-term neurological conditions associated with the ... read more

NPJ Parkinsons Dis. 2022 Jan 21;8(1):12. doi: 10.1038/s41531-021-00269-5.ABSTRACTBalance dysfunction is a disabling symptom in people with Parkinson's disease (PD). Evidence suggests that exercise can improve balance performance and induce neuroplastic effects. We hypothesised that a 10-week balance intervention (HiBalance) would improve balance, other motor and cognitive symptoms, and alter task-evoked brain activity in people with PD. We performed a double-blind ... read more

NPJ Parkinsons Dis. 2022 Jan 21;8(1):13. doi: 10.1038/s41531-021-00266-8.ABSTRACTParkinson's disease (PD) is a common, progressive, and currently incurable neurodegenerative movement disorder. The diagnosis of PD is challenging, especially in the differential diagnosis of parkinsonism and in early PD detection. Due to the advantages of machine learning such as learning complex data patterns and making inferences for individuals, machine-learning techniques have been ... read more

Sci Rep. 2022 Jan 21;12(1):1163. doi: 10.1038/s41598-022-04780-4.ABSTRACTAccumulation of phosphorylated α-synuclein aggregates has been implicated in several diseases, such as Parkinson's disease (PD) and dementia with Lewy bodies (DLB), and is thought to spread in a prion-like manner. Elucidating the mechanisms of prion-like transmission of α-synuclein is important for the development of therapies for these diseases, but little is known about ... read more

Cancer Gene Ther. 2022 Jan 21. doi: 10.1038/s41417-022-00425-w. Online ahead of print.ABSTRACTAlpha-synuclein (α-syn), encoded by the SNCA gene, is a major participant in the pathophysiology of Parkinson's disease (PD). Its functions have been reported to be related to apoptosis induction, the elevation of oxidative stress, mitochondrial homeostasis, cell-cycle aberrations, and DNA-related interactions. Evidence obtained in recent studies suggests a possible ... read more

Biol Psychiatry. 2021 Nov 22:S0006-3223(21)01747-9. doi: 10.1016/j.biopsych.2021.11.007. Online ahead of print.ABSTRACTThe success of deep brain stimulation (DBS) for treating Parkinson's disease has led to its application to several other disorders, including treatment-resistant depression. Results with DBS for treatment-resistant depression have been heterogeneous, with inconsistencies largely driven by incomplete understanding of the brain networks regulating mood, especially on an individual basis. ... read more

Parkinsonism Relat Disord. 2022 Jan 8;95:86-91. doi: 10.1016/j.parkreldis.2022.01.003. Online ahead of print.ABSTRACTBACKGROUND: Speech disorders are amongst the first symptoms to appear in Parkinson's disease (PD).OBJECTIVES: We aimed to characterize PD voice signature from the prodromal stage (isolated rapid eye movement sleep behavior disorder, iRBD) to early PD using an automated acoustic analysis and compare male and female patients. We carried ... read more

Brain Sci. 2022 Jan 14;12(1):111. doi: 10.3390/brainsci12010111.ABSTRACTParkinson's disease (PD) is a chronic, progressive, neurodegenerative disease involving both motor and non-motor symptoms (NMS). In the late stage of the disease, Hoehn and Yahr (HY) stages IV-V, the symptomatology is often severe and patients become increasingly dependent on help in their daily life, resulting in an increased burden for the informal caregivers. ... read more

Diagnostics (Basel). 2022 Jan 4;12(1):112. doi: 10.3390/diagnostics12010112.ABSTRACTThe second most common progressive neurodegenerative disorder, Parkinson's disease (PD), is characterized by a broad spectrum of symptoms that are associated with its progression. Several studies have attempted to classify PD according to its clinical manifestations and establish objective biomarkers for early diagnosis and for predicting the prognosis of the disease. Recent comprehensive research ... read more