PD Latest Research

Related ArticlesStructural and molecular heterogeneity of calretinin-expressing interneurons in the rodent and primate striatum. J Comp Neurol. 2018 04 01;526(5):877-898 Authors: Garas FN, Kormann E, Shah RS, Vinciati F, Smith Y, Magill PJ, Sharott A Abstract Calretinin-expressing (CR+) interneurons are the most common type of striatal interneuron in primates. However, because CR+ interneurons are relatively scarce in rodent ... read more

Alteration of the fecal microbiota in North-eastern Han Chinese population with sporadic Parkinson's disease. Neurosci Lett. 2019 Jun 11;:134297 Authors: Li F, Wang P, Chen Z, Sui X, Xie X, Zhang J Abstract Studies have confirmed that the gut microbiota may be involved in the pathogenesis of Parkinson's disease(PD). However, the alterations in fecal microbiome in North-eastern Han sporadic PD ... read more

The association between Parkinson's disease and temporomandibular disorder. PLoS One. 2019;14(6):e0217763 Authors: Chen YY, Fan HC, Tung MC, Chang YK Abstract The prevalence of temporomandibular disorder (TMD) among elderly people with Parkinson's disease (PD) is relatively high, but a population-based study of the relationship between PD and TMD is still lacking. This study, therefore, sought to investigate the association between ... read more

Using PROMs during routine medical consultations: The perspectives of people with Parkinson's disease and their health professionals. Health Expect. 2019 Jun 14;: Authors: Damman OC, Verbiest MEA, Vonk SI, Berendse HW, Bloem BR, de Bruijne MC, Faber MJ Abstract BACKGROUND: The use of patient-reported outcomes measures (PROMs), such as quality of life or symptoms like pain or fatigue, is increasingly ... read more

Identification of potential diagnostic biomarkers for Parkinson's disease. FEBS Open Bio. 2019 Jun 14;: Authors: Jiang F, Wu Q, Sun S, Bi G, Guo L Abstract The identification of biomarkers for early diagnosis of Parkinson's disease (PD) prior to the onset of symptoms may improve the effectiveness of therapy. To identify potential biomarkers, here we downloaded microarray datasets of PD ... read more

Dairy foods and health: an umbrella review of observational studies. Int J Food Sci Nutr. 2019 Jun 14;:1-14 Authors: Godos J, Tieri M, Ghelfi F, Titta L, Marventano S, Lafranconi A, Gambera A, Alonzo E, Sciacca S, Buscemi S, Ray S, Del Rio D, Galvano F, Grosso G Abstract Evidence on consumption of dairy foods and human health is contradictory. ... read more

Temporal Associations between Sleep and Daytime Functioning in Parkinson's Disease: A Smartphone-Based Ecological Momentary Assessment. Behav Sleep Med. 2019 Jun 14;: Authors: Wu JQ, Cronin-Golomb A Abstract Objectives/Background: Disruptions to mood, cognition, and other daytime functioning are common and debilitating symptoms of Parkinson's disease (PD), and there is evidence that sleep problems contribute to these symptoms. However, previous studies are ... read more

The protective effect of Korean Red Ginseng against rotenone-induced Parkinson's disease in rat model: modulation of nuclear factor-κβ and caspase-3. Curr Pharm Biotechnol. 2019 Jun 11;: Authors: Zaafan MA, Abdelhamid AM, Ibrahim SM Abstract OBJECTIVE: Korean red ginseng was reported to have many biological effects like the antioxidant and the anti-inflammatory activities. Oxidative stress and neuro-inflammation play major roles in ... read more

Natural Terpenoids as Neuroinflammatory Inhibitors in LPS-stimulated BV-2 Microglia. Mini Rev Med Chem. 2019 Jun 11;: Authors: Xu Y, Wei H, Gao J Abstract BACKGROUND: Neuroinflammation is a typical feature of many neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. Microglia, the resident immune cells of the brain, readily become activated in response to infection or injury. Uncontrolled and overactivated ... read more

Related ArticlesAutophagy Stimulation Decreases Dopaminergic Neuronal Death Mediated by Oxidative Stress. Mol Neurobiol. 2019 Jun 13;: Authors: Ramirez-Moreno MJ, Duarte-Jurado AP, Gopar-Cuevas Y, Gonzalez-Alcocer A, Loera-Arias MJ, Saucedo-Cardenas O, Montes de Oca-Luna R, Rodriguez-Rocha H, Garcia-Garcia A Abstract The neurodegenerative process of Parkinson's disease (PD) involves autophagy impairment and oxidative stress. Therefore, we wanted to determine whether stimulation of autophagy ... read more

1H NMR profiling of the 6-OHDA parkinsonian rat brain reveals metabolic alterations and signs of recovery after N-acetylcysteine treatment. Mol Cell Neurosci. 2019 Jun 11;: Authors: Virel A, Dudka I, Laterveer R, Bjerkén SA Abstract Parkinson's disease is the second most common neurodegenerative disease caused by degeneration of dopamine neurons in the substantia nigra. The origin and causes of dopamine ... read more

Related ArticlesPatient-adjusted deep-brain stimulation programming is time saving in dystonia patients. J Neurol. 2019 Jun 13;: Authors: Bally JF, Rohani M, Ruiz-Lopez M, Paramanandam V, Munhoz RP, Hodaie M, Kalia SK, Lozano AM, Burkhard PR, Poncet A, Fasano A Abstract BACKGROUND: Deep-brain stimulation (DBS) programming for dystonia patients is a complex and time-consuming task. OBJECTIVE: To analyze whether programming a ... read more

Related ArticlesParkinson's disease protein DJ-1 regulates ATP synthase protein components to increase neuronal process outgrowth. Cell Death Dis. 2019 Jun 13;10(6):469 Authors: Chen R, Park HA, Mnatsakanyan N, Niu Y, Licznerski P, Wu J, Miranda P, Graham M, Tang J, Boon AJW, Cossu G, Mandemakers W, Bonifati V, Smith PJS, Alavian KN, Jonas EA Abstract Familial Parkinson's disease (PD) protein ... read more

Related ArticlesNon-Motor Symptoms after One Week of High Cadence Cycling in Parkinson's Disease. Int J Environ Res Public Health. 2019 Jun 14;16(12): Authors: Harper SA, Dowdell BT, Kim JH, Pollock BS, Ridgel AL Abstract The objective was to investigate if high cadence cycling altered non-motor cognition and depression symptoms in individuals with Parkinson's disease (PD) and whether exercise responses were ... read more

Related ArticlesGut microbes metabolize Parkinson's disease drug. Science. 2019 Jun 14;364(6445):1030-1031 Authors: O'Neill C PMID: 31196998 [PubMed - in process] ... read more

Related ArticlesDiscovery and inhibition of an interspecies gut bacterial pathway for Levodopa metabolism. Science. 2019 06 14;364(6445): Authors: Maini Rekdal V, Bess EN, Bisanz JE, Turnbaugh PJ, Balskus EP Abstract The human gut microbiota metabolizes the Parkinson's disease medication Levodopa (l-dopa), potentially reducing drug availability and causing side effects. However, the organisms, genes, and enzymes responsible for this activity in ... read more

Related ArticlesAnti-oligomerization sheet molecules: Design, synthesis and evaluation of inhibitory activities against α-synuclein aggregation. Bioorg Med Chem. 2019 Jun 04;: Authors: Liu H, Chen L, Zhou F, Zhang YX, Xu J, Xu M, Bai SP Abstract Aggregation of α-synuclein (α-Syn) play a key role in the development of Parkinson Disease (PD). One of the effective approaches is to stabilize the ... read more

Related ArticlesImaging Parkinson's disease using functional and diffusion MRI. Parkinsonism Relat Disord. 2019 Jun 07;: Authors: Rektorova I PMID: 31196700 [PubMed - as supplied by publisher] ... read more

Related ArticlesIncobotulinumtoxinA and Deep Brain Stimulation. Can J Neurol Sci. 2019 Jun 14;:1-4 Authors: Soh D, Fasano A Abstract Guidelines recommend Botulinum toxin-A (BoNT-A) after deep brain stimulation (DBS), although the effectiveness of their combined use is uncertain. A chart review of Parkinson's disease (17) and dystonia (7) patients undergoing 302 injections with IncobotulinumtoxinA before or after DBS was performed. ... read more

Related ArticlesGene Therapy for Neurological Disorders: Challenges and Recent Advancements. J Drug Target. 2019 Jun 14;:1-61 Authors: Pena SA, Iyengar R, Eshraghi RS, Bencie N, Mittal J, Aljohani A, Mittal R, Eshraghi AA Abstract Major advancements in targeted gene therapy have opened up avenues for the treatment of major neurological disorders through a range of versatile modalities varying from expression ... read more

Related ArticlesParkin Mutation Affects Clock Gene-Dependent Energy Metabolism. Int J Mol Sci. 2019 Jun 05;20(11): Authors: Pacelli C, Rotundo G, Lecce L, Menga M, Bidollari E, Scrima R, Cela O, Piccoli C, Cocco T, Vescovi AL, Mazzoccoli G, Rosati J, Capitanio N Abstract Growing evidence highlights a tight connection between circadian rhythms, molecular clockworks, and mitochondrial function. In particular, mitochondrial ... read more

Related ArticlesMetalloproteinases and their tissue inhibitors in Alzheimer's disease and other neurodegenerative disorders. Cell Mol Life Sci. 2019 Jun 13;: Authors: Rivera S, García-González L, Khrestchatisky M, Baranger K Abstract As life expectancy increases worldwide, age-related neurodegenerative diseases will increase in parallel. The lack of effective treatment strategies may soon lead to an unprecedented health, social and economic crisis. Any attempt to halt ... read more

The mediating roles of caregiver social support and self-efficacy on caregiver burden in Parkinson's disease. J Affect Disord. 2019 May 28;256:302-308 Authors: Yang Z, Tian Y, Fan Y, Liu L, Luo Y, Zhou L, Yu H Abstract BACKGROUND: Most studies in Parkinson's disease (PD) have focused on the direct effects of social support and self-efficacy on caregiver burden. This study ... read more

56 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: parkinson's disease These pubmed results were generated on 2019/06/14PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher ... read more

Related ArticlesLycopodium Attenuates Loss of Dopaminergic Neurons by Suppressing Oxidative Stress and Neuroinflammation in a Rat Model of Parkinson's Disease. Molecules. 2019 Jun 10;24(11): Authors: Jayaraj RL, Beiram R, Azimullah S, Meeran MFN, Ojha SK, Adem A, Jalal FY Abstract Parkinson's disease, a chronic, age related neurodegenerative disorder, is characterized by a progressive loss of nigrostriatal dopaminergic neurons. Several studies ... read more