PD Latest Research

EClinicalMedicine. 2023 Mar 17;58:101888. doi: 10.1016/j.eclinm.2023.101888. eCollection 2023 Apr.ABSTRACTBACKGROUND: Faecal microbiota transplantation (FMT) has demonstrated efficacy in treating gastrointestinal (GI) diseases, such as Clostridium difficile infection (CDI) and inflammatory bowel disease (IBD). GI dysfunction is a frequent and occasionally dominating symptom of progressive supranuclear palsy-Richardson's syndrome (PSP-RS). However, it is not known whether FMT has clinical efficacy for PSP-RS.METHODS: This ... read more

J Parkinsons Dis. 2023 Mar 22. doi: 10.3233/JPD-223537. Online ahead of print.ABSTRACTBACKGROUND: Nausea is common upon initiating dopamine agonists in patients with Parkinson's disease (PD); however, pretreatment with an antiemetic is recommended only when initiating apomorphine formulations.OBJECTIVE: Evaluate the need for prophylactic antiemetic use during dose optimization of apomorphine sublingual film (SL-APO).METHODS: A post hoc analysis of a Phase III ... read more

Hum Mol Genet. 2023 Mar 27:ddad047. doi: 10.1093/hmg/ddad047. Online ahead of print.ABSTRACTConformational diseases, such as Alzheimer, Parkinson and Huntington diseases, are part of a common class of neurological disorders characterized by the aggregation and progressive accumulation of proteins bearing aberrant conformations. Huntington disease (HD) has autosomal dominant inheritance and is caused by mutations leading to an abnormal expansion in the ... read more

J Neurol. 2023 Mar 27. doi: 10.1007/s00415-023-11629-x. Online ahead of print.ABSTRACTBACKGROUND: Misdiagnosis and delayed diagnosis in progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) are common. Few studies have systematically evaluated the diagnostic process from symptom onset to death in representative cohorts.METHODS: All PSP/CBD cases (n = 28/2) and age-sex matched Parkinson's disease (PD) cases (n = 30) were identified ... read more

Front Immunol. 2023 Mar 9;14:1117726. doi: 10.3389/fimmu.2023.1117726. eCollection 2023.ABSTRACTINTRODUCTION: Generalized anxiety disorder (GAD) is one of the most enduring anxiety disorders, being associated with increased systemic inflammation. However, the trigger and mechanisms underlying the activation of inflammatory cytokine responses in GAD remain poorly understood.MATERIALS AND METHODS: We characterized the ear canal microbiome in GAD patients through 16S rRNA gene sequencing ... read more

IEEE Trans Emerg Top Comput Intell. 2023 Apr;7(2):308-318. doi: 10.1109/tetci.2021.3136587. Epub 2022 Jan 5.ABSTRACTConventional clustering techniques for neuroimaging applications usually focus on capturing differences between given subjects, while neglecting arising differences between features and the potential bias caused by degraded data quality. In practice, collected neuroimaging data are often inevitably contaminated by noise, which may lead to errors in clustering ... read more

Front Aging Neurosci. 2023 Mar 10;15:1133705. doi: 10.3389/fnagi.2023.1133705. eCollection 2023.ABSTRACTOBJECTIVE: To assess the prevalence, evolution, clinical characteristics, correlates and predictors of fatigue as well as to investigate the influence of comorbid fatigue on the longitudinal changes in motor and non-motor symptoms over a 2-year longitudinal follow-up period in a large cohort of patients with Parkinson's disease (PD).MATERIALS AND METHODS: A ... read more

Front Genet. 2023 Mar 9;14:881638. doi: 10.3389/fgene.2023.881638. eCollection 2023.ABSTRACTTransactive response DNA binding protein-43 (TDP-43) is known to mediate neurodegeneration associated with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). The exact mechanism by which TDP-43 exerts toxicity in the brains, spinal cord, and lower motor neurons of affected patients remains unclear. In a novel Drosophila melanogaster model, we report ... read more

Clin Auton Res. 2023 Mar 27. doi: 10.1007/s10286-023-00934-0. Online ahead of print.ABSTRACTPURPOSE: Despite the availability of the Unified Multiple System Atrophy (MSA) Rating Scale (UMSARS) for almost two decades, studies still use scales developed for Parkinson's disease (PD) or ataxia (ATX). Our aim was to evaluate the use of UMSARS (part II, motor) compared to other motor rating scales in ... read more

Ann Clin Transl Neurol. 2023 Mar 27. doi: 10.1002/acn3.51753. Online ahead of print.ABSTRACTOBJECTIVES: Detection of α-synuclein aggregates by seed amplification is a promising Parkinson disease biomarker assay. Understanding intraindividual relationships of α-synuclein measures could inform optimal biomarker development. The objectives were to test accuracy of α-synuclein seed amplification assay in central (cerebrospinal fluid) and peripheral (submandibular gland) sources, compare to ... read more

Front Immunol. 2023 Mar 9;14:1117726. doi: 10.3389/fimmu.2023.1117726. eCollection 2023.ABSTRACTINTRODUCTION: Generalized anxiety disorder (GAD) is one of the most enduring anxiety disorders, being associated with increased systemic inflammation. However, the trigger and mechanisms underlying the activation of inflammatory cytokine responses in GAD remain poorly understood.MATERIALS AND METHODS: We characterized the ear canal microbiome in GAD patients through 16S rRNA gene sequencing ... read more

Front Aging Neurosci. 2023 Mar 9;15:1117473. doi: 10.3389/fnagi.2023.1117473. eCollection 2023.ABSTRACTParkinson's disease (PD) affects the language processes, with a significant impact on the patients' daily communication. We aimed to describe specific alterations in the comprehension of syntactically complex sentences in patients with PD (PwPD) as compared to healthy controls (HC) and to identify the neural underpinnings of these deficits using a ... read more

J Int Neuropsychol Soc. 2023 Mar 27:1-8. doi: 10.1017/S1355617723000097. Online ahead of print.ABSTRACTOBJECTIVES: This study aims to address a gap in the data on cognitive sex differences in persons living with Parkinson disease (PD). There is some evidence that cognitive dysfunction is more severe in male PD, however data on episodic memory and processing speed is incomplete.METHODS: One hundred and ... read more

Front Neurol. 2023 Mar 8;14:1117188. doi: 10.3389/fneur.2023.1117188. eCollection 2023.ABSTRACTTranscranial ultrasound stimulation is a neurostimulation technique that has gradually attracted the attention of researchers, especially as a potential therapy for neurological disorders, because of its high spatial resolution, its good penetration depth, and its non-invasiveness. Ultrasound can be categorized as high-intensity and low-intensity based on the intensity of its acoustic wave. ... read more

IEEE Trans Emerg Top Comput Intell. 2023 Apr;7(2):308-318. doi: 10.1109/tetci.2021.3136587. Epub 2022 Jan 5.ABSTRACTConventional clustering techniques for neuroimaging applications usually focus on capturing differences between given subjects, while neglecting arising differences between features and the potential bias caused by degraded data quality. In practice, collected neuroimaging data are often inevitably contaminated by noise, which may lead to errors in clustering ... read more

Brain Commun. 2023 Mar 2;5(2):fcad049. doi: 10.1093/braincomms/fcad049. eCollection 2023.ABSTRACTOculomotor tasks generate a potential wealth of behavioural biomarkers for neurodegenerative diseases. Overlap between oculomotor and disease-impaired circuitry reveals the location and severity of disease processes via saccade parameters measured from eye movement tasks such as prosaccade and antisaccade. Existing studies typically examine few saccade parameters in single diseases, using multiple separate ... read more

Arch Rehabil Res Clin Transl. 2022 Dec 5;5(1):100250. doi: 10.1016/j.arrct.2022.100250. eCollection 2023 Mar.ABSTRACTOBJECTIVE: The objective of this pilot study was to examine the feasibility of a remote physical activity monitoring program, quantify baseline activity levels, and examine predictors of activity among rurally residing adults with Parkinson disease (PD) or stroke.DESIGN: Thirty-day observational study. Participants completed standardized assessments, connected a wearable ... read more

Front Neurosci. 2023 Mar 3;17:1128157. doi: 10.3389/fnins.2023.1128157. eCollection 2023.ABSTRACTAdvent of the acute respiratory coronavirus SARS-CoV-2 has resulted in the search for novel antiviral agents and in the repurposing of existing agents with demonstrated efficacy against other known coronaviruses in the search for an agent with antiviral activity for use during the COVID-19 pandemic. Adamantanes including amantadine, rimantadine, and memantine have ... read more

NPJ Parkinsons Dis. 2023 Mar 27;9(1):46. doi: 10.1038/s41531-023-00493-1.ABSTRACTThe neurophysiology of selective attention in visual and auditory systems has been studied in animal models but not with single unit recordings in human. Here, we recorded neuronal activity in the ventral intermediate nucleus as well as the ventral oral anterior, and posterior nuclei of the motor thalamus in 25 patients with parkinsonian ... read more

Ann Fam Med. 2023 Jan 1;(21 Suppl 1). doi: 10.1370/afm.21.s1.3730.ABSTRACTContext: The applicability of randomised controlled trials of pharmacological agents to older people with frailty/multimorbidity is often uncertain, due to concerns that trials are not representative. However, assessing trial representativeness is challenging and complex. Objectives: We explore an approach assessing trial representativeness by comparing rates of trial Serious Adverse Events (SAEs: ... read more

Palliat Med Rep. 2023 Mar 22;4(1):79-88. doi: 10.1089/pmr.2022.0034. eCollection 2023.ABSTRACTOBJECTIVE: With Huntington disease (HD), a fatal neurodegenerative disease where the prevalence of suicidal thoughts and behavior (STB) remains elevated as compared to other neurological disorders, it is unknown whether STB and health-related quality of life (HRQoL) affect plans for the end of life or more broadly, advance care planning (ACP). ... read more

Front Aging Neurosci. 2023 Mar 8;15:1068943. doi: 10.3389/fnagi.2023.1068943. eCollection 2023.ABSTRACTBACKGROUND: Freezing of gait (FoG) is a severely disabling symptom in Parkinson's disease (PD). The cortical mechanisms underlying FoG during locomotion tasks have rarely been investigated.OBJECTIVES: We aimed to compare the cerebral haemodynamic response during FoG-prone locomotion tasks in patients with PD and FoG (PD-FoG), patients with PD but without FoG ... read more

Front Cell Dev Biol. 2023 Mar 10;11:1146564. doi: 10.3389/fcell.2023.1146564. eCollection 2023.ABSTRACTThe disturbance in mitochondrial functions and homeostasis are the major features of neuron degenerative conditions, like Parkinson's disease, Amyotrophic Lateral Sclerosis, and Alzheimer's disease, along with protein misfolding. The aberrantly folded proteins are known to link with impaired mitochondrial pathways, further contributing to disease pathogenesis. Despite their central significance, the ... read more

Front Neurol. 2023 Mar 8;14:1103349. doi: 10.3389/fneur.2023.1103349. eCollection 2023.ABSTRACTRehabilomics is an important research framework that allows omics research built upon rehabilitation practice, especially in function evaluation, outcome prediction, and individualized rehabilitation. In the field of rehabilomics, biomarkers can serve as objectively measured indicators for body functioning, so as to complement the International Classification of Functioning, Disability, and Health (ICF) assessment. ... read more

Appl Bionics Biomech. 2023 Mar 15;2023:6630913. doi: 10.1155/2023/6630913. eCollection 2023.ABSTRACTBACKGROUND: Arm swing has a crucial role in gait. It is essential in terms of regulating gait parameters and balance during walking. In the case of bradykinesia, the arms act as a generator to maintain lower extremity movement while walking. The way gyroscopes work makes them useful in arm swings. In ... read more