PD Latest Research


  • Impact of fatty acid-binding proteins and dopamine receptors on α-synucleinopathy
    J Pharmacol Sci. 2022 Feb;148(2):248-254. doi: 10.1016/j.jphs.2021.12.003. Epub 2021 Dec 14.ABSTRACTAn aging society leads to an increased number of patients with cognitive and movement disorders, such as Parkinson's disease and dementia with Lewy bodies. α-Synuclein accumulation in neuronal cells is a pathological hallmark of α-synucleinopathies. Aberrant soluble oligomeric units of α-synuclein are toxic and disrupt neuronal homeostasis. Fatty acids partially ... read more
    Source: PubMedPublished on 2022-01-22By Ichiro Kawahata
  • Genomic study of a large family with complex neurological phenotype including hearing loss, imbalance and action tremor
    Neurobiol Aging. 2021 Dec 25:S0197-4580(21)00361-4. doi: 10.1016/j.neurobiolaging.2021.12.004. Online ahead of print.ABSTRACTNeurological disorders are often associated with a variety of symptoms, which can result from the combined action of genetic variants. We conducted a whole-genome analysis of a previously unreported unique multigenerational Dutch-Canadian family with a complex phenotype presenting with a combination of hearing loss, balance issues or action tremor. Ten ... read more
    Source: PubMedPublished on 2022-01-22By Julien F Bally
  • Case report on ear numbness following deep brain stimulation implantation
    Int J Surg Case Rep. 2022 Jan 15;91:106773. doi: 10.1016/j.ijscr.2022.106773. Online ahead of print.ABSTRACTINTRODUCTION AND IMPORTANCE: Deep brain stimulation (DBS) implantation is a neurosurgical procedure in which electrodes are implanted in the brain. Complications that may occur include wound infection, issues with the DBS hardware, and others. This case report presents a patient who suffered ear numbness following DBS implantation.CASE ... read more
    Source: PubMedPublished on 2022-01-22By Agus Turchan
  • The impact of lifetime coffee and tea loads on Multiple Sclerosis severity
    Clin Nutr ESPEN. 2022 Feb;47:199-205. doi: 10.1016/j.clnesp.2021.12.014. Epub 2021 Dec 23.ABSTRACTBACKGROUND AND AIMS: The association between lifestyle factors and Multiple Sclerosis (MS) disease severity and progression has been investigated to a lesser extent compared with susceptibility to the disease. We aimed to assess the impact of lifetime coffee and tea consumption on MS severity.METHODS: Design: cross-sectional study. Two hundred and ... read more
    Source: PubMedPublished on 2022-01-22By Andrei Ivashynka
  • Patients’ Self-Report and Handwriting Performance Features as Indicators for Suspected Mild Cognitive Impairment in Parkinson’s Disease
    Sensors (Basel). 2022 Jan 12;22(2):569. doi: 10.3390/s22020569.ABSTRACTEarly identification of mild cognitive impairment (MCI) in Parkinson's disease (PD) patients can lessen emotional and physical complications. In this study, a cognitive functional (CF) feature using cognitive and daily living items of the Unified Parkinson's Disease Rating Scale served to define PD patients as suspected or not for MCI. The study aimed to ... read more
    Source: PubMedPublished on 2022-01-22By Sara Rosenblum
  • A prospective multi-centre study of susceptibility map-weighted MRI for the diagnosis of neurodegenerative parkinsonism
    Eur Radiol. 2022 Jan 22. doi: 10.1007/s00330-021-08454-z. Online ahead of print.ABSTRACTOBJECTIVES: This study aimed to compare susceptibility map-weighted imaging (SMwI) using various MRI machines (three vendors) with N-3-fluoropropyl-2-β-carbomethoxy-3-β-(4-iodophe nyl)nortropane (18F-FP-CIT) PET in the diagnosis of neurodegenerative parkinsonism in a multi-centre setting.METHODS: We prospectively recruited 257 subjects, including 157 patients with neurodegenerative parkinsonism, 54 patients with non-neurodegenerative parkinsonism, and 46 healthy ... read more
    Source: PubMedPublished on 2022-01-22By Young Hee Sung
  • Neural correlates of impaired response inhibition in the antisaccade task in Parkinson’s disease
    Behav Brain Res. 2022 Jan 18:113763. doi: 10.1016/j.bbr.2022.113763. Online ahead of print.ABSTRACTDeficits in response inhibition are a central feature of the highly prevalent dysexecutive syndrome found in Parkinson's disease (PD). Such deficits are related to a range of common clinically relevant symptoms including cognitive impairment as well as impulsive and compulsive behaviors. In this study, we explored the cortical dynamics ... read more
    Source: PubMedPublished on 2022-01-22By Josefine Waldthaler
  • The three sisters of fate: Genetics, pathophysiology and outcomes of animal models of neurodegenerative diseases
    Neurosci Biobehav Rev. 2022 Jan 18:104541. doi: 10.1016/j.neubiorev.2022.104541. Online ahead of print.ABSTRACTAlzheimer's disease (AD), Parkinson's disease (PD), and Huntington's disease (HD) are neurodegenerative disorders characterized by progressive structural and functional loss of specific neuronal populations, protein aggregation, an insidious adult onset, and chronic progression. Modeling AD, PD, and HD in animal models is useful for studying the relationship between neuronal ... read more
    Source: PubMedPublished on 2022-01-22By Michael Klonarakis
  • Predicting Axial Impairment in Parkinson’s Disease through a Single Inertial Sensor
    Sensors (Basel). 2022 Jan 6;22(2):412. doi: 10.3390/s22020412.ABSTRACTBACKGROUND: Current telemedicine approaches lack standardised procedures for the remote assessment of axial impairment in Parkinson's disease (PD). Unobtrusive wearable sensors may be a feasible tool to provide clinicians with practical medical indices reflecting axial dysfunction in PD. This study aims to predict the postural instability/gait difficulty (PIGD) score in PD patients by monitoring ... read more
    Source: PubMedPublished on 2022-01-22By Luigi Borzì
  • Neuroinflammation in aucher disease, neuronal ceroid lipofuscinosis, and commonalities with Parkinson’s disease
    Brain Res. 2022 Jan 18:147798. doi: 10.1016/j.brainres.2022.147798. Online ahead of print.ABSTRACTLysosomal storage diseases (LSDs) are rare genetic disorders caused by a disruption in cellular clearance, resulting in pathological storage of undegraded lysosomal substrates. Recent clinical and genetic studies have uncovered links between multiple LSDs and common neurodegenerative diseases such as Parkinson's disease (PD). Here, we review recent literature describing the ... read more
    Source: PubMedPublished on 2022-01-22By Laetitia Francelle
  • Therapeutic promise of carotenoids as antioxidants and anti-inflammatory agents in neurodegenerative disorders
    Biomed Pharmacother. 2022 Feb;146:112610. doi: 10.1016/j.biopha.2021.112610. Epub 2022 Jan 4.ABSTRACTNeurodegenerative disorders (NDs) including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, and multiple sclerosis have various disease-specific causal factors and pathological features. A very common characteristic of NDs is oxidative stress (OS), which takes place due to the elevated generation of reactive oxygen species during the progression of NDs. ... read more
    Source: PubMedPublished on 2022-01-22By Md Tanvir Kabir
  • How Long Should GPS Recording Lengths Be to Capture the Community Mobility of An Older Clinical Population? A Parkinson’s Example
    Sensors (Basel). 2022 Jan 12;22(2):563. doi: 10.3390/s22020563.ABSTRACTWearable global position system (GPS) technology can help those working with older populations and people living with movement disorders monitor and maintain their mobility level. Health research using GPS often employs inconsistent recording lengths due to the lack of a standard minimum GPS recording length for a clinical context. Our work aimed to recommend ... read more
    Source: PubMedPublished on 2022-01-22By Lynn Zhu
  • Exploring multifunctional antioxidants as potential agents for management of neurological disorders
    Environ Sci Pollut Res Int. 2022 Jan 22. doi: 10.1007/s11356-021-17667-0. Online ahead of print.ABSTRACTFree radical or oxidative stress may be a fundamental mechanism underlying several human neurologic diseases. Therapy using free radical scavengers (antioxidants) has the potential to prevent, delay, or ameliorate many neurologic disorders. However, the biochemistry of oxidative pathobiology is complex, and optimum antioxidant therapeutic options may vary ... read more
    Source: PubMedPublished on 2022-01-22By Rakesh K Sindhu
  • A Sensor-Based Perspective in Early-Stage Parkinson’s Disease: Current State and the Need for Machine Learning Processes
    Sensors (Basel). 2022 Jan 6;22(2):409. doi: 10.3390/s22020409.ABSTRACTParkinson's disease (PD) is a progressive neurodegenerative disorder associated with dysfunction of dopaminergic neurons in the brain, lack of dopamine and the formation of abnormal Lewy body protein particles. PD is an idiopathic disease of the nervous system, characterized by motor and nonmotor manifestations without a discrete onset of symptoms until a substantial loss ... read more
    Source: PubMedPublished on 2022-01-22By Marios G Krokidis
  • Functional brain neuroimaging as a tool to study gastrointestinal manifestations in patients with Parkinson’s disease
    Clin Auton Res. 2022 Jan 21. doi: 10.1007/s10286-022-00852-7. Online ahead of print.NO ABSTRACTPMID:35064348 | DOI:10.1007/s10286-022-00852-7 ... read more
    Source: PubMedPublished on 2022-01-22By Ryuji Sakakibara
  • Disease-Modifying Antirheumatic Drugs and Risk of Parkinson Disease: Nested Case-Control Study of People With Rheumatoid Arthritis
    Neurology. 2022 Jan 21:10.1212/WNL.0000000000013303. doi: 10.1212/WNL.0000000000013303. Online ahead of print.ABSTRACTBACKGROUND: Epidemiological studies have suggested a link between rheumatoid arthritis and Parkinson's disease (PD). Disease-modifying anti-rheumatic drugs (DMARDs) might explain this association.OBJECTIVE: To evaluate the association between DMARDs and risk of PD in persons with rheumatoid arthritis.METHODS: Nested nationwide case-control study was conducted within the Finnish Parkinson's disease (FINPARK) cohort that ... read more
    Source: PubMedPublished on 2022-01-22By Anne Paakinaho
  • How Does Severe Acute Respiratory Syndrome-Coronavirus-2 Affect the Brain and Its Implications for the Vaccines Currently in Use
    Vaccines (Basel). 2021 Dec 21;10(1):1. doi: 10.3390/vaccines10010001.ABSTRACTThis mini-review focuses on the mechanisms of how severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) affects the brain, with an emphasis on the role of the spike protein in patients with neurological symptoms. Following infection, patients with a history of neurological complications may be at a higher risk of developing long-term neurological conditions associated with the ... read more
    Source: PubMedPublished on 2022-01-22By Philip R Oldfield
  • Behavioural and neuroplastic effects of a double-blind randomised controlled balance exercise trial in people with Parkinson’s disease
    NPJ Parkinsons Dis. 2022 Jan 21;8(1):12. doi: 10.1038/s41531-021-00269-5.ABSTRACTBalance dysfunction is a disabling symptom in people with Parkinson's disease (PD). Evidence suggests that exercise can improve balance performance and induce neuroplastic effects. We hypothesised that a 10-week balance intervention (HiBalance) would improve balance, other motor and cognitive symptoms, and alter task-evoked brain activity in people with PD. We performed a double-blind ... read more
    Source: PubMedPublished on 2022-01-22By Malin Freidle
  • Mining imaging and clinical data with machine learning approaches for the diagnosis and early detection of Parkinson’s disease
    NPJ Parkinsons Dis. 2022 Jan 21;8(1):13. doi: 10.1038/s41531-021-00266-8.ABSTRACTParkinson's disease (PD) is a common, progressive, and currently incurable neurodegenerative movement disorder. The diagnosis of PD is challenging, especially in the differential diagnosis of parkinsonism and in early PD detection. Due to the advantages of machine learning such as learning complex data patterns and making inferences for individuals, machine-learning techniques have been ... read more
    Source: PubMedPublished on 2022-01-22By Jing Zhang
  • Phosphorylation of endogenous α-synuclein induced by extracellular seeds initiates at the pre-synaptic region and spreads to the cell body
    Sci Rep. 2022 Jan 21;12(1):1163. doi: 10.1038/s41598-022-04780-4.ABSTRACTAccumulation of phosphorylated α-synuclein aggregates has been implicated in several diseases, such as Parkinson's disease (PD) and dementia with Lewy bodies (DLB), and is thought to spread in a prion-like manner. Elucidating the mechanisms of prion-like transmission of α-synuclein is important for the development of therapies for these diseases, but little is known about ... read more
    Source: PubMedPublished on 2022-01-22By Shiori Awa
  • Adeno-associated virus-delivered alpha synuclein inhibits bladder cancer growth via the p53/p21 signaling pathway
    Cancer Gene Ther. 2022 Jan 21. doi: 10.1038/s41417-022-00425-w. Online ahead of print.ABSTRACTAlpha-synuclein (α-syn), encoded by the SNCA gene, is a major participant in the pathophysiology of Parkinson's disease (PD). Its functions have been reported to be related to apoptosis induction, the elevation of oxidative stress, mitochondrial homeostasis, cell-cycle aberrations, and DNA-related interactions. Evidence obtained in recent studies suggests a possible ... read more
    Source: PubMedPublished on 2022-01-22By Zhengcun Wu
  • Deep Brain Stimulation for Depression Informed by Intracranial Recordings
    Biol Psychiatry. 2021 Nov 22:S0006-3223(21)01747-9. doi: 10.1016/j.biopsych.2021.11.007. Online ahead of print.ABSTRACTThe success of deep brain stimulation (DBS) for treating Parkinson's disease has led to its application to several other disorders, including treatment-resistant depression. Results with DBS for treatment-resistant depression have been heterogeneous, with inconsistencies largely driven by incomplete understanding of the brain networks regulating mood, especially on an individual basis. ... read more
    Source: PubMedPublished on 2022-01-22By Sameer A Sheth
  • Voice characteristics from isolated rapid eye movement sleep behavior disorder to early Parkinson’s disease
    Parkinsonism Relat Disord. 2022 Jan 8;95:86-91. doi: 10.1016/j.parkreldis.2022.01.003. Online ahead of print.ABSTRACTBACKGROUND: Speech disorders are amongst the first symptoms to appear in Parkinson's disease (PD).OBJECTIVES: We aimed to characterize PD voice signature from the prodromal stage (isolated rapid eye movement sleep behavior disorder, iRBD) to early PD using an automated acoustic analysis and compare male and female patients. We carried ... read more
    Source: PubMedPublished on 2022-01-22By Laetitia Jeancolas
  • Caregiver Burden and Quality of Life in Late Stage Parkinson’s Disease
    Brain Sci. 2022 Jan 14;12(1):111. doi: 10.3390/brainsci12010111.ABSTRACTParkinson's disease (PD) is a chronic, progressive, neurodegenerative disease involving both motor and non-motor symptoms (NMS). In the late stage of the disease, Hoehn and Yahr (HY) stages IV-V, the symptomatology is often severe and patients become increasingly dependent on help in their daily life, resulting in an increased burden for the informal caregivers. ... read more
    Source: PubMedPublished on 2022-01-21By Kristina Rosqvist
  • Parkinson’s Disease Subtyping Using Clinical Features and Biomarkers: Literature Review and Preliminary Study of Subtype Clustering
    Diagnostics (Basel). 2022 Jan 4;12(1):112. doi: 10.3390/diagnostics12010112.ABSTRACTThe second most common progressive neurodegenerative disorder, Parkinson's disease (PD), is characterized by a broad spectrum of symptoms that are associated with its progression. Several studies have attempted to classify PD according to its clinical manifestations and establish objective biomarkers for early diagnosis and for predicting the prognosis of the disease. Recent comprehensive research ... read more
    Source: PubMedPublished on 2022-01-21By Seung Hyun Lee
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