PD Latest Research

Related ArticlesFeeling controlled or being in control? Apps for self-management among older people with neurological disability. Disabil Rehabil Assist Technol. 2019 Nov 11;:1-6 Authors: Winberg C, Kylberg M, Pettersson C, Harnett T, Hedvall PO, Mattsson T, Månsson Lexell E Abstract Purpose: The aim of this paper was to describe how people living with a neurological disability such as multiple sclerosis, ... read more

Towards a wearable system for predicting the freezing of gait in people affected by Parkinson's disease. IEEE J Biomed Health Inform. 2019 Nov 11;: Authors: Demrozi F, Bacchin R, Tamburin S, Cristani M, Pravadelli G Abstract Some wearable solutions exploiting on-body acceleration sensors have been proposed to recognize Freezing of Gait (FoG) in people affected by Parkinson Disease (PD). Once ... read more

Application of reinforcement learning to deep brain stimulation in a computational model of Parkinson's disease. IEEE Trans Neural Syst Rehabil Eng. 2019 Nov 11;: Authors: Lu M, Wei X, Che Y, Wang J, Loparo KA Abstract Deep brain stimulation (DBS) has been proven to be an effective treatment to deal with the symptoms of Parkinson's disease (PD). Currently, the DBS ... read more

Pre-stimulus beta power modulation during motor sequence learning is reduced in 'Parkinson's disease. Neuroimage Clin. 2019 Oct 24;24:102057 Authors: Meissner SN, Krause V, Südmeyer M, Hartmann CJ, Pollok B Abstract Beta oscillations within motor-cortical areas have been linked to sensorimotor function. In line with this, pathologically altered beta activity in cortico-basal ganglia pathways has been suggested to contribute to the ... read more

Generation of an induced pluripotent stem cell line (EURACi005-A) from a Parkinson's disease patient carrying a homozygous exon 3 deletion in the PRKNgene. Stem Cell Res. 2019 Oct 25;41:101624 Authors: Zanon A, Riekschnitz D, von Troyer M, Volpato C, Picard A, Cantaloni C, Di Segni M, Silipigni R, Pramstaller PP, Hicks AA, Pichler I Abstract Mutations in the PRKN gene, ... read more

Multimodal visual exploration disturbances in Parkinson's disease detected with an infrared eye-movement assessment system. Neurosci Res. 2019 Nov 09;: Authors: Nagai K, Kaneko Y, Suzuki M, Teramoto H, Morita A, Kamei S, Watanabe Y, Okada M, Uchiyama M Abstract Parkinson's disease (PD) reportedly show disturbed visual exploration. However, whether this disturbance is due to dysfunctional visual information processing remains unclear. ... read more

Human Autologous iPSC-Derived Dopaminergic Progenitors Restore Motor Function in Parkinson's Disease Models. J Clin Invest. 2019 Nov 12;: Authors: Song B, Cha Y, Ko S, Jeon J, Lee N, Seo H, Park KJ, Lee IH, Lopes C, Feitosa M, Luna MJ, Jung JH, Kim J, Hwang D, Cohen B, Teicher M, Leblanc P, Carter B, Kordower JH, Bolshakov VY, Kong ... read more

Levodopa-responsive retrocollis on the background of choreic dyskinesia. Int J Neurosci. 2019 Nov 12;:1-4 Authors: Kataoka H, Sawada Y, Shimozato N, Inatomi S, Yoshiji H, Sugie K Abstract Retrocollis can substantially disturb the daily living of individuals with Parkinson's disease (PD). The study patient showed levodopa-responsive retrocollis on the background of choreic dyskinesia. Severe retrocollis can be superimposed on choreic ... read more

Plasma urate concentrations and possible REM sleep behavior disorder. Ann Clin Transl Neurol. 2019 Nov 12;: Authors: Shen Y, Li J, Schwarzschild M, Pavlova M, He S, Ascherio A, Wu S, Cui L, Gao X Abstract OBJECTIVE: To examine how urate concentrations are related to the risk of having possible REM sleep behavior disorder (pRBD) in a community-based cohort. METHODS: ... read more

A machine learning algorithm successfully screens for Parkinson's in web users. Ann Clin Transl Neurol. 2019 Nov 12;: Authors: Youngmann B, Allerhand L, Paltiel O, Yom-Tov E, Arkadir D Abstract OBJECTIVE: To develop, apply, and evaluate, a novel web-based classifier for screening for Parkinson disease among a large cohort of search engine users. METHODS: A supervised machine learning classifier learned ... read more

Adult onset tubulo-interstitial nephropathy in MT-ND5-related phenotypes. Clin Genet. 2019 Nov 12;: Authors: Bakis H, Trimouille A, Vermorel A, Redonnet I, Goizet C, Boulestreau R, Lacombe D, Combe C, Martin-Négrier ML, Rigothier C Abstract Kidney is a highly ATP dependent organ in human body. Healthy and functional mitochondria are essential for normal kidney function. Clinical and genetic variability are the ... read more

Effect of different music genres on gait patterns in Parkinson's disease. Neurol Sci. 2019 Nov 12;: Authors: De Bartolo D, Morone G, Giordani G, Antonucci G, Russo V, Fusco A, Marinozzi F, Bini F, Spitoni GF, Paolucci S, Iosa M Abstract The timing and size of repetitive, internally generated, automatic sequences of movements are particularly affected in Parkinson's disease. The ... read more

VGF peptides as novel biomarkers in Parkinson's disease. Cell Tissue Res. 2019 Nov 12;: Authors: Cocco C, Corda G, Lisci C, Noli B, Carta M, Brancia C, Manca E, Masala C, Marrosu F, Solla P, Manconi B, Bongioanni P, Ferri GL Abstract Parkinson's disease (PD) is characterized by a progressive degeneration of dopaminergic neurons in the substantia nigra (SN). At ... read more

Is 123I-MIBG Scintigraphy Beneficial or Excessive for the Diagnosis of Parkinson's Disease in the Early Phase? Neurodegener Dis. 2019 Nov 12;19(2):88-95 Authors: Ikeda T, Ikenoshita S, Sakamoto F, Shiraishi S, Nakahara K, Masuda T, Yamashita S Abstract INTRODUCTION/OBJECTIVE: In most cases, abnormal cardiac 123I-meta-iodobenzylguanidine (MIBG) scintigraphy increases the probability of a diagnosis of Parkinson's disease (PD) in patients with parkinsonian ... read more

An Ultra High Performance Liquid Chromatography-High Resolution Mass Spectrometry Metabolomics and Lipidomics Study of Stool from Transgenic Parkinson's Disease Mice Following Immunotherapy. J Proteome Res. 2019 Nov 12;: Authors: Gill EL, Koelmel JP, Meke L, Yost RA, Garrett TJ, Okun MS, Flores C, Vedam-Mai V Abstract Parkinson's disease (PD) is characterized by the loss of dopaminergic neurons in the substantia ... read more

Related ArticlesThe distribution and density of monocarboxylate transporter 2 in cerebral cortex, hippocampus and cerebellum of wild-type mice. J Anat. 2019 Nov 11;: Authors: Pang R, Wang X, Du Z, Pei F, Li Z, Sun L, Wang S, Peng Y, Lu X, Gao X, Chang C Abstract Monocarboxylates cannot cross the blood-brain barrier freely to participate in brain energy metabolism. ... read more

Related ArticlesValidation and reproducibility of the Glittre activities of daily living test for individuals with Parkinson's disease. Rev Neurol. 2019 Nov 16;69(10):395-401 Authors: Silva DDO, Corrêa JCF, de Sá MAF, Normando VMF, Silva SM, Dal Corso S, Corrêa FI Abstract AIM: To investigate the validity and reproducibility of the Glittre Activities of Daily Living (Glittre-ADL) test for individuals with Parkinson's ... read more

Related ArticlesInitiation and Transmission of α-Synuclein Pathology in Parkinson's Disease. Neurochem Res. 2019 Nov 11;: Authors: Mazurskyy A, Howitt J Abstract The pathogenesis of Parkinson's disease (PD) involves the accumulation of aggregated forms of α-synuclein in the body. The location for the initiation of misfolded forms of α-synuclein is now a contentious issue, what was once thought to be a ... read more

Related ArticlesGenetics of leprosy: today and beyond. Hum Genet. 2019 Nov 11;: Authors: Fava VM, Dallmann-Sauer M, Schurr E Abstract Leprosy is a chronic infectious disease of the skin and peripheral nerves that presents a strong link with the host genetic background. Different approaches in genetic studies have been applied to leprosy and today leprosy is among the infectious diseases with ... read more

Related ArticlesB cells in autoimmune and neurodegenerative central nervous system diseases. Nat Rev Neurosci. 2019 Nov 11;: Authors: Sabatino JJ, Pröbstel AK, Zamvil SS Abstract B cells are essential components of the adaptive immune system and have important roles in the pathogenesis of several central nervous system (CNS) diseases. Besides producing antibodies, B cells perform other functions, including antigen presentation ... read more

Related ArticlesDifferentiation of multiple system atrophy from Parkinson's disease by structural connectivity derived from probabilistic tractography. Sci Rep. 2019 Nov 11;9(1):16488 Authors: Abos A, Baggio HC, Segura B, Campabadal A, Uribe C, Giraldo DM, Perez-Soriano A, Muñoz E, Compta Y, Junque C, Marti MJ Abstract Recent studies combining diffusion tensor-derived metrics and machine learning have shown promising results in the ... read more

Related ArticlesMultistable properties of human subthalamic nucleus neurons in Parkinson's disease. Proc Natl Acad Sci U S A. 2019 Nov 11;: Authors: Chopek JW, Hultborn H, Brownstone RM Abstract To understand the function and dysfunction of neural circuits, it is necessary to understand the properties of the neurons participating in the behavior, the connectivity between these neurons, and the neuromodulatory ... read more

Related ArticlesDepletion of hypothalamic hypocretin/orexin neurons correlates with impaired memory in a Parkinson's disease animal model. Exp Neurol. 2019 Nov 08;:113110 Authors: Oliveira LM, Henrique E, Bustelli IB, Netto NFC, Moreira TS, Takakura AC, Caetano AL Abstract Parkinson's disease (PD) is a progressive and chronic neurodegenerative disorder characterized by loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) ... read more

Related ArticlesAssociation of age-related macular degeneration on Alzheimer's or Parkinson's disease: a retrospective cohort study. Am J Ophthalmol. 2019 Nov 08;: Authors: Choi S, Jahng WJ, Park SM, Jee D Abstract PURPOSE: To determine the association of age-related macular degeneration (AMD) with Alzheimer's disease (AD) and Parkinson's disease (PD). DESIGN: Retrospective cohort study. METHODS: The study population consisted of 308,340 ... read more

Related ArticlesRegulatory impairment in untreated Parkinson's disease is not restricted to Tregs: other regulatory populations are also involved. J Neuroinflammation. 2019 Nov 11;16(1):212 Authors: Álvarez-Luquín DD, Arce-Sillas A, Leyva-Hernández J, Sevilla-Reyes E, Boll MC, Montes-Moratilla E, Vivas-Almazán V, Pérez-Correa C, Rodríguez-Ortiz U, Espinoza-Cárdenas R, Fragoso G, Sciutto E, Adalid-Peralta L Abstract BACKGROUND: Parkinson's disease (PD) is the second most common ... read more