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- Clinical characteristics of PD patients with LRRK2 G2385R and R1628P variants.
Clinical characteristics of PD patients with LRRK2 G2385R and R1628P variants. Neurosci Lett. 2018 Aug 16;: Authors: Liang D, Shu L, Pan H, Xu Q, Guo J, Yan X, Tang B, Sun Q Abstract LRRK2 is the most common genetic cause of PD. G2385R and R1628 P variants are the most ... read more - Genetic background and outcome of Deep Brain Stimulation in Parkinson’s disease.Genetic background and outcome of Deep Brain Stimulation in Parkinson's disease. Parkinsonism Relat Disord. 2018 Aug 09;: Authors: Rizzone MG, Martone T, Balestrino R, Lopiano L Abstract Deep Brain Stimulation (DBS) is a well-established therapeutic option for patients with Parkinson's disease (PD). The high variability observed in the outcome demands ... read more
- Single unit activity of subthalamic nucleus of patients with Parkinson’s disease under local and generalized anaesthesia: multifactor analysis.Single unit activity of subthalamic nucleus of patients with Parkinson's disease under local and generalized anaesthesia: multifactor analysis. Neurosci Res. 2018 Aug 16;: Authors: Myrov V, Sedov A, Salova E, Tomskiy A, Belova E Abstract The analysis of neuronal activity in human brain is a complicated task as it meets ... read more
- Cannabinoid pharmacology/therapeutics in chronic degenerative disorders affecting the central nervous system.Cannabinoid pharmacology/therapeutics in chronic degenerative disorders affecting the central nervous system. Biochem Pharmacol. 2018 Aug 16;: Authors: Aymerich MS, Aso E, Abellanas MA, Tolon RM, Ramos JA, Ferrer I, Romero J, Fernández-Ruiz J Abstract The endocannabinoid system (ECS) exerts a modulatory effect of important functions such as neurotransmission, glial activation, ... read more
- Virtual Reality for Neurorehabilitation: Insights from Three European Clinics.Virtual Reality for Neurorehabilitation: Insights from Three European Clinics. PM R. 2018 Aug 16;: Authors: O'Neil O, Fernandez MM, Herzog J, Beorchia M, Gower V, Gramatica F, Starrost K, Kiwull L Abstract Virtual reality for the treatment of motor impairment is a burgeoning application of digital technology in neurorehabilitation. Virtual ... read more
- Association between olfactory loss and cognitive deficits in Parkinson’s disease.Association between olfactory loss and cognitive deficits in Parkinson's disease. Clin Neurol Neurosurg. 2018 Aug 13;173:120-123 Authors: Camargo CHF, Jobbins VA, Serpa RA, Berbetz FA, Sabatini JS, Teive HAG Abstract OBJECTIVE: The aim of this study was to compare the cognitive deficits and olfaction in PD patients. PATIENTS AND METHODS: ... read more
- Lethal Factor Domain-Mediated Delivery of Nurr1 Transcription Factor Enhances Tyrosine Hydroxylase Activity and Protects from Neurotoxin-Induced Degeneration of Dopaminergic Cells.Lethal Factor Domain-Mediated Delivery of Nurr1 Transcription Factor Enhances Tyrosine Hydroxylase Activity and Protects from Neurotoxin-Induced Degeneration of Dopaminergic Cells. Mol Neurobiol. 2018 Aug 18;: Authors: Paliga D, Raudzus F, Leppla SH, Heumann R, Neumann S Abstract The orphan transcription factor nuclear receptor-related 1 protein (Nurr1, also known as NR4A2) ... read more
- Cellular phenotypes as inflammatory mediators in Parkinson’s disease: Interventional targets and role of natural products.Related ArticlesCellular phenotypes as inflammatory mediators in Parkinson's disease: Interventional targets and role of natural products. Biomed Pharmacother. 2018 Jul 16;106:1052-1062 Authors: Jiang X, Ganesan P, Rengarajan T, Choi DK, Arulselvan P Abstract Pathogenesis of Parkinson's disease (PD) is undoubtedly a multifactorial phenomenon, with diverse etiological agents. Pro-inflammatory mediators act ... read more
- Puerarin promoted proliferation and differentiation of dopamine-producing cells in Parkinson’s animal models.Related ArticlesPuerarin promoted proliferation and differentiation of dopamine-producing cells in Parkinson's animal models. Biomed Pharmacother. 2018 Jul 19;106:1236-1242 Authors: Shiying L, Xinhui Q, Guanghua J, Feng N, Feng L, Shumei C, Fan H Abstract BACKGROUND: Parkinson's disease (PD) is caused by the gradual loss of dopamine-producing cells in the brain. ... read more
- Prevalence of pre-diagnostic symptoms did not differ between LRRK2-related, GBA-related and idiopathic patients with Parkinson’s disease.Related ArticlesPrevalence of pre-diagnostic symptoms did not differ between LRRK2-related, GBA-related and idiopathic patients with Parkinson's disease. Parkinsonism Relat Disord. 2018 Aug 14;: Authors: Liu SY, Zheng Z, Gu ZQ, Wang CD, Tang BS, Xu YM, Ma JH, Zhou YT, Feng T, Chen SD, Chan P, Chinese Parkinson Study Group ... read more
- Cell-penetrating artificial mitochondria-targeting peptide-conjugated metallothionein 1A alleviates mitochondrial damage in Parkinson’s disease models.Related ArticlesCell-penetrating artificial mitochondria-targeting peptide-conjugated metallothionein 1A alleviates mitochondrial damage in Parkinson's disease models. Exp Mol Med. 2018 Aug 17;50(8):105 Authors: Kang YC, Son M, Kang S, Im S, Piao Y, Lim KS, Song MY, Park KS, Kim YH, Pak YK Abstract An excess of reactive oxygen species (ROS) relative ... read more
- Locus Coeruleus atrophy doesn’t relate to fatigue in Parkinson’s disease.Related ArticlesLocus Coeruleus atrophy doesn't relate to fatigue in Parkinson's disease. Sci Rep. 2018 Aug 17;8(1):12381 Authors: Solopchuk O, Sebti M, Bouvy C, Benoit CE, Warlop T, Jeanjean A, Zénon A Abstract Fatigue is a frequent complaint among healthy population and one of the earliest and most debilitating symptoms in ... read more
- Arrestin recruitment to dopamine D2 receptor mediates locomotion but not incentive motivation.Related ArticlesArrestin recruitment to dopamine D2 receptor mediates locomotion but not incentive motivation. Mol Psychiatry. 2018 Aug 17;: Authors: Donthamsetti P, Gallo EF, Buck DC, Stahl EL, Zhu Y, Lane JR, Bohn LM, Neve KA, Kellendonk C, Javitch JA Abstract The dopamine (DA) D2 receptor (D2R) is an important target ... read more
- Endosomal sorting and trafficking, the retromer complex and neurodegeneration.Related ArticlesEndosomal sorting and trafficking, the retromer complex and neurodegeneration. Mol Psychiatry. 2018 Aug 17;: Authors: Vagnozzi AN, Praticò D Abstract The retromer is a highly conserved multimeric protein complex present in all eukaryotic cells whose activity is essential for regulating the recycling and retrieval of numerous protein cargos from ... read more
- Unstable impedance of a single electrode contact resulting in loss of DBS therapy-a case report.Related ArticlesUnstable impedance of a single electrode contact resulting in loss of DBS therapy-a case report. Acta Neurochir (Wien). 2018 Aug 17;: Authors: Allert N, Lindlau A, Quindt R, Reker P, Timmermann L, Barbe MT Abstract Open and short circuits of electrode contacts are important technical dysfunctions of DBS. Here, ... read more
- Correction to: Effectiveness of Rotigotine plus intensive and goal‑based rehabilitation versus Rotigotine alone in “de‑novo” Parkinsonian subjects: a randomized controlled trial with 18‑month follow‑up.Related ArticlesCorrection to: Effectiveness of Rotigotine plus intensive and goal‑based rehabilitation versus Rotigotine alone in "de‑novo" Parkinsonian subjects: a randomized controlled trial with 18‑month follow‑up. J Neurol. 2018 Aug 17;: Authors: Ferrazzoli D, Ortelli P, Riboldazzi G, Maestri R, Frazzitta G Abstract The original version of this article unfortunately contained ... read more
- An updated analysis with 45,078 subjects confirms the association between SNCA rs11931074 and Parkinson’s disease.Related ArticlesAn updated analysis with 45,078 subjects confirms the association between SNCA rs11931074 and Parkinson's disease. Neurol Sci. 2018 Aug 17;: Authors: Liu X, Zhu R, Xiao T, Li Q, Zhu Y, He Z Abstract Large-scale genome-wide association study (GWAS) has identified that the alpha-synuclein (SNCA) rs11931074 polymorphism is associated ... read more
- Mitral cells and the glucagon-like peptide 1 receptor: the sweet smell of success?Mitral cells and the glucagon-like peptide 1 receptor: the sweet smell of success? Eur J Neurosci. 2018 Aug 18;: Authors: Bagnoli E, FitzGerald U Abstract The olfactory bulb (OB) is often affected at very early stages of neurodegenerative disorders, in the so-called 'prodromal' phase. In Parkinson's disease (PD), olfactory disturbances ... read more
- Feature selection using Logistic Regression in Case-Control DNA methylation data of Parkinson’s disease: A Comparative study.Feature selection using Logistic Regression in Case-Control DNA methylation data of Parkinson's disease: A Comparative study. J Theor Biol. 2018 Aug 15;: Authors: Kakade A, Kumari B, Dholaniya PS Abstract Parkinson's Disease (PD) is described as a progressive neurological disorder caused by the degeneration of dopaminergic neurons in substantia nigra ... read more
- Should Exercise Be Prescribed Differently Between Women and Men? An Emphasis on Women Diagnosed With Parkinson’s Disease.Related ArticlesShould Exercise Be Prescribed Differently Between Women and Men? An Emphasis on Women Diagnosed With Parkinson's Disease. Front Physiol. 2018;9:1040 Authors: Rigby BR, Davis RW PMID: 30116203 [PubMed] ... read more
- Excitatory Dendritic Mitochondrial Calcium Toxicity: Implications for Parkinson’s and Other Neurodegenerative Diseases.Related ArticlesExcitatory Dendritic Mitochondrial Calcium Toxicity: Implications for Parkinson's and Other Neurodegenerative Diseases. Front Neurosci. 2018;12:523 Authors: Verma M, Wills Z, Chu CT Abstract Dysregulation of calcium homeostasis has been linked to multiple neurological diseases. In addition to excitotoxic neuronal cell death observed following stroke, a growing number of studies ... read more
- Utilization of Chinese Herbal Medicine and its Association with the Risk of Fracture in Patients with Parkinson’s Disease in Taiwan.Utilization of Chinese Herbal Medicine and its Association with the Risk of Fracture in Patients with Parkinson's Disease in Taiwan. J Ethnopharmacol. 2018 Aug 14;: Authors: Chen KY, Wu MY, Yang PS, Chiang JH, Hsu CY, Chen CY, Yen HR Abstract ETHNOPHARMACOLOGICAL RELEVANCE: Traditional Chinese medicine (TCM) has been used ... read more
- Planning for an uncertain future in progressive neurological disease: a qualitative study of patient and family decision-making with a focus on eating and drinking.Related ArticlesPlanning for an uncertain future in progressive neurological disease: a qualitative study of patient and family decision-making with a focus on eating and drinking. BMC Neurol. 2018 Aug 16;18(1):115 Authors: Clarke G, Fistein E, Holland A, Tobin J, Barclay S, Barclay S Abstract BACKGROUND: Dysphagia and other eating and ... read more
- Motor, cognitive, emotional and neurochemical alterations induced by repeated administration of deltamethrin in rats.Motor, cognitive, emotional and neurochemical alterations induced by repeated administration of deltamethrin in rats. Brain Res Bull. 2018 Aug 14;: Authors: Souza MF, Freire MAM, Medeiros KAAL, Lins LCRF, Bispo JMM, Gois AM, Leal PC, Engelberth RCGJ, Ribeiro AM, Silva RH, Marchioro M, Santos JR Abstract Pesticide exposure is a ... read more
- Center of pressure-based balance evaluation in individuals with Parkinson’s disease: a reliability study.Center of pressure-based balance evaluation in individuals with Parkinson's disease: a reliability study. Physiother Theory Pract. 2018 Aug 17;:1-8 Authors: Terra MB, Da Silva RA, Bueno MEB, Ferraz HB, Smaili SM Abstract OBJECTIVE: The purpose of this study was to assess the test-retest reliability of different balance task outcomes, based ... read more