PD Latest Research

Neurology. 2021 Oct 14:10.1212/WNL.0000000000012952. doi: 10.1212/WNL.0000000000012952. Online ahead of print.ABSTRACTOBJECTIVE: To report final, 36-month safety and clinical outcomes from the PD-1101 trial of NBIb-1817 (VY-AADC01) in participants with moderately advanced Parkinson's disease (PD) and motor fluctuations.METHODS: PD-1101 was a phase 1b, open-label, dose escalation trial of VY-AADC01, an experimental AAV2 gene therapy encoding the human aromatic L-amino acid decarboxylase (AADC) ... read more

NPJ Parkinsons Dis. 2021 Oct 14;7(1):94. doi: 10.1038/s41531-021-00239-x.ABSTRACTCharacterisation and diagnosis of idiopathic Parkinson's disease (iPD) is a current challenge that hampers both clinical assessment and clinical trial development with the potential inclusion of non-PD cases. Here, we used a targeted mass spectrometry approach to quantify 38 metabolites extracted from the serum of 231 individuals. This cohort is currently one of ... read more

Front Microbiol. 2021 Sep 28;12:728479. doi: 10.3389/fmicb.2021.728479. eCollection 2021.ABSTRACTGastrointestinal dysfunction plays an important role in the occurrence and development of Parkinson's disease (PD). This study investigates the composition of the gut microbiome using shotgun metagenomic sequencing in PD patients in central China. Fecal samples from 39 PD patients (PD group) and the corresponding 39 healthy spouses of the patients (SP) ... read more

Front Aging Neurosci. 2021 Sep 28;13:713084. doi: 10.3389/fnagi.2021.713084. eCollection 2021.ABSTRACTObjective: To establish a workflow for mitochondrial DNA (mtDNA) CpG methylation using Nanopore whole-genome sequencing and perform first pilot experiments on affected Parkin biallelic mutation carriers (Parkin-PD) and healthy controls. Background: Mitochondria, including mtDNA, are established key players in Parkinson's disease (PD) pathogenesis. Mutations in Parkin, essential for degradation of damaged ... read more

Neurology. 2021 Oct 14:10.1212/WNL.0000000000012942. doi: 10.1212/WNL.0000000000012942. Online ahead of print.ABSTRACTOBJECTIVE: Many previous studies, mostly performed in Western countries, on the effects of lifestyle factors on Parkinson's disease, used baseline lifestyle characteristics without directly accounting for changes in covariate values over time. The objective of this study was to evaluate the association of repeatedly measured lifestyle factors with Parkinson's disease risk ... read more

Endocr Metab Immune Disord Drug Targets. 2021 Oct 14. doi: 10.2174/1871530321666211014170107. Online ahead of print.ABSTRACTINTRODUCTION: The pre-supplementary motor area (Pre-SMA) plays a pivotal role in the control of voluntary motor control and freezing of gait (FOG) pathophysiological mechanism. Here, we aimed to modulate if the pre-SMA would have beneficial effects on motor and behavioural outcomes in freezing of gait. To ... read more

Neurology. 2021 Oct 14:10.1212/WNL.0000000000012942. doi: 10.1212/WNL.0000000000012942. Online ahead of print.ABSTRACTOBJECTIVE: Many previous studies, mostly performed in Western countries, on the effects of lifestyle factors on Parkinson's disease, used baseline lifestyle characteristics without directly accounting for changes in covariate values over time. The objective of this study was to evaluate the association of repeatedly measured lifestyle factors with Parkinson's disease risk ... read more

Orphanet J Rare Dis. 2021 Oct 14;16(1):431. doi: 10.1186/s13023-021-02034-6.ABSTRACTBACKGROUND: The Gaucher Investigative Therapy Evaluation is a national clinical cohort of 250 patients aged 5-87 years with Gaucher disease in the United Kingdom-an ultra-rare genetic disorder. To inform clinical decision-making and improve pathophysiological understanding, we characterized the course of Gaucher disease and explored the influence of costly innovative medication and other ... read more

Front Med (Lausanne). 2021 Sep 28;8:753295. doi: 10.3389/fmed.2021.753295. eCollection 2021.ABSTRACTObjective: This study aimed to assess the status of intrinsic capacity (IC)-a novel function-centered construct proposed by the WHO and examine whether impairment in IC predicts subsequent 1-year activities of daily living (ADL) disability better than a disease-based approach, i. e., multimorbidity status. Methods: This study included data of community-dwelling older ... read more

Front Neurol. 2021 Sep 28;12:736784. doi: 10.3389/fneur.2021.736784. eCollection 2021.ABSTRACTIt is an unmet need to estimate survival duration for patients with progressive supranuclear palsy (PSP). The objective of this study was to identify factors associated with the survival duration in patients with PSP. We followed up 23 patients with probable PSP-RS (Richardson syndrome) or PSP-P (parkinsonism) in our PSP center until ... read more

NPJ Parkinsons Dis. 2021 Oct 14;7(1):94. doi: 10.1038/s41531-021-00239-x.ABSTRACTCharacterisation and diagnosis of idiopathic Parkinson's disease (iPD) is a current challenge that hampers both clinical assessment and clinical trial development with the potential inclusion of non-PD cases. Here, we used a targeted mass spectrometry approach to quantify 38 metabolites extracted from the serum of 231 individuals. This cohort is currently one of ... read more

Front Aging Neurosci. 2021 Sep 28;13:703984. doi: 10.3389/fnagi.2021.703984. eCollection 2021.ABSTRACTParkinson's disease, dementia with Lewy bodies, and multiple system atrophy are characterized by aggregation of abnormal α-synuclein (α-syn) and collectively referred to as α-synucleinopathy. Because these diseases have different prognoses and treatments, it is desirable to diagnose them early and accurately. However, it is difficult to accurately diagnose these diseases by ... read more

Parkinsons Dis. 2021 Oct 5;2021:1713496. doi: 10.1155/2021/1713496. eCollection 2021.ABSTRACTRecent epidemiological studies have revealed a correlation between atypical features and worse functional outcomes in Parkinson's disease (PD) patients with cerebrovascular disease (CVD). We aimed to evaluate the brain hemodynamics of PD patients with risk factors for CVD using Doppler ultrasonography. In this prospective pilot study, we randomly included 27 outpatients diagnosed ... read more

Parkinsons Dis. 2021 Oct 5;2021:1713496. doi: 10.1155/2021/1713496. eCollection 2021.ABSTRACTRecent epidemiological studies have revealed a correlation between atypical features and worse functional outcomes in Parkinson's disease (PD) patients with cerebrovascular disease (CVD). We aimed to evaluate the brain hemodynamics of PD patients with risk factors for CVD using Doppler ultrasonography. In this prospective pilot study, we randomly included 27 outpatients diagnosed ... read more

Biomed Pharmacother. 2021 Nov;143:112236. doi: 10.1016/j.biopha.2021.112236. Epub 2021 Sep 30.ABSTRACTThe increased oxidative stress in the acceleration of the aging process and development of the neuronal disorder are the common feature detected in neurodegenerative illness, such as Alzheimer's disease, Parkinson's disease, and Amyotrophic lateral sclerosis. Searching for new treatment against these diseases, the inclusion of exogenous antioxidant agents has shown good ... read more

J Pept Sci. 2021 Oct 14:e3374. doi: 10.1002/psc.3374. Online ahead of print.ABSTRACTProtein misfolding and aggregation play a vital role in several human diseases such as Parkinson's, Alzheimer's, and prion diseases. The development of nanoparticles that modulate aggregation could be potential drug candidates for these neurodegenerative disorders. Parkinson's disease pathogenesis is closely associated with the accumulation of α-synuclein oligomers and fibrils ... read more

Nat Commun. 2021 Oct 14;12(1):5999. doi: 10.1038/s41467-021-25966-w.ABSTRACTMolecular chaperones contribute to the maintenance of cellular protein homoeostasis through assisting de novo protein folding and preventing amyloid formation. Chaperones of the Hsp70 family can further disaggregate otherwise irreversible aggregate species such as α-synuclein fibrils, which accumulate in Parkinson's disease. However, the mechanisms and kinetics of this key functionality are only partially understood. ... read more

Biomed Pharmacother. 2021 Nov;143:112175. doi: 10.1016/j.biopha.2021.112175. Epub 2021 Sep 27.ABSTRACTWithania somnifera (L.) Dunal (Solanaceae) has been used as a traditional Rasayana herb for a long time. Traditional uses of this plant indicate its ameliorative properties against a plethora of human medical conditions, viz. hypertension, stress, diabetes, asthma, cancer etc. This review presents a comprehensive summary of the geographical distribution, traditional ... read more

Eur J Nucl Med Mol Imaging. 2021 Oct 15. doi: 10.1007/s00259-021-05569-9. Online ahead of print.ABSTRACTPURPOSE: Deep convolutional neural networks (CNN) provide high accuracy for automatic classification of dopamine transporter (DAT) SPECT images. However, CNN are inherently black-box in nature lacking any kind of explanation for their decisions. This limits their acceptance for clinical use. This study tested layer-wise relevance propagation ... read more

Front Neurosci. 2021 Sep 28;15:721387. doi: 10.3389/fnins.2021.721387. eCollection 2021.ABSTRACTThe movement-related cortical potential (MRCP) is a brain signal that can be recorded using surface electroencephalography (EEG) and represents the cortical processes involved in movement preparation. The MRCP has been widely researched in simple, single-joint movements, however, these movements often lack ecological validity. Ecological validity refers to the generalizability of the findings ... read more

J Pept Sci. 2021 Oct 14:e3374. doi: 10.1002/psc.3374. Online ahead of print.ABSTRACTProtein misfolding and aggregation play a vital role in several human diseases such as Parkinson's, Alzheimer's, and prion diseases. The development of nanoparticles that modulate aggregation could be potential drug candidates for these neurodegenerative disorders. Parkinson's disease pathogenesis is closely associated with the accumulation of α-synuclein oligomers and fibrils ... read more

PLoS One. 2021 Oct 15;16(10):e0258786. doi: 10.1371/journal.pone.0258786. eCollection 2021.ABSTRACTOBJECTIVE: To determine whether arytenoid cartilage position and dynamics change with advancing duration and severity (as graded by MDS-UPDRS part III scores) in Parkinson's disease, in a cross-sectional study design, we performed laryngeal four-dimensional computed tomography (4D-CT) in people with Parkinson's disease and controls.METHODS: 31 people with Parkinson's disease covering a range ... read more

NPJ Digit Med. 2021 Oct 14;4(1):149. doi: 10.1038/s41746-021-00513-5.ABSTRACTPhysical mobility is essential to health, and patients often rate it as a high-priority clinical outcome. Digital mobility outcomes (DMOs), such as real-world gait speed or step count, show promise as clinical measures in many medical conditions. However, current research is nascent and fragmented by discipline. This scoping review maps existing evidence on ... read more

Eur J Nucl Med Mol Imaging. 2021 Oct 15. doi: 10.1007/s00259-021-05569-9. Online ahead of print.ABSTRACTPURPOSE: Deep convolutional neural networks (CNN) provide high accuracy for automatic classification of dopamine transporter (DAT) SPECT images. However, CNN are inherently black-box in nature lacking any kind of explanation for their decisions. This limits their acceptance for clinical use. This study tested layer-wise relevance propagation ... read more

Brain Inform. 2021 Oct 15;8(1):22. doi: 10.1186/s40708-021-00143-3.ABSTRACTThe ability to characterize muscle activities or skilled movements controlled by signals from neurons in the motor cortex of the brain has many useful implications, ranging from biomedical perspectives to brain-computer interfaces. This paper presents the method of recurrence eigenvalues for differentiating moving patterns in non-mammalian and human models. The non-mammalian models of Caenorhabditis ... read more