PD Latest Research

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  • What Do Randomized Controlled Trials Inform Us About Potential Disease-Modifying Strategies for Parkinson’s Disease?
    Neuromolecular Med. 2022 Jul 1. doi: 10.1007/s12017-022-08718-x. Online ahead of print.ABSTRACTResearch advances have shed new insight into cellular pathways contributing to PD pathogenesis and offer increasingly compelling therapeutic targets. In this review, we made a broad survey of the published literature that report possible disease-modifying effects on PD. While there are many studies that demonstrate benefits for various therapies for ... read more
    Source: PubMedPublished on 2022-07-01By Wei-Yi Ong
  • Assessment of Dopaminergic Neurodegeneration in Mice
    Methods Mol Biol. 2022;2515:151-169. doi: 10.1007/978-1-0716-2409-8_10.ABSTRACTNeuron death is a key feature of neurological disorders like Alzheimer's or Parkinson's disease (PD). As a result, analysis of neurodegeneration is often considered a central experiment in the postmortem characterization of preclinical PD animal models. Stereology provides a precise estimate of particles, like neurons, in three-dimensional objects, like the brain, and is the gold ... read more
    Source: PubMedPublished on 2022-07-01By Haley M Geertsma
  • Apathy and impulsiveness in Parkinson disease: Two faces of the same coin?
    Medicine (Baltimore). 2022 Jul 1;101(26):e29766. doi: 10.1097/MD.0000000000029766.ABSTRACTApathy and impulsiveness are 2 common non-motor symptoms in Parkinson disease that could occur in different periods or simultaneously. Apathy and impulsiveness could be interpreted as opposite extremes of a spectrum of motivated behavior dependent on dopaminergic dysfunction, in which, impulsivity, is a result of a hyperdopaminergic state, whereas apathy is viewed as a ... read more
    Source: PubMedPublished on 2022-07-01By Rosanna Palmeri
  • Risk factors for in-hospital death in elderly patients over 65 years of age with dementia: A retrospective cross-sectional study
    Medicine (Baltimore). 2022 Jul 1;101(26):e29737. doi: 10.1097/MD.0000000000029737.ABSTRACTAs the population continues to age, dementia is becoming a huge social, economic, and healthcare burden. However, the risk factors for in-hospital death in elderly patients over 65 years of age with dementia are not well understood. Identifying factors that affect their prognosis could help clinicians with scientific decision-making. To examine the risk factors ... read more
    Source: PubMedPublished on 2022-07-01By Zhangmin Meng
  • Monitoring Autophagy in Neural Stem and Progenitor Cells
    Methods Mol Biol. 2022;2515:99-116. doi: 10.1007/978-1-0716-2409-8_7.ABSTRACTAutophagy is a critical cellular program that is necessary for cellular survival and adaptation to nutrient and metabolic stress. In addition to homeostatic maintenance and adaptive response functions, autophagy also plays an active role during development and tissue regeneration. Within the neural system, autophagy is important for stem cell maintenance and the ability of neural ... read more
    Source: PubMedPublished on 2022-07-01By Romina L Filippelli
  • Paclitaxel Treatment Effects on Neurofilament Light Chain (NF-L), a Possible Biomarker of Chemotherapy-Induced Peripheral Neuropathy (CIPN)
    Cancer Epidemiol Biomarkers Prev. 2022 Jul 1;31(7):1510-1511. doi: 10.1158/1055-9965.EPI-22-0474.ABSTRACTPURPOSE: The purpose of the study was to determine if neurofilament light chain (NF-L), a biomarker of neurologic damage in disease states such as ALS, diabetes, and Parkinson's disease increases with neurotoxic chemotherapy.METHODS: Female breast cancer patients (N=21) at two sites (Tucson and Flagstaff. AZ) receiving weekly or biweekly paclitaxel chemotherapy for ... read more
    Source: PubMedPublished on 2022-07-01By L W Benashley
  • Acupuncture Regulates Symptoms of Parkinson’s Disease via Brain Neural Activity and Functional Connectivity in Mice
    Front Aging Neurosci. 2022 Jun 14;14:885396. doi: 10.3389/fnagi.2022.885396. eCollection 2022.ABSTRACTParkinson's disease (PD) is a multilayered progressive brain disease characterized by motor dysfunction and a variety of other symptoms. Although acupuncture has been used to ameliorate various symptoms of neurodegenerative disorders, including PD, the underlying mechanisms are unclear. Here, we investigated the mechanism of acupuncture by revealing the effects of acupuncture ... read more
    Source: PubMedPublished on 2022-07-01By Ju-Young Oh
  • Protective effects of cyclosporine A on neurodegeneration and motor impairment in rotenone-induced experimental models of Parkinson’s disease
    Eur J Pharmacol. 2022 Jun 28:175129. doi: 10.1016/j.ejphar.2022.175129. Online ahead of print.ABSTRACTThe development of neuroprotective drugs targeting mitochondria could be an important strategy in combating the progressive clinical course of Parkinson's disease. In the current study, we demonstrated that in SH-SY5Y cells (human dopaminergic neuroblastoma cell line), rotenone caused a dose-dependent (0.25-1 μM) and time-dependent (up to 48 h) loss ... read more
    Source: PubMedPublished on 2022-07-01By Sukhpal Singh
  • Long-Term Clinical Experience with Directional Deep Brain Stimulation Programming: A Retrospective Review
    Neurol Ther. 2022 Jul 1. doi: 10.1007/s40120-022-00381-5. Online ahead of print.ABSTRACTINTRODUCTION: Directional deep brain stimulation (d-DBS) axially displaces the volume of tissue activated (VTA) towards the intended target and away from neighboring structures potentially improving benefit and reducing side effects (SE) of stimulation. A clinical trial evaluating d-DBS demonstrated a wider therapeutic window (TW) with directional electrodes. While this seems ... read more
    Source: PubMedPublished on 2022-07-01By Jessica A Karl
  • Dual task effect on upper and lower extremity skills in different stages of Parkinson’s disease
    Acta Neurol Belg. 2022 Jul 1. doi: 10.1007/s13760-022-02007-x. Online ahead of print.ABSTRACTBACKGROUND AND PURPOSE: Loss of automaticity and deteriorated executive function give rise to dual task deficits in Parkinson's disease (PD). This study aimed to compare single task and dual task upper and lower extremity skills in people with PD (PwPD) at different stages of PD and to examine the ... read more
    Source: PubMedPublished on 2022-07-01By Elvan Ozcan Gulsen
  • Opicapone, a Novel Catechol-O-methyl Transferase Inhibitor, for Treatment of Parkinson’s Disease “Off” Episodes
    Health Psychol Res. 2022 Jun 28;10(3):36074. doi: 10.52965/001c.36074. eCollection 2022.ABSTRACTParkinson's Disease (PD) is a common neurodegenerative disorder and the leading cause of disability. It causes significant morbidity and disability through a plethora of symptoms, including movement disorders, sleep disturbances, and cognitive and psychiatric symptoms. The traditional pathogenesis theory of PD involves the loss of dopaminergic neurons in the substantia nigra ... read more
    Source: PubMedPublished on 2022-07-01By Amnon A Berger
  • EMF promote BMSCs differentiation and functional recovery in hemiparkinsonian rats
    Neurosci Lett. 2022 Jun 28:136765. doi: 10.1016/j.neulet.2022.136765. Online ahead of print.ABSTRACTBone marrow mesenchymal stem cells (BMSCs) have self-renewal ability while maintaining the proliferation facility. The BMSCs reproducing ability could affect by electromagnetic fields (EMFs) as a physical inducing factor. We focused on the EMF (400 µT, 75 Hz) exposed multi-potential BMSCs which differentiated and successfully implanted in the substantia nigra ... read more
    Source: PubMedPublished on 2022-07-01By Taha Jadidi
  • Editorial: Neurodegeneration: From Disease Mechanism to Therapeutic Advancement
    Front Genet. 2022 Jun 14;13:941846. doi: 10.3389/fgene.2022.941846. eCollection 2022.NO ABSTRACTPMID:35774497 | PMC:PMC9237536 | DOI:10.3389/fgene.2022.941846 ... read more
    Source: PubMedPublished on 2022-07-01By Partha S Sarkar
  • Long-Term Clinical Experience with Directional Deep Brain Stimulation Programming: A Retrospective Review
    Neurol Ther. 2022 Jul 1. doi: 10.1007/s40120-022-00381-5. Online ahead of print.ABSTRACTINTRODUCTION: Directional deep brain stimulation (d-DBS) axially displaces the volume of tissue activated (VTA) towards the intended target and away from neighboring structures potentially improving benefit and reducing side effects (SE) of stimulation. A clinical trial evaluating d-DBS demonstrated a wider therapeutic window (TW) with directional electrodes. While this seems ... read more
    Source: PubMedPublished on 2022-07-01By Jessica A Karl
  • Patient Experience in Early-Stage Parkinson’s Disease: Using a Mixed Methods Analysis to Identify Which Concepts Are Cardinal for Clinical Trial Outcome Assessment
    Neurol Ther. 2022 Jul 1. doi: 10.1007/s40120-022-00375-3. Online ahead of print.ABSTRACTINTRODUCTION: Qualitative research on patient experiences in early-stage Parkinson's disease (PD) is limited. It is increasingly acknowledged that clinical outcome assessments used in trials do not fully capture the range of symptoms/impacts that are meaningful to people with early-stage PD. We aimed to conceptualize the patient experience in early-stage PD ... read more
    Source: PubMedPublished on 2022-07-01By Thomas Morel
  • Examining Mitochondrial Morphology in Mouse Brains
    Methods Mol Biol. 2022;2515:17-28. doi: 10.1007/978-1-0716-2409-8_2.ABSTRACTMitochondria are dynamic organelles that rely on a balance of opposing fission and fusion events to sustain mitochondrial function and efficiently meet the energy demands of a cell. As high-energy demanding cells, neurons rely heavily on optimally functional mitochondria with balanced mitochondrial dynamics, to ensure a sufficient energy supply required to maintain cell survival, establish ... read more
    Source: PubMedPublished on 2022-07-01By Jessika Royea
  • COVID-19 and neurodegenerative diseases
    Eur Rev Med Pharmacol Sci. 2022 Jun;26(12):4535-4544. doi: 10.26355/eurrev_202206_29093.ABSTRACTOBJECTIVE: The pandemic of Coronavirus Disease 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) continues, and SARS-CoV-2 variants continue to emerge. In addition to typical fever and respiratory symptoms, many patients with COVID-19 experience a variety of neurological complications. In this review, we analyzed and reviewed the current status ... read more
    Source: PubMedPublished on 2022-07-01By Y-W Fu
  • The Influence of Wearables on Health Care Outcomes in Chronic Disease: Systematic Review
    J Med Internet Res. 2022 Jul 1;24(7):e36690. doi: 10.2196/36690.ABSTRACTBACKGROUND: Chronic diseases contribute to high rates of disability and mortality. Patient engagement in chronic disease self-management is an essential component of chronic disease models of health care. Wearables provide patient-centered health data in real time, which can help inform self-management decision-making. Despite the perceived benefits of wearables in improving chronic disease ... read more
    Source: PubMedPublished on 2022-07-01By Graeme Mattison
  • Monitoring Autophagy in Neural Stem and Progenitor Cells
    Methods Mol Biol. 2022;2515:99-116. doi: 10.1007/978-1-0716-2409-8_7.ABSTRACTAutophagy is a critical cellular program that is necessary for cellular survival and adaptation to nutrient and metabolic stress. In addition to homeostatic maintenance and adaptive response functions, autophagy also plays an active role during development and tissue regeneration. Within the neural system, autophagy is important for stem cell maintenance and the ability of neural ... read more
    Source: PubMedPublished on 2022-07-01By Romina L Filippelli
  • Assessment of Dopaminergic Neurodegeneration in Mice
    Methods Mol Biol. 2022;2515:151-169. doi: 10.1007/978-1-0716-2409-8_10.ABSTRACTNeuron death is a key feature of neurological disorders like Alzheimer's or Parkinson's disease (PD). As a result, analysis of neurodegeneration is often considered a central experiment in the postmortem characterization of preclinical PD animal models. Stereology provides a precise estimate of particles, like neurons, in three-dimensional objects, like the brain, and is the gold ... read more
    Source: PubMedPublished on 2022-07-01By Haley M Geertsma
  • Opicapone, a Novel Catechol-O-methyl Transferase Inhibitor, for Treatment of Parkinson’s Disease “Off” Episodes
    Health Psychol Res. 2022 Jun 28;10(3):36074. doi: 10.52965/001c.36074. eCollection 2022.ABSTRACTParkinson's Disease (PD) is a common neurodegenerative disorder and the leading cause of disability. It causes significant morbidity and disability through a plethora of symptoms, including movement disorders, sleep disturbances, and cognitive and psychiatric symptoms. The traditional pathogenesis theory of PD involves the loss of dopaminergic neurons in the substantia nigra ... read more
    Source: PubMedPublished on 2022-07-01By Amnon A Berger
  • Acupuncture Regulates Symptoms of Parkinson’s Disease via Brain Neural Activity and Functional Connectivity in Mice
    Front Aging Neurosci. 2022 Jun 14;14:885396. doi: 10.3389/fnagi.2022.885396. eCollection 2022.ABSTRACTParkinson's disease (PD) is a multilayered progressive brain disease characterized by motor dysfunction and a variety of other symptoms. Although acupuncture has been used to ameliorate various symptoms of neurodegenerative disorders, including PD, the underlying mechanisms are unclear. Here, we investigated the mechanism of acupuncture by revealing the effects of acupuncture ... read more
    Source: PubMedPublished on 2022-07-01By Ju-Young Oh
  • Sublingual apomorphine therapy as an alternative to complex continuous infusion pumps in advanced Parkinson’s disease treatment: a district nurse-led intervention
    Br J Community Nurs. 2022 Jul 2;27(7):328-335. doi: 10.12968/bjcn.2022.27.7.328.ABSTRACTIn the UK, Parkinson's disease (PD) is estimated to affect an annual incidence of 15-20 per 100 000 of the population over the age of 60. Service users living with advanced-stage PD require the use of apomorphine, which is generally used to control symptoms. The district nursing service plays a key role ... read more
    Source: PubMedPublished on 2022-07-01By Karis Macaulay
  • Bone Marrow Stem Cell-Exo-Derived TSG-6 Attenuates 1-Methyl-4-Phenylpyridinium+-Induced Neurotoxicity via the STAT3/miR-7/NEDD4/LRRK2 Axis
    J Neuropathol Exp Neurol. 2022 Jun 30:nlac049. doi: 10.1093/jnen/nlac049. Online ahead of print.ABSTRACTBone marrow mesenchymal stem cell-derived exosome (BMSCs-Exo)-derived TNF-stimulated gene-6 (TSG-6) has anti-inflammatory and antioxidative stress-related properties that may be beneficial in the treatment of Parkinson disease (PD) patients. To elucidate the mechanisms involved, we analyzed the effects of BMSCs-Exo-derived TSG-6 on in vitro models of PD induced with ... read more
    Source: PubMedPublished on 2022-07-01By Dezhi Huang
  • The LRRK2 signaling network converges on a centriolar phospho-Rab10/RILPL1 complex to cause deficits in centrosome cohesion and cell polarization
    Biol Open. 2022 Jul 1:bio.059468. doi: 10.1242/bio.059468. Online ahead of print.ABSTRACTThe Parkinsońs disease-associated LRRK2 kinase phosphorylates multiple Rab GTPases including Rab8 and Rab10, which enhances their binding to RILPL1 and RILPL2. The nascent interaction between phospho-Rab10 and RILPL1 blocks ciliogenesis in vitro and in the intact brain, and interferes with the cohesion of duplicated centrosomes in dividing cells. We show ... read more
    Source: PubMedPublished on 2022-07-01By Antonio Jesús Lara Ordóñez
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