PD Latest Research

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  • Predictive modelling of spread in adult-onset isolated dystonia: key properties and effect of tremor inclusion
    Eur J Neurol. 2021 Jul 22. doi: 10.1111/ene.15031. Online ahead of print.ABSTRACTBACKGROUND: Several clinical and demographic factors relate to anatomic spread of adult-onset isolated dystonia, but a predictive model is still lacking.OBJECTIVES: 1) To develop and validate a predictive model of anatomic spread of adult-onset isolated dystonia; 2) to evaluate whether presence of tremor associated with dystonia influences model predictions ... read more
    Source: PubMedPublished on 2021-07-23By Meng Wang
  • Lateralized effects of deep brain stimulation in Parkinson’s disease: evidence and controversies
    NPJ Parkinsons Dis. 2021 Jul 22;7(1):64. doi: 10.1038/s41531-021-00209-3.ABSTRACTThe bilateral effects of deep brain stimulation (DBS) on motor and non-motor symptoms of Parkinson's disease (PD) have been extensively studied and reviewed. However, the unilateral effects-in particular, the potential lateralized effects of left- versus right-sided DBS-have not been adequately recognized or studied. Here we summarized the current evidence and controversies in the ... read more
    Source: PubMedPublished on 2021-07-23By Zhengyu Lin
  • Clinical Spectrum of Movement Disorders in Neurology Inpatients in a Tertiary Care Centre
    J Neurosci Rural Pract. 2021 Jul;12(3):581-585. doi: 10.1055/s-0041-1730086. Epub 2021 May 10.ABSTRACTBackground Little data are available on the spectrum of movement disorders in inpatients, particularly those admitted in neurology specialty. This may be related to the fact that patients presenting with movement disorders are usually evaluated from outpatient clinics. Objective The aim of this study is to provide data on ... read more
    Source: PubMedPublished on 2021-07-23By Shabeer Ahmad Paul
  • Diagnostic accuracy of dual-phase 18F-FP-CIT PET imaging for detection and differential diagnosis of Parkinsonism
    Sci Rep. 2021 Jul 22;11(1):14992. doi: 10.1038/s41598-021-94040-8.ABSTRACTDelayed phase 18F-FP-CIT PET (dCIT) can assess the striatal dopamine transporter binding to detect degenerative parkinsonism (DP). Early phase 18F-FP-CIT (eCIT) can assess the regional brain activity for differential diagnosis among parkinsonism similar with 18F-FDG PET. We evaluated the diagnostic performance of dual phase 18F-FP-CIT PET (dual CIT) and 18F-FDG PET compared with clinical ... read more
    Source: PubMedPublished on 2021-07-23By Minyoung Oh
  • PARK Genes Link Mitochondrial Dysfunction and Alpha-Synuclein Pathology in Sporadic Parkinson’s Disease
    Front Cell Dev Biol. 2021 Jul 6;9:612476. doi: 10.3389/fcell.2021.612476. eCollection 2021.ABSTRACTParkinson's disease (PD) is an age-related neurodegenerative disorder affecting millions of people worldwide. The disease is characterized by the progressive loss of dopaminergic neurons and spread of Lewy pathology (α-synuclein aggregates) in the brain but the pathogenesis remains elusive. PD presents substantial clinical and genetic variability. Although its complex etiology ... read more
    Source: PubMedPublished on 2021-07-23By Wen Li
  • Corrigendum: Dl-3-n-Butylphthalide Exerts Dopaminergic Neuroprotection Through Inhibition of Neuroinflammation
    Front Aging Neurosci. 2021 Jul 6;13:620015. doi: 10.3389/fnagi.2021.620015. eCollection 2021.ABSTRACT[This corrects the article DOI: 10.3389/fnagi.2019.00044.].PMID:34295236 | PMC:PMC8290916 | DOI:10.3389/fnagi.2021.620015 ... read more
    Source: PubMedPublished on 2021-07-23By Yajing Chen
  • Selective Neuron Vulnerability in Common and Rare Diseases-Mitochondria in the Focus
    Front Mol Biosci. 2021 Jun 30;8:676187. doi: 10.3389/fmolb.2021.676187. eCollection 2021.ABSTRACTMitochondrial dysfunction is a central feature of neurodegeneration within the central and peripheral nervous system, highlighting a strong dependence on proper mitochondrial function of neurons with especially high energy consumptions. The fitness of mitochondria critically depends on preservation of distinct processes, including the maintenance of their own genome, mitochondrial dynamics, quality ... read more
    Source: PubMedPublished on 2021-07-23By Thomas Paß
  • 123I-Metaiodobenzylguanidine Myocardial Scintigraphy in Discriminating Degenerative Parkinsonisms
    Mov Disord Clin Pract. 2021 May 7;8(5):717-724. doi: 10.1002/mdc3.13227. eCollection 2021 Jul.ABSTRACTBACKGROUND: 123I-Metaiodobenzylguanidine (123I-MIBG) myocardial scintigraphy is a useful technique to differentiate Parkinson's disease (PD) from atypical parkinsonisms, since it is generally abnormal in PD and normal in the latter. Reduction of myocardial MIBG uptake is a supportive feature in the latest PD diagnostic criteria.OBJECTIVES: To explore the clinical contribution ... read more
    Source: PubMedPublished on 2021-07-23By Mauro Catalan
  • Iron reduces the propagation of pathological α-synuclein: An Editorial Highlight for “Brain iron enrichment attenuates α-synuclein spreading after injection of preformed fibrils”
    J Neurochem. 2021 Jul 23. doi: 10.1111/jnc.15467. Online ahead of print.ABSTRACTIron accumulation and α-synuclein aggregates (e.g., Lewy bodies) have been linked with the pathogenesis of Parkinson's disease (PD), with yet-to-be-determined interaction. Previous studies have indicated that iron binds to α-synuclein and triggers its aggregation in vitro, and iron is found enriched in Lewy bodies. In the current study, Joppe et ... read more
    Source: PubMedPublished on 2021-07-23By Yu-Jie Guo
  • Electroconvulsive Therapy for Parkinson’s Disease with Depression and Neuroleptic Malignant Syndrome: A Case Report
    Clin Psychopharmacol Neurosci. 2021 Aug 31;19(3):572-575. doi: 10.9758/cpn.2021.19.3.572.ABSTRACTParkinson's disease is often complicated by psychiatric symptoms. Psychiatrists are caught in a dilemma between such symptoms and physical treatment since Parkinson's disease sometimes shows treatment resistance based on pharmacological treatment-induced dopamine dysfunction. Here, we report on a 64-year-old woman with a 15-year history of Parkinson's disease with stage IV severity based on ... read more
    Source: PubMedPublished on 2021-07-23By Yuhei Mori
  • Rationale and design to evaluate the PRIME Parkinson care model: a prospective observational evaluation of proactive, integrated and patient-centred Parkinson care in The Netherlands (PRIME-NL)
    BMC Neurol. 2021 Jul 23;21(1):286. doi: 10.1186/s12883-021-02308-3.ABSTRACTBACKGROUND: Culminating evidence shows that current care does not optimally meet the needs of persons with parkinsonism, their carers and healthcare professionals. Recently, a new model of care was developed to address the limitations of usual care: Proactive and Integrated Management and Empowerment in Parkinson's Disease (PRIME Parkinson). From 2021 onwards, PRIME Parkinson care ... read more
    Source: PubMedPublished on 2021-07-23By Jan H L Ypinga
  • The protective effects of Ramelteon against 6-OHDA-induced cellular senescence in human SH-SY5Y neuronal cells
    Brain Behav. 2021 Jul 23. doi: 10.1002/brb3.2278. Online ahead of print.ABSTRACTBACKGROUND AND PURPOSE: Parkinson's disease (PD) is a severe neurodegenerative disease with high morbidity in the elderly population. 6-OHDA-induced cell senescence is reported to be involved in the pathogenesis of PD. Ramelteon is an oral hypnotic agent that specifically targets the receptors of the suprachiasmatic nucleus in the human hypothalamus. ... read more
    Source: PubMedPublished on 2021-07-23By Dan Liu
  • Salivary Heme Oxygenase-1: A Potential Biomarker for Central Neurodegeneration
    J Cent Nerv Syst Dis. 2021 Jul 7;13:11795735211029114. doi: 10.1177/11795735211029114. eCollection 2021.ABSTRACTBACKGROUND: Parkinson disease (PD) is the second most common neurodegenerative disease, affecting 2% of the population over 65 years of age. PD diagnosis is based on clinical examination and can only be confirmed during autopsy. In 2018, we reported that heme oxygenase-1 (HO-1), an inducible stress response protein important ... read more
    Source: PubMedPublished on 2021-07-22By Julia M Galindez
  • The Metallome as a Link Between the “Omes” in Autism Spectrum Disorders
    Front Mol Neurosci. 2021 Jul 5;14:695873. doi: 10.3389/fnmol.2021.695873. eCollection 2021.ABSTRACTMetal dyshomeostasis plays a significant role in various neurological diseases such as Alzheimer's disease, Parkinson's disease, Autism Spectrum Disorders (ASD), and many more. Like studies investigating the proteome, transcriptome, epigenome, microbiome, etc., for years, metallomics studies have focused on data from their domain, i.e., trace metal composition, only. Still, few have ... read more
    Source: PubMedPublished on 2021-07-22By Janelle E Stanton
  • Subthalamic low frequency stimulation in Parkinson’s disease: Ready for everyday use to improve cognition?
    Brain Stimul. 2021 Jul 19:S1935-861X(21)00145-5. doi: 10.1016/j.brs.2021.07.008. Online ahead of print.NO ABSTRACTPMID:34293512 | DOI:10.1016/j.brs.2021.07.008 ... read more
    Source: PubMedPublished on 2021-07-22By Lars Wojtecki
  • Neuropeptide-S Affects Cognitive Impairment and Depression-like Behavior on MPTP Induced Experimental Mouse Model of Parkinson’s Disease
    Turk J Med Sci. 2021 Jul 22. doi: 10.3906/sag-2105-74. Online ahead of print.ABSTRACTBACKGROUND/AIM: The present study proposes to investigate the effect of neuropeptide-S (NPS) on cognitive functions and depression-like behavior of MPTP-induced experimental model of Parkinson?s disease (PD).MATERIALS AND METHODS: Three-month-old C57BL/6 mice were randomly divided into three groups as; Control, Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and MPTP+NPS 0.1 nmol (received intraperitoneal injection ... read more
    Source: PubMedPublished on 2021-07-22By Ayşe Özkan
  • I Feel Like I Am Flying and Full of Life: Contemporary Dance for Parkinson’s Patients
    Front Psychol. 2021 Jul 5;12:623721. doi: 10.3389/fpsyg.2021.623721. eCollection 2021.ABSTRACTParkinson's is a neurodegenerative disease characterized by motor and non-motor symptoms which are strongly associated with patients' quality of life, affecting social skills and support. It strikes not only the motor abilities but may harm cognitive and emotional functioning. For the past 15 years, contemporary dance has been employed as an intervention ... read more
    Source: PubMedPublished on 2021-07-22By Anat Bar
  • Vortioxetine Improved Depressive State In Parkinson’s Disease
    Cureus. 2021 Jun 18;13(6):e15750. doi: 10.7759/cureus.15750. eCollection 2021 Jun.ABSTRACTWe report the case of a 67-year-old Japanese Parkinson's disease (PD) patient with depression who was successfully treated with vortioxetine. The patient's PD was being treated with levodopa (100 mg/day). As improvement was noted in PD symptoms, levodopa was continued. Subsequently, she was referred to our department due to worsening of her ... read more
    Source: PubMedPublished on 2021-07-22By Reiji Yoshimura
  • Visualization of early oligomeric α-synuclein pathology and its impact on the dopaminergic system in the (Thy-1)-h[A30P]α-syn transgenic mouse model
    J Neurosci Res. 2021 Jul 22. doi: 10.1002/jnr.24927. Online ahead of print.ABSTRACTAggregation of alpha-synuclein (α-syn) into Lewy bodies and Lewy neurites is a pathological hallmark in the Parkinson´s disease (PD) brain. The formation of α-syn oligomers is believed to be an early pathogenic event and the A30P mutation in the gene encoding α-syn, causing familial PD, has been shown to ... read more
    Source: PubMedPublished on 2021-07-22By Anish Behere
  • Case-control study of hypertension and Parkinson’s disease
    NPJ Parkinsons Dis. 2021 Jul 21;7(1):63. doi: 10.1038/s41531-021-00202-w.ABSTRACTWe evaluate the association of hypertension with PD in an Asian population and performed a meta-analysis on similar studies to address the effect of hypertension on PD risk. A matched case-control study involving 1342 Chinese subjects (671 PD and 671 age and gender-matched controls (with a mean age of 63.9 ± 9.7 and ... read more
    Source: PubMedPublished on 2021-07-22By Yuen-Fann Ng
  • The Metallome as a Link Between the “Omes” in Autism Spectrum Disorders
    Front Mol Neurosci. 2021 Jul 5;14:695873. doi: 10.3389/fnmol.2021.695873. eCollection 2021.ABSTRACTMetal dyshomeostasis plays a significant role in various neurological diseases such as Alzheimer's disease, Parkinson's disease, Autism Spectrum Disorders (ASD), and many more. Like studies investigating the proteome, transcriptome, epigenome, microbiome, etc., for years, metallomics studies have focused on data from their domain, i.e., trace metal composition, only. Still, few have ... read more
    Source: PubMedPublished on 2021-07-22By Janelle E Stanton
  • Immunomodulation with IL-17 and TNF-α in spondyloarthritis: focus on the eye and the central nervous system
    Ther Adv Musculoskelet Dis. 2021 Jul 9;13:1759720X211025894. doi: 10.1177/1759720X211025894. eCollection 2021.ABSTRACTTumor necrosis factor alpha (TNF-α) and interleukin-17 (IL-17) are two pro-inflammatory cytokines involved in the pathophysiology of spondyloarthritis (SpA). Therapies targeting TNF-α or IL-17 are used as a second line among SpA patients failing non-steroidal anti-inflammatory drugs. The choice of such treatment has to take into account the patient's comorbidities. ... read more
    Source: PubMedPublished on 2021-07-22By Elsa How Shing Koy
  • Monoamine oxidase-B inhibition facilitates alpha-synuclein secretion in vitro and delays its aggregation in rAAV-based rat models of Parkinson’s disease
    J Neurosci. 2021 Jul 21:JN-RM-0476-21. doi: 10.1523/JNEUROSCI.0476-21.2021. Online ahead of print.ABSTRACTCell-to-cell transmission of α-synuclein (α-syn) pathology is considered to underlie the spread of neurodegeneration in Parkinson's disease. Previous studies have demonstrated that α-syn is secreted under physiological conditions in neuronal cell lines and primary neurons. However, the molecular mechanisms that regulate extracellular α-syn secretion remain unclear. In this study, we ... read more
    Source: PubMedPublished on 2021-07-22By Yoshitsugu Nakamura
  • Direct Targeting of the Anterior Nucleus of the Thalamus via 3 T Quantitative Susceptibility Mapping
    Front Neurosci. 2021 Jul 5;15:685050. doi: 10.3389/fnins.2021.685050. eCollection 2021.ABSTRACTObjective: Deep brain stimulation (DBS) of the anterior nucleus of the thalamus (ANT) is a potentially effective, minimally invasive, and reversible method for treating epilepsy. The goal of this study was to explore whether 3 T quantitative susceptibility mapping (QSM) could delineate the ANT from surrounding structures, which is important for the ... read more
    Source: PubMedPublished on 2021-07-22By Kaijia Yu
  • Vortioxetine Improved Depressive State In Parkinson’s Disease
    Cureus. 2021 Jun 18;13(6):e15750. doi: 10.7759/cureus.15750. eCollection 2021 Jun.ABSTRACTWe report the case of a 67-year-old Japanese Parkinson's disease (PD) patient with depression who was successfully treated with vortioxetine. The patient's PD was being treated with levodopa (100 mg/day). As improvement was noted in PD symptoms, levodopa was continued. Subsequently, she was referred to our department due to worsening of her ... read more
    Source: PubMedPublished on 2021-07-22By Reiji Yoshimura
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