Parkinson’s Disease Latest Research

Related ArticlesThe Emerging Role of Energy Metabolism and Neuroprotective Strategies in Parkinson's Disease. Front Aging Neurosci. 2018;10:301 Authors: Błaszczyk JW PMID: 30344487 [PubMed] ... read more

Related ArticlesThe small molecule AUTEN-99 (autophagy enhancer-99) prevents the progression of neurodegenerative symptoms. Sci Rep. 2017 02 16;7:42014 Authors: Kovács T, Billes V, Komlós M, Hotzi B, Manzéger A, Tarnóci A, Papp D, Szikszai F, Szinyákovics J, Rácz Á, Noszál B, Veszelka S, Walter FR, Deli MA, Hackler ... read more

An integrative tissue-network approach to identify and test human disease genes. Nat Biotechnol. 2018 Oct 22;: Authors: Yao V, Kaletsky R, Keyes W, Mor DE, Wong AK, Sohrabi S, Murphy CT, Troyanskaya OG Abstract Effective discovery of causal disease genes must overcome the statistical challenges of quantitative genetics studies and ... read more

Progress in dopaminergic cell-replacement and regenerative strategies for Parkinson's disease. ACS Chem Neurosci. 2018 Oct 16;: Authors: Chen W, Huang Q, Ma S, Li M Abstract Parkinson's disease (PD) is a chronic progressive neurodegenerative disorder symptomatically characterized by resting tremor, rigidity, bradykinesia and gait impairment. These motor deficits suffered by ... read more

[Eye as an object of investigation of cognitive impairment in Parkinson's disease]. Zh Nevrol Psikhiatr Im S S Korsakova. 2018;118(6. Vyp. 2):105-114 Authors: Litvinenko IV, Dynin PS, Trufanov AG, Gimadutdinov RF, Maltsev DS Abstract AIM: To study visual and spatial disorders in Parkinson's disease (PD). MATERIAL AND METHODS: One hundred ... read more

[Possibilities of retention of work capacity in patients with Parkinson's disease]. Zh Nevrol Psikhiatr Im S S Korsakova. 2018;118(6. Vyp. 2):95-98 Authors: Gankina OA, Vasenina EE, Pokhabov DD, Voronov DB, Zhukova IA, Baitimerov AR, Radyuk MA, Bojenkina TV, Razdorskaya VV, Levin OS Abstract AIM: To study the efficacy of replacement ... read more

[Hardware- software complex for the differential diagnosis and evaluation of the effictiveness of treatment of extrapyramidal diseases]. Zh Nevrol Psikhiatr Im S S Korsakova. 2018;118(6. Vyp. 2):99-104 Authors: Khutorskaya OE Abstract The hardware-software system of differential diagnosis and evaluation of the efficacy of treatment of a number of extrapyramidal diseases ... read more

[Dysfunction of the orexin system in Parkinson's disease]. Zh Nevrol Psikhiatr Im S S Korsakova. 2018;118(6. Vyp. 2):82-89 Authors: Yakovleva OV, Lyashenko EA, Poluektov MG Abstract Traditionally, Parkinson's disease (PD) is associated with the lesion of the substantia nigra and dopamine system dysfunction. However, current studies show the involvement of ... read more

[Vestibular disorders in patients with Parkinson's disease]. Zh Nevrol Psikhiatr Im S S Korsakova. 2018;118(6. Vyp. 2):73-76 Authors: Gergova AA, Zamergrad MV, Artemiev DV, Levin OS Abstract The article addresses causes of dizziness and a role of vestibular dysfunction in the instability structure in patients with Parkinson's disease. An analysis ... read more

[Rate of progression of Parkinson's disease with early and delayed prescription of levodopa preparations.] Zh Nevrol Psikhiatr Im S S Korsakova. 2018;118(6. Vyp. 2):77-81 Authors: Rosinskaya AV, Vasenina EE, Khaybullin TN, Levin OS Abstract AIM: To optimize therapy with levodopa preparations in relation to the rate of disease progression. MATERIAL ... read more

[Parkinson's disease and glutamate excitotoxicity]. Zh Nevrol Psikhiatr Im S S Korsakova. 2018;118(6. Vyp. 2):50-54 Authors: Mironova YS, Zhukova IA, Zhukova NG, Alifirova VM, Izhboldina OP, Latypova AV Abstract AIM: To measure the concentration of glutamate in the serum of patients with Parkinson's disease (PD) and determine its association with ... read more

Identifying mild-moderate Parkinson's disease using whole-brain functional connectivity. Clin Neurophysiol. 2018 Sep 24;129(12):2507-2516 Authors: Tang Y, Liu B, Yang Y, Wang CM, Meng L, Tang BS, Guo JF Abstract OBJECTIVE: Our study aims to extract significant disorder-associated patterns from whole brain functional connectivity to distinguish mild-moderate Parkinson's disease (PD) patients ... read more

The Role of Atomoxetine for Parkinson Disease-Related Executive Dysfunction: A Systematic Review. J Clin Psychopharmacol. 2018 Oct 19;: Authors: Warner CB, Ottman AA, Brown JN Abstract BACKGROUND: Atomoxetine selectively inhibits the reuptake of norepinephrine. Given the noradrenergic system's role in executive function, pharmacotherapy options that affect norepinephrine are of particular ... read more

Effects of anodal tDCS on motor and cognitive function in a patient with multiple system atrophy. Disabil Rehabil. 2018 Oct 21;:1-5 Authors: Alexoudi A, Patrikelis P, Fasilis T, Deftereos S, Sakas D, Gatzonis S Abstract PURPOSE: Multiple system atrophy (MSA) is a progressive neurodegenerative disease characterized by postural instability, autonomic ... read more

Related ArticlesElectroencephalography-based machine learning for cognitive profiling in Parkinson's disease: Preliminary results. Mov Disord. 2018 Oct 21;: Authors: Betrouni N, Delval A, Chaton L, Defebvre L, Duits A, Moonen A, Leentjens AFG, Dujardin K Abstract BACKGROUND: Cognitive symptoms are common in patients with Parkinson's disease. Characterization of a patient's cognitive ... read more

Related ArticlesHigher serum triglyceride levels are associated with Parkinson's disease mild cognitive impairment. Mov Disord. 2018 Oct 21;: Authors: Huang X, Ng SY, Chia NS, Acharyya S, Setiawan F, Lu Z, Tan YJ, Ng E, Wen MC, Ng ASL, Tay KY, Au WL, Tan EK, Tan LC PMID: 30345542 [PubMed ... read more

Related ArticlesInterleukin-1 Beta and Tumor Necrosis Factor Alpha Upregulation and Nuclear Factor Kappa B Activation in Skeletal Muscle from a Mouse Model of Chronic/Progressive Parkinson Disease. Med Sci Monit. 2018 Oct 22;24:7524-7531 Authors: Erekat N, Al-Jarrah MD Abstract BACKGROUND Skeletal muscle atrophy has been reported in patients with Parkinson disease ... read more

Related ArticlesTreatment response in osmotic demyelination syndrome presenting as severe parkinsonism, ptosis and gaze palsy. BMJ Case Rep. 2018 Oct 21;2018: Authors: Abdul Halim S, Mohd Amin NA Abstract Osmotic demyelination syndrome commonly affects the pons and infrequently involves the extrapontine region. We report a patient with severe hyponatraemia who ... read more

Related ArticlesT-type Calcium Channels Determine the Vulnerability of Dopaminergic Neurons to Mitochondrial Stress in Familial Parkinson Disease. Stem Cell Reports. 2018 Oct 03;: Authors: Tabata Y, Imaizumi Y, Sugawara M, Andoh-Noda T, Banno S, Chai M, Sone T, Yamazaki K, Ito M, Tsukahara K, Saya H, Hattori N, Kohyama J, ... read more

Related ArticlesContribution of white matter lesions to cognitive decline in Parkinson's disease. Parkinsonism Relat Disord. 2018 Oct 16;: Authors: Grey MT, Veselý B, Gajdoš M, Klobušiaková P, Rektor I PMID: 30343982 [PubMed - as supplied by publisher] ... read more

Baseline concentration of misfolded α-synuclein aggregates in cerebrospinal fluid predicts risk of cognitive decline in Parkinson's disease. Neuropathol Appl Neurobiol. 2018 Oct 22;: Authors: Ning H, Wu Q, Han D, Yao T, Wang J, Lu W, Lv S, Jia Q, Li X Abstract BACKGROUND: The prognostic significance of misfolded α-synuclein ... read more

Levodopa-carbidopa intestinal gel infusion and weight loss in Parkinson's disease. Eur J Neurol. 2018 Oct 22;: Authors: Fabbri M, Zibetti M, Beccaria L, Merola A, Romagnolo A, Montanaro E, Ferreira JJ, Palermo S, Lopiano L Abstract INTRODUCTION: Weight loss (WL) is a frequent yet under-recognized complication of levodopa/carbidopa intestinal gel ... read more

Early detection of Parkinson's disease through patient questionnaire and predictive modelling. Int J Med Inform. 2018 Nov;119:75-87 Authors: Prashanth R, Dutta Roy S Abstract Early detection of Parkinson's disease (PD) is important which can enable early initiation of therapeutic interventions and management strategies. However, methods for early detection still remain ... read more

CHCHD2 mutational screening in Brazilian patients with familial Parkinson's disease. Neurobiol Aging. 2018 Sep 27;: Authors: Voigt DD, Nascimento CM, de Souza RB, Cabello Acero PH, Campos Júnior M, da Silva CP, Pereira JS, Rosso AL, Araujo Leite MA, Vasconcellos LFR, Della Coletta MV, da Silva DJ, Nicaretta DH, Gonçalves ... read more

Triggers, Facilitators, and Aggravators: Redefining Parkinson's Disease Pathogenesis. Trends Neurosci. 2018 Oct 17;: Authors: Johnson ME, Labrie V, Brundin L, Brundin P Abstract We hypothesize that Parkinson's disease (PD) pathogenesis can be divided into three temporal phases. During the first phase, 'triggers', such as viral infections or environmental toxins, spark ... read more