PD Latest Research

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  • Apomorphine Targets the Pleiotropic Bacterial Regulator Hfq
    Antibiotics (Basel). 2021 Mar 4;10(3):257. doi: 10.3390/antibiotics10030257.ABSTRACTHfq is a bacterial regulator with key roles in gene expression. The protein notably regulates translation efficiency and RNA decay in Gram-negative bacteria, thanks to its binding to small regulatory noncoding RNAs. This property is of primary importance for bacterial adaptation and survival in hosts. Small RNAs and Hfq are, for instance, involved in ... read more
    Source: PubMedPublished on 2021-04-03By Florian Turbant
  • Processing of Degraded Speech in Brain Disorders
    Brain Sci. 2021 Mar 20;11(3):394. doi: 10.3390/brainsci11030394.ABSTRACTThe speech we hear every day is typically "degraded" by competing sounds and the idiosyncratic vocal characteristics of individual speakers. While the comprehension of "degraded" speech is normally automatic, it depends on dynamic and adaptive processing across distributed neural networks. This presents the brain with an immense computational challenge, making degraded speech processing vulnerable ... read more
    Source: PubMedPublished on 2021-04-03By Jessica Jiang
  • Assessment of Motor Dysfunction with Virtual Reality in Patients Undergoing [123I]FP-CIT SPECT/CT Brain Imaging
    Tomography. 2021 Mar 26;7(2):95-106. doi: 10.3390/tomography7020009.ABSTRACT[123I]FP-CIT SPECT has been valuable for distinguishing Parkinson disease (PD) from essential tremor. However, its performance for quantitative assessment of motor dysfunction has not been established. A virtual reality (VR) application was developed and compared with [123I]FP-CIT SPECT/CT for detection of severity of motor dysfunction. Forty-four patients (21 males, 23 females, age 64.5 ± 12.4) ... read more
    Source: PubMedPublished on 2021-04-03By Jeanne P Vu
  • Oxidative Stress Conditions Result in Trapping of PHF-Core Tau (297-391) Intermediates
    Cells. 2021 Mar 22;10(3):703. doi: 10.3390/cells10030703.ABSTRACTThe self-assembly of tau into paired helical filaments (PHFs) in neurofibrillary tangles (NFTs) is a significant event in Alzheimer's disease (AD) pathogenesis. Numerous post-translational modifications enhance or inhibit tau assembly into NFTs. Oxidative stress, which accompanies AD, induces multiple post-translational modifications in proteins, including the formation of dityrosine (DiY) cross-links. Previous studies have revealed that ... read more
    Source: PubMedPublished on 2021-04-03By Mahmoud B Maina
  • Calmodulin and Its Binding Proteins in Parkinson’s Disease
    Int J Mol Sci. 2021 Mar 16;22(6):3016. doi: 10.3390/ijms22063016.ABSTRACTParkinson's disease (PD) is a neurodegenerative disorder that manifests with rest tremor, muscle rigidity and movement disturbances. At the microscopic level it is characterized by formation of specific intraneuronal inclusions, called Lewy bodies (LBs), and by a progressive loss of dopaminergic neurons in the striatum and substantia nigra. All living cells, among ... read more
    Source: PubMedPublished on 2021-04-03By Anastasiia Bohush
  • Disclosing the potential of eleganolone for Parkinson’s disease therapeutics: Neuroprotective and anti-inflammatory activities
    Pharmacol Res. 2021 Mar 31:105589. doi: 10.1016/j.phrs.2021.105589. Online ahead of print.ABSTRACTThe treatment of Parkinson´s disease (PD) has benefited from significant advances resulting from the increasing research efforts focused on new therapeutics. However, the current treatments for PD are mostly symptomatic, alleviating disease symptoms without reversing or retarding disease progression. Thus, it is critical to find new molecules that can result ... read more
    Source: PubMedPublished on 2021-04-03By Joana Silva
  • A Goal Intervention Improves Language Fluency: Evidence from Parkinson’s Disease and Healthy Aging
    Medicines (Basel). 2021 Mar 22;8(3):15. doi: 10.3390/medicines8030015.ABSTRACTBackground: Parkinson's disease [PD] is associated with reduced motor and cognitive initiation, and decreased goal-directed behavior including language generation. The current study investigated a novel goal intervention for language generation impairments in PD patients. Methods: Twenty-one PD patients and 22 healthy controls, matched for gender, age, and education, completed a cognitive baseline and language ... read more
    Source: PubMedPublished on 2021-04-03By Gail A Robinson
  • A Flavonoid-Rich Extract of Mandarin Juice Counteracts 6-OHDA-Induced Oxidative Stress in SH-SY5Y Cells and Modulates Parkinson-Related Genes
    Antioxidants (Basel). 2021 Mar 30;10(4):539. doi: 10.3390/antiox10040539.ABSTRACTParkinson's disease (PD) is a degenerative disorder of the nervous system due to unceasing impairment of dopaminergic neurons situated in the substantia nigra. At present, anti-PD drugs acting on dopamine receptors are mainly symptomatic and have only very limited neuroprotective effects, whereas drugs slowing down neurodegeneration of dopaminergic neurons and deterioration of clinical symptoms ... read more
    Source: PubMedPublished on 2021-04-03By Santa Cirmi
  • EEG-Derived Functional Connectivity Patterns Associated with Mild Cognitive Impairment in Parkinson’s Disease
    Behav Sci (Basel). 2021 Mar 23;11(3):40. doi: 10.3390/bs11030040.ABSTRACTOBJECTIVE: To evaluate EEG-derived functional connectivity (FC) patterns associated with mild cognitive impairment (MCI) in Parkinson's disease (PD).METHODS: A sample of 15 patients without cognitive impairment (PD-WCI), 15 with MCI (PD-MCI), and 26 healthy subjects were studied. The EEG was performed in the waking functional state with eyes closed, for the functional analysis ... read more
    Source: PubMedPublished on 2021-04-03By Alejandro Armando Peláez Suárez
  • Assessment of Motor Dysfunction with Virtual Reality in Patients Undergoing [123I]FP-CIT SPECT/CT Brain Imaging
    Tomography. 2021 Mar 26;7(2):95-106. doi: 10.3390/tomography7020009.ABSTRACT[123I]FP-CIT SPECT has been valuable for distinguishing Parkinson disease (PD) from essential tremor. However, its performance for quantitative assessment of motor dysfunction has not been established. A virtual reality (VR) application was developed and compared with [123I]FP-CIT SPECT/CT for detection of severity of motor dysfunction. Forty-four patients (21 males, 23 females, age 64.5 ± 12.4) ... read more
    Source: PubMedPublished on 2021-04-03By Jeanne P Vu
  • The Novel Alpha-2 Adrenoceptor Inhibitor Beditin Reduces Cytotoxicity and Huntingtin Aggregates in Cell Models of Huntington’s Disease
    Pharmaceuticals (Basel). 2021 Mar 12;14(3):257. doi: 10.3390/ph14030257.ABSTRACTHuntington's disease (HD) is a monogenetic neurodegenerative disorder characterized by the accumulation of polyglutamine-expanded huntingtin (mHTT). There is currently no cure, and therefore disease-slowing remedies are sought to alleviate symptoms of the multifaceted disorder. Encouraging findings in Alzheimer's and Parkinson's disease on alpha-2 adrenoceptor (α2-AR) inhibition have shown neuroprotective and aggregation-reducing effects in cell ... read more
    Source: PubMedPublished on 2021-04-03By Elisabeth Singer
  • Early Detection of Freezing of Gait during Walking Using Inertial Measurement Unit and Plantar Pressure Distribution Data
    Sensors (Basel). 2021 Mar 23;21(6):2246. doi: 10.3390/s21062246.ABSTRACTFreezing of gait (FOG) is a sudden and highly disruptive gait dysfunction that appears in mid to late-stage Parkinson's disease (PD) and can lead to falling and injury. A system that predicts freezing before it occurs or detects freezing immediately after onset would generate an opportunity for FOG prevention or mitigation and thus enhance ... read more
    Source: PubMedPublished on 2021-04-03By Scott Pardoel
  • Dopamine: The Neuromodulator of Long-Term Synaptic Plasticity, Reward and Movement Control
    Cells. 2021 Mar 26;10(4):735. doi: 10.3390/cells10040735.ABSTRACTDopamine (DA) is a key neurotransmitter involved in multiple physiological functions including motor control, modulation of affective and emotional states, reward mechanisms, reinforcement of behavior, and selected higher cognitive functions. Dysfunction in dopaminergic transmission is recognized as a core alteration in several devastating neurological and psychiatric disorders, including Parkinson's disease (PD), schizophrenia, bipolar disorder, attention ... read more
    Source: PubMedPublished on 2021-04-03By Luisa Speranza
  • A Flavonoid-Rich Extract of Mandarin Juice Counteracts 6-OHDA-Induced Oxidative Stress in SH-SY5Y Cells and Modulates Parkinson-Related Genes
    Antioxidants (Basel). 2021 Mar 30;10(4):539. doi: 10.3390/antiox10040539.ABSTRACTParkinson's disease (PD) is a degenerative disorder of the nervous system due to unceasing impairment of dopaminergic neurons situated in the substantia nigra. At present, anti-PD drugs acting on dopamine receptors are mainly symptomatic and have only very limited neuroprotective effects, whereas drugs slowing down neurodegeneration of dopaminergic neurons and deterioration of clinical symptoms ... read more
    Source: PubMedPublished on 2021-04-03By Santa Cirmi
  • Pre-Clinical Neuroprotective Evidences and Plausible Mechanisms of Sulforaphane in Alzheimer’s Disease
    Int J Mol Sci. 2021 Mar 13;22(6):2929. doi: 10.3390/ijms22062929.ABSTRACTSulforaphane, a potent dietary bioactive agent obtainable from cruciferous vegetables, has been extensively studied for its effects in disease prevention and therapy. Sulforaphane potently induces transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2)-mediated expression of detoxification, anti-oxidation, and immune system-modulating enzymes, and possibly acts as an anti-carcinogenic agent. Several clinical trials ... read more
    Source: PubMedPublished on 2021-04-03By Jiyoung Kim
  • Dopamine D3 Receptor Plasticity in Parkinson’s Disease and L-DOPA-Induced Dyskinesia
    Biomedicines. 2021 Mar 19;9(3):314. doi: 10.3390/biomedicines9030314.ABSTRACTParkinson's Disease (PD) is characterized by primary and secondary plasticity that occurs in response to progressive degeneration and long-term L-DOPA treatment. Some of this plasticity contributes to the detrimental side effects associated with chronic L-DOPA treatment, namely L-DOPA-induced dyskinesia (LID). The dopamine D3 receptor (D3R) has emerged as a promising target in LID management as ... read more
    Source: PubMedPublished on 2021-04-03By Kathryn Lanza
  • Deep brain stimulation outcomes in the malignant end of Parkinson’s disease spectrum
    Parkinsonism Relat Disord. 2021 Mar 28;86:5-9. doi: 10.1016/j.parkreldis.2021.03.017. Online ahead of print.ABSTRACTBACKGROUND: Heterogeneity of Parkinson's Disease (PD) phenotype may influence deep brain stimulation (DBS) outcome. However, DBS response in the malignant end of the PD spectrum has been poorly investigated.OBJECTIVE: To evaluate and compare DBS outcomes in malignant and benign PD patients, defined according to motor and non-motor symptom presentation ... read more
    Source: PubMedPublished on 2021-04-03By Carlo Alberto Artusi
  • Pre-Clinical Neuroprotective Evidences and Plausible Mechanisms of Sulforaphane in Alzheimer’s Disease
    Int J Mol Sci. 2021 Mar 13;22(6):2929. doi: 10.3390/ijms22062929.ABSTRACTSulforaphane, a potent dietary bioactive agent obtainable from cruciferous vegetables, has been extensively studied for its effects in disease prevention and therapy. Sulforaphane potently induces transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2)-mediated expression of detoxification, anti-oxidation, and immune system-modulating enzymes, and possibly acts as an anti-carcinogenic agent. Several clinical trials ... read more
    Source: PubMedPublished on 2021-04-03By Jiyoung Kim
  • Docosahexaenoic and Arachidonic Acids as Neuroprotective Nutrients throughout the Life Cycle
    Nutrients. 2021 Mar 18;13(3):986. doi: 10.3390/nu13030986.ABSTRACTThe role of docosahexaenoic acid (DHA) and arachidonic acid (AA) in neurogenesis and brain development throughout the life cycle is fundamental. DHA and AA are long-chain polyunsaturated fatty acids (LCPUFA) vital for many human physiological processes, such as signaling pathways, gene expression, structure and function of membranes, among others. DHA and AA are deposited into ... read more
    Source: PubMedPublished on 2021-04-03By Verónica Sambra
  • Validation of Cognitive Rehabilitation as a Balance Rehabilitation Strategy in Patients with Parkinson’s Disease: Study Protocol for a Randomized Controlled Trial
    Medicina (Kaunas). 2021 Mar 26;57(4):314. doi: 10.3390/medicina57040314.ABSTRACTBackground: Parkinson's disease (PD) is the second most common neurodegenerative disorder. This disease is characterized by motor symptoms, such as bradykinesia, tremor, and rigidity. Although balance impairment is characteristic of advanced stages, it can be present with less intensity since the beginning of the disease. Approximately 60% of PD patients fall once a year ... read more
    Source: PubMedPublished on 2021-04-03By Aida Arroyo-Ferrer
  • Predicting the Severity of Parkinson’s Disease Dementia by Assessing the Neuropsychiatric Symptoms with an SVM Regression Model
    Int J Environ Res Public Health. 2021 Mar 4;18(5):2551. doi: 10.3390/ijerph18052551.ABSTRACTIn this study, we measured the convergence rate using the mean-squared error (MSE) of the standardized neuropsychological test to determine the severity of Parkinson's disease dementia (PDD), which is based on support vector machine (SVM) regression (SVR) and present baseline data in order to develop a model to predict the ... read more
    Source: PubMedPublished on 2021-04-03By Haewon Byeon
  • Quantitative Assessment of Occipital Metabolic and Energetic Changes in Parkinson’s Patients, Using In Vivo (31)P MRS-Based Metabolic Imaging at 7T
    Metabolites. 2021 Mar 1;11(3):145. doi: 10.3390/metabo11030145.ABSTRACTAbnormal energy metabolism associated with mitochondrial dysfunction is thought to be a major contributor to the progression of neurodegenerative diseases such as Parkinson's disease (PD). Recent advancements in the field of magnetic resonance (MR) based metabolic imaging provide state-of-the-art technologies for non-invasively probing cerebral energy metabolism under various brain conditions. In this proof-of-principle clinical study, ... read more
    Source: PubMedPublished on 2021-04-03By Xiao-Hong Zhu
  • Validation of Cognitive Rehabilitation as a Balance Rehabilitation Strategy in Patients with Parkinson’s Disease: Study Protocol for a Randomized Controlled Trial
    Medicina (Kaunas). 2021 Mar 26;57(4):314. doi: 10.3390/medicina57040314.ABSTRACTBackground: Parkinson's disease (PD) is the second most common neurodegenerative disorder. This disease is characterized by motor symptoms, such as bradykinesia, tremor, and rigidity. Although balance impairment is characteristic of advanced stages, it can be present with less intensity since the beginning of the disease. Approximately 60% of PD patients fall once a year ... read more
    Source: PubMedPublished on 2021-04-03By Aida Arroyo-Ferrer
  • Dopamine: The Neuromodulator of Long-Term Synaptic Plasticity, Reward and Movement Control
    Cells. 2021 Mar 26;10(4):735. doi: 10.3390/cells10040735.ABSTRACTDopamine (DA) is a key neurotransmitter involved in multiple physiological functions including motor control, modulation of affective and emotional states, reward mechanisms, reinforcement of behavior, and selected higher cognitive functions. Dysfunction in dopaminergic transmission is recognized as a core alteration in several devastating neurological and psychiatric disorders, including Parkinson's disease (PD), schizophrenia, bipolar disorder, attention ... read more
    Source: PubMedPublished on 2021-04-03By Luisa Speranza
  • Mechanisms of Neurodegeneration in Various Forms of Parkinsonism-Similarities and Differences
    Cells. 2021 Mar 16;10(3):656. doi: 10.3390/cells10030656.ABSTRACTParkinson's disease (PD), dementia with Lewy body (DLB), progressive supranuclear palsy (PSP), corticobasal degeneration (CBD) and multiple system atrophy (MSA) belong to a group of neurodegenerative diseases called parkinsonian syndromes. They share several clinical, neuropathological and genetic features. Neurodegenerative diseases are characterized by the progressive dysfunction of specific populations of neurons, determining clinical presentation. Neuronal ... read more
    Source: PubMedPublished on 2021-04-03By Dariusz Koziorowski
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