PD Latest Research

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  • Could Small Heat Shock Protein HSP27 Be a First-Line Target for Preventing Protein Aggregation in Parkinson’s Disease?
    Int J Mol Sci. 2021 Mar 16;22(6):3038. doi: 10.3390/ijms22063038.ABSTRACTSmall heat shock proteins (HSPs), such as HSP27, are ubiquitously expressed molecular chaperones and are essential for cellular homeostasis. The major functions of HSP27 include chaperoning misfolded or unfolded polypeptides and protecting cells from toxic stress. Dysregulation of stress proteins is associated with many human diseases including neurodegenerative diseases, such as Parkinson's ... read more
    Source: PubMedPublished on 2021-04-03By Javier Navarro-Zaragoza
  • Axonal Modulation of Striatal Dopamine Release by Local γ-Aminobutyric Acid (GABA) Signalling
    Cells. 2021 Mar 23;10(3):709. doi: 10.3390/cells10030709.ABSTRACTStriatal dopamine (DA) release is critical for motivated actions and reinforcement learning, and is locally influenced at the level of DA axons by other striatal neurotransmitters. Here, we review a wealth of historical and more recently refined evidence indicating that DA output is inhibited by striatal γ-aminobutyric acid (GABA) acting via GABAA and GABAB receptors. ... read more
    Source: PubMedPublished on 2021-04-03By Bradley M Roberts
  • Calmodulin and Its Binding Proteins in Parkinson’s Disease
    Int J Mol Sci. 2021 Mar 16;22(6):3016. doi: 10.3390/ijms22063016.ABSTRACTParkinson's disease (PD) is a neurodegenerative disorder that manifests with rest tremor, muscle rigidity and movement disturbances. At the microscopic level it is characterized by formation of specific intraneuronal inclusions, called Lewy bodies (LBs), and by a progressive loss of dopaminergic neurons in the striatum and substantia nigra. All living cells, among ... read more
    Source: PubMedPublished on 2021-04-03By Anastasiia Bohush
  • Step Length Is a Promising Progression Marker in Parkinson’s Disease
    Sensors (Basel). 2021 Mar 25;21(7):2292. doi: 10.3390/s21072292.ABSTRACTCurrent research on Parkinson's disease (PD) is increasingly concerned with the identification of objective and specific markers to make reliable statements about the effect of therapy and disease progression. Parameters from inertial measurement units (IMUs) are objective and accurate, and thus an interesting option to be included in the regular assessment of these patients. ... read more
    Source: PubMedPublished on 2021-04-03By Julius Welzel
  • Advancing Personalized Medicine in Common Forms of Parkinson’s Disease through Genetics: Current Therapeutics and the Future of Individualized Management
    J Pers Med. 2021 Mar 1;11(3):169. doi: 10.3390/jpm11030169.ABSTRACTParkinson's disease (PD) is a condition with heterogeneous clinical manifestations that vary in age at onset, rate of progression, disease course, severity, motor and non-motor symptoms, and a variable response to antiparkinsonian drugs. It is considered that there are multiple PD etiological subtypes, some of which could be predicted by genetics. The characterization ... read more
    Source: PubMedPublished on 2021-04-03By Xylena Reed
  • Oxidative Stress Conditions Result in Trapping of PHF-Core Tau (297-391) Intermediates
    Cells. 2021 Mar 22;10(3):703. doi: 10.3390/cells10030703.ABSTRACTThe self-assembly of tau into paired helical filaments (PHFs) in neurofibrillary tangles (NFTs) is a significant event in Alzheimer's disease (AD) pathogenesis. Numerous post-translational modifications enhance or inhibit tau assembly into NFTs. Oxidative stress, which accompanies AD, induces multiple post-translational modifications in proteins, including the formation of dityrosine (DiY) cross-links. Previous studies have revealed that ... read more
    Source: PubMedPublished on 2021-04-03By Mahmoud B Maina
  • The Novel Alpha-2 Adrenoceptor Inhibitor Beditin Reduces Cytotoxicity and Huntingtin Aggregates in Cell Models of Huntington’s Disease
    Pharmaceuticals (Basel). 2021 Mar 12;14(3):257. doi: 10.3390/ph14030257.ABSTRACTHuntington's disease (HD) is a monogenetic neurodegenerative disorder characterized by the accumulation of polyglutamine-expanded huntingtin (mHTT). There is currently no cure, and therefore disease-slowing remedies are sought to alleviate symptoms of the multifaceted disorder. Encouraging findings in Alzheimer's and Parkinson's disease on alpha-2 adrenoceptor (α2-AR) inhibition have shown neuroprotective and aggregation-reducing effects in cell ... read more
    Source: PubMedPublished on 2021-04-03By Elisabeth Singer
  • Selective Activation of CNS and Reference PPARGC1A Promoters Is Associated with Distinct Gene Programs Relevant for Neurodegenerative Diseases
    Int J Mol Sci. 2021 Mar 24;22(7):3296. doi: 10.3390/ijms22073296.ABSTRACTThe transcriptional regulator peroxisome proliferator activated receptor gamma coactivator 1A (PGC-1α), encoded by PPARGC1A, has been linked to neurodegenerative diseases. Recently discovered CNS-specific PPARGC1A transcripts are initiated far upstream of the reference promoter, spliced to exon 2 of the reference gene, and are more abundant than reference gene transcripts in post-mortem human ... read more
    Source: PubMedPublished on 2021-04-03By Markus Kwik
  • Pre-Clinical Neuroprotective Evidences and Plausible Mechanisms of Sulforaphane in Alzheimer’s Disease
    Int J Mol Sci. 2021 Mar 13;22(6):2929. doi: 10.3390/ijms22062929.ABSTRACTSulforaphane, a potent dietary bioactive agent obtainable from cruciferous vegetables, has been extensively studied for its effects in disease prevention and therapy. Sulforaphane potently induces transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2)-mediated expression of detoxification, anti-oxidation, and immune system-modulating enzymes, and possibly acts as an anti-carcinogenic agent. Several clinical trials ... read more
    Source: PubMedPublished on 2021-04-03By Jiyoung Kim
  • Epigallocatechin-3-Gallate-Loaded Liposomes Favor Anti-Inflammation of Microglia Cells and Promote Neuroprotection
    Int J Mol Sci. 2021 Mar 16;22(6):3037. doi: 10.3390/ijms22063037.ABSTRACTMicroglia-mediated neuroinflammation is recognized to mainly contribute to the progression of neurodegenerative diseases. Epigallocatechin-3-gallate (EGCG), known as a natural antioxidant in green tea, can inhibit microglia-mediated inflammation and protect neurons but has disadvantages such as high instability and low bioavailability. We developed an EGCG liposomal formulation to improve its bioavailability and evaluated ... read more
    Source: PubMedPublished on 2021-04-03By Chun-Yuan Cheng
  • Current State-of-the-Art and Unresolved Problems in Using Human Induced Pluripotent Stem Cell-Derived Dopamine Neurons for Parkinson’s Disease Drug Development
    Int J Mol Sci. 2021 Mar 25;22(7):3381. doi: 10.3390/ijms22073381.ABSTRACTHuman induced pluripotent stem (iPS) cells have the potential to give rise to a new era in Parkinson's disease (PD) research. As a unique source of midbrain dopaminergic (DA) neurons, iPS cells provide unparalleled capabilities for investigating the pathogenesis of PD, the development of novel anti-parkinsonian drugs, and personalized therapy design. Significant ... read more
    Source: PubMedPublished on 2021-04-03By S A Antonov
  • Validation of Cognitive Rehabilitation as a Balance Rehabilitation Strategy in Patients with Parkinson’s Disease: Study Protocol for a Randomized Controlled Trial
    Medicina (Kaunas). 2021 Mar 26;57(4):314. doi: 10.3390/medicina57040314.ABSTRACTBackground: Parkinson's disease (PD) is the second most common neurodegenerative disorder. This disease is characterized by motor symptoms, such as bradykinesia, tremor, and rigidity. Although balance impairment is characteristic of advanced stages, it can be present with less intensity since the beginning of the disease. Approximately 60% of PD patients fall once a year ... read more
    Source: PubMedPublished on 2021-04-03By Aida Arroyo-Ferrer
  • Could Small Heat Shock Protein HSP27 Be a First-Line Target for Preventing Protein Aggregation in Parkinson’s Disease?
    Int J Mol Sci. 2021 Mar 16;22(6):3038. doi: 10.3390/ijms22063038.ABSTRACTSmall heat shock proteins (HSPs), such as HSP27, are ubiquitously expressed molecular chaperones and are essential for cellular homeostasis. The major functions of HSP27 include chaperoning misfolded or unfolded polypeptides and protecting cells from toxic stress. Dysregulation of stress proteins is associated with many human diseases including neurodegenerative diseases, such as Parkinson's ... read more
    Source: PubMedPublished on 2021-04-03By Javier Navarro-Zaragoza
  • Prevalence of QTc Prolongation in Patients with Parkinson’s Disease. Assessment of the Effects of Drugs, Clinical Risk Factors and Used Correction Formula
    J Clin Med. 2021 Mar 31;10(7):1396. doi: 10.3390/jcm10071396.ABSTRACTBACKGROUND: Parkinson's disease (PD) is a possible risk factor for corrected QT interval (QTc) prolongation. PD patients frequently take QTc-prolonging drugs. The aim of the study was to assess the prevalence of QTc prolongation in PD and the influence of drugs and other potential risk factors on the QTc length in PD.METHODS: 101 ... read more
    Source: PubMedPublished on 2021-04-03By Jakub J Malkiewicz
  • Silk Fibroin: An Ancient Material for Repairing the Injured Nervous System
    Pharmaceutics. 2021 Mar 23;13(3):429. doi: 10.3390/pharmaceutics13030429.ABSTRACTSilk refers to a family of natural fibers spun by several species of invertebrates such as spiders and silkworms. In particular, silkworm silk, the silk spun by Bombyx mori larvae, has been primarily used in the textile industry and in clinical settings as a main component of sutures for tissue repairing and wound ligation. The ... read more
    Source: PubMedPublished on 2021-04-03By Mahdi Yonesi
  • Could Small Heat Shock Protein HSP27 Be a First-Line Target for Preventing Protein Aggregation in Parkinson’s Disease?
    Int J Mol Sci. 2021 Mar 16;22(6):3038. doi: 10.3390/ijms22063038.ABSTRACTSmall heat shock proteins (HSPs), such as HSP27, are ubiquitously expressed molecular chaperones and are essential for cellular homeostasis. The major functions of HSP27 include chaperoning misfolded or unfolded polypeptides and protecting cells from toxic stress. Dysregulation of stress proteins is associated with many human diseases including neurodegenerative diseases, such as Parkinson's ... read more
    Source: PubMedPublished on 2021-04-03By Javier Navarro-Zaragoza
  • Camptocormia in idiopathic normal pressure hydrocephalus: a case report
    Acta Neurol Belg. 2021 Apr 3. doi: 10.1007/s13760-021-01666-6. Online ahead of print.NO ABSTRACTPMID:33811617 | DOI:10.1007/s13760-021-01666-6 ... read more
    Source: PubMedPublished on 2021-04-03By Massimiliano Todisco
  • Assessment of Gastrointestinal Autonomic Dysfunction: Present and Future Perspectives
    J Clin Med. 2021 Mar 31;10(7):1392. doi: 10.3390/jcm10071392.ABSTRACTThe autonomic nervous system delicately regulates the function of several target organs, including the gastrointestinal tract. Thus, nerve lesions or other nerve pathologies may cause autonomic dysfunction (AD). Some of the most common causes of AD are diabetes mellitus and α-synucleinopathies such as Parkinson's disease. Widespread dysmotility throughout the gastrointestinal tract is a ... read more
    Source: PubMedPublished on 2021-04-03By Ditte S Kornum
  • Is Chelation Therapy a Potential Treatment for Parkinson’s Disease?
    Int J Mol Sci. 2021 Mar 24;22(7):3338. doi: 10.3390/ijms22073338.ABSTRACTIron loading in some brain regions occurs in Parkinson's Disease (PD), and it has been considered that its removal by iron chelators could be an appropriate therapeutic approach. Since neuroinflammation with microgliosis is also a common feature of PD, it is possible that iron is sequestered within cells as a result of ... read more
    Source: PubMedPublished on 2021-04-03By Roberta J Ward
  • Advancing Personalized Medicine in Common Forms of Parkinson’s Disease through Genetics: Current Therapeutics and the Future of Individualized Management
    J Pers Med. 2021 Mar 1;11(3):169. doi: 10.3390/jpm11030169.ABSTRACTParkinson's disease (PD) is a condition with heterogeneous clinical manifestations that vary in age at onset, rate of progression, disease course, severity, motor and non-motor symptoms, and a variable response to antiparkinsonian drugs. It is considered that there are multiple PD etiological subtypes, some of which could be predicted by genetics. The characterization ... read more
    Source: PubMedPublished on 2021-04-03By Xylena Reed
  • Visit-to-visit blood pressure variability is common in primary care patients: Retrospective cohort study of 221,803 adults
    PLoS One. 2021 Apr 2;16(4):e0248362. doi: 10.1371/journal.pone.0248362. eCollection 2021.ABSTRACTOBJECTIVE: Although high visit-to-visit blood pressure variability (BPV) is an independent risk factor for cardiovascular events, the frequency of high BPV is unknown. We conducted this study to define the frequency of high BPV in primary care patients, clinical correlates, and association with antihypertensive therapies.METHODS: Retrospective cohort study using electronic medical record ... read more
    Source: PubMedPublished on 2021-04-02By Finlay A McAlister
  • Translating Evidence to Advanced Parkinson’s Disease Patients: A Systematic Review and Meta-Analysis
    Mov Disord. 2021 Apr 2. doi: 10.1002/mds.28599. Online ahead of print.ABSTRACTIn the advanced stages of Parkinson's disease (PD), patients frequently experience disabling motor complications. Treatment options include deep brain stimulation (DBS), levodopa-carbidopa intestinal gel (LCIG), and continuous subcutaneous apomorphine infusion (CSAI). Choosing among these treatments is influenced by scientific evidence, clinical expertise, and patient preferences. To foster patient engagement in ... read more
    Source: PubMedPublished on 2021-04-02By Frouke A P Nijhuis
  • Improving estimation of Parkinson’s disease risk-the enhanced PREDICT-PD algorithm
    NPJ Parkinsons Dis. 2021 Apr 1;7(1):33. doi: 10.1038/s41531-021-00176-9.ABSTRACTWe previously reported a basic algorithm to identify the risk of Parkinson's disease (PD) using published data on risk factors and prodromal features. Using this algorithm, the PREDICT-PD study identified individuals at increased risk of PD and used tapping speed, hyposmia and REM sleep behaviour disorder (RBD) as "intermediate" markers of prodromal PD ... read more
    Source: PubMedPublished on 2021-04-02By Jonathan P Bestwick
  • Perceived walking difficulties in Parkinson’s disease – predictors and changes over time
    BMC Geriatr. 2021 Apr 1;21(1):221. doi: 10.1186/s12877-021-02113-0.ABSTRACTBACKGROUND: People with Parkinson's disease (PD) have described their walking difficulties as linked to activity avoidance, social isolation, reduced independence and quality of life. There is a knowledge gap regarding predictive factors of perceived walking difficulties in people with PD. Such knowledge could be useful when designing intervention studies. This study aimed to investigate ... read more
    Source: PubMedPublished on 2021-04-02By Magnus Lindh-Rengifo
  • Neuroprotective and Neurorescue Mode of Action of Bacopa monnieri (L.) Wettst in 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Induced Parkinson’s Disease: An In Silico and In Vivo Study
    Front Pharmacol. 2021 Mar 16;12:616413. doi: 10.3389/fphar.2021.616413. eCollection 2021.ABSTRACTEthnopharmacological Relevance: Parkinson's disease (PD) is characterized by progressive death of dopaminergic neurons. The presently used medicines only tackle the symptoms of PD, but none makes a dent on the processes that underpin the disease's development. Herbal medicines have attracted considerable attention in recent years. Bacopa monnieri (L.) Wettst (Brahmi) has been ... read more
    Source: PubMedPublished on 2021-04-02By Babita Singh
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