PD Latest Research

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  • Genetic diversity of axon degenerative mechanisms in models of Parkinson’s disease
    Neurobiol Dis. 2021 Apr 20:105368. doi: 10.1016/j.nbd.2021.105368. Online ahead of print.ABSTRACTParkinson's disease (PD) is the most common form of neurodegenerative movement disorder, associated with profound loss of dopaminergic neurons from the basal ganglia. Though loss of dopaminergic neuron cell bodies from the substantia nigra pars compacta is a well-studied feature, atrophy and loss of their axons within the nigrostriatal tract ... read more
    Source: PubMedPublished on 2021-04-23By Owen M Peters
  • Pramipexole attenuates 6-OHDA-induced Parkinson’s disease by mediating the Nurr1/NF-kappaB pathway
    Mol Biol Rep. 2021 Apr 23. doi: 10.1007/s11033-021-06343-8. Online ahead of print.ABSTRACTNeuroinflammation is the key factor associated with the progression of Parkinson's disease (PD). Pramipexole (PPX) has anti-inflammatory and antioxidant properties. This study explored the effects of PPX on PD and its related mechanisms. A PD rat model was established using 6-hydroxydopamine (6-OHDA). Thirty rats were divided into the following ... read more
    Source: PubMedPublished on 2021-04-23By Hua Gao
  • Differences in predictors for gait speed and gait endurance in Parkinson’s disease
    Gait Posture. 2021 Apr 20;87:49-53. doi: 10.1016/j.gaitpost.2021.04.019. Online ahead of print.ABSTRACTINTRODUCTION: Both gait speed and gait endurance directly impact independence and community engagement for individuals with Parkinson's disease (PD). However, factors accounting for variability in gait speed and gait endurance performance are unclear. The purpose of this study was to investigate whether key factors associated with gait speed in individuals ... read more
    Source: PubMedPublished on 2021-04-23By Staci Shearin
  • Oxidative modification impairs SERCA activity in Drosophila and human cell models of Parkinson’s disease
    Biochim Biophys Acta Mol Basis Dis. 2021 Apr 20:166152. doi: 10.1016/j.bbadis.2021.166152. Online ahead of print.ABSTRACTDJ-1 is a causative gene for familial Parkinson's disease (PD) with different functions, standing out its role against oxidative stress (OS). Accordingly, PD model flies harboring a mutation in the DJ-1β gene (the Drosophila ortholog of human DJ-1) show high levels of OS markers like protein ... read more
    Source: PubMedPublished on 2021-04-23By Cristina Solana-Manrique
  • Pramipexole attenuates 6-OHDA-induced Parkinson’s disease by mediating the Nurr1/NF-kappaB pathway
    Mol Biol Rep. 2021 Apr 23. doi: 10.1007/s11033-021-06343-8. Online ahead of print.ABSTRACTNeuroinflammation is the key factor associated with the progression of Parkinson's disease (PD). Pramipexole (PPX) has anti-inflammatory and antioxidant properties. This study explored the effects of PPX on PD and its related mechanisms. A PD rat model was established using 6-hydroxydopamine (6-OHDA). Thirty rats were divided into the following ... read more
    Source: PubMedPublished on 2021-04-23By Hua Gao
  • Coordinated Reset Vibrotactile Stimulation Induces Sustained Cumulative Benefits in Parkinson’s Disease
    Front Physiol. 2021 Apr 6;12:624317. doi: 10.3389/fphys.2021.624317. eCollection 2021.ABSTRACTBACKGROUND: Abnormal synchronization of neuronal activity in dopaminergic circuits is related to motor impairment in Parkinson's disease (PD). Vibrotactile coordinated reset (vCR) fingertip stimulation aims to counteract excessive synchronization and induce sustained unlearning of pathologic synaptic connectivity and neuronal synchrony. Here, we report two clinical feasibility studies that examine the effect of ... read more
    Source: PubMedPublished on 2021-04-23By Kristina J Pfeifer
  • Antimuscarinic use among older adults with dementia and overactive bladder: a medicare beneficiaries study
    Curr Med Res Opin. 2021 Apr 23:1. doi: 10.1080/03007995.2021.1920899. Online ahead of print.ABSTRACTOBJECTIVES: This study examined the incidence and predictors of antimuscarinic medication use including non-selective antimuscarinics among older adults with dementia and overactive bladder (OAB).METHODS: The study used a new-user cohort design involving older adults (≥65 years) with dementia and OAB based on 2013-2015 Medicare Data. Antimuscarinics included non-selective ... read more
    Source: PubMedPublished on 2021-04-23By Nandita Kachru
  • Pramipexole attenuates 6-OHDA-induced Parkinson’s disease by mediating the Nurr1/NF-kappaB pathway
    Mol Biol Rep. 2021 Apr 23. doi: 10.1007/s11033-021-06343-8. Online ahead of print.ABSTRACTNeuroinflammation is the key factor associated with the progression of Parkinson's disease (PD). Pramipexole (PPX) has anti-inflammatory and antioxidant properties. This study explored the effects of PPX on PD and its related mechanisms. A PD rat model was established using 6-hydroxydopamine (6-OHDA). Thirty rats were divided into the following ... read more
    Source: PubMedPublished on 2021-04-23By Hua Gao
  • Genetic diversity of axon degenerative mechanisms in models of Parkinson’s disease
    Neurobiol Dis. 2021 Apr 20:105368. doi: 10.1016/j.nbd.2021.105368. Online ahead of print.ABSTRACTParkinson's disease (PD) is the most common form of neurodegenerative movement disorder, associated with profound loss of dopaminergic neurons from the basal ganglia. Though loss of dopaminergic neuron cell bodies from the substantia nigra pars compacta is a well-studied feature, atrophy and loss of their axons within the nigrostriatal tract ... read more
    Source: PubMedPublished on 2021-04-23By Owen M Peters
  • BRCA1 degradation in response to mitochondrial damage in breast cancer cells
    Sci Rep. 2021 Apr 22;11(1):8735. doi: 10.1038/s41598-021-87698-7.ABSTRACTBRCA1 is a well-studied tumor suppressor involved in the homologous repair of DNA damage, whereas PINK1, a mitochondrial serine/threonine kinase, is known to be involved in mitochondrial quality control. Genetic mutations of PINK1 and Parkin cause autosomal recessive early-onset Parkinson's disease. We found that in breast cancer cells, the mitochondrial targeting reagents, which all ... read more
    Source: PubMedPublished on 2021-04-23By Kana Miyahara
  • Improved motor outcome prediction in Parkinson’s disease applying deep learning to DaTscan SPECT images
    Comput Biol Med. 2021 Mar 6;132:104312. doi: 10.1016/j.compbiomed.2021.104312. Online ahead of print.ABSTRACTPURPOSE: Dopamine transporter (DAT) SPECT imaging is routinely used in the diagnosis of Parkinson's disease (PD). Our previous efforts demonstrated the use of DAT SPECT images in a data-driven manner by improving prediction of PD clinical assessment outcome using radiomic features. In this work, we develop a convolutional neural ... read more
    Source: PubMedPublished on 2021-04-23By Matthew P Adams
  • Structural and functional neuroimaging changes associated with cognitive impairment and dementia in Parkinson’s disease
    Psychiatry Res Neuroimaging. 2021 Apr 8;312:111273. doi: 10.1016/j.pscychresns.2021.111273. Online ahead of print.ABSTRACTThis study seeks a better understanding of possible pathophysiological mechanisms associated with cognitive impairment and dementia in Parkinson's disease using structural and functional MRI. We investigated resting-state functional connectivity of important subdivisions of the caudate nucleus, putamen and thalamus, and also how the morphology of these structures are impacted ... read more
    Source: PubMedPublished on 2021-04-23By Conor Owens-Walton
  • Correlation between the brain activity with gait imagery and gait performance in adults with Parkinson’s disease: A data set
    Data Brief. 2021 Mar 23;36:106993. doi: 10.1016/j.dib.2021.106993. eCollection 2021 Jun.ABSTRACTThis article describes data related to the research study entitled "The neural correlate of gait improvement by rhythmic sound stimulation in adults with Parkinson's disease - A functional magnetic resonance imaging study" [1]. We evaluated gait performance using the 10-meter walk test (10MWT) in adults with Parkinson's disease (PD) and age-matched ... read more
    Source: PubMedPublished on 2021-04-23By Daisuke Nishida
  • Simple, rapid and sensitive detection of Parkinson’s disease related alpha-synuclein using a DNA aptamer assisted liquid crystal biosensor
    Soft Matter. 2021 Apr 23. doi: 10.1039/d1sm00298h. Online ahead of print.ABSTRACTAlpha-synuclein (αS) has been proposed as a potential biomarker for the diagnosis of Parkinson's disease (PD). However, the detection of αS using a simple, rapid and sensitive approach is still challenging. Herein, we construct a new type of biosensor for the detection of αS, combining the stimuli-responsiveness of liquid crystals ... read more
    Source: PubMedPublished on 2021-04-23By Xiuxiu Yang
  • Apathy: Neurobiology, Assessment and Treatment
    Clin Psychopharmacol Neurosci. 2021 May 31;19(2):181-189. doi: 10.9758/cpn.2021.19.2.181.ABSTRACTApathy is a highly prevalent, disabling and treatment resistant syndrome. It is defined as a quantitative reduction of goal-directed activity in comparison to the patient's previous level of in multiple dimensions including behavior/cognition, emotion and social interaction. It has been described in major depressive disorder, Alzheimer's disease, frontotemporal dementia, Parkinson's Disease, cerebrovascular disease, ... read more
    Source: PubMedPublished on 2021-04-23By Mario Fahed
  • Editorial: Celebrating the Diversity of Genetic Research to Dissect the Pathogenesis of Parkinson’s Disease
    Front Neurol. 2021 Apr 6;12:648417. doi: 10.3389/fneur.2021.648417. eCollection 2021.NO ABSTRACTPMID:33889126 | PMC:PMC8056125 | DOI:10.3389/fneur.2021.648417 ... read more
    Source: PubMedPublished on 2021-04-23By Matthew J Farrer
  • BRCA1 degradation in response to mitochondrial damage in breast cancer cells
    Sci Rep. 2021 Apr 22;11(1):8735. doi: 10.1038/s41598-021-87698-7.ABSTRACTBRCA1 is a well-studied tumor suppressor involved in the homologous repair of DNA damage, whereas PINK1, a mitochondrial serine/threonine kinase, is known to be involved in mitochondrial quality control. Genetic mutations of PINK1 and Parkin cause autosomal recessive early-onset Parkinson's disease. We found that in breast cancer cells, the mitochondrial targeting reagents, which all ... read more
    Source: PubMedPublished on 2021-04-23By Kana Miyahara
  • Apathy: Neurobiology, Assessment and Treatment
    Clin Psychopharmacol Neurosci. 2021 May 31;19(2):181-189. doi: 10.9758/cpn.2021.19.2.181.ABSTRACTApathy is a highly prevalent, disabling and treatment resistant syndrome. It is defined as a quantitative reduction of goal-directed activity in comparison to the patient's previous level of in multiple dimensions including behavior/cognition, emotion and social interaction. It has been described in major depressive disorder, Alzheimer's disease, frontotemporal dementia, Parkinson's Disease, cerebrovascular disease, ... read more
    Source: PubMedPublished on 2021-04-23By Mario Fahed
  • Cannabinoid receptor-1 has an effect on CD200 under rotenone and alpha-synuclein induced stress
    Neurosci Lett. 2021 Apr 20:135908. doi: 10.1016/j.neulet.2021.135908. Online ahead of print.ABSTRACTDecades after identifying cannabinoids and their beneficial effects on Parkinson's disease (PD), many gaps are still missing. Although, CB2-dependent actions have been shown as underlying positive effects of cannabinoid treatment, in recent years, another receptor of cannabinoids, CB1, emerged as a valuable player in cannabinoid-induced neuroprotection. Remarkably, the effects of ... read more
    Source: PubMedPublished on 2021-04-23By Fatma Nihan Cankara
  • High-fat diet-induced activation of SGK1 promotes Alzheimer’s disease-associated tau pathology
    Hum Mol Genet. 2021 Apr 22:ddab115. doi: 10.1093/hmg/ddab115. Online ahead of print.ABSTRACTType2 diabetes mellitus (T2DM) has long been considered a risk factor for Alzheimer's disease (ad). However, the molecular links between T2DM and ad remain obscure. Here, we reported that serum/glucocorticoid-regulated kinase1 (SGK1) is activated by administering a chronic high-fat diet (HFD), which increases the risk of T2DM, and thus ... read more
    Source: PubMedPublished on 2021-04-23By Montasir Elahi
  • Coordinated Reset Vibrotactile Stimulation Induces Sustained Cumulative Benefits in Parkinson’s Disease
    Front Physiol. 2021 Apr 6;12:624317. doi: 10.3389/fphys.2021.624317. eCollection 2021.ABSTRACTBACKGROUND: Abnormal synchronization of neuronal activity in dopaminergic circuits is related to motor impairment in Parkinson's disease (PD). Vibrotactile coordinated reset (vCR) fingertip stimulation aims to counteract excessive synchronization and induce sustained unlearning of pathologic synaptic connectivity and neuronal synchrony. Here, we report two clinical feasibility studies that examine the effect of ... read more
    Source: PubMedPublished on 2021-04-23By Kristina J Pfeifer
  • Excessive daytime sleepiness is associated with an increased frequency of falls and sarcopenia
    Exp Gerontol. 2021 Apr 20:111364. doi: 10.1016/j.exger.2021.111364. Online ahead of print.ABSTRACTBACKGROUND: This cross-sectional study aimed to examine associations between excessive daytime sleepiness (EDS) with falls and falls related conditions in older adults.METHODS: To assess EDS, the Epworth Sleepiness Scale was used, with a score of ≥11/24 points indicating EDS. Number of falls and fall history (at least one) in the ... read more
    Source: PubMedPublished on 2021-04-23By Pinar Soysal
  • VPS13D bridges the ER to mitochondria and peroxisomes via Miro
    J Cell Biol. 2021 May 3;220(5):e202010004. doi: 10.1083/jcb.202010004.ABSTRACTMitochondria, which are excluded from the secretory pathway, depend on lipid transport proteins for their lipid supply from the ER, where most lipids are synthesized. In yeast, the outer mitochondrial membrane GTPase Gem1 is an accessory factor of ERMES, an ER-mitochondria tethering complex that contains lipid transport domains and that functions, partially redundantly ... read more
    Source: PubMedPublished on 2021-04-23By Andrés Guillén-Samander
  • Impact of Subthalamic Deep Brain Stimulation on Hyposmia in Patients With Parkinson’s Disease Is Influenced by Constipation and Dysbiosis of Microbiota
    Front Neurol. 2021 Apr 6;12:653833. doi: 10.3389/fneur.2021.653833. eCollection 2021.ABSTRACTBackground: Non-motor symptoms in PD usually arise at very early stage and vary during the whole disease progression. Deep brain stimulation (DBS) is considered as a highly efficient treatment option for PD's motor function. However, the effect of DBS on NMS, especially hyposmia, has not been fully understood and the deep connection ... read more
    Source: PubMedPublished on 2021-04-23By Chao Li
  • Identification of a nanomolar affinity α-synuclein fibril imaging probe by ultra-high throughput in silico screening
    Chem Sci. 2020 Sep 10;11(47):12746-12754. doi: 10.1039/d0sc02159h. eCollection 2020 Dec 21.ABSTRACTSmall molecules that bind with high affinity and specificity to fibrils of the α-synuclein (αS) protein have the potential to serve as positron emission tomography (PET) imaging probes to aid in the diagnosis of Parkinson's disease and related synucleinopathies. To identify such molecules, we employed an ultra-high throughput in silico ... read more
    Source: PubMedPublished on 2021-04-23By John J Ferrie
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