PD Latest Research

Related ArticlesBeta Amyloid Deposition Is Not Associated With Cognitive Impairment in Parkinson's Disease. Front Neurol. 2019;10:391 Authors: Melzer TR, Stark MR, Keenan RJ, Myall DJ, MacAskill MR, Pitcher TL, Livingston L, Grenfell S, Horne KL, Young BN, Pascoe MJ, Almuqbel MM, Wang J, Marsh SH, Miller DH, Dalrymple-Alford JC, Anderson TJ Abstract The extent to which Alzheimer neuropathology, particularly the ... read more

Related ArticlesEffects of Neurotrophic Factors in Glial Cells in the Central Nervous System: Expression and Properties in Neurodegeneration and Injury. Front Physiol. 2019;10:486 Authors: Pöyhönen S, Er S, Domanskyi A, Airavaara M Abstract Astrocytes, oligodendrocytes, and microglia are abundant cell types found in the central nervous system and have been shown to play crucial roles in regulating both normal and ... read more

Related ArticlesInhibition of SIRT2 by Targeting GSK3β-Mediated Phosphorylation Alleviates SIRT2 Toxicity in SH-SY5Y Cells. Front Cell Neurosci. 2019;13:148 Authors: Liu S, Zhou Z, Zhang L, Meng S, Li S, Wang X Abstract Sirtuin 2 (SIRT2) is thought to be important in the pathogenesis of Parkinson's disease (PD), and the inhibition of SIRT2 rescues α-synuclein toxicity in a cellular model of ... read more

Related ArticlesSpreading of α-Synuclein and Tau: A Systematic Comparison of the Mechanisms Involved. Front Mol Neurosci. 2019;12:107 Authors: Vasili E, Dominguez-Meijide A, Outeiro TF Abstract Alzheimer's disease (AD) and Parkinson's disease (PD) are age-associated neurodegenerative disorders characterized by the misfolding and aggregation of alpha-synuclein (aSyn) and tau, respectively. The coexistence of aSyn and tau aggregates suggests a strong overlap between ... read more

Related ArticlesLipostatic Mechanisms Preserving Cerebellar Lipids in MPTP-Treated Mice: Focus on Membrane Microdomains and Lipid-Related Gene Expression. Front Mol Neurosci. 2019;12:93 Authors: Díaz M, Luis-Amaro AC, Rodriguez Barreto D, Casañas-Sánchez V, Pérez JA, Marin R Abstract The cerebellum is an essential component in the control of motor patterns. Despite dramatic alteration of basal ganglia morpho-functionality in Parkinson's disease (PD), cerebellar ... read more

Endurance exercise reduces cortisol in Parkinson's disease with mild cognitive impairment. Mov Disord. 2019 May 20;: Authors: Smyth N, Skender E, David FJ, Munoz MJ, Fantuzzi G, Clow A, Goldman JG, Corcos DM PMID: 31107979 [PubMed - as supplied by publisher] ... read more

Related ArticlesMammalian Models of Traumatic Brain Injury and a Place for Drosophila in TBI Research. Front Neurosci. 2019;13:409 Authors: Shah EJ, Gurdziel K, Ruden DM Abstract Traumatic brain injury (TBI), caused by a sudden blow or jolt to the brain that disrupts normal function, is an emerging health epidemic with ∼2.5 million cases occurring annually in the United States that ... read more

Related ArticlesAnti-HMGB1 monoclonal antibody therapy for a wide range of CNS and PNS diseases. J Pharmacol Sci. 2019 May 04;: Authors: Nishibori M, Mori S, Takahashi HK Abstract High mobility group box-1 (HMGB1), a representative damage associated-molecular pattern (DAMP), has been reported to be involved in many inflammatory diseases. Several drugs are thought to have potential to control the translocation ... read more

Related ArticlesIntraoperative test stimulation of the subthalamic nucleus aids postoperative programming of chronic stimulation settings in Parkinson's disease. Parkinsonism Relat Disord. 2019 May 11;: Authors: Geraedts VJ, van Ham RAP, Marinus J, van Hilten JJ, Mosch A, Hoffmann CFE, van der Gaag NA, Contarino MF Abstract BACKGROUND: It is unknown whether intraoperative testing during awake Deep Brain Stimulation (DBS) of ... read more

Related ArticlesParkinsonian patients do not utilize probabilistic advance information in a grip-lift task. Parkinsonism Relat Disord. 2019 May 10;: Authors: Trampenau L, Kuhtz-Buschbeck JP, van Eimeren T Abstract INTRODUCTION: Patients with Parkinson's disease (PD) are known to have decision-making impairments in tasks involving probabilistic information. How PD patients utilize task-relevant probabilistic advance information to plan and initiate common motor tasks ... read more

Related ArticlesL-dopa responsiveness in early Parkinson's disease is associated with the rate of motor progression. Parkinsonism Relat Disord. 2019 May 14;: Authors: Malek N, Kanavou S, Lawton MA, Pitz V, Grosset KA, Bajaj N, Barker RA, Ben-Shlomo Y, Burn DJ, Foltynie T, Hardy J, Williams NM, Wood N, Morris HR, Grosset DG, PRoBaND clinical consortium Abstract BACKGROUND: L-dopa responsiveness in ... read more

Related ArticlesCVT-301 for the treatment of Parkinson's disease. Expert Rev Neurother. 2019 May 19;: Authors: Shpiner DS, Bette S, Di Luca DG, Margolesky J Abstract INTRODUCTION: For patients with Parkinson's disease (PD), the treatment of motor and nonmotor fluctuations is tantamount to maintaining quality of life. Subcutaneous apomorphine has been the only commercially available rescue therapy for the treatment of ... read more

Related ArticlesBehavioural and Cognitive Changes in Lewy Body Dementias. Behav Neurol. 2018;2018:2404191 Authors: Kung WM, Ho YJ, Yoshizawa H, Matsuo S, Wei CY PMID: 30534208 [PubMed - indexed for MEDLINE] ... read more

Related ArticlesCorrespondence relating to "an updated diagnostic approach to subtype definition of vascular parkinsonism - Recommendations from an expert working group". Parkinsonism Relat Disord. 2018 07;52:109-110 Authors: Levin OS PMID: 29555417 [PubMed - indexed for MEDLINE] ... read more

Related ArticlesCharacteristics of iodine-123 IQ-SPECT/CT imaging compared with conventional SPECT/CT. Ann Nucl Med. 2019 Feb;33(2):103-111 Authors: Shibutani T, Onoguchi M, Yoneyama H, Konishi T, Matsuo S, Nakajima K Abstract OBJECTIVES: Although the utility of IQ-SPECT imaging using 99mTc and 201Tl myocardial perfusion SPECT has been reported, 123I-labeled myocardial SPECT has not been fully evaluated. We determined the characteristics and ... read more

Related ArticlesSubtype definition of vascular parkinsonism. Parkinsonism Relat Disord. 2018 07;52:107-108 Authors: Rektor I, Bohnen NI, Korczyn AD PMID: 29544882 [PubMed - indexed for MEDLINE] ... read more

Related Articles[Bilateral Pallidal Deep Brain Stimulation for Dystonic Camptocormia Induced by Repetitive Abdominal Muscle Exercise:A Case Report]. No Shinkei Geka. 2019 May;47(5):537-541 Authors: Oka M, Horisawa S, Takeda N, Taira T, Kawamata T Abstract Camptocormia is a rare and disabling movement disorder resulting in forward bending of the trunk. Camptocormia has many etiologies, although it is frequently observed patients with ... read more

Early- vs late-start levodopa relieved symptoms but did not affect disease progression in Parkinson disease. Ann Intern Med. 2019 May 21;170(10):JC56 Authors: Friedman JH PMID: 31108518 [PubMed - in process] ... read more

Video-based assessments of the hind limb stepping in a mouse model of hemi-parkinsonism. Neurosci Res. 2019 May 16;: Authors: Ogawa M, Zhou Y, Tsuji R, Goto S, Kasahara J Abstract Unilateral injection of 6-hydroxydopamine (6-OHDA) is commonly used to generate a rodent model of Parkinson's disease (PD). Although motor deficits of the lower extremities represent one of the major clinical ... read more

Similarities And Differences Of Gait Patterns In Women And Men With Parkinson's Disease With Mild Disability. Arch Phys Med Rehabil. 2019 May 16;: Authors: Porta M, Pilloni G, Arippa F, Casula C, Cossu G, Pau M Abstract OBJECTIVE: This study aimed to quantitatively investigate the existence of differences in spatio-temporal and kinematic parameters of gait in men and women with ... read more

Progression of Parkinson's disease patients' subtypes based on cortical thinning: 4-year follow-up. Parkinsonism Relat Disord. 2019 May 11;: Authors: Uribe C, Segura B, Baggio HC, Abos A, Garcia-Diaz AI, Campabadal A, Marti MJ, Valldeoriola F, Compta Y, Bargallo N, Junque C Abstract BACKGROUND: Three cortical atrophy patterns were previously identified in non-demented Parkinson's disease patients using a data-driven approach based ... read more

McLeod syndrome: Five new pedigrees with novel mutations. Parkinsonism Relat Disord. 2019 May 02;: Authors: Weaver J, Sarva H, Barone D, Bobker S, Bushara K, Hiller A, Ishii M, Jankovic J, Lakhani S, Niotis K, Scharre DW, Tuite P, Stutz A, Westhoff CM, Walker RH Abstract OBJECTIVE: To present five new McLeod Syndrome (MLS) pedigrees with novel XK gene mutations, ... read more

Nocebo response in Parkinson's disease: A systematic review and meta-analysis. Parkinsonism Relat Disord. 2019 Apr 20;: Authors: Leal Rato M, Duarte GS, Ferreira AN, Alves M, Mainoli B, Teodoro T, Mestre TA, Costa J, Ferreira JJ Abstract OBJECTIVE: To estimate the magnitude of the nocebo response in Parkinson's disease and explore possible associations with study characteristics. METHODS: Databases were searched ... read more

Improvements in temporal and postural aspects of gait vary following single- and multi-modal training in individuals with Parkinson's disease. Parkinsonism Relat Disord. 2019 May 14;: Authors: Rosenfeldt AB, Penko AL, Streicher MC, Zimmerman NM, Koop MM, Alberts JL Abstract INTRODUCTION: Gait deteriorates under dual task conditions in individuals with Parkinson's disease (PD). Therapeutic interventions have the potential to improve dual ... read more

T2*-weighted MRI values correlate with motor and cognitive dysfunction in Parkinson's disease. Neurobiol Aging. 2019 Apr 11;80:91-98 Authors: Tambasco N, Paolini Paoletti F, Chiappiniello A, Lisetti V, Nigro P, Eusebi P, Chiarini P, Romoli M, Brahimi E, Simoni S, Filidei M, Floridi P, Tarducci R, Parnetti L, Calabresi P Abstract Brain iron load is one of the main neuropathologic hallmarks ... read more