Parkinson’s Disease Latest Research

Ultrasound-Guided Botulinum Toxin Injections into the Salivary Glands for the Treatment of Drooling. Isr Med Assoc J. 2019 Feb;21(2):116-119 Authors: Abboud WA, Nadel S, Hassin-Baer S, Arad A, Dobriyan A, Yahalom R Abstract BACKGROUND: Drooling is the unintentional loss of saliva from the mouth, usually caused by poor coordination of ... read more

Related ArticlesPill swallowing in Parkinson's disease: A prospective study based on flexible endoscopic evaluation of swallowing. Parkinsonism Relat Disord. 2019 Feb 04;: Authors: Buhmann C, Bihler M, Emich K, Hidding U, Pötter-Nerger M, Gerloff C, Niessen A, Flügel T, Koseki JC, Nienstedt JC, Pflug C Abstract BACKGROUND: This study evaluates ... read more

Related ArticlesCumulative multiple early life hits- a potent threat leading to neurological disorders. Brain Res Bull. 2019 Feb 13;: Authors: Sarkar T, Patro N, Patro IK Abstract Early life Stress is a worldwide concern linked with development of later life neurological disorder. Early developmental age is sensitive to many prominent ... read more

Related ArticlesAuthors' reply to: Takotsubo syndrome in Parkinson's disease requires extensive diagnostic workup. Hellenic J Cardiol. 2019 Feb 13;: Authors: Lazaros G, Dimitriadis K, Xanthopoulou M, Latsios G, Antoniou C, Lazarou E, Tousoulis D PMID: 30771480 [PubMed - as supplied by publisher] ... read more

Related ArticlesEffects of amantadine on corneal endothelium. Exp Eye Res. 2019 Feb 13;: Authors: Dudley CE, Morell AJ, Duffey ME, Patel SP Abstract PURPOSE: An adverse effect of amantadine, a drug used for Parkinson's disease, is corneal edema. While corneal endothelial cell loss is noted with amantadine toxicity, the reversibility ... read more

Related ArticlesCell Therapies for Parkinson's Disease. Clin Transl Sci. 2019 Feb 16;: Authors: Irion S PMID: 30771274 [PubMed - as supplied by publisher] ... read more

Related ArticlesGeneration and Analysis of Viral Vector-Mediated Rodent Models for Parkinson's Disease. Methods Mol Biol. 2019;1948:271-286 Authors: Karikari AA, Koprich JB, Ip CW Abstract The use of viral vector-mediated α-synuclein-overexpressing rodent models for Parkinson's disease has become increasingly accepted to study associated pathology and to use as a platform for ... read more

Related ArticlesExpression and Purification of Untagged α-Synuclein. Methods Mol Biol. 2019;1948:261-269 Authors: Powers AE, Patel DS Abstract α-Synuclein (αS) is an abundant neuronal protein which has been implicated, among others, in the pathogenesis of neurodegenerative diseases like Parkinson's disease (PD) and dementia with Lewy bodies (DLB). In fact, αS is ... read more

Related ArticlesSingle-Molecule FRET Detection of Early-Stage Conformations in α-Synuclein Aggregation. Methods Mol Biol. 2019;1948:221-233 Authors: Moosa MM, Ferreon JC, Ferreon ACM Abstract Misfolding and aggregation of α-synuclein are linked to many neurodegenerative disorders, including Parkinson's and Alzheimer's disease. Despite intense research efforts, detailed structural characterization of early conformational transitions that ... read more

Related ArticlesIn Situ Peroxidase Labeling and Mass Spectrometry of Alpha-Synuclein in Rat Cortical Neurons. Methods Mol Biol. 2019;1948:235-246 Authors: Sanz R, Ovando-Roche P, Udeshi ND, Carr SA, Chung CY, Khurana V Abstract In this chapter, we describe a novel ascorbate peroxidase (APEX)-based labeling method that in combination with mass spectrometry ... read more

Related ArticlesDetection of α-Synuclein in Biological Samples Using Mass Spectrometry. Methods Mol Biol. 2019;1948:209-220 Authors: Brinkmalm A, Öhrfelt A, Bhattacharjee P, Zetterberg H Abstract Here we describe a method using mass spectrometry to characterize and quantify immuno-enriched α-synuclein forms from biochemically fractionated brain tissue.PMID: 30771180 [PubMed - in process] ... read more

Related ArticlesMonitoring α-Synuclein Proteotoxicity in Drosophila Models. Methods Mol Biol. 2019;1948:199-208 Authors: Szabo A, Tofaris GK Abstract Parkinson's disease is the second most common neurodegenerative disease without cure. It is characterized by α-synuclein accumulation and aggregation in dopaminergic and other types of neurons. Because α-synuclein accumulation leads to a toxic ... read more

Related ArticlesMeasuring Mitochondrial Dysfunction Caused by Soluble α-Synuclein Oligomers. Methods Mol Biol. 2019;1948:183-198 Authors: Luth ES, Stavrovskaya IG Abstract Accumulation of misfolded αSyn and mitochondrial dysfunction are central features of Parkinson's disease. Growing evidence points to a relationship between these two phenomena as oligomeric α-synuclein (αSyn) can interact with mitochondria ... read more

Related ArticlesNeurotoxic effects of MPTP on mouse cerebral cortex: Modulation of neuroinflammation as a neuroprotective strategy. Mol Cell Neurosci. 2019 Feb 13;: Authors: Mendes MO, Rosa AI, Carvalho AN, Nunes MJ, Dionísio P, Rodrigues E, Costa D, Duarte-Silva S, Maciel P, Rodrigues CMP, Gama MJ, Castro-Caldas M Abstract Parkinson's disease ... read more

Related ArticlesProbing Structural Changes in Alpha-Synuclein by Nuclear Magnetic Resonance Spectroscopy. Methods Mol Biol. 2019;1948:157-181 Authors: Das T, Eliezer D Abstract Alpha-synuclein, the principal protein involved in the pathogenesis of Parkinson's disease, has been shown to exchange between multiple conformational states, with hitherto unclear physiological role of such conformational changes. ... read more

Related ArticlesYeast-Based Screens to Target Alpha-Synuclein Toxicity. Methods Mol Biol. 2019;1948:145-156 Authors: Brás IC, Popova B, Braus GH, Outeiro TF Abstract The budding yeast Saccharomyces cerevisiae (S. cerevisiae) has been a remarkable experimental model for the discovery of fundamental biological processes. The high degree of conservation of cellular and molecular ... read more

Related ArticlesAlpha-Synuclein Proximity Ligation Assay (AS-PLA) in Brain Sections to Probe for Alpha-Synuclein Oligomers. Methods Mol Biol. 2019;1948:69-76 Authors: Roberts RF, Bengoa-Vergniory N, Alegre-Abarrategui J Abstract Alpha-synuclein oligomers are thought to be toxic mediators of Parkinson's disease and other alpha-synucleinopathies, but their histological detection in situ in diseased brain has ... read more

Related ArticlesStudying α-Synuclein Conformation by Intact-Cell Cross-Linking. Methods Mol Biol. 2019;1948:77-91 Authors: Imberdis T, Fanning S, Newman A, Ramalingam N, Dettmer U Abstract β-Sheet-rich aggregates of α-synuclein (αS) are the hallmark neuropathology of Parkinson's disease (PD) and related synucleinopathies, whereas the native conformations of αS in healthy cells are under ... read more

Related ArticlesQuantification of Alpha-Synuclein in Biological Fluids by Electrochemiluminescence-Based Detection. Methods Mol Biol. 2019;1948:59-68 Authors: Kruse N, Mollenhauer B Abstract Several potential marker candidates for Parkinson's disease (PD) in cerebrospinal fluid (CSF) have been identified. These include α-synuclein, a major constituent of the intracellular aggregates Lewy bodies, a neuropathological hallmark ... read more

Related ArticlesStereotaxic Targeting of Alpha-Synuclein Pathology in Mouse Brain Using Preformed Fibrils. Methods Mol Biol. 2019;1948:45-57 Authors: Zhang B, Kehm V, Gathagan R, Leight SN, Trojanowski JQ, Lee VM, Luk KC Abstract The accumulation of intraneuronal inclusions containing misfolded alpha-synuclein (aSyn) within the central nervous system (CNS) is a common ... read more

Related ArticlesDetection of Misfolded α-Synuclein Aggregates in Cerebrospinal Fluid by the Protein Misfolding Cyclic Amplification Platform. Methods Mol Biol. 2019;1948:35-44 Authors: Concha-Marambio L, Shahnawaz M, Soto C Abstract Here, we describe a detailed protocol to set up the αS-PMCA assay using αS synthetic aggregates in buffer and to accurately detect ... read more

Related ArticlesKinetic Measurements of Endocytosis and Exocytosis in Cultured Neurons. Methods Mol Biol. 2019;1948:23-33 Authors: Vargas KJ Abstract The measurement of synaptic vesicle recycling in live neurons transfected with vesicular glutamate transporter fused to pHluorin (vGLUT-pHluorin) allows us to study exocytosis and endocytosis in neurons. When neurons are transfected with ... read more

Related ArticlesAssays for Neuronal Defects Caused by Early Formation of α-Synuclein Inclusions in Primary Cultured Neurons. Methods Mol Biol. 2019;1948:1-14 Authors: Volpicelli-Daley LA Abstract Parkinson's disease (PD) and dementia with Lewy bodies (DLB) are characterized by intracellular inclusions composed mostly of α-synuclein (Baba et al., Am J Pathol 152:879-884, 1998). ... read more

Related ArticlesAbnormal α-synuclein deposits in skin nerves: intra- and inter-laboratory reproducibility. Eur J Neurol. 2019 Feb 15;: Authors: Donadio V, Doppler K, Incensi A, Kuzkina A, Janzen A, Mayer G, Volkmann J, Rizzo G, Antelmi E, Plazzi G, Sommer C, Liguori R, Oertel WH Abstract BACKGROUND: Visualization of phosphorylated α-synuclein ... read more

Related ArticlesEnlightened PD: A novel treatment for Parkinson disease? Neurology. 2019 Feb 15;: Authors: Videnovic A, Messinis L PMID: 30770427 [PubMed - as supplied by publisher] ... read more