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  • Milestones in Tremor Research: 10 Years Later
    Mov Disord Clin Pract. 2022 Feb 26;9(4):429-435. doi: 10.1002/mdc3.13418. eCollection 2022 May.ABSTRACTMajor progress has occurred during the last decade in the field of tremor. From the clinical standpoint, a new classification has completely revised the nosology of tremor syndromes and has re-conceptualized essential tremor as a syndrome rather than a single disease entity, fueling an ongoing enlightened debate. Significant advances ... read more
    Source: PubMedPublished on 2022-05-18By Roberto Erro
  • Calcium carbonate supplementation causes motor dysfunction
    Exp Anim. 2022 May 17. doi: 10.1538/expanim.22-0011. Online ahead of print.ABSTRACTWe previously showed that a diet containing calcium carbonate causes impairments in spatial and recognition memory in mice. In this study, we investigated the effects of calcium carbonate supplementation on motor function. Motor function was determined using different tests that have been used to analyze different aspects of Parkinsonism. A ... read more
    Source: PubMedPublished on 2022-05-18By Ami Sugiura
  • Managing Parkinson’s during the COVID-19 pandemic: Perspectives from people living with Parkinson’s and health professionals
    J Clin Nurs. 2022 May 17. doi: 10.1111/jocn.16367. Online ahead of print.ABSTRACTOBJECTIVES: The aim of this study was to understand how people living with Parkinson's and healthcare professionals perceived their care management and interactions with health services were affected during the COVID-19 pandemic.BACKGROUND: During the COVID-19 pandemic, many governments introduced restrictions and services that support Parkinson's care management had to ... read more
    Source: PubMedPublished on 2022-05-18By Dia Soilemezi
  • Pearls & Oy-sters: Marionette walk in Parkinson’s disease: a rare dyskinetic-dystonic gait pattern complication improved by visual cueing
    Neurology. 2022 May 18:10.1212/WNL.0000000000200714. doi: 10.1212/WNL.0000000000200714. Online ahead of print.ABSTRACTWe report a case of a 60-year-old patient with a 10-year history of Parkinson's disease who developed a dyskinetic-dystonic gait pattern highly impacting his personal and social life. After multiple unsuccessful attempts to improve the clinical condition by adapting the pharmacological treatment, the patient underwent gait rehabilitation based on the use ... read more
    Source: PubMedPublished on 2022-05-18By Micol Avenali
  • Recent Advances in the Neural Control of Movements: Lessons for Functional Recovery
    Phys Ther Res. 2021 Sep 29;25(1):1-11. doi: 10.1298/ptr.R0018. eCollection 2022.ABSTRACTWe review the current views on the control and coordination of movements following the traditions set by Nikolai Bernstein. In particular, we focus on the theory of neural control of effectors - from motor units to individual muscles, to joints, limbs, and to the whole body - with spatial referent coordinates ... read more
    Source: PubMedPublished on 2022-05-18By Mark L Latash
  • Level I PD-MCI Using Global Cognitive Tests and the Risk for Parkinson’s Disease Dementia
    Mov Disord Clin Pract. 2022 Apr 29;9(4):479-483. doi: 10.1002/mdc3.13451. eCollection 2022 May.ABSTRACTBACKGROUND: The criteria for PD-MCI allow the use of global cognitive tests. Their predictive value for conversion from PD-MCI to PDD, especially compared to comprehensive neuropsychological assessment, is unknown.METHODS: The MDS PD-MCI Study Group combined four datasets containing global cognitive tests as well as a comprehensive neuropsychological assessment to ... read more
    Source: PubMedPublished on 2022-05-18By Judith A Boel
  • Negative DAT-SPECT in Old Onset Parkinson’s Disease: An Additional Pitfall?
    Mov Disord Clin Pract. 2022 Apr 15;9(4):530-534. doi: 10.1002/mdc3.13441. eCollection 2022 May.ABSTRACTBACKGROUND: Scans without evidence of dopaminergic deficit (SWEDDs) refer to patients clinically diagnosed with Parkinson's disease (PD), but showing normal findings on dopamine transporter single-photon emission computed tomography (DAT-SPECT). This entity remains highly debated, but recent findings suggesting that DAT-SPECT does not reflect either nigral cell bodies or striatal ... read more
    Source: PubMedPublished on 2022-05-18By Giovanni Palermo
  • Calcium carbonate supplementation causes motor dysfunction
    Exp Anim. 2022 May 17. doi: 10.1538/expanim.22-0011. Online ahead of print.ABSTRACTWe previously showed that a diet containing calcium carbonate causes impairments in spatial and recognition memory in mice. In this study, we investigated the effects of calcium carbonate supplementation on motor function. Motor function was determined using different tests that have been used to analyze different aspects of Parkinsonism. A ... read more
    Source: PubMedPublished on 2022-05-18By Ami Sugiura
  • Level I PD-MCI Using Global Cognitive Tests and the Risk for Parkinson’s Disease Dementia
    Mov Disord Clin Pract. 2022 Apr 29;9(4):479-483. doi: 10.1002/mdc3.13451. eCollection 2022 May.ABSTRACTBACKGROUND: The criteria for PD-MCI allow the use of global cognitive tests. Their predictive value for conversion from PD-MCI to PDD, especially compared to comprehensive neuropsychological assessment, is unknown.METHODS: The MDS PD-MCI Study Group combined four datasets containing global cognitive tests as well as a comprehensive neuropsychological assessment to ... read more
    Source: PubMedPublished on 2022-05-18By Judith A Boel
  • Managing Parkinson’s during the COVID-19 pandemic: Perspectives from people living with Parkinson’s and health professionals
    J Clin Nurs. 2022 May 17. doi: 10.1111/jocn.16367. Online ahead of print.ABSTRACTOBJECTIVES: The aim of this study was to understand how people living with Parkinson's and healthcare professionals perceived their care management and interactions with health services were affected during the COVID-19 pandemic.BACKGROUND: During the COVID-19 pandemic, many governments introduced restrictions and services that support Parkinson's care management had to ... read more
    Source: PubMedPublished on 2022-05-18By Dia Soilemezi
  • Antiphospholipid-Related Chorea: Two Case Reports and Role of Metabolic Imaging
    Mov Disord Clin Pract. 2022 Mar 28;9(4):516-521. doi: 10.1002/mdc3.13432. eCollection 2022 May.ABSTRACTBACKGROUND: Antiphospholipid syndrome (APS) is a complex acquired autoimmune disease with a wide clinical spectrum. Chorea is a rare neurological manifestation of APS.CASES: We report two elderly patients with APS-related chorea in whom functional imaging (18F-FDG positron emission tomography, FDG-PET) supported the diagnosis and compare our findings with existing ... read more
    Source: PubMedPublished on 2022-05-18By Lisa Lerjefors
  • Pearls & Oy-sters: Marionette walk in Parkinson’s disease: a rare dyskinetic-dystonic gait pattern complication improved by visual cueing
    Neurology. 2022 May 18:10.1212/WNL.0000000000200714. doi: 10.1212/WNL.0000000000200714. Online ahead of print.ABSTRACTWe report a case of a 60-year-old patient with a 10-year history of Parkinson's disease who developed a dyskinetic-dystonic gait pattern highly impacting his personal and social life. After multiple unsuccessful attempts to improve the clinical condition by adapting the pharmacological treatment, the patient underwent gait rehabilitation based on the use ... read more
    Source: PubMedPublished on 2022-05-18By Micol Avenali
  • Negative DAT-SPECT in Old Onset Parkinson’s Disease: An Additional Pitfall?
    Mov Disord Clin Pract. 2022 Apr 15;9(4):530-534. doi: 10.1002/mdc3.13441. eCollection 2022 May.ABSTRACTBACKGROUND: Scans without evidence of dopaminergic deficit (SWEDDs) refer to patients clinically diagnosed with Parkinson's disease (PD), but showing normal findings on dopamine transporter single-photon emission computed tomography (DAT-SPECT). This entity remains highly debated, but recent findings suggesting that DAT-SPECT does not reflect either nigral cell bodies or striatal ... read more
    Source: PubMedPublished on 2022-05-18By Giovanni Palermo
  • Caffeine, Chocolate and Adenosine A2A Receptor Antagonists in the Treatment of Parkinson’s Disease
    Fortschr Neurol Psychiatr. 2022 May 18. doi: 10.1055/a-1785-3632. Online ahead of print.ABSTRACTBACKGROUND: Patients with Parkinson's disease can apparently benefit from caffeine consumption, as a number of experimental and clinical studies have already shown.METHODS: The review examined the available literature on caffeine and Parkinson's disease.RESULTS: Caffeine can penetrate the blood-brain barrier and exerts its biological effects mainly by antagonizing adenosine receptors. ... read more
    Source: PubMedPublished on 2022-05-18By Heinz Reichmann
  • Milestones in Tremor Research: 10 Years Later
    Mov Disord Clin Pract. 2022 Feb 26;9(4):429-435. doi: 10.1002/mdc3.13418. eCollection 2022 May.ABSTRACTMajor progress has occurred during the last decade in the field of tremor. From the clinical standpoint, a new classification has completely revised the nosology of tremor syndromes and has re-conceptualized essential tremor as a syndrome rather than a single disease entity, fueling an ongoing enlightened debate. Significant advances ... read more
    Source: PubMedPublished on 2022-05-18By Roberto Erro
  • Recent Advances in the Neural Control of Movements: Lessons for Functional Recovery
    Phys Ther Res. 2021 Sep 29;25(1):1-11. doi: 10.1298/ptr.R0018. eCollection 2022.ABSTRACTWe review the current views on the control and coordination of movements following the traditions set by Nikolai Bernstein. In particular, we focus on the theory of neural control of effectors - from motor units to individual muscles, to joints, limbs, and to the whole body - with spatial referent coordinates ... read more
    Source: PubMedPublished on 2022-05-18By Mark L Latash
  • Level I PD-MCI Using Global Cognitive Tests and the Risk for Parkinson’s Disease Dementia
    Mov Disord Clin Pract. 2022 Apr 29;9(4):479-483. doi: 10.1002/mdc3.13451. eCollection 2022 May.ABSTRACTBACKGROUND: The criteria for PD-MCI allow the use of global cognitive tests. Their predictive value for conversion from PD-MCI to PDD, especially compared to comprehensive neuropsychological assessment, is unknown.METHODS: The MDS PD-MCI Study Group combined four datasets containing global cognitive tests as well as a comprehensive neuropsychological assessment to ... read more
    Source: PubMedPublished on 2022-05-18By Judith A Boel
  • Negative DAT-SPECT in Old Onset Parkinson’s Disease: An Additional Pitfall?
    Mov Disord Clin Pract. 2022 Apr 15;9(4):530-534. doi: 10.1002/mdc3.13441. eCollection 2022 May.ABSTRACTBACKGROUND: Scans without evidence of dopaminergic deficit (SWEDDs) refer to patients clinically diagnosed with Parkinson's disease (PD), but showing normal findings on dopamine transporter single-photon emission computed tomography (DAT-SPECT). This entity remains highly debated, but recent findings suggesting that DAT-SPECT does not reflect either nigral cell bodies or striatal ... read more
    Source: PubMedPublished on 2022-05-18By Giovanni Palermo
  • Exploring the multifactorial aspects of Gut Microbiome in Parkinson’s Disease
    Folia Microbiol (Praha). 2022 May 18. doi: 10.1007/s12223-022-00977-2. Online ahead of print.ABSTRACTAdvanced research in health science has broadened our view in approaching and understanding the pathophysiology of diseases and has also revolutionised diagnosis and treatment. Ever since the establishment of Braak's hypothesis in the propagation of alpha-synuclein from the distant olfactory and enteric nervous system towards the brain in Parkinson's ... read more
    Source: PubMedPublished on 2022-05-18By Sujith Pavan
  • Milestones in Tremor Research: 10 Years Later
    Mov Disord Clin Pract. 2022 Feb 26;9(4):429-435. doi: 10.1002/mdc3.13418. eCollection 2022 May.ABSTRACTMajor progress has occurred during the last decade in the field of tremor. From the clinical standpoint, a new classification has completely revised the nosology of tremor syndromes and has re-conceptualized essential tremor as a syndrome rather than a single disease entity, fueling an ongoing enlightened debate. Significant advances ... read more
    Source: PubMedPublished on 2022-05-18By Roberto Erro
  • Antiphospholipid-Related Chorea: Two Case Reports and Role of Metabolic Imaging
    Mov Disord Clin Pract. 2022 Mar 28;9(4):516-521. doi: 10.1002/mdc3.13432. eCollection 2022 May.ABSTRACTBACKGROUND: Antiphospholipid syndrome (APS) is a complex acquired autoimmune disease with a wide clinical spectrum. Chorea is a rare neurological manifestation of APS.CASES: We report two elderly patients with APS-related chorea in whom functional imaging (18F-FDG positron emission tomography, FDG-PET) supported the diagnosis and compare our findings with existing ... read more
    Source: PubMedPublished on 2022-05-18By Lisa Lerjefors
  • Antiphospholipid-Related Chorea: Two Case Reports and Role of Metabolic Imaging
    Mov Disord Clin Pract. 2022 Mar 28;9(4):516-521. doi: 10.1002/mdc3.13432. eCollection 2022 May.ABSTRACTBACKGROUND: Antiphospholipid syndrome (APS) is a complex acquired autoimmune disease with a wide clinical spectrum. Chorea is a rare neurological manifestation of APS.CASES: We report two elderly patients with APS-related chorea in whom functional imaging (18F-FDG positron emission tomography, FDG-PET) supported the diagnosis and compare our findings with existing ... read more
    Source: PubMedPublished on 2022-05-18By Lisa Lerjefors
  • A Novel High-Throughput Screening Strategy for Targeting Alpha-Synuclein and Other Long-Lived Proteins
    SLAS Discov. 2022 May 14:S2472-5552(22)13673-7. doi: 10.1016/j.slasd.2022.05.001. Online ahead of print.ABSTRACTSmall-molecule high-throughput screening (HTS) campaigns have frequently been used to identify lead molecules that can alter expression of disease-relevant proteins in cell-based assays. However, most cell-based HTS assays require short compound exposure periods to avoid toxicity and ensure that compounds are stable in media for the duration of the exposure. ... read more
    Source: PubMedPublished on 2022-05-17By Evan Casalino
  • Association of angiotensin receptor blockers with incident Parkinson’s disease in patients with hypertension: A retrospective cohort study
    Am J Med. 2022 May 14:S0002-9343(22)00351-5. doi: 10.1016/j.amjmed.2022.04.029. Online ahead of print.ABSTRACTBACKGROUND: Angiotensin receptor blockers (ARBs), which are commonly used antihypertensives, have been proposed to lower the risk of Parkinson's disease by reducing oxidative stress based on animal and in vitro studies. Thus, this study aimed to test this association in patients with newly diagnosed hypertension.METHODS: This retrospective cohort study ... read more
    Source: PubMedPublished on 2022-05-17By Hsiu-Chen Lin
  • Functional connectivity maps of theta/alpha and beta coherence within the subthalamic nucleus region
    Neuroimage. 2022 May 14:119320. doi: 10.1016/j.neuroimage.2022.119320. Online ahead of print.ABSTRACTThe subthalamic nucleus (STN) is a primary target for deep brain stimulation in Parkinson's disease (PD). Although small in size, the STN is commonly partitioned into sensorimotor, cognitive/associative, and limbic subregions based on its structural connectivity profile to cortical areas. We investigated whether such a regional specialization is also supported by ... read more
    Source: PubMedPublished on 2022-05-17By Bernadette C M van Wijk
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