PD Latest Research

Mov Disord Clin Pract. 2022 Feb 26;9(4):429-435. doi: 10.1002/mdc3.13418. eCollection 2022 May.ABSTRACTMajor progress has occurred during the last decade in the field of tremor. From the clinical standpoint, a new classification has completely revised the nosology of tremor syndromes and has re-conceptualized essential tremor as a syndrome rather than a single disease entity, fueling an ongoing enlightened debate. Significant advances ... read more

Exp Anim. 2022 May 17. doi: 10.1538/expanim.22-0011. Online ahead of print.ABSTRACTWe previously showed that a diet containing calcium carbonate causes impairments in spatial and recognition memory in mice. In this study, we investigated the effects of calcium carbonate supplementation on motor function. Motor function was determined using different tests that have been used to analyze different aspects of Parkinsonism. A ... read more

J Clin Nurs. 2022 May 17. doi: 10.1111/jocn.16367. Online ahead of print.ABSTRACTOBJECTIVES: The aim of this study was to understand how people living with Parkinson's and healthcare professionals perceived their care management and interactions with health services were affected during the COVID-19 pandemic.BACKGROUND: During the COVID-19 pandemic, many governments introduced restrictions and services that support Parkinson's care management had to ... read more

Neurology. 2022 May 18:10.1212/WNL.0000000000200714. doi: 10.1212/WNL.0000000000200714. Online ahead of print.ABSTRACTWe report a case of a 60-year-old patient with a 10-year history of Parkinson's disease who developed a dyskinetic-dystonic gait pattern highly impacting his personal and social life. After multiple unsuccessful attempts to improve the clinical condition by adapting the pharmacological treatment, the patient underwent gait rehabilitation based on the use ... read more

Phys Ther Res. 2021 Sep 29;25(1):1-11. doi: 10.1298/ptr.R0018. eCollection 2022.ABSTRACTWe review the current views on the control and coordination of movements following the traditions set by Nikolai Bernstein. In particular, we focus on the theory of neural control of effectors - from motor units to individual muscles, to joints, limbs, and to the whole body - with spatial referent coordinates ... read more

Mov Disord Clin Pract. 2022 Apr 29;9(4):479-483. doi: 10.1002/mdc3.13451. eCollection 2022 May.ABSTRACTBACKGROUND: The criteria for PD-MCI allow the use of global cognitive tests. Their predictive value for conversion from PD-MCI to PDD, especially compared to comprehensive neuropsychological assessment, is unknown.METHODS: The MDS PD-MCI Study Group combined four datasets containing global cognitive tests as well as a comprehensive neuropsychological assessment to ... read more

Mov Disord Clin Pract. 2022 Apr 15;9(4):530-534. doi: 10.1002/mdc3.13441. eCollection 2022 May.ABSTRACTBACKGROUND: Scans without evidence of dopaminergic deficit (SWEDDs) refer to patients clinically diagnosed with Parkinson's disease (PD), but showing normal findings on dopamine transporter single-photon emission computed tomography (DAT-SPECT). This entity remains highly debated, but recent findings suggesting that DAT-SPECT does not reflect either nigral cell bodies or striatal ... read more

Exp Anim. 2022 May 17. doi: 10.1538/expanim.22-0011. Online ahead of print.ABSTRACTWe previously showed that a diet containing calcium carbonate causes impairments in spatial and recognition memory in mice. In this study, we investigated the effects of calcium carbonate supplementation on motor function. Motor function was determined using different tests that have been used to analyze different aspects of Parkinsonism. A ... read more

Mov Disord Clin Pract. 2022 Apr 29;9(4):479-483. doi: 10.1002/mdc3.13451. eCollection 2022 May.ABSTRACTBACKGROUND: The criteria for PD-MCI allow the use of global cognitive tests. Their predictive value for conversion from PD-MCI to PDD, especially compared to comprehensive neuropsychological assessment, is unknown.METHODS: The MDS PD-MCI Study Group combined four datasets containing global cognitive tests as well as a comprehensive neuropsychological assessment to ... read more

J Clin Nurs. 2022 May 17. doi: 10.1111/jocn.16367. Online ahead of print.ABSTRACTOBJECTIVES: The aim of this study was to understand how people living with Parkinson's and healthcare professionals perceived their care management and interactions with health services were affected during the COVID-19 pandemic.BACKGROUND: During the COVID-19 pandemic, many governments introduced restrictions and services that support Parkinson's care management had to ... read more

Mov Disord Clin Pract. 2022 Mar 28;9(4):516-521. doi: 10.1002/mdc3.13432. eCollection 2022 May.ABSTRACTBACKGROUND: Antiphospholipid syndrome (APS) is a complex acquired autoimmune disease with a wide clinical spectrum. Chorea is a rare neurological manifestation of APS.CASES: We report two elderly patients with APS-related chorea in whom functional imaging (18F-FDG positron emission tomography, FDG-PET) supported the diagnosis and compare our findings with existing ... read more

Neurology. 2022 May 18:10.1212/WNL.0000000000200714. doi: 10.1212/WNL.0000000000200714. Online ahead of print.ABSTRACTWe report a case of a 60-year-old patient with a 10-year history of Parkinson's disease who developed a dyskinetic-dystonic gait pattern highly impacting his personal and social life. After multiple unsuccessful attempts to improve the clinical condition by adapting the pharmacological treatment, the patient underwent gait rehabilitation based on the use ... read more

Mov Disord Clin Pract. 2022 Apr 15;9(4):530-534. doi: 10.1002/mdc3.13441. eCollection 2022 May.ABSTRACTBACKGROUND: Scans without evidence of dopaminergic deficit (SWEDDs) refer to patients clinically diagnosed with Parkinson's disease (PD), but showing normal findings on dopamine transporter single-photon emission computed tomography (DAT-SPECT). This entity remains highly debated, but recent findings suggesting that DAT-SPECT does not reflect either nigral cell bodies or striatal ... read more

Fortschr Neurol Psychiatr. 2022 May 18. doi: 10.1055/a-1785-3632. Online ahead of print.ABSTRACTBACKGROUND: Patients with Parkinson's disease can apparently benefit from caffeine consumption, as a number of experimental and clinical studies have already shown.METHODS: The review examined the available literature on caffeine and Parkinson's disease.RESULTS: Caffeine can penetrate the blood-brain barrier and exerts its biological effects mainly by antagonizing adenosine receptors. ... read more

Mov Disord Clin Pract. 2022 Feb 26;9(4):429-435. doi: 10.1002/mdc3.13418. eCollection 2022 May.ABSTRACTMajor progress has occurred during the last decade in the field of tremor. From the clinical standpoint, a new classification has completely revised the nosology of tremor syndromes and has re-conceptualized essential tremor as a syndrome rather than a single disease entity, fueling an ongoing enlightened debate. Significant advances ... read more

Phys Ther Res. 2021 Sep 29;25(1):1-11. doi: 10.1298/ptr.R0018. eCollection 2022.ABSTRACTWe review the current views on the control and coordination of movements following the traditions set by Nikolai Bernstein. In particular, we focus on the theory of neural control of effectors - from motor units to individual muscles, to joints, limbs, and to the whole body - with spatial referent coordinates ... read more

Mov Disord Clin Pract. 2022 Apr 29;9(4):479-483. doi: 10.1002/mdc3.13451. eCollection 2022 May.ABSTRACTBACKGROUND: The criteria for PD-MCI allow the use of global cognitive tests. Their predictive value for conversion from PD-MCI to PDD, especially compared to comprehensive neuropsychological assessment, is unknown.METHODS: The MDS PD-MCI Study Group combined four datasets containing global cognitive tests as well as a comprehensive neuropsychological assessment to ... read more

Mov Disord Clin Pract. 2022 Apr 15;9(4):530-534. doi: 10.1002/mdc3.13441. eCollection 2022 May.ABSTRACTBACKGROUND: Scans without evidence of dopaminergic deficit (SWEDDs) refer to patients clinically diagnosed with Parkinson's disease (PD), but showing normal findings on dopamine transporter single-photon emission computed tomography (DAT-SPECT). This entity remains highly debated, but recent findings suggesting that DAT-SPECT does not reflect either nigral cell bodies or striatal ... read more

Folia Microbiol (Praha). 2022 May 18. doi: 10.1007/s12223-022-00977-2. Online ahead of print.ABSTRACTAdvanced research in health science has broadened our view in approaching and understanding the pathophysiology of diseases and has also revolutionised diagnosis and treatment. Ever since the establishment of Braak's hypothesis in the propagation of alpha-synuclein from the distant olfactory and enteric nervous system towards the brain in Parkinson's ... read more

Mov Disord Clin Pract. 2022 Feb 26;9(4):429-435. doi: 10.1002/mdc3.13418. eCollection 2022 May.ABSTRACTMajor progress has occurred during the last decade in the field of tremor. From the clinical standpoint, a new classification has completely revised the nosology of tremor syndromes and has re-conceptualized essential tremor as a syndrome rather than a single disease entity, fueling an ongoing enlightened debate. Significant advances ... read more

Mov Disord Clin Pract. 2022 Mar 28;9(4):516-521. doi: 10.1002/mdc3.13432. eCollection 2022 May.ABSTRACTBACKGROUND: Antiphospholipid syndrome (APS) is a complex acquired autoimmune disease with a wide clinical spectrum. Chorea is a rare neurological manifestation of APS.CASES: We report two elderly patients with APS-related chorea in whom functional imaging (18F-FDG positron emission tomography, FDG-PET) supported the diagnosis and compare our findings with existing ... read more

Mov Disord Clin Pract. 2022 Mar 28;9(4):516-521. doi: 10.1002/mdc3.13432. eCollection 2022 May.ABSTRACTBACKGROUND: Antiphospholipid syndrome (APS) is a complex acquired autoimmune disease with a wide clinical spectrum. Chorea is a rare neurological manifestation of APS.CASES: We report two elderly patients with APS-related chorea in whom functional imaging (18F-FDG positron emission tomography, FDG-PET) supported the diagnosis and compare our findings with existing ... read more

SLAS Discov. 2022 May 14:S2472-5552(22)13673-7. doi: 10.1016/j.slasd.2022.05.001. Online ahead of print.ABSTRACTSmall-molecule high-throughput screening (HTS) campaigns have frequently been used to identify lead molecules that can alter expression of disease-relevant proteins in cell-based assays. However, most cell-based HTS assays require short compound exposure periods to avoid toxicity and ensure that compounds are stable in media for the duration of the exposure. ... read more

Am J Med. 2022 May 14:S0002-9343(22)00351-5. doi: 10.1016/j.amjmed.2022.04.029. Online ahead of print.ABSTRACTBACKGROUND: Angiotensin receptor blockers (ARBs), which are commonly used antihypertensives, have been proposed to lower the risk of Parkinson's disease by reducing oxidative stress based on animal and in vitro studies. Thus, this study aimed to test this association in patients with newly diagnosed hypertension.METHODS: This retrospective cohort study ... read more

Neuroimage. 2022 May 14:119320. doi: 10.1016/j.neuroimage.2022.119320. Online ahead of print.ABSTRACTThe subthalamic nucleus (STN) is a primary target for deep brain stimulation in Parkinson's disease (PD). Although small in size, the STN is commonly partitioned into sensorimotor, cognitive/associative, and limbic subregions based on its structural connectivity profile to cortical areas. We investigated whether such a regional specialization is also supported by ... read more