PD Latest Research

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  • Proteomic profiling of idiopathic Parkinson’s disease primary patient cells by SWATH-MS
    Proteomics Clin Appl. 2022 May 17:e2200015. doi: 10.1002/prca.202200015. Online ahead of print.ABSTRACTPURPOSE: Parkinson's disease (PD) is the second most prevalent neurodegenerative disease. It is generally diagnosed clinically after the irreversible loss of dopaminergic neurons and no general biomarkers currently exist. To gain insight into the underlying cellular causes of PD we aimed to quantify the proteomic differences between healthy control ... read more
    Source: PubMedPublished on 2022-05-17By Stephen A Wood
  • The Effect of Rotigotine on Cognitive Function, Daytime Sleepiness, and Sleep Problems in Parkinson Disease: An Open-Label Pilot Study
    Clin Neuropharmacol. 2022 May-Jun 01;45(3):61-64. doi: 10.1097/WNF.0000000000000501.ABSTRACTBACKGROUND: We hypothesized that rotigotine may have a positive effect on cognitive function in patients with Parkinson disease (PD) by improving daytime motor function and sleep status.METHODS: Fifteen PD patients with sleep disturbances, defined as a PD Sleep Scale (PDSS)-2 score of 15 or greater, were included in this single-center, 3-month open-label study. Participants ... read more
    Source: PubMedPublished on 2022-05-17By Keisuke Suzuki
  • The Effect of Rotigotine on Cognitive Function, Daytime Sleepiness, and Sleep Problems in Parkinson Disease: An Open-Label Pilot Study
    Clin Neuropharmacol. 2022 May-Jun 01;45(3):61-64. doi: 10.1097/WNF.0000000000000501.ABSTRACTBACKGROUND: We hypothesized that rotigotine may have a positive effect on cognitive function in patients with Parkinson disease (PD) by improving daytime motor function and sleep status.METHODS: Fifteen PD patients with sleep disturbances, defined as a PD Sleep Scale (PDSS)-2 score of 15 or greater, were included in this single-center, 3-month open-label study. Participants ... read more
    Source: PubMedPublished on 2022-05-17By Keisuke Suzuki
  • Effect of an Amyloidogenic SARS-COV-2 Protein Fragment on α-Synuclein Monomers and Fibrils
    J Phys Chem B. 2022 May 17. doi: 10.1021/acs.jpcb.2c01254. Online ahead of print.ABSTRACTAggregates of α-synuclein are thought to be the disease-causing agent in Parkinson's disease. Various case studies have hinted at a correlation between COVID-19 and the onset of Parkinson's disease. For this reason, we use molecular dynamics simulations to study whether amyloidogenic regions in SARS-COV-2 proteins can initiate and ... read more
    Source: PubMedPublished on 2022-05-17By Asis K Jana
  • Proteomic profiling of idiopathic Parkinson’s disease primary patient cells by SWATH-MS
    Proteomics Clin Appl. 2022 May 17:e2200015. doi: 10.1002/prca.202200015. Online ahead of print.ABSTRACTPURPOSE: Parkinson's disease (PD) is the second most prevalent neurodegenerative disease. It is generally diagnosed clinically after the irreversible loss of dopaminergic neurons and no general biomarkers currently exist. To gain insight into the underlying cellular causes of PD we aimed to quantify the proteomic differences between healthy control ... read more
    Source: PubMedPublished on 2022-05-17By Stephen A Wood
  • Association of angiotensin receptor blockers with incident Parkinson’s disease in patients with hypertension: A retrospective cohort study
    Am J Med. 2022 May 14:S0002-9343(22)00351-5. doi: 10.1016/j.amjmed.2022.04.029. Online ahead of print.ABSTRACTBACKGROUND: Angiotensin receptor blockers (ARBs), which are commonly used antihypertensives, have been proposed to lower the risk of Parkinson's disease by reducing oxidative stress based on animal and in vitro studies. Thus, this study aimed to test this association in patients with newly diagnosed hypertension.METHODS: This retrospective cohort study ... read more
    Source: PubMedPublished on 2022-05-17By Hsiu-Chen Lin
  • Association of angiotensin receptor blockers with incident Parkinson’s disease in patients with hypertension: A retrospective cohort study
    Am J Med. 2022 May 14:S0002-9343(22)00351-5. doi: 10.1016/j.amjmed.2022.04.029. Online ahead of print.ABSTRACTBACKGROUND: Angiotensin receptor blockers (ARBs), which are commonly used antihypertensives, have been proposed to lower the risk of Parkinson's disease by reducing oxidative stress based on animal and in vitro studies. Thus, this study aimed to test this association in patients with newly diagnosed hypertension.METHODS: This retrospective cohort study ... read more
    Source: PubMedPublished on 2022-05-17By Hsiu-Chen Lin
  • Effect of an Amyloidogenic SARS-COV-2 Protein Fragment on α-Synuclein Monomers and Fibrils
    J Phys Chem B. 2022 May 17. doi: 10.1021/acs.jpcb.2c01254. Online ahead of print.ABSTRACTAggregates of α-synuclein are thought to be the disease-causing agent in Parkinson's disease. Various case studies have hinted at a correlation between COVID-19 and the onset of Parkinson's disease. For this reason, we use molecular dynamics simulations to study whether amyloidogenic regions in SARS-COV-2 proteins can initiate and ... read more
    Source: PubMedPublished on 2022-05-17By Asis K Jana
  • Effect of an Amyloidogenic SARS-COV-2 Protein Fragment on α-Synuclein Monomers and Fibrils
    J Phys Chem B. 2022 May 17. doi: 10.1021/acs.jpcb.2c01254. Online ahead of print.ABSTRACTAggregates of α-synuclein are thought to be the disease-causing agent in Parkinson's disease. Various case studies have hinted at a correlation between COVID-19 and the onset of Parkinson's disease. For this reason, we use molecular dynamics simulations to study whether amyloidogenic regions in SARS-COV-2 proteins can initiate and ... read more
    Source: PubMedPublished on 2022-05-17By Asis K Jana
  • A Novel High-Throughput Screening Strategy for Targeting Alpha-Synuclein and Other Long-Lived Proteins
    SLAS Discov. 2022 May 14:S2472-5552(22)13673-7. doi: 10.1016/j.slasd.2022.05.001. Online ahead of print.ABSTRACTSmall-molecule high-throughput screening (HTS) campaigns have frequently been used to identify lead molecules that can alter expression of disease-relevant proteins in cell-based assays. However, most cell-based HTS assays require short compound exposure periods to avoid toxicity and ensure that compounds are stable in media for the duration of the exposure. ... read more
    Source: PubMedPublished on 2022-05-17By Evan Casalino
  • Association of angiotensin receptor blockers with incident Parkinson’s disease in patients with hypertension: A retrospective cohort study
    Am J Med. 2022 May 14:S0002-9343(22)00351-5. doi: 10.1016/j.amjmed.2022.04.029. Online ahead of print.ABSTRACTBACKGROUND: Angiotensin receptor blockers (ARBs), which are commonly used antihypertensives, have been proposed to lower the risk of Parkinson's disease by reducing oxidative stress based on animal and in vitro studies. Thus, this study aimed to test this association in patients with newly diagnosed hypertension.METHODS: This retrospective cohort study ... read more
    Source: PubMedPublished on 2022-05-17By Hsiu-Chen Lin
  • Functional connectivity maps of theta/alpha and beta coherence within the subthalamic nucleus region
    Neuroimage. 2022 May 14:119320. doi: 10.1016/j.neuroimage.2022.119320. Online ahead of print.ABSTRACTThe subthalamic nucleus (STN) is a primary target for deep brain stimulation in Parkinson's disease (PD). Although small in size, the STN is commonly partitioned into sensorimotor, cognitive/associative, and limbic subregions based on its structural connectivity profile to cortical areas. We investigated whether such a regional specialization is also supported by ... read more
    Source: PubMedPublished on 2022-05-17By Bernadette C M van Wijk
  • Neuromodulation for lower urinary tract symptoms in special populations
    Neurourol Urodyn. 2022 May 17. doi: 10.1002/nau.24954. Online ahead of print.ABSTRACTAIMS: Discuss the efficacy, safety, and future directions of neuromodulation in special populations of patients with neurological conditions.METHODS: A literature review was done to find meta-analyses, review articles, studies, and case reports of the use of neuromodulation, either sacral neuromodulation or percutaneous tibial nerve stimulation, in patients with various neurological ... read more
    Source: PubMedPublished on 2022-05-17By Connie N Wang
  • A Novel High-Throughput Screening Strategy for Targeting Alpha-Synuclein and Other Long-Lived Proteins
    SLAS Discov. 2022 May 14:S2472-5552(22)13673-7. doi: 10.1016/j.slasd.2022.05.001. Online ahead of print.ABSTRACTSmall-molecule high-throughput screening (HTS) campaigns have frequently been used to identify lead molecules that can alter expression of disease-relevant proteins in cell-based assays. However, most cell-based HTS assays require short compound exposure periods to avoid toxicity and ensure that compounds are stable in media for the duration of the exposure. ... read more
    Source: PubMedPublished on 2022-05-17By Evan Casalino
  • Directing LRRK2 to membranes of the endolysosomal pathway triggers RAB phosphorylation and JIP4 recruitment
    Neurobiol Dis. 2022 May 14:105769. doi: 10.1016/j.nbd.2022.105769. Online ahead of print.ABSTRACTCoding mutations in the Leucine-rich repeat kinase 2 (LRRK2) gene, which are associated with dominantly inherited Parkinson's disease (PD), lead to an increased activity of the encoded LRRK2 protein kinase. As such, kinase inhibitors are being considered as therapeutic agents for PD. It is therefore of interest to understand the ... read more
    Source: PubMedPublished on 2022-05-17By Jillian H Kluss
  • Association between new-onset Parkinson’s disease and suicide risk in South Korea: a nationwide cohort study
    BMC Psychiatry. 2022 May 17;22(1):341. doi: 10.1186/s12888-022-03990-4.ABSTRACTBACKGROUND: Parkinson's disease (PD) is an increasingly common neurodegenerative disease in an aging society. Whether PD is associated with an increased suicide risk is unclear. Thus, we investigated the effect of new-onset PD on suicide.METHODS: Using the National Health Insurance Service Senior Sample Cohort of South Korea, 17,143 incident PD patients and 17,143 risk ... read more
    Source: PubMedPublished on 2022-05-17By Sung Hoon Jeong
  • Functional connectivity maps of theta/alpha and beta coherence within the subthalamic nucleus region
    Neuroimage. 2022 May 14:119320. doi: 10.1016/j.neuroimage.2022.119320. Online ahead of print.ABSTRACTThe subthalamic nucleus (STN) is a primary target for deep brain stimulation in Parkinson's disease (PD). Although small in size, the STN is commonly partitioned into sensorimotor, cognitive/associative, and limbic subregions based on its structural connectivity profile to cortical areas. We investigated whether such a regional specialization is also supported by ... read more
    Source: PubMedPublished on 2022-05-17By Bernadette C M van Wijk
  • Synergistic deciphering of bioenergy production and electron transport characteristics to screen traditional Chinese medicine (TCM) for COVID-19 drug development
    J Taiwan Inst Chem Eng. 2022 Jun;135:104365. doi: 10.1016/j.jtice.2022.104365. Epub 2022 May 12.ABSTRACTBACKGROUND: Traditional Chinese medicine (TCM) has been used as an "immune booster" for disease prevention and clinical treatment since ancient China. However, many studies were focused on the organic herbal extract rather than aqueous herbal extract (AHE; decoction). Due to the COVID-19 pandemics, this study tended to decipher ... read more
    Source: PubMedPublished on 2022-05-17By Po-Wei Tsai
  • Can We Treat Neurodegenerative Proteinopathies by Enhancing Protein Degradation?
    Mov Disord. 2022 May 17. doi: 10.1002/mds.29058. Online ahead of print.ABSTRACTNeurodegenerative proteinopathies are defined as a class of neurodegenerative disorders, with either genetic or sporadic age-related onset, characterized by the pathological accumulation of aggregated protein deposits. These mainly include Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), Huntington's disease (HD) as well as frontotemporal lobar degeneration (FTLD). The ... read more
    Source: PubMedPublished on 2022-05-17By Simone Engelender
  • Directing LRRK2 to membranes of the endolysosomal pathway triggers RAB phosphorylation and JIP4 recruitment
    Neurobiol Dis. 2022 May 14:105769. doi: 10.1016/j.nbd.2022.105769. Online ahead of print.ABSTRACTCoding mutations in the Leucine-rich repeat kinase 2 (LRRK2) gene, which are associated with dominantly inherited Parkinson's disease (PD), lead to an increased activity of the encoded LRRK2 protein kinase. As such, kinase inhibitors are being considered as therapeutic agents for PD. It is therefore of interest to understand the ... read more
    Source: PubMedPublished on 2022-05-17By Jillian H Kluss
  • Prevalence and Correlates of Psychiatric Comorbidity and Multimorbidity in Parkinson’s Disease and Atypical Parkinsonian Syndromes
    J Geriatr Psychiatry Neurol. 2022 May 17:8919887221103575. doi: 10.1177/08919887221103575. Online ahead of print.ABSTRACTPURPOSE: Psychiatric comorbidity in Parkinson's disease (PD) and atypical parkinsonian syndromes (APS) has been consistently associated with poor outcomes. However, the co-occurrence of multiple psychiatric disorders has been sparsely studied. This study examines the prevalence, patterns, and correlates of psychiatric comorbidity and multimorbidity among in-patients hospitalised with PD/APS.METHODS: ... read more
    Source: PubMedPublished on 2022-05-17By Vinit Patel
  • Nasal Caffeine Thermo-Sensitive in Situ Gel for Enhanced Cognition after Sleep-Deprivation
    Curr Drug Deliv. 2022 May 9. doi: 10.2174/1567201819666220509192200. Online ahead of print.ABSTRACTBACKGROUND: Caffeine abundant in coffee has strong excitation effect on the central nerve system (CNS).METHODS: In order to combat the adverse effects of sleep deprivation on physical and mental health, this article designed a new nasal temperature-sensitive gel loaded with caffeine, whose effects of awakening and improving cognition in ... read more
    Source: PubMedPublished on 2022-05-17By Siqing Zhu
  • Prevalence and Correlates of Psychiatric Comorbidity and Multimorbidity in Parkinson’s Disease and Atypical Parkinsonian Syndromes
    J Geriatr Psychiatry Neurol. 2022 May 17:8919887221103575. doi: 10.1177/08919887221103575. Online ahead of print.ABSTRACTPURPOSE: Psychiatric comorbidity in Parkinson's disease (PD) and atypical parkinsonian syndromes (APS) has been consistently associated with poor outcomes. However, the co-occurrence of multiple psychiatric disorders has been sparsely studied. This study examines the prevalence, patterns, and correlates of psychiatric comorbidity and multimorbidity among in-patients hospitalised with PD/APS.METHODS: ... read more
    Source: PubMedPublished on 2022-05-17By Vinit Patel
  • The implications of the foot health status in Parkinson patients: A case-control study
    Int Wound J. 2022 May 17. doi: 10.1111/iwj.13844. Online ahead of print.ABSTRACTParkinson's disease (PD) is a neurodegenerative disorder that affects both health of the feet, as to gait patterns. This study aimed to find out about foot problems and their impact on self-perceived quality of life and related to foot health in Parkinson's patients compared to a group of healthy ... read more
    Source: PubMedPublished on 2022-05-17By Ana María Jiménez-Cebrián
  • Association between new-onset Parkinson’s disease and suicide risk in South Korea: a nationwide cohort study
    BMC Psychiatry. 2022 May 17;22(1):341. doi: 10.1186/s12888-022-03990-4.ABSTRACTBACKGROUND: Parkinson's disease (PD) is an increasingly common neurodegenerative disease in an aging society. Whether PD is associated with an increased suicide risk is unclear. Thus, we investigated the effect of new-onset PD on suicide.METHODS: Using the National Health Insurance Service Senior Sample Cohort of South Korea, 17,143 incident PD patients and 17,143 risk ... read more
    Source: PubMedPublished on 2022-05-17By Sung Hoon Jeong
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