PD Latest Research

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  • Probiotic Enhancement of Antioxidant Capacity and Alterations of Gut Microbiota Composition in 6-Hydroxydopamin-Induced Parkinson’s Disease Rats
    Antioxidants (Basel). 2021 Nov 17;10(11):1823. doi: 10.3390/antiox10111823.ABSTRACTOxidative stress plays a key role in the degeneration of dopaminergic neurons in Parkinson's disease (PD), which may be aggravated by concomitant PD-associated gut dysbiosis. Probiotics and prebiotics are therapeutically relevant to these conditions due to their antioxidant, anti-inflammatory, and gut microbiome modulation properties. However, the mechanisms by which probiotic/prebiotic supplementation affects antioxidant capacity ... read more
    Source: PubMedPublished on 2021-11-27By Shu-Ping Tsao
  • Advancement of PD Is Reflected by White Matter Changes in Olfactory Areas: A Pilot Study
    Medicina (Kaunas). 2021 Nov 1;57(11):1183. doi: 10.3390/medicina57111183.ABSTRACTLoss of sense of smell is a well-known non-motor symptom of Parkinson's disease (PD). Here, we present insight into the association between PD advancement and equivalents of smell loss in olfactory-eloquent brain areas, such as the posterior cortex and orbitofrontal cortex. Twelve PD patients in different Hoehn and Yahr stages and 12 healthy normosmic ... read more
    Source: PubMedPublished on 2021-11-27By Thomas Hummel
  • Anti-Inflammatory Effects of the Novel Barbiturate Derivative MHY2699 in an MPTP-Induced Mouse Model of Parkinson’s Disease
    Antioxidants (Basel). 2021 Nov 22;10(11):1855. doi: 10.3390/antiox10111855.ABSTRACTParkinson's disease (PD) is one of the most common neurodegenerative disorders, and is caused by the death of dopamine neurons and neuroinflammation in the striatum and substantia nigra. Furthermore, the inflammatory response in PD is closely related to glial cell activation. This study examined the neuroprotective effects of the barbiturate derivative, MHY2699 [5-(4-hydroxy 3,5-dimethoxybenzyl)-2 ... read more
    Source: PubMedPublished on 2021-11-27By Seulah Lee
  • Metals in ALS TDP-43 Pathology
    Int J Mol Sci. 2021 Nov 11;22(22):12193. doi: 10.3390/ijms222212193.ABSTRACTAmyotrophic lateral sclerosis (ALS), Alzheimer's disease, Parkinson's disease and similar neurodegenerative disorders take their toll on patients, caregivers and society. A common denominator for these disorders is the accumulation of aggregated proteins in nerve cells, yet the triggers for these aggregation processes are currently unknown. In ALS, protein aggregation has been described ... read more
    Source: PubMedPublished on 2021-11-27By Lassi Koski
  • L-dopa-Dependent Effects of GLP-1R Agonists on the Survival of Dopaminergic Cells Transplanted into a Rat Model of Parkinson Disease
    Int J Mol Sci. 2021 Nov 16;22(22):12346. doi: 10.3390/ijms222212346.ABSTRACTCell therapy is a promising treatment for Parkinson's disease (PD), however clinical trials to date have shown relatively low survival and significant patient-to-patient variability. Glucagon Like Peptide-1 receptor (GLP-1R) agonists have potential neuroprotective effects on endogenous dopaminergic neurons. This study explores whether these agents could similarly support the growth and survival of ... read more
    Source: PubMedPublished on 2021-11-27By Osama F Elabi
  • Autophagy in α-Synucleinopathies-An Overstrained System
    Cells. 2021 Nov 12;10(11):3143. doi: 10.3390/cells10113143.ABSTRACTAlpha-synucleinopathies comprise progressive neurodegenerative diseases, including Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). They all exhibit the same pathological hallmark, which is the formation of α-synuclein positive deposits in neuronal or glial cells. The aggregation of α-synuclein in the cell body of neurons, giving rise to the so-called Lewy ... read more
    Source: PubMedPublished on 2021-11-27By Lisa Fellner
  • Protein Misfolding and Aggregation: The Relatedness between Parkinson’s Disease and Hepatic Endoplasmic Reticulum Storage Disorders
    Int J Mol Sci. 2021 Nov 18;22(22):12467. doi: 10.3390/ijms222212467.ABSTRACTDysfunction of cellular homeostasis can lead to misfolding of proteins thus acquiring conformations prone to polymerization into pathological aggregates. This process is associated with several disorders, including neurodegenerative diseases, such as Parkinson's disease (PD), and endoplasmic reticulum storage disorders (ERSDs), like alpha-1-antitrypsin deficiency (AATD) and hereditary hypofibrinogenemia with hepatic storage (HHHS). Given ... read more
    Source: PubMedPublished on 2021-11-27By Francisco J Padilla-Godínez
  • Future Trends in Semiconducting Gas-Selective Sensing Probes for Skin Diagnostics
    Sensors (Basel). 2021 Nov 13;21(22):7554. doi: 10.3390/s21227554.ABSTRACTThis paper presents sensor nanotechnologies that can be used for the skin-based gas "smelling" of disease. Skin testing may provide rapid and reliable results, using specific "fingerprints" or unique patterns for a variety of diseases and conditions. These can include metabolic diseases, such as diabetes and cholesterol-induced heart disease; neurological diseases, such as Alzheimer's ... read more
    Source: PubMedPublished on 2021-11-27By Anthony Annerino
  • Lentiviral Vectors Expressing Chimeric NEDD4 Ubiquitin Ligases: An Innovative Approach for Interfering with Alpha-Synuclein Accumulation
    Cells. 2021 Nov 21;10(11):3256. doi: 10.3390/cells10113256.ABSTRACTOne of the main pathological features of Parkinson's disease (PD) is a diffuse accumulation of alpha-synuclein (aS) aggregates in neurons. The NEDD4 E3 Ub ligase promotes aS degradation by the endosomal-lysosomal route. Interestingly, NEDD4, as well as being a small molecule able to trigger its functions, is protective against human aS toxicity in evolutionary distant ... read more
    Source: PubMedPublished on 2021-11-27By Stefania Vogiatzis
  • The Clinical Significance of Cerebrospinal Fluid Reticulon 4 (RTN4) Levels in the Differential Diagnosis of Neurodegenerative Diseases
    J Clin Med. 2021 Nov 13;10(22):5281. doi: 10.3390/jcm10225281.ABSTRACTNeurodegenerative diseases (NDs) belong to the top global causes of mortality. Diagnostic approaches to improve early diagnosis and differentiation of these diseases are constantly being sought. Therefore, we aimed to assess the cerebrospinal fluid (CSF) concentrations of Reticulon 4 (RTN4) in patients with neurodegenerative diseases and evaluate the potential clinical usefulness of this ... read more
    Source: PubMedPublished on 2021-11-27By Agnieszka Kulczyńska-Przybik
  • The Clinical Significance of Cerebrospinal Fluid Reticulon 4 (RTN4) Levels in the Differential Diagnosis of Neurodegenerative Diseases
    J Clin Med. 2021 Nov 13;10(22):5281. doi: 10.3390/jcm10225281.ABSTRACTNeurodegenerative diseases (NDs) belong to the top global causes of mortality. Diagnostic approaches to improve early diagnosis and differentiation of these diseases are constantly being sought. Therefore, we aimed to assess the cerebrospinal fluid (CSF) concentrations of Reticulon 4 (RTN4) in patients with neurodegenerative diseases and evaluate the potential clinical usefulness of this ... read more
    Source: PubMedPublished on 2021-11-27By Agnieszka Kulczyńska-Przybik
  • Altered Development of Mesencephalic Dopaminergic Neurons in SIDS: New Insights into Understanding Sudden Infant Death Pathogenesis
    Biomedicines. 2021 Oct 26;9(11):1534. doi: 10.3390/biomedicines9111534.ABSTRACTSudden infant death syndrome (SIDS) is defined as the unexpected sudden death of an infant under 1 year of age that remains unexplained after a thorough case investigation. The SIDS pathogenesis is still unknown; however, abnormalities in brain centers that control breathing and arousal from sleep, including dramatic changes in neurotransmitter levels, have been supposed ... read more
    Source: PubMedPublished on 2021-11-27By Anna Maria Lavezzi
  • Diet Quality and Risk of Parkinson’s Disease: The Rotterdam Study
    Nutrients. 2021 Nov 7;13(11):3970. doi: 10.3390/nu13113970.ABSTRACTThe Mediterranean diet has been associated with the risk of Parkinson's disease (PD), but limited research has been performed on other dietary patterns. We studied the relationship between overall diet quality and PD risk in the general population. We included 9414 participants from the Rotterdam Study, a prospective population-based study in the Netherlands. Diet was ... read more
    Source: PubMedPublished on 2021-11-27By Anne J Strikwerda
  • Validation of a Sensor-Based Gait Analysis System with a Gold-Standard Motion Capture System in Patients with Parkinson’s Disease
    Sensors (Basel). 2021 Nov 18;21(22):7680. doi: 10.3390/s21227680.ABSTRACTDigital technologies provide the opportunity to analyze gait patterns in patients with Parkinson's Disease using wearable sensors in clinical settings and a home environment. Confirming the technical validity of inertial sensors with a 3D motion capture system is a necessary step for the clinical application of sensor-based gait analysis. Therefore, the objective of this ... read more
    Source: PubMedPublished on 2021-11-27By Verena Jakob
  • A Possible Role for HMG-CoA Reductase Inhibitors and Its Association with HMGCR Genetic Variation in Parkinson’s Disease
    Int J Mol Sci. 2021 Nov 11;22(22):12198. doi: 10.3390/ijms222212198.ABSTRACTParkinson's disease (PD) is the second most common neurodegenerative disease characterised by both motor- and non-motor symptoms, including cognitive impairment. The aetiopathogenesis of PD, as well as its protective and susceptibility factors, are still elusive. Neuroprotective effects of 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase inhibitors-statins-via both cholesterol-dependent and independent mechanisms have been shown in ... read more
    Source: PubMedPublished on 2021-11-27By Anna Pierzchlińska
  • BiP Heterozigosity Aggravates Pathological Deterioration in Experimental Amyotrophic Lateral Sclerosis
    Int J Mol Sci. 2021 Nov 20;22(22):12533. doi: 10.3390/ijms222212533.ABSTRACTIn the present study, we investigated the involvement of the chaperone protein BiP (also known as GRP78 or Hspa5), a master regulator of intracellular proteostasis, in two mouse models of neurodegenerative diseases: amyotrophic lateral sclerosis (ALS) and Parkinson's disease (PD). To this end, we used mice bearing partial genetic deletion of the ... read more
    Source: PubMedPublished on 2021-11-27By Marta Gómez-Almería
  • Role of Vitamin D in Cognitive Dysfunction: New Molecular Concepts and Discrepancies between Animal and Human Findings
    Nutrients. 2021 Oct 20;13(11):3672. doi: 10.3390/nu13113672.ABSTRACTPURPOSE OF REVIEW: increasing evidence suggests that besides the several metabolic, endocrine, and immune functions of 1alpha,25-dihydroxyvitamin D (1,25(OH)2D), the neuronal effects of 1,25(OH)2D should also be considered an essential contributor to the development of cognition in the early years and its maintenance in aging. The developmental disabilities induced by vitamin D deficiency (VDD) include ... read more
    Source: PubMedPublished on 2021-11-27By Zsolt Gáll
  • Aberrant Patterns of Sensory-Evoked Activity in the Olfactory Bulb of LRRK2 Knockout Mice
    Cells. 2021 Nov 17;10(11):3212. doi: 10.3390/cells10113212.ABSTRACTThe LRRK2 gene is the major genetic determinant of familiar Parkinson's disease (PD). Leucine-rich repeat kinase 2 (LRRK2) is a multidomain protein involved in several intracellular signaling pathways. A wealth of evidence indicates that LRRK2 is enriched at the presynaptic compartment where it regulates vesicle trafficking and neurotransmitter release. However, whether the role of LRRK2 ... read more
    Source: PubMedPublished on 2021-11-27By Andrea Maset
  • Ferroptosis as a Major Factor and Therapeutic Target for Neuroinflammation in Parkinson’s Disease
    Biomedicines. 2021 Nov 12;9(11):1679. doi: 10.3390/biomedicines9111679.ABSTRACTMounting evidence suggests that ferroptosis is not just a consequence but also a fundamental contributor to the development and progression of Parkinson's disease (PD). Ferroptosis is characterized as iron-dependent regulated cell death caused by excessive lipid peroxidation, leading to plasma membrane rupture, release of damage-associated molecular patterns, and neuroinflammation. Due to the crucial role of ... read more
    Source: PubMedPublished on 2021-11-27By Chih-Jan Ko
  • Diet Quality and Risk of Parkinson’s Disease: The Rotterdam Study
    Nutrients. 2021 Nov 7;13(11):3970. doi: 10.3390/nu13113970.ABSTRACTThe Mediterranean diet has been associated with the risk of Parkinson's disease (PD), but limited research has been performed on other dietary patterns. We studied the relationship between overall diet quality and PD risk in the general population. We included 9414 participants from the Rotterdam Study, a prospective population-based study in the Netherlands. Diet was ... read more
    Source: PubMedPublished on 2021-11-27By Anne J Strikwerda
  • (De)stabilization of Alpha-Synuclein Fibrillary Aggregation by Charged and Uncharged Surfactants
    Int J Mol Sci. 2021 Nov 19;22(22):12509. doi: 10.3390/ijms222212509.ABSTRACTParkinson's disease (PD) is the second most common neurodegenerative disorder. An important hallmark of PD involves the pathological aggregation of proteins in structures known as Lewy bodies. The major component of these proteinaceous inclusions is alpha (α)-synuclein. In different conditions, α-synuclein can assume conformations rich in either α-helix or β-sheets. The mechanisms ... read more
    Source: PubMedPublished on 2021-11-27By Joana Angélica Loureiro
  • Fabrication of Skin-Mountable Flexible Sensor Patch for Monitoring of Swallowing Function
    Methods Mol Biol. 2022;2393:863-876. doi: 10.1007/978-1-0716-1803-5_46.ABSTRACTSwallowing is a critical function that enables humans to sustain life. When swallowing is compromised, the consequences can be devastating and include malnutrition, dehydration, respiratory compromise, and even death. Swallowing disorders (i.e., dysphagia) are very common in many disorders and diseases, such as stroke, ALS, Parkinson disease, and more, and in fact millions of people ... read more
    Source: PubMedPublished on 2021-11-27By Heun Park
  • Correlation between Serum Zinc Levels and Levodopa in Parkinson’s Disease
    Nutrients. 2021 Nov 17;13(11):4114. doi: 10.3390/nu13114114.ABSTRACTLong-term intake of potential zinc-chelating drugs may cause zinc deficiency. We postulated that zinc deficiency in Parkinson's disease (PD) patients was related to the intake of drugs such as levodopa. We investigated the relationship between zinc levels and levodopa administration period, dosage, and symptoms of zinc deficiency in PD patients. We measured serum zinc levels ... read more
    Source: PubMedPublished on 2021-11-27By Hirofumi Matsuyama
  • Examining the Toxicity of α-Synuclein in Neurodegenerative Disorders
    Life (Basel). 2021 Oct 22;11(11):1126. doi: 10.3390/life11111126.ABSTRACTα-synuclein is considered the main pathological protein in a variety of neurodegenerative disorders, such as Parkinson's disease, multiple system atrophy, and dementia with Lewy bodies. As of now, numerous studies have been aimed at examining the post-translational modifications of α-synuclein to determine their effects on α-synuclein aggregation, propagation, and oligomerization, as well as the ... read more
    Source: PubMedPublished on 2021-11-27By Frank Y Shan
  • Aberrant Patterns of Sensory-Evoked Activity in the Olfactory Bulb of LRRK2 Knockout Mice
    Cells. 2021 Nov 17;10(11):3212. doi: 10.3390/cells10113212.ABSTRACTThe LRRK2 gene is the major genetic determinant of familiar Parkinson's disease (PD). Leucine-rich repeat kinase 2 (LRRK2) is a multidomain protein involved in several intracellular signaling pathways. A wealth of evidence indicates that LRRK2 is enriched at the presynaptic compartment where it regulates vesicle trafficking and neurotransmitter release. However, whether the role of LRRK2 ... read more
    Source: PubMedPublished on 2021-11-27By Andrea Maset
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