PD Research News

Researchers injected a modified segment of the amyloid precursor protein into mouse models of Alzheimer's disease. The treatment appeared to reverse a number of the cognitive and memory problems associated with the neurodegenerative disease. ... read more

Moral emotions are significantly more impaired than emotions without moral content in those with frontotemporal dementia (FTD). By contrast, those with Alzheimer's disease exhibit similar performance in both moral and extra-moral emotions as healthy subjects. The findings provide a novel biomarker for the diagnosis of FTD. ... read more

Study provides first concrete examples of how the microbiome can interfere with a drug's intended path throughout the body. ... read more

Intelligence, education and participating in cognitively challenging tasks may stave off the effects of dementia for longer, but can not protect against the inevitable Alzheimer's pathology in those at risk. ... read more

Mouse study shows that focused ultrasound and injected microbubbles can help curb early Parkinson's disease by allowing drugs to access the brain. ... read more

Researchers from Japan have tested a new gene therapy against Parkinson's disease using mouse models. Their results suggest that the approach is effective. ... read more

Using transcranial focused ultrasound in combination with injectable microbubbles, researchers open a pathway through the blood-brain barrier. The technique allows drugs to penetrate the brain and trigger therapeutic effects for those with neurodegenerative diseases. ... read more

Using induced pluripotent stem cells derived from patients with neurodegenerative disorders, researcher recreated the blood-brain barrier inside Organ-Chips. ... read more

Researchers have discovered a new mechanism that brain cells use to protect themselves from protein aggregates. Such aggregates play a key role in Parkinson's and other neurodegenerative diseases. ... read more

Researchers have developed a technique that could open up new ways to facilitate targeted drug delivery into the brain, enabling drugs to treat brain diseases more focally. They used transcranial, focused ultrasound and intravenously injected microbubbles into the blood-brain barrier (BBB) to make a localized, transient opening that allows drugs to cross through the BBB reversibly and noninvasively. ... read more

(Columbia University School of Engineering and Applied Science) Researchers have developed a technique that could open up new ways to facilitate targeted drug delivery into the brain, enabling drugs to treat brain diseases more focally. They used transcranial, focused ultrasound and intravenously injected microbubbles into the blood-brain barrier (BBB) to make a localized, transient opening that allows drugs to cross ... read more

(ETH Zurich) ETH researchers have discovered a new mechanism that brain cells use to protect themselves from protein aggregates. Such aggregates play a key role in Parkinson's and other neurodegenerative diseases. This new finding might provide the basis for new therapeutic approaches. ... read more

  This post provides an overview of activities on Day 1 at the World Parkinson’s Congress meeting in Kyoto. After a spectacular opening ceremony the night before, Day 1 began with some impressive keynote presentations. Then came a series of fascinating workshops and roundtables before ... read more

(Osaka University) Parkinson's disease (PD) is a progressive neurodegenerative disease affecting millions of people worldwide. Characterized by accumulation of the protein α-synuclein, there is currently no cure for PD. In a new study published this month in Scientific Reports, a research team led by Osaka University designed small fragments of DNA that bind to α-synuclein mRNA, preventing it from being ... read more

(American Friends of Tel Aviv University) New research from Tel Aviv University may lead to the early detection of Parkinson's disease, which can lead to treatment that has the potential to significantly delay the progression of the disease. ... read more

(Parkinson's UK) Results from a study published today looking at a molecule targeting clumps of alpha-synuclein, a key protein linked to Parkinson's, offers hope that it may be possible to slow down or prevent the progression of the condition in humans. ... read more

  Every three years the Parkinson’s community – patients, families, researchers, and clinicians – comes together to learn from each other, discuss where we are, and explore where we should be going. The World Parkinson’s Congress (or WPC) is a very special event – rather ... read more

Brushing your teeth may be a way to stave off the development of Alzheimer's disease. Study provides new evidence of how bacteria associated with gingivitis contributes to the development of the neurodegenerative disease. ... read more

A new study will investigate the effects of exercise and eating a Mediterranean style diet has on the development of dementia, and whether a change in lifestyle has neuroprotective properties. Researchers are looking for volunteers between 55 and 74 years of age to participate in the study. ... read more

  At the end of each month the SoPD writes a post which provides an overview of some of the major pieces of Parkinson’s-related research that were made available during May 2019. The post is divided into seven parts based on the type of research: ... read more

  On 31st May in 2017, Tom Isaacs – one of the co-founder of the the Cure Parkinson’s Trust – passed away suddenly. It was a terrible shock for the Parkinson’s community, many of whom saw Tom as a leader of advocacy efforts. In today’s ... read more

(Cleveland Clinic) The National Institutes of Health has awarded Cleveland Clinic researcher Jay Alberts, Ph.D, a 5-year, $3 million grant to conduct a multi-site clinical trial to study the long-term effects of aerobic exercise on slowing the progression of Parkinson's disease. ... read more

Older adults who experience problems completing simple financial tasks, such as calculating their change, may be at increased risk of Alzheimer's disease. Problems with financial management have often been associated with later stage dementia. A new study reveals this could be one of the earliest signs of dementia and may be correlated with a build-up of amyloid plaque deposits. ... read more

Connexins play a critical role in the uptake and transfer of Parkinson's related proteins from one cell to another. The findings may help with the development of new treatments for Parkinson's disease. ... read more

Tiny channels between nerve cells are involved in a newly discovered mechanism of how Parkinson's disease can spread throughout the brain, according to new research from Linköping University, Sweden. The results demonstrate that harmful protein aggregates, or deposits, can bind and 'hitch a lift' with channel-forming proteins, and in this way spread to healthy cells. The study has been published ... read more