autophagy

In an otherwise slow holiday week, University of Cambridge researchers are suggesting that an existing high blood pressure medication might be repurposed to treat Parkinson’s Disease. Felodipine, at proportionally low doses was able to induce autophagy and clean out misfolded proteins in a mouse model of Parkinson’s. There is a lot more research needed as more PD research increasingly targets autophagy: https://www.eurekalert.org/pub_releases/2019-04/uoc-bpd041619.php This study reminds me of another high blood pressure medication, isradipine, which saw positive results in an animal model study 12 years ago. Researchers have recently completed a 3 year phase 3 study of isradipine, and these latest ...

Why I am experimenting with intermittent fasting to see if it helps my Parkinson's symptoms... Let me state this categorically, I am not suggesting that anyone should begin fasting in an attempt to help with their Parkinson's symptoms. Amongst other concerns, many people who are diagnosed with PD experience unexpected weight loss, and fasting does not seem safe in that scenario. There also may be concerns about fasting and some prescription medications. If you are considering this at all, please discuss with your doctor first. That said, fasting, or more specifically intermittent fasting (IF) is something that I am experimenting ...